4jsf - Revision history

OCA at 11:16, 13 August 2026

2026-08-13T11:16:26Z

← Older revision		Revision as of 11:16, 13 August 2026
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	==Structure of rat neuronal nitric oxide synthase heme domain in complex with 6,6'-(heptane-1,7-diyl)bis(4-methylpyridin-2-amine)==		==Structure of rat neuronal nitric oxide synthase heme domain in complex with 6,6'-(heptane-1,7-diyl)bis(4-methylpyridin-2-amine)==
	<StructureSection load='4jsf' size='340' side='right' caption='[[4jsf]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='4jsf' size='340' side='right'caption='[[4jsf]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4jsf]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JSF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4JSF FirstGlance]. <br>		<table><tr><td colspan='2'>[[4jsf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JSF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JSF FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=QJ4:6,6-HEPTANE-1,7-DIYLBIS(4-METHYLPYRIDIN-2-AMINE)'>QJ4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.05Å</td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4jse\|4jse]], [[4jsg\|4jsg]], [[4jsh\|4jsh]], [[4jsi\|4jsi]], [[4jsj\|4jsj]], [[4jsk\|4jsk]], [[4jsl\|4jsl]], [[4jsm\|4jsm]]</td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=QJ4:6,6-HEPTANE-1,7-DIYLBIS(4-METHYLPYRIDIN-2-AMINE)'>QJ4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Nos1, Bnos ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jsf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jsf OCA], [https://pdbe.org/4jsf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jsf RCSB], [https://www.ebi.ac.uk/pdbsum/4jsf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jsf ProSAT]</span></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NADPH_dependent) Nitric-oxide synthase (NADPH dependent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4jsf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jsf OCA], [~~http~~://pdbe.org/4jsf PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4jsf RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4jsf PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4jsf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/NOS1_RAT NOS1_RAT]] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum.		[https://www.uniprot.org/uniprot/NOS1_RAT NOS1_RAT] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	==See Also==		==See Also==
	*[[Nitric Oxide Synthase\|Nitric Oxide Synthase]]		*[[Nitric Oxide Synthase 3D structures\|Nitric Oxide Synthase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Buffalo rat~~]]		[[Category: Large Structures]]
	[[Category: ~~Li, H~~]]		[[Category: Rattus norvegicus]]
	[[Category: ~~Poulos, T L~~]]		[[Category: Li H]]
	[[Category: ~~Nitric oxide synthase]]~~		[[Category: Poulos TL]]
	~~[[Category: Oxidoreductase-oxidoreductase inhibitor complex~~]]

OCA at 20:41, 4 August 2016

2016-08-04T20:41:10Z

← Older revision		Revision as of 20:41, 4 August 2016
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	==Structure of rat neuronal nitric oxide synthase heme domain in complex with 6,6'-(heptane-1,7-diyl)bis(4-methylpyridin-2-amine)==		==Structure of rat neuronal nitric oxide synthase heme domain in complex with 6,6'-(heptane-1,7-diyl)bis(4-methylpyridin-2-amine)==
	<StructureSection load='4jsf' size='340' side='right' caption='[[4jsf]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='4jsf' size='340' side='right' caption='[[4jsf]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4jsf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Rattus_norvegicus Rattus norvegicus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JSF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JSF FirstGlance]. <br>		<table><tr><td colspan='2'>[[4jsf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JSF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JSF FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=QJ4:6,6-HEPTANE-1,7-DIYLBIS(4-METHYLPYRIDIN-2-AMINE)'>QJ4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=QJ4:6,6-HEPTANE-1,7-DIYLBIS(4-METHYLPYRIDIN-2-AMINE)'>QJ4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4jse\|4jse]], [[4jsg\|4jsg]], [[4jsh\|4jsh]], [[4jsi\|4jsi]], [[4jsj\|4jsj]], [[4jsk\|4jsk]], [[4jsl\|4jsl]], [[4jsm\|4jsm]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4jse\|4jse]], [[4jsg\|4jsg]], [[4jsh\|4jsh]], [[4jsi\|4jsi]], [[4jsj\|4jsj]], [[4jsk\|4jsk]], [[4jsl\|4jsl]], [[4jsm\|4jsm]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Nos1, Bnos ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 ~~Rattus norvegicus~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Nos1, Bnos ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NADPH_dependent) Nitric-oxide synthase (NADPH dependent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NADPH_dependent) Nitric-oxide synthase (NADPH dependent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jsf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jsf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jsf RCSB], [http://www.ebi.ac.uk/pdbsum/4jsf PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jsf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jsf OCA], [http://pdbe.org/4jsf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4jsf RCSB], [http://www.ebi.ac.uk/pdbsum/4jsf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4jsf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4jsf" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 26:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Rattus norvegicus~~]]		[[Category: Buffalo rat]]
	[[Category: Li, H]]		[[Category: Li, H]]
	[[Category: Poulos, T L]]		[[Category: Poulos, T L]]
	[[Category: Nitric oxide synthase]]		[[Category: Nitric oxide synthase]]
	[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]		[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]

