4jvb - Revision history

OCA at 15:49, 20 September 2023

2023-09-20T15:49:34Z

← Older revision		Revision as of 15:49, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4jvb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JVB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JVB FirstGlance]. <br>		<table><tr><td colspan='2'>[[4jvb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JVB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JVB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1M0:1-BENZYL-2-(4-{[(2R)-2-(2-PHENYL-1H-BENZIMIDAZOL-1-YL)PENT-4-EN-1-YL]OXY}PHENYL)-1H-BENZIMIDAZOLE'>1M0</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.75Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1M0:1-BENZYL-2-(4-{[(2R)-2-(2-PHENYL-1H-BENZIMIDAZOL-1-YL)PENT-4-EN-1-YL]OXY}PHENYL)-1H-BENZIMIDAZOLE'>1M0</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jvb OCA], [https://pdbe.org/4jvb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jvb RCSB], [https://www.ebi.ac.uk/pdbsum/4jvb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jvb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jvb OCA], [https://pdbe.org/4jvb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jvb RCSB], [https://www.ebi.ac.uk/pdbsum/4jvb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jvb ProSAT]</span></td></tr>
	</table>		</table>

OCA at 11:27, 30 November 2022

2022-11-30T11:27:09Z

← Older revision		Revision as of 11:27, 30 November 2022
Line 1:		Line 1:

	==Crystal structure of PDE6D in complex with the inhibitor rac-2==		==Crystal structure of PDE6D in complex with the inhibitor rac-2==
	<StructureSection load='4jvb' size='340' side='right' caption='[[4jvb]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='4jvb' size='340' side='right'caption='[[4jvb]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4jvb]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JVB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4JVB FirstGlance]. <br>		<table><tr><td colspan='2'>[[4jvb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JVB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JVB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1M0:1-BENZYL-2-(4-{[(2R)-2-(2-PHENYL-1H-BENZIMIDAZOL-1-YL)PENT-4-EN-1-YL]OXY}PHENYL)-1H-BENZIMIDAZOLE'>1M0</scene>~~</td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1M0:1-BENZYL-2-(4-{[(2R)-2-(2-PHENYL-1H-BENZIMIDAZOL-1-YL)PENT-4-EN-1-YL]OXY}PHENYL)-1H-BENZIMIDAZOLE'>1M0</scene></td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4jv6\|4jv6]], [[4jv8\|4jv8]], [[4jvf\|4jvf]]</td></tr>~~		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jvb OCA], [https://pdbe.org/4jvb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jvb RCSB], [https://www.ebi.ac.uk/pdbsum/4jvb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jvb ProSAT]</span></td></tr>
	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PDE6D, PDED ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4jvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jvb OCA], [~~http~~://pdbe.org/4jvb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4jvb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4jvb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4jvb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/PDE6D_HUMAN PDE6D_HUMAN]] Acts as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude and does so by decreasing the nucleotide dissociation rate. Stabilizes Arl3-GTP by decreasing the nucleotide dissociation (By similarity).		[https://www.uniprot.org/uniprot/PDE6D_HUMAN PDE6D_HUMAN] Acts as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude and does so by decreasing the nucleotide dissociation rate. Stabilizes Arl3-GTP by decreasing the nucleotide dissociation (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 20:

	==See Also==		==See Also==
	*[[Phosphodiesterase\|Phosphodiesterase]]		*[[Phosphodiesterase 3D structures\|Phosphodiesterase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Bastiaens, P]]		[[Category: Large Structures]]
	[[Category: Chandra, A]]		[[Category: Bastiaens P]]
	[[Category: Gunther, Z]]		[[Category: Chandra A]]
	[[Category: Hahn, S]]		[[Category: Gunther Z]]
	[[Category: Hoffmann, M]]		[[Category: Hahn S]]
	[[Category: Ismail, S]]		[[Category: Hoffmann M]]
	[[Category: Papke, B]]		[[Category: Ismail S]]
	[[Category: Triola, G]]		[[Category: Papke B]]
	[[Category: Vartak, N]]		[[Category: Triola G]]
	[[Category: Waldmann, H]]		[[Category: Vartak N]]
	[[Category: Wittinghofer, A]]		[[Category: Waldmann H]]
	~~[[Category: Gdi-like solubilizing factor]]~~		[[Category: Wittinghofer A]]
	~~[[Category: Immunoglobulin-like beta-sandwich]]~~
	~~[[Category: Prenyl binding]]~~
	~~[[Category: Protein binding-inhibitor complex~~]]

OCA at 22:14, 4 August 2016

2016-08-04T22:14:14Z

← Older revision		Revision as of 22:14, 4 August 2016
Line 1:		Line 1:

	==Crystal structure of PDE6D in complex with the inhibitor rac-2==		==Crystal structure of PDE6D in complex with the inhibitor rac-2==
	<StructureSection load='4jvb' size='340' side='right' caption='[[4jvb]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='4jvb' size='340' side='right' caption='[[4jvb]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4jvb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JVB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JVB FirstGlance]. <br>		<table><tr><td colspan='2'>[[4jvb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JVB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JVB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1M0:1-BENZYL-2-(4-{[(2R)-2-(2-PHENYL-1H-BENZIMIDAZOL-1-YL)PENT-4-EN-1-YL]OXY}PHENYL)-1H-BENZIMIDAZOLE'>1M0</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1M0:1-BENZYL-2-(4-{[(2R)-2-(2-PHENYL-1H-BENZIMIDAZOL-1-YL)PENT-4-EN-1-YL]OXY}PHENYL)-1H-BENZIMIDAZOLE'>1M0</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4jv6\|4jv6]], [[4jv8\|4jv8]], [[4jvf\|4jvf]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4jv6\|4jv6]], [[4jv8\|4jv8]], [[4jvf\|4jvf]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PDE6D, PDED ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PDE6D, PDED ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jvb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jvb RCSB], [http://www.ebi.ac.uk/pdbsum/4jvb PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jvb OCA], [http://pdbe.org/4jvb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4jvb RCSB], [http://www.ebi.ac.uk/pdbsum/4jvb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4jvb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4jvb" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Bastiaens, P]]		[[Category: Bastiaens, P]]
	[[Category: Chandra, A]]		[[Category: Chandra, A]]

OCA at 13:35, 25 December 2014

2014-12-25T13:35:05Z

← Older revision		Revision as of 13:35, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jvb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jvb RCSB], [http://www.ebi.ac.uk/pdbsum/4jvb PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jvb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jvb RCSB], [http://www.ebi.ac.uk/pdbsum/4jvb PDBsum]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/PDE6D_HUMAN PDE6D_HUMAN]] Acts as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude and does so by decreasing the nucleotide dissociation rate. Stabilizes Arl3-GTP by decreasing the nucleotide dissociation (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 14:56, 21 December 2014

2014-12-21T14:56:53Z

← Older revision		Revision as of 14:56, 21 December 2014
Line 1:		Line 1:
	~~{{STRUCTURE_4jvb\| PDB=4jvb \| SCENE= }}~~		==Crystal structure of PDE6D in complex with the inhibitor rac-2==
	===Crystal structure of PDE6D in complex with the inhibitor rac-2===		<StructureSection load='4jvb' size='340' side='right' caption='[[4jvb]], [[Resolution\|resolution]] 1.75Å' scene=''>
	{~~{ABSTRACT_PUBMED_23698361}~~}		== Structural highlights ==
			<table><tr><td colspan='2'>[[4jvb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JVB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JVB FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1M0:1-BENZYL-2-(4-{[(2R)-2-(2-PHENYL-1H-BENZIMIDAZOL-1-YL)PENT-4-EN-1-YL]OXY}PHENYL)-1H-BENZIMIDAZOLE'>1M0</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4jv6\|4jv6]], [[4jv8\|4jv8]], [[4jvf\|4jvf]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PDE6D, PDED ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jvb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jvb RCSB], [http://www.ebi.ac.uk/pdbsum/4jvb PDBsum]</span></td></tr>
			</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The KRAS oncogene product is considered a major target in anticancer drug discovery. However, direct interference with KRAS signalling has not yet led to clinically useful drugs. Correct localization and signalling by farnesylated KRAS is regulated by the prenyl-binding protein PDEdelta, which sustains the spatial organization of KRAS by facilitating its diffusion in the cytoplasm. Here we report that interfering with binding of mammalian PDEdelta to KRAS by means of small molecules provides a novel opportunity to suppress oncogenic RAS signalling by altering its localization to endomembranes. Biochemical screening and subsequent structure-based hit optimization yielded inhibitors of the KRAS-PDEdelta interaction that selectively bind to the prenyl-binding pocket of PDEdelta with nanomolar affinity, inhibit oncogenic RAS signalling and suppress in vitro and in vivo proliferation of human pancreatic ductal adenocarcinoma cells that are dependent on oncogenic KRAS. Our findings may inspire novel drug discovery efforts aimed at the development of drugs targeting oncogenic RAS.

	~~==Function==~~		Small molecule inhibition of the KRAS-PDEdelta interaction impairs oncogenic KRAS signalling.,Zimmermann G, Papke B, Ismail S, Vartak N, Chandra A, Hoffmann M, Hahn SA, Triola G, Wittinghofer A, Bastiaens PI, Waldmann H Nature. 2013 May 30;497(7451):638-42. doi: 10.1038/nature12205. Epub 2013 May 22. PMID:23698361<ref>PMID:23698361</ref>
	~~[[http://www~~.~~uniprot~~.~~org/uniprot/PDE6D_HUMAN PDE6D_HUMAN]] Acts as a GTP specific dissociation inhibitor~~ (~~GDI~~). ~~Increases the affinity of ARL3 for GTP by several orders of magnitude and does so by decreasing the nucleotide dissociation rate~~. ~~Stabilizes Arl3-GTP by decreasing the nucleotide dissociation (By similarity)~~.

