4m4e - Revision history

OCA at 14:41, 8 November 2023

2023-11-08T14:41:21Z

← Older revision		Revision as of 14:41, 8 November 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4m4e]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M4E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M4E FirstGlance]. <br>		<table><tr><td colspan='2'>[[4m4e]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M4E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M4E FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m4e OCA], [https://pdbe.org/4m4e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m4e RCSB], [https://www.ebi.ac.uk/pdbsum/4m4e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m4e ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6Å</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m4e OCA], [https://pdbe.org/4m4e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m4e RCSB], [https://www.ebi.ac.uk/pdbsum/4m4e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m4e ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 10:54, 21 December 2022

2022-12-21T10:54:23Z

← Older revision		Revision as of 10:54, 21 December 2022
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	==TRAF domain of human TRAF4==		==TRAF domain of human TRAF4==
	<StructureSection load='4m4e' size='340' side='right' caption='[[4m4e]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='4m4e' size='340' side='right'caption='[[4m4e]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4m4e]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M4E OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4M4E FirstGlance]. <br>		<table><tr><td colspan='2'>[[4m4e]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M4E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M4E FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TRAF4, CART1, MLN62, RNF83 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m4e OCA], [https://pdbe.org/4m4e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m4e RCSB], [https://www.ebi.ac.uk/pdbsum/4m4e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m4e ProSAT]</span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4m4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m4e OCA], [~~http~~://pdbe.org/4m4e PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4m4e RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4m4e PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4m4e ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/TRAF4_HUMAN TRAF4_HUMAN]] Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. Plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract (By similarity). Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions.<ref>PMID:12023963</ref> <ref>PMID:12801526</ref> <ref>PMID:16052631</ref> <ref>PMID:16157600</ref> <ref>PMID:18953416</ref> <ref>PMID:19937093</ref>		[https://www.uniprot.org/uniprot/TRAF4_HUMAN TRAF4_HUMAN] Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. Plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract (By similarity). Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions.<ref>PMID:12023963</ref> <ref>PMID:12801526</ref> <ref>PMID:16052631</ref> <ref>PMID:16157600</ref> <ref>PMID:18953416</ref> <ref>PMID:19937093</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 4m4e" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4m4e" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[TNF receptor-associated factor 3D structures\|TNF receptor-associated factor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Ding, W]]		[[Category: Large Structures]]
	[[Category: Liu~~, Z J~~]]		[[Category: Ding W]]
	[[Category: Niu, F]]		[[Category: Liu ZJ]]
	[[Category: Ouyang, S]]		[[Category: Niu F]]
	[[Category: Ru, H]]		[[Category: Ouyang S]]
	~~[[Category: Adaptor protein]]~~		[[Category: Ru H]]
	~~[[Category: Regular protein]]~~
	~~[[Category: Signaling protein]]~~
	~~[[Category: Traf domain]]~~
	~~[[Category: Traf4~~]]

OCA at 10:41, 5 August 2016

2016-08-05T10:41:36Z

← Older revision		Revision as of 10:41, 5 August 2016
Line 1:		Line 1:

	==TRAF domain of human TRAF4==		==TRAF domain of human TRAF4==
	<StructureSection load='4m4e' size='340' side='right' caption='[[4m4e]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='4m4e' size='340' side='right' caption='[[4m4e]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4m4e]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M4E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4M4E FirstGlance]. <br>		<table><tr><td colspan='2'>[[4m4e]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M4E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4M4E FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TRAF4, CART1, MLN62, RNF83 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TRAF4, CART1, MLN62, RNF83 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m4e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4m4e RCSB], [http://www.ebi.ac.uk/pdbsum/4m4e PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m4e OCA], [http://pdbe.org/4m4e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4m4e RCSB], [http://www.ebi.ac.uk/pdbsum/4m4e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4m4e ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4m4e" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Ding, W]]		[[Category: Ding, W]]
	[[Category: Liu, Z J]]		[[Category: Liu, Z J]]

