4mcd - Revision history

OCA at 12:25, 1 March 2024

2024-03-01T12:25:40Z

← Older revision		Revision as of 12:25, 1 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4mcd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemophilus_influenzae_Rd_KW20 Haemophilus influenzae Rd KW20]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MCD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MCD FirstGlance]. <br>		<table><tr><td colspan='2'>[[4mcd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemophilus_influenzae_Rd_KW20 Haemophilus influenzae Rd KW20]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MCD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MCD FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=22L:5-PHENYLTHIENO[2,3-D]PYRIMIDIN-4(3H)-ONE'>22L</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.55Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=22L:5-PHENYLTHIENO[2,3-D]PYRIMIDIN-4(3H)-ONE'>22L</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mcd OCA], [https://pdbe.org/4mcd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mcd RCSB], [https://www.ebi.ac.uk/pdbsum/4mcd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mcd ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mcd OCA], [https://pdbe.org/4mcd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mcd RCSB], [https://www.ebi.ac.uk/pdbsum/4mcd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mcd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/TRMD_HAEIN TRMD_HAEIN] Specifically methylates guanosine-37 in various tRNAs (By similarity).[HAMAP-Rule:MF_00605]		[https://www.uniprot.org/uniprot/TRMD_HAEIN TRMD_HAEIN] Specifically methylates guanosine-37 in various tRNAs (By similarity).[HAMAP-Rule:MF_00605]
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	The t-RNA-(N1G37) methyl transferase (TrmD) is essential for growth and highly conserved in both Gram-positive and Gram-negative bacterial pathogens. Additionally, TrmD is very distinct from its human ortholog TRM5, and thus is a suitable target for the design of novel antibacterials. Screening of a collection of compound fragments using Haemophilus influenzae TrmD identified inhibitory, fused thieno-pyrimidones that were competitive with S-adenosylmethionine (SAM), the physiological methyl donor substrate. Guided by x-ray co-crystal structures, fragment 1 was elaborated into a nanomolar inhibitor of a broad range of Gram-negative TrmD isozymes. These compounds demonstrated no activity against representative human SAM utilizing enzymes, PRMT1 and SET7/9. This is the first report of selective, nanomolar inhibitors of TrmD with demonstrated ability to order the TrmD lid in the absence of tRNA.

	Selective Inhibitors of Bacterial t-RNA-(NG37) Methyltransferase (TrmD) that Demonstrate Novel Ordering of the Lid Domain.,Hill PJ, Abibi A, Albert R, Andrews B, Gagnon MM, Gao N, Grebe T, Hajec LI, Huang J, Livchak S, Lahiri SD, McKinney DC, Thresher J, Wang H, Olivier N, Buurman ET J Med Chem. 2013 Aug 27. PMID:23981144<ref>PMID:23981144</ref>

	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~<div class="pdbe-citations 4mcd" style="background-color:#fffaf0;"></div>~~

	==See Also==		==See Also==
	*[[TRNA methyltransferase 3D structures\|TRNA methyltransferase 3D structures]]		*[[TRNA methyltransferase 3D structures\|TRNA methyltransferase 3D structures]]
	~~== References ==~~
	~~<references/>~~
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 11:09, 21 December 2022

2022-12-21T11:09:14Z

← Older revision		Revision as of 11:09, 21 December 2022
Line 1:		Line 1:

	==hinTrmD in complex with 5-PHENYLTHIENO[2,3-D]PYRIMIDIN-4(3H)-ONE==		==hinTrmD in complex with 5-PHENYLTHIENO[2,3-D]PYRIMIDIN-4(3H)-ONE==
	<StructureSection load='4mcd' size='340' side='right' caption='[[4mcd]], [[Resolution\|resolution]] 1.55Å' scene=''>		<StructureSection load='4mcd' size='340' side='right'caption='[[4mcd]], [[Resolution\|resolution]] 1.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4mcd]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Haein Haein~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MCD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4MCD FirstGlance]. <br>		<table><tr><td colspan='2'>[[4mcd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemophilus_influenzae_Rd_KW20 Haemophilus influenzae Rd KW20]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MCD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MCD FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=22L:5-PHENYLTHIENO[2,3-D]PYRIMIDIN-4(3H)-ONE'>22L</scene~~></td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=22L:5-PHENYLTHIENO[2,3-D]PYRIMIDIN-4(3H)-ONE'>22L</scene></td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4mcb\|4mcb]], [[4mcc\|4mcc]]</td></tr>~~		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mcd OCA], [https://pdbe.org/4mcd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mcd RCSB], [https://www.ebi.ac.uk/pdbsum/4mcd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mcd ProSAT]</span></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HI_0202, trmD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=71421 HAEIN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/tRNA_(guanine(37)-N(1))-methyltransferase tRNA (guanine(37)-N(1))-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.228 2.1.1.228] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4mcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mcd OCA], [~~http~~://pdbe.org/4mcd PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4mcd RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4mcd PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4mcd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/TRMD_HAEIN TRMD_HAEIN]] Specifically methylates guanosine-37 in various tRNAs (By similarity).[HAMAP-Rule:MF_00605]		[https://www.uniprot.org/uniprot/TRMD_HAEIN TRMD_HAEIN] Specifically methylates guanosine-37 in various tRNAs (By similarity).[HAMAP-Rule:MF_00605]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 20:

	==See Also==		==See Also==
	*[[TRNA methyltransferase\|TRNA methyltransferase]]		*[[TRNA methyltransferase 3D structures\|TRNA methyltransferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Haein~~]]		[[Category: Haemophilus influenzae Rd KW20]]
	[[Category: ~~Lahiri, S~~]]		[[Category: Large Structures]]
	[[Category: ~~Hmt]]~~		[[Category: Lahiri S]]
	~~[[Category: Sah]]~~
	~~[[Category: Sam]]~~
	~~[[Category: Sinefungin]]~~
	~~[[Category: Structural genomic]]~~
	~~[[Category: Transferase-transferase inhibitor complex]]~~
	~~[[Category: Trefoil]]~~
	~~[[Category: Trmd~~]]

OCA at 18:01, 5 August 2016

2016-08-05T18:01:06Z

← Older revision		Revision as of 18:01, 5 August 2016
Line 1:		Line 1:

	==hinTrmD in complex with 5-PHENYLTHIENO[2,3-D]PYRIMIDIN-4(3H)-ONE==		==hinTrmD in complex with 5-PHENYLTHIENO[2,3-D]PYRIMIDIN-4(3H)-ONE==
	<StructureSection load='4mcd' size='340' side='right' caption='[[4mcd]], [[Resolution\|resolution]] 1.55Å' scene=''>		<StructureSection load='4mcd' size='340' side='right' caption='[[4mcd]], [[Resolution\|resolution]] 1.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4mcd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Haemophilus_influenzae_rd_kw20 Haemophilus influenzae rd kw20~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MCD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MCD FirstGlance]. <br>		<table><tr><td colspan='2'>[[4mcd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Haein Haein]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MCD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MCD FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=22L:5-PHENYLTHIENO[2,3-D]PYRIMIDIN-4(3H)-ONE'>22L</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=22L:5-PHENYLTHIENO[2,3-D]PYRIMIDIN-4(3H)-ONE'>22L</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4mcb\|4mcb]], [[4mcc\|4mcc]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4mcb\|4mcb]], [[4mcc\|4mcc]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HI_0202, trmD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=71421 ~~Haemophilus influenzae Rd KW20~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HI_0202, trmD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=71421 HAEIN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/tRNA_(guanine(37)-N(1))-methyltransferase tRNA (guanine(37)-N(1))-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.228 2.1.1.228] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/tRNA_(guanine(37)-N(1))-methyltransferase tRNA (guanine(37)-N(1))-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.228 2.1.1.228] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mcd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mcd RCSB], [http://www.ebi.ac.uk/pdbsum/4mcd PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mcd OCA], [http://pdbe.org/4mcd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4mcd RCSB], [http://www.ebi.ac.uk/pdbsum/4mcd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4mcd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4mcd" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 26:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Haemophilus influenzae rd kw20~~]]		[[Category: Haein]]
	[[Category: Lahiri, S]]		[[Category: Lahiri, S]]
	[[Category: Hmt]]		[[Category: Hmt]]