OCA at 19:27, 24 December 2014

2014-12-24T19:27:47Z

← Older revision		Revision as of 19:27, 24 December 2014
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jsf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jsf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jsf RCSB], [http://www.ebi.ac.uk/pdbsum/4jsf PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jsf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jsf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jsf RCSB], [http://www.ebi.ac.uk/pdbsum/4jsf PDBsum]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/NOS1_RAT NOS1_RAT]] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 15:25, 21 December 2014

2014-12-21T15:25:46Z

← Older revision		Revision as of 15:25, 21 December 2014
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	~~{{STRUCTURE_4jsf\| PDB=4jsf \| SCENE= }}~~		==Structure of rat neuronal nitric oxide synthase heme domain in complex with 6,6'-(heptane-1,7-diyl)bis(4-methylpyridin-2-amine)==
	===Structure of rat neuronal nitric oxide synthase heme domain in complex with 6,6'-(heptane-1,7-diyl)bis(4-methylpyridin-2-amine)===		<StructureSection load='4jsf' size='340' side='right' caption='[[4jsf]], [[Resolution\|resolution]] 2.05Å' scene=''>
	~~{{ABSTRACT_PUBMED_23867386}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[4jsf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JSF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JSF FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=QJ4:6,6-HEPTANE-1,7-DIYLBIS(4-METHYLPYRIDIN-2-AMINE)'>QJ4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4jse\|4jse]], [[4jsg\|4jsg]], [[4jsh\|4jsh]], [[4jsi\|4jsi]], [[4jsj\|4jsj]], [[4jsk\|4jsk]], [[4jsl\|4jsl]], [[4jsm\|4jsm]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Nos1, Bnos ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>
			<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NADPH_dependent) Nitric-oxide synthase (NADPH dependent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] </span></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jsf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jsf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jsf RCSB], [http://www.ebi.ac.uk/pdbsum/4jsf PDBsum]</span></td></tr>
			</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			In certain neurodegenerative diseases damaging levels of nitric oxide (NO) are produced by neuronal nitric oxide synthase (nNOS). It, therefore, is important to develop inhibitors selective for nNOS that do not interfere with other NOS isoforms, especially endothelial NOS (eNOS), which is critical for proper functioning of the cardiovascular system. While we have been successful in developing potent and isoform-selective inhibitors, such as lead compounds 1 and 2, the ease of synthesis and bioavailability have been problematic. Here we describe a new series of compounds including crystal structures of NOS-inhibitor complexes that integrate the advantages of easy synthesis and good biological properties compared to the lead compounds. These results provide the basis for additional structure-activity relationship (SAR) studies to guide further improvement of isozyme selective inhibitors.

	~~==Function==~~		In search of potent and selective inhibitors of neuronal nitric oxide synthase with more simple structures.,Jing Q, Li H, Fang J, Roman LJ, Martasek P, Poulos TL, Silverman RB Bioorg Med Chem. 2013 Jun 15. pii: S0968-0896(13)00545-2. doi:, 10.1016/j.bmc.2013.06.014. PMID:23867386<ref>PMID:23867386</ref>
	~~[[http://www.uniprot.org/uniprot/NOS1_RAT NOS1_RAT]] Produces~~ nitric oxide ~~(NO) which is a messenger molecule~~ with ~~diverse functions throughout the body~~. ~~In the brain and peripheral nervous system~~, ~~NO displays many properties of a neurotransmitter~~. ~~Inhibitory transmitter for non~~-~~adrenergic and non~~-~~cholinergic nerves in the colorectum~~. ~~Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR~~. ~~Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum~~.

