4js2 - Revision history

OCA at 19:23, 29 May 2024

2024-05-29T19:23:47Z

← Older revision		Revision as of 19:23, 29 May 2024
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	<table><tr><td colspan='2'>[[4js2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JS2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JS2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4js2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JS2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JS2 FirstGlance]. <br>
	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=C5P:CYTIDINE-5-MONOPHOSPHATE'>C5P</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4js2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4js2 OCA], [https://pdbe.org/4js2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4js2 RCSB], [https://www.ebi.ac.uk/pdbsum/4js2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4js2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4js2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4js2 OCA], [https://pdbe.org/4js2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4js2 RCSB], [https://www.ebi.ac.uk/pdbsum/4js2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4js2 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 14:25, 8 November 2023

2023-11-08T14:25:42Z

← Older revision		Revision as of 14:25, 8 November 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4js2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JS2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JS2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4js2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JS2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JS2 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4js2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4js2 OCA], [https://pdbe.org/4js2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4js2 RCSB], [https://www.ebi.ac.uk/pdbsum/4js2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4js2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4js2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4js2 OCA], [https://pdbe.org/4js2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4js2 RCSB], [https://www.ebi.ac.uk/pdbsum/4js2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4js2 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 11:33, 24 November 2022

2022-11-24T11:33:46Z

← Older revision		Revision as of 11:33, 24 November 2022
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	<StructureSection load='4js2' size='340' side='right'caption='[[4js2]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='4js2' size='340' side='right'caption='[[4js2]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4js2]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JS2 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4JS2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4js2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JS2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JS2 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene~~></td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4js1\|4js1]]</td></tr>~~		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4js2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4js2 OCA], [https://pdbe.org/4js2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4js2 RCSB], [https://www.ebi.ac.uk/pdbsum/4js2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4js2 ProSAT]</span></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ST6GAL1, SIAT1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-galactoside_alpha-2,6-sialyltransferase Beta-galactoside alpha-2,6-sialyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.99.1 2.4.99.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4js2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4js2 OCA], [~~http~~://pdbe.org/4js2 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4js2 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4js2 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4js2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/SIAT1_HUMAN SIAT1_HUMAN]] Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates.<ref>PMID:21081508</ref>		[https://www.uniprot.org/uniprot/SIAT1_HUMAN SIAT1_HUMAN] Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates.<ref>PMID:21081508</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	==See Also==		==See Also==
	*[[Sialyltransferase\|Sialyltransferase]]		*[[Sialyltransferase 3D structures\|Sialyltransferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Beta-galactoside alpha-2,6-sialyltransferase]]~~		[[Category: Homo sapiens]]
	~~[[Category: Human~~]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Benz, J]]		[[Category: Benz J]]
	[[Category: Engel~~, A M~~]]		[[Category: Engel AM]]
	[[Category: Greif, M]]		[[Category: Greif M]]
	[[Category: Kuhn, B]]		[[Category: Kuhn B]]
	[[Category: Rudolph~~, M G~~]]		[[Category: Rudolph MG]]
	[[Category: Sobek, H]]		[[Category: Sobek H]]
	~~[[Category: Endoplasmatic reticulum]]~~
	~~[[Category: Glycoprotein]]~~
	~~[[Category: Golgi]]~~
	~~[[Category: Gt-a]]~~
	~~[[Category: Rossmann]]~~
	~~[[Category: Sialylation]]~~
	~~[[Category: Sialyltransferase]]~~
	~~[[Category: Transferase~~]]

OCA at 08:19, 18 December 2019

2019-12-18T08:19:02Z

← Older revision		Revision as of 08:19, 18 December 2019
Line 1:		Line 1:

	==Crystal structure of human Beta-galactoside alpha-2,6-sialyltransferase 1 in complex with CMP==		==Crystal structure of human Beta-galactoside alpha-2,6-sialyltransferase 1 in complex with CMP==
	<StructureSection load='4js2' size='340' side='right' caption='[[4js2]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='4js2' size='340' side='right'caption='[[4js2]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4js2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JS2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JS2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4js2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JS2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JS2 FirstGlance]. <br>
Line 12:		Line 12:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/SIAT1_HUMAN SIAT1_HUMAN]] Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates.<ref>PMID:21081508</ref>		[[http://www.uniprot.org/uniprot/SIAT1_HUMAN SIAT1_HUMAN]] Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates.<ref>PMID:21081508</ref>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Human beta-galactoside alpha-2,6-sialyltransferase I (ST6Gal-I) establishes the final glycosylation pattern of many glycoproteins by transferring a sialyl moiety to a terminal galactose. Complete sialylation of therapeutic immunoglobulins is essential for their anti-inflammatory activity and protein stability, but is difficult to achieve in vitro owing to the limited activity of ST6Gal-I towards some galactose acceptors. No structural information on ST6Gal-I that could help to improve the enzymatic properties of ST6Gal-I for biotechnological purposes is currently available. Here, the crystal structures of human ST6Gal-I in complex with the product cytidine 5'-monophosphate and in complex with cytidine and phosphate are described. These complexes allow the rationalization of the inhibitory activity of cytosine-based nucleotides. ST6Gal-I adopts a variant of the canonical glycosyltransferase A fold and differs from related sialyltransferases by several large insertions and deletions that determine its regiospecificity and substrate specificity. A large glycan from a symmetry mate localizes to the active site of ST6Gal-I in an orientation compatible with catalysis. The glycan binding mode can be generalized to any glycoprotein that is a substrate of ST6Gal-I. Comparison with a bacterial sialyltransferase in complex with a modified sialyl donor lends insight into the Michaelis complex. The results support an SN2 mechanism with inversion of configuration at the sialyl residue and suggest substrate-assisted catalysis with a charge-relay mechanism that bears a conceptual similarity to serine proteases.

			The structure of human alpha-2,6-sialyltransferase reveals the binding mode of complex glycans.,Kuhn B, Benz J, Greif M, Engel AM, Sobek H, Rudolph MG Acta Crystallogr D Biol Crystallogr. 2013 Sep;69(Pt 9):1826-38. doi:, 10.1107/S0907444913015412. Epub 2013 Aug 17. PMID:23999306<ref>PMID:23999306</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 4js2" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Sialyltransferase\|Sialyltransferase]]
	== References ==		== References ==
	<references/>		<references/>
Line 18:		Line 30:
	[[Category: Beta-galactoside alpha-2,6-sialyltransferase]]		[[Category: Beta-galactoside alpha-2,6-sialyltransferase]]
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Benz, J]]		[[Category: Benz, J]]
	[[Category: Engel, A M]]		[[Category: Engel, A M]]

OCA at 08:04, 5 August 2016

2016-08-05T08:04:38Z

← Older revision		Revision as of 08:04, 5 August 2016
Line 1:		Line 1:

	==Crystal structure of human Beta-galactoside alpha-2,6-sialyltransferase 1 in complex with CMP==		==Crystal structure of human Beta-galactoside alpha-2,6-sialyltransferase 1 in complex with CMP==
	<StructureSection load='4js2' size='340' side='right' caption='[[4js2]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='4js2' size='340' side='right' caption='[[4js2]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4js2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JS2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JS2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4js2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JS2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JS2 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4js1\|4js1]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4js1\|4js1]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ST6GAL1, SIAT1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ST6GAL1, SIAT1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-galactoside_alpha-2,6-sialyltransferase Beta-galactoside alpha-2,6-sialyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.99.1 2.4.99.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-galactoside_alpha-2,6-sialyltransferase Beta-galactoside alpha-2,6-sialyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.99.1 2.4.99.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4js2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4js2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4js2 RCSB], [http://www.ebi.ac.uk/pdbsum/4js2 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4js2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4js2 OCA], [http://pdbe.org/4js2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4js2 RCSB], [http://www.ebi.ac.uk/pdbsum/4js2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4js2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	</StructureSection>		</StructureSection>
	[[Category: Beta-galactoside alpha-2,6-sialyltransferase]]		[[Category: Beta-galactoside alpha-2,6-sialyltransferase]]
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Benz, J]]		[[Category: Benz, J]]
	[[Category: Engel, A M]]		[[Category: Engel, A M]]