OCA at 04:39, 25 December 2014

2014-12-25T04:39:35Z

← Older revision		Revision as of 04:39, 25 December 2014
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mcd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mcd RCSB], [http://www.ebi.ac.uk/pdbsum/4mcd PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mcd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mcd RCSB], [http://www.ebi.ac.uk/pdbsum/4mcd PDBsum]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/TRMD_HAEIN TRMD_HAEIN]] Specifically methylates guanosine-37 in various tRNAs (By similarity).[HAMAP-Rule:MF_00605]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 15:34, 21 December 2014

2014-12-21T15:34:57Z

← Older revision		Revision as of 15:34, 21 December 2014
Line 1:		Line 1:
	~~{{STRUCTURE_4mcd\| PDB~~=4mcd \| ~~SCENE~~= }}		==hinTrmD in complex with 5-PHENYLTHIENO[2,3-D]PYRIMIDIN-4(3H)-ONE==
	===~~hinTrmD in complex~~ with 5-PHENYLTHIENO[2,3-D]PYRIMIDIN-4(3H)-ONE===		<StructureSection load='4mcd' size='340' side='right' caption='[[4mcd]], [[Resolution\|resolution]] 1.55Å' scene=''>
	~~{{ABSTRACT_PUBMED_23981144}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[4mcd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Haemophilus_influenzae_rd_kw20 Haemophilus influenzae rd kw20]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MCD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MCD FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=22L:5-PHENYLTHIENO[2,3-D]PYRIMIDIN-4(3H)-ONE'>22L</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4mcb\|4mcb]], [[4mcc\|4mcc]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HI_0202, trmD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=71421 Haemophilus influenzae Rd KW20])</td></tr>
			<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/tRNA_(guanine(37)-N(1))-methyltransferase tRNA (guanine(37)-N(1))-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.228 2.1.1.228] </span></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mcd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mcd RCSB], [http://www.ebi.ac.uk/pdbsum/4mcd PDBsum]</span></td></tr>
			</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The t-RNA-(N1G37) methyl transferase (TrmD) is essential for growth and highly conserved in both Gram-positive and Gram-negative bacterial pathogens. Additionally, TrmD is very distinct from its human ortholog TRM5, and thus is a suitable target for the design of novel antibacterials. Screening of a collection of compound fragments using Haemophilus influenzae TrmD identified inhibitory, fused thieno-pyrimidones that were competitive with S-adenosylmethionine (SAM), the physiological methyl donor substrate. Guided by x-ray co-crystal structures, fragment 1 was elaborated into a nanomolar inhibitor of a broad range of Gram-negative TrmD isozymes. These compounds demonstrated no activity against representative human SAM utilizing enzymes, PRMT1 and SET7/9. This is the first report of selective, nanomolar inhibitors of TrmD with demonstrated ability to order the TrmD lid in the absence of tRNA.