	~~==About this Structure==~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~[[4jsf]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Rattus_norvegicus Rattus norvegicus]~~. ~~Full crystallographic information is available from [http:/~~/~~oca.weizmann.ac.il/oca-bin/ocashort?id=4JSF OCA].~~		</div>

	==~~Reference~~==		==See Also==
	~~<ref group~~=~~"xtra">PMID:023867386</ref>~~<references ~~group="xtra"~~/><~~references~~/>		*[[Nitric Oxide Synthase\|Nitric Oxide Synthase]]
			== References ==
			<references/>
			__TOC__
			</StructureSection>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
	[[Category: Li, H.]]		[[Category: Li, H]]
	[[Category: Poulos, T L.]]		[[Category: Poulos, T L]]
	[[Category: Nitric oxide synthase]]		[[Category: Nitric oxide synthase]]
	[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]		[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]

OCA at 20:52, 7 August 2013

2013-08-07T20:52:42Z

← Older revision		Revision as of 20:52, 7 August 2013
Line 1:		Line 1:
	'~~''Unreleased structure'''~~		{{STRUCTURE_4jsf\| PDB=4jsf \| SCENE= }}
			===Structure of rat neuronal nitric oxide synthase heme domain in complex with 6,6'-(heptane-1,7-diyl)bis(4-methylpyridin-2-amine)===
			{{ABSTRACT_PUBMED_23867386}}

	~~The entry 4jsf~~ is ~~ON HOLD until Paper Publication~~		==Function==
			[[http://www.uniprot.org/uniprot/NOS1_RAT NOS1_RAT]] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum.

	~~Authors~~: ~~Li, H~~.~~, Poulos, T~~.L.		==About this Structure==
			[[4jsf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JSF OCA].

	~~Description~~: ~~Structure of rat neuronal nitric~~ oxide synthase ~~heme domain in~~ complex ~~with 6,6'-(heptane-1,7-diyl)bis(4-methylpyridin-2-amine)~~		==Reference==
			<ref group="xtra">PMID:023867386</ref><references group="xtra"/><references/>
			[[Category: Rattus norvegicus]]
			[[Category: Li, H.]]
			[[Category: Poulos, T L.]]
			[[Category: Nitric oxide synthase]]
			[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]

OCA at 19:58, 17 April 2013

2013-04-17T19:58:54Z

← Older revision		Revision as of 19:58, 17 April 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4jsf is ON HOLD		The entry 4jsf is ON HOLD until Paper Publication

	Authors: Li, H., Poulos, T.L.		Authors: Li, H., Poulos, T.L.

	Description: Structure of rat neuronal nitric oxide synthase heme domain in complex with 6,6'-(heptane-1,7-diyl)bis(4-methylpyridin-2-amine)		Description: Structure of rat neuronal nitric oxide synthase heme domain in complex with 6,6'-(heptane-1,7-diyl)bis(4-methylpyridin-2-amine)

OCA: Protected "4jsf" [edit=sysop:move=sysop]

2013-04-04T00:59:45Z

Protected "4jsf" [edit=sysop:move=sysop]

← Older revision	Revision as of 00:59, 4 April 2013
(No difference)

OCA: New page: '''Unreleased structure''' The entry 4jsf is ON HOLD Authors: Li, H., Poulos, T.L. Description: Structure of rat neuronal nitric oxide synthase heme domain in complex with 6,6'-(heptan...

2013-04-04T00:59:39Z

New page: '''Unreleased structure''' The entry 4jsf is ON HOLD Authors: Li, H., Poulos, T.L. Description: Structure of rat neuronal nitric oxide synthase heme domain in complex with 6,6'-(heptan...

New page

'''Unreleased structure'''

The entry 4jsf is ON HOLD

Authors: Li, H., Poulos, T.L.

Description: Structure of rat neuronal nitric oxide synthase heme domain in complex with 6,6'-(heptane-1,7-diyl)bis(4-methylpyridin-2-amine)