	~~==About this Structure==~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~[[4jvb]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:/~~/~~oca.weizmann.ac.il/oca-bin/ocashort?id=4JVB OCA].~~		</div>

	==~~Reference~~==		==See Also==
	~~<ref group~~=~~"xtra">PMID:023698361</ref>~~<references ~~group="xtra"~~/><~~references~~/>		*[[Phosphodiesterase\|Phosphodiesterase]]
			== References ==
			<references/>
			__TOC__
			</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Bastiaens, P.]]		[[Category: Bastiaens, P]]
	[[Category: Chandra, A.]]		[[Category: Chandra, A]]
	[[Category: Gunther, Z.]]		[[Category: Gunther, Z]]
	[[Category: Hahn, S.]]		[[Category: Hahn, S]]
	[[Category: Hoffmann, M.]]		[[Category: Hoffmann, M]]
	[[Category: Ismail, S.]]		[[Category: Ismail, S]]
	[[Category: Papke, B.]]		[[Category: Papke, B]]
	[[Category: Triola, G.]]		[[Category: Triola, G]]
	[[Category: Vartak, N.]]		[[Category: Vartak, N]]
	[[Category: Waldmann, H.]]		[[Category: Waldmann, H]]
	[[Category: Wittinghofer, A.]]		[[Category: Wittinghofer, A]]
	[[Category: Gdi-like solubilizing factor]]		[[Category: Gdi-like solubilizing factor]]
	[[Category: Immunoglobulin-like beta-sandwich]]		[[Category: Immunoglobulin-like beta-sandwich]]
	[[Category: Prenyl binding]]		[[Category: Prenyl binding]]
	[[Category: Protein binding-inhibitor complex]]		[[Category: Protein binding-inhibitor complex]]

OCA at 17:56, 19 June 2013

2013-06-19T17:56:52Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4jvb|  PDB=4jvb  |  SCENE=  }}
-The entry 4jvb is ON HOLD  until Paper Publication
+==Function==
-Authors: Gunther, Z., Papke, B., Ismail, S., Vartak, N., Chandra, A., Hoffmann, M., Hahn, S., Triola, G., Wittinghofer, A., Bastiaens, P., Waldmann, H.
+==About this Structure==
-Description: Crystal structure of PDE6D in complex with the inhibitor rac-2
+==Reference==

OCA at 20:00, 17 April 2013

2013-04-17T20:00:51Z

← Older revision		Revision as of 20:00, 17 April 2013
Line 5:		Line 5:
	Authors: Gunther, Z., Papke, B., Ismail, S., Vartak, N., Chandra, A., Hoffmann, M., Hahn, S., Triola, G., Wittinghofer, A., Bastiaens, P., Waldmann, H.		Authors: Gunther, Z., Papke, B., Ismail, S., Vartak, N., Chandra, A., Hoffmann, M., Hahn, S., Triola, G., Wittinghofer, A., Bastiaens, P., Waldmann, H.

	Description: Crystal structure of PDE6D in complex with the inhibitor ~~Rasin~~-3		Description: Crystal structure of PDE6D in complex with the inhibitor rac-2

OCA: Protected "4jvb" [edit=sysop:move=sysop]

2013-04-04T01:04:28Z

Protected "4jvb" [edit=sysop:move=sysop]

← Older revision	Revision as of 01:04, 4 April 2013
(No difference)

OCA: New page: '''Unreleased structure''' The entry 4jvb is ON HOLD until Paper Publication Authors: Gunther, Z., Papke, B., Ismail, S., Vartak, N., Chandra, A., Hoffmann, M., Hahn, S., Triola, G., Wi...

2013-04-04T01:04:27Z

New page: '''Unreleased structure''' The entry 4jvb is ON HOLD until Paper Publication Authors: Gunther, Z., Papke, B., Ismail, S., Vartak, N., Chandra, A., Hoffmann, M., Hahn, S., Triola, G., Wi...

New page

'''Unreleased structure'''

The entry 4jvb is ON HOLD until Paper Publication

Authors: Gunther, Z., Papke, B., Ismail, S., Vartak, N., Chandra, A., Hoffmann, M., Hahn, S., Triola, G., Wittinghofer, A., Bastiaens, P., Waldmann, H.

Description: Crystal structure of PDE6D in complex with the inhibitor Rasin-3