OCA at 01:41, 25 December 2014

2014-12-25T01:41:16Z

← Older revision		Revision as of 01:41, 25 December 2014
Line 1:		Line 1:
	~~{{STRUCTURE_4m4e~~\| ~~PDB~~=4m4e ~~\| SCENE~~= }}		==TRAF domain of human TRAF4==
	===~~TRAF domain of human~~ TRAF4===		<StructureSection load='4m4e' size='340' side='right' caption='[[4m4e]], [[Resolution\|resolution]] 2.60Å' scene=''>
	~~{{ABSTRACT_PUBMED_23982741}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[4m4e]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M4E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4M4E FirstGlance]. <br>
	==Function==		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TRAF4, CART1, MLN62, RNF83 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m4e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4m4e RCSB], [http://www.ebi.ac.uk/pdbsum/4m4e PDBsum]</span></td></tr>
			</table>
			== Function ==
	[[http://www.uniprot.org/uniprot/TRAF4_HUMAN TRAF4_HUMAN]] Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. Plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract (By similarity). Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions.<ref>PMID:12023963</ref> <ref>PMID:12801526</ref> <ref>PMID:16052631</ref> <ref>PMID:16157600</ref> <ref>PMID:18953416</ref> <ref>PMID:19937093</ref>		[[http://www.uniprot.org/uniprot/TRAF4_HUMAN TRAF4_HUMAN]] Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. Plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract (By similarity). Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions.<ref>PMID:12023963</ref> <ref>PMID:12801526</ref> <ref>PMID:16052631</ref> <ref>PMID:16157600</ref> <ref>PMID:18953416</ref> <ref>PMID:19937093</ref>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			TRAF4 is a unique member of TRAF family, which is essential for innate immune response, nervous system and other systems. In addition to be an adaptor protein, TRAF4 was identified as a regulator protein in recent studies. We have determined the crystal structure of TRAF domain of TRAF4 (residues 292-466) at 2.60 A resolution by X-ray crystallography method. The trimericly assembled TRAF4 resembles a mushroom shape, containing a super helical "stalk" which is made of three right-handed intertwined alpha helixes and a C-terminal "cap", which is divided at residue L302 as a boundary. Similar to other TRAFs, both intermolecular hydrophobic interaction in super helical "stalk" and hydrogen bonds in "cap" regions contribute directly to the formation of TRAF4 trimer. However, differing from other TRAFs, there is an additional flexible loop (residues 421-426), which contains a previously identified phosphorylated site S426 exposing on the surface. This S426 was reported to be phosphorylated by IKKalpha which is the pre-requisite for TRAF4-NOD2 complex formation and thus to inhibit NOD2-induced NF-kappaB activation. Therefore, the crystal structure of TRAF4-TRAF is valuable for understanding its molecular basis for its special function and provides structural information for further studies.

	~~==About this Structure==~~		Structural biology study of human TNF receptor associated factor 4 TRAF domain.,Niu F, Ru H, Ding W, Ouyang S, Liu ZJ Protein Cell. 2013 Aug 27. PMID:23982741<ref>PMID:23982741</ref>
	~~[[4m4e]] is a 3 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http~~:/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4M4E OCA].~~

	==~~Reference~~==		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~<ref group="xtra">PMID:023982741</ref>~~<references ~~group="xtra"~~/><~~references~~/>		</div>
			== References ==
			<references/>
			__TOC__
			</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Ding, W.]]		[[Category: Ding, W]]
	[[Category: Liu, Z J.]]		[[Category: Liu, Z J]]
	[[Category: Niu, F.]]		[[Category: Niu, F]]
	[[Category: Ouyang, S.]]		[[Category: Ouyang, S]]
	[[Category: Ru, H.]]		[[Category: Ru, H]]
	[[Category: Adaptor protein]]		[[Category: Adaptor protein]]
	[[Category: Regular protein]]		[[Category: Regular protein]]

OCA at 05:22, 12 September 2013

2013-09-12T05:22:32Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4m4e|  PDB=4m4e  |  SCENE=  }}
-The entry 4m4e is ON HOLD  until Paper Publication
+==Function==
-Authors: Niu, F., Ru, H., Ding, W., Ouyang, S., Liu, Z.J.
+==About this Structure==
-Description: An adaptor protein
+==Reference==

OCA at 07:55, 21 August 2013

2013-08-21T07:55:24Z

← Older revision		Revision as of 07:55, 21 August 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4m4e is ON HOLD		The entry 4m4e is ON HOLD until Paper Publication

	Authors: Niu, F., Ru, H., Ding, W., Ouyang, S., Liu, Z.J.		Authors: Niu, F., Ru, H., Ding, W., Ouyang, S., Liu, Z.J.

	Description: An adaptor protein		Description: An adaptor protein

OCA: Protected "4m4e" [edit=sysop:move=sysop]

2013-08-14T07:25:59Z

Protected "4m4e" [edit=sysop:move=sysop]

← Older revision	Revision as of 07:25, 14 August 2013
(No difference)

OCA: New page: '''Unreleased structure''' The entry 4m4e is ON HOLD Authors: Niu, F., Ru, H., Ding, W., Ouyang, S., Liu, Z.J. Description: An adaptor protein

2013-08-14T07:25:58Z

New page: '''Unreleased structure''' The entry 4m4e is ON HOLD Authors: Niu, F., Ru, H., Ding, W., Ouyang, S., Liu, Z.J. Description: An adaptor protein

New page

'''Unreleased structure'''

The entry 4m4e is ON HOLD

Authors: Niu, F., Ru, H., Ding, W., Ouyang, S., Liu, Z.J.

Description: An adaptor protein