	~~==Function==~~		Selective Inhibitors of Bacterial t-RNA-(NG37) Methyltransferase (TrmD) that Demonstrate Novel Ordering of the Lid Domain.,Hill PJ, Abibi A, Albert R, Andrews B, Gagnon MM, Gao N, Grebe T, Hajec LI, Huang J, Livchak S, Lahiri SD, McKinney DC, Thresher J, Wang H, Olivier N, Buurman ET J Med Chem. 2013 Aug 27. PMID:23981144<ref>PMID:23981144</ref>
	~~[[http://www.uniprot.org/uniprot/TRMD_HAEIN TRMD_HAEIN]] Specifically methylates guanosine~~-~~37 in various tRNAs~~ (~~By similarity~~).~~[HAMAP-Rule~~:~~MF_00605]~~

	~~==About this Structure==~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~[[4mcd]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Haemophilus_influenzae_rd_kw20 Haemophilus influenzae rd kw20]~~. ~~Full crystallographic information is available from [http:/~~/~~oca.weizmann.ac.il/oca-bin/ocashort?id=4MCD OCA].~~		</div>

	==~~Reference~~==		==See Also==
	~~<ref group~~=~~"xtra">PMID:023981144</ref>~~<references ~~group="xtra"~~/><~~references~~/>		*[[TRNA methyltransferase\|TRNA methyltransferase]]
			== References ==
			<references/>
			__TOC__
			</StructureSection>
	[[Category: Haemophilus influenzae rd kw20]]		[[Category: Haemophilus influenzae rd kw20]]
	[[Category: Lahiri, S.]]		[[Category: Lahiri, S]]
	[[Category: Hmt]]		[[Category: Hmt]]
	[[Category: Sah]]		[[Category: Sah]]

OCA at 08:13, 29 September 2013

2013-09-29T08:13:12Z

← Older revision		Revision as of 08:13, 29 September 2013
Line 1:		Line 1:
	~~'''Unreleased structure'''~~		{{STRUCTURE_4mcd\| PDB=4mcd \| SCENE= }}
			===hinTrmD in complex with 5-PHENYLTHIENO[2,3-D]PYRIMIDIN-4(3H)-ONE===
			{{ABSTRACT_PUBMED_23981144}}

	~~The entry 4mcd is ON HOLD~~		==Function==
			[[http://www.uniprot.org/uniprot/TRMD_HAEIN TRMD_HAEIN]] Specifically methylates guanosine-37 in various tRNAs (By similarity).[HAMAP-Rule:MF_00605]

	~~Authors~~: ~~Lahiri, S~~.		==About this Structure==
			[[4mcd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Haemophilus_influenzae_rd_kw20 Haemophilus influenzae rd kw20]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MCD OCA].

	~~Description~~:		==Reference==
			<ref group="xtra">PMID:023981144</ref><references group="xtra"/><references/>
			[[Category: Haemophilus influenzae rd kw20]]
			[[Category: Lahiri, S.]]
			[[Category: Hmt]]
			[[Category: Sah]]
			[[Category: Sam]]
			[[Category: Sinefungin]]
			[[Category: Structural genomic]]
			[[Category: Transferase-transferase inhibitor complex]]
			[[Category: Trefoil]]
			[[Category: Trmd]]

OCA at 10:01, 4 September 2013

2013-09-04T10:01:31Z

← Older revision		Revision as of 10:01, 4 September 2013
Line 3:		Line 3:
	The entry 4mcd is ON HOLD		The entry 4mcd is ON HOLD

	Authors: Lahiri, ~~N/A~~		Authors: Lahiri, S.

	Description: ~~hinTrmD in complex with compound 1~~		Description:

OCA: Protected "4mcd" [edit=sysop:move=sysop]

2013-08-28T06:58:10Z

Protected "4mcd" [edit=sysop:move=sysop]

← Older revision	Revision as of 06:58, 28 August 2013
(No difference)

OCA: New page: '''Unreleased structure''' The entry 4mcd is ON HOLD Authors: Lahiri, N/A Description: hinTrmD in complex with compound 1

2013-08-28T06:58:09Z

New page: '''Unreleased structure''' The entry 4mcd is ON HOLD Authors: Lahiri, N/A Description: hinTrmD in complex with compound 1

New page

'''Unreleased structure'''

The entry 4mcd is ON HOLD

Authors: Lahiri, N/A

Description: hinTrmD in complex with compound 1