OCA at 17:07, 25 December 2014

2014-12-25T17:07:57Z

← Older revision		Revision as of 17:07, 25 December 2014
Line 1:		Line 1:
	~~{{STRUCTURE_4js2\| PDB=4js2 \| SCENE= }}~~		==Crystal structure of human Beta-galactoside alpha-2,6-sialyltransferase 1 in complex with CMP==
	===Crystal structure of human Beta-galactoside alpha-2,6-sialyltransferase 1 in complex with CMP===		<StructureSection load='4js2' size='340' side='right' caption='[[4js2]], [[Resolution\|resolution]] 2.30Å' scene=''>
			== Structural highlights ==
	==Function==		<table><tr><td colspan='2'>[[4js2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JS2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JS2 FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4js1\|4js1]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ST6GAL1, SIAT1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-galactoside_alpha-2,6-sialyltransferase Beta-galactoside alpha-2,6-sialyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.99.1 2.4.99.1] </span></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4js2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4js2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4js2 RCSB], [http://www.ebi.ac.uk/pdbsum/4js2 PDBsum]</span></td></tr>
			</table>
			== Function ==
	[[http://www.uniprot.org/uniprot/SIAT1_HUMAN SIAT1_HUMAN]] Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates.<ref>PMID:21081508</ref>		[[http://www.uniprot.org/uniprot/SIAT1_HUMAN SIAT1_HUMAN]] Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates.<ref>PMID:21081508</ref>
			== References ==
	==~~About this Structure==~~		<references/>
	[[4js2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JS2 OCA].		__TOC__
			</StructureSection>
	~~==Reference~~==
	<references ~~group="xtra"~~/><~~references~~/>
	[[Category: Beta-galactoside alpha-2,6-sialyltransferase]]		[[Category: Beta-galactoside alpha-2,6-sialyltransferase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Benz, J.]]		[[Category: Benz, J]]
	[[Category: Engel, A M.]]		[[Category: Engel, A M]]
	[[Category: Greif, M.]]		[[Category: Greif, M]]
	[[Category: Kuhn, B.]]		[[Category: Kuhn, B]]
	[[Category: Rudolph, M G.]]		[[Category: Rudolph, M G]]
	[[Category: Sobek, H.]]		[[Category: Sobek, H]]
	[[Category: Endoplasmatic reticulum]]		[[Category: Endoplasmatic reticulum]]
	[[Category: Glycoprotein]]		[[Category: Glycoprotein]]

OCA at 05:04, 28 August 2013

2013-08-28T05:04:29Z

← Older revision		Revision as of 05:04, 28 August 2013
Line 12:		Line 12:
	[[Category: Beta-galactoside alpha-2,6-sialyltransferase]]		[[Category: Beta-galactoside alpha-2,6-sialyltransferase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
			[[Category: Benz, J.]]
			[[Category: Engel, A M.]]
			[[Category: Greif, M.]]
			[[Category: Kuhn, B.]]
	[[Category: Rudolph, M G.]]		[[Category: Rudolph, M G.]]
			[[Category: Sobek, H.]]
	[[Category: Endoplasmatic reticulum]]		[[Category: Endoplasmatic reticulum]]
	[[Category: Glycoprotein]]		[[Category: Glycoprotein]]

OCA at 05:21, 1 August 2013

2013-08-01T05:21:52Z

← Older revision		Revision as of 05:21, 1 August 2013
Line 1:		Line 1:
	~~'''Unreleased~~ structure~~'''~~		{{STRUCTURE_4js2\| PDB=4js2 \| SCENE= }}
			===Crystal structure of human Beta-galactoside alpha-2,6-sialyltransferase 1 in complex with CMP===

	~~The entry 4js2 is ON HOLD~~ ~~until Paper Publication~~		==Function==
			[[http://www.uniprot.org/uniprot/SIAT1_HUMAN SIAT1_HUMAN]] Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates.<ref>PMID:21081508</ref>

	~~Authors~~: ~~Rudolph, M~~.G.		==About this Structure==
			[[4js2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JS2 OCA].

	~~Description~~:		==Reference==
			<references group="xtra"/><references/>
			[[Category: Beta-galactoside alpha-2,6-sialyltransferase]]
			[[Category: Homo sapiens]]
			[[Category: Rudolph, M G.]]
			[[Category: Endoplasmatic reticulum]]
			[[Category: Glycoprotein]]
			[[Category: Golgi]]
			[[Category: Gt-a]]
			[[Category: Rossmann]]
			[[Category: Sialylation]]
			[[Category: Sialyltransferase]]
			[[Category: Transferase]]

OCA at 10:55, 24 April 2013

2013-04-24T10:55:26Z

← Older revision		Revision as of 10:55, 24 April 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4js2 is ON HOLD		The entry 4js2 is ON HOLD until Paper Publication

	Authors: Rudolph, M.G.		Authors: Rudolph, M.G.

	Description:		Description:

OCA: Protected "4js2" [edit=sysop:move=sysop]

2013-04-04T00:59:10Z

Protected "4js2" [edit=sysop:move=sysop]

← Older revision	Revision as of 00:59, 4 April 2013
(No difference)