4mo8 - Revision history

OCA at 16:40, 20 September 2023

2023-09-20T16:40:05Z

← Older revision		Revision as of 16:40, 20 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4mo8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MO8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MO8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4mo8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MO8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MO8 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2VQ:N-[2-(2-METHYL-5-NITRO-1H-IMIDAZOL-1-YL)ETHYL]SULFAMIDE'>2VQ</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.85Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2VQ:N-[2-(2-METHYL-5-NITRO-1H-IMIDAZOL-1-YL)ETHYL]SULFAMIDE'>2VQ</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mo8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mo8 OCA], [https://pdbe.org/4mo8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mo8 RCSB], [https://www.ebi.ac.uk/pdbsum/4mo8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mo8 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mo8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mo8 OCA], [https://pdbe.org/4mo8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mo8 RCSB], [https://www.ebi.ac.uk/pdbsum/4mo8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mo8 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 09:57, 28 December 2022

2022-12-28T09:57:13Z

← Older revision		Revision as of 09:57, 28 December 2022
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	==The crystal structure of the human carbonic anhydrase II in complex with N-[2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl]sulfamide==		==The crystal structure of the human carbonic anhydrase II in complex with N-[2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl]sulfamide==
	<StructureSection load='4mo8' size='340' side='right' caption='[[4mo8]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='4mo8' size='340' side='right'caption='[[4mo8]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4mo8]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MO8 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4MO8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4mo8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MO8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MO8 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2VQ:N-[2-(2-METHYL-5-NITRO-1H-IMIDAZOL-1-YL)ETHYL]SULFAMIDE'>2VQ</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2VQ:N-[2-(2-METHYL-5-NITRO-1H-IMIDAZOL-1-YL)ETHYL]SULFAMIDE'>2VQ</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4l84\|4l84]]</td></tr>~~		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mo8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mo8 OCA], [https://pdbe.org/4mo8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mo8 RCSB], [https://www.ebi.ac.uk/pdbsum/4mo8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mo8 ProSAT]</span></td></tr>
	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CA2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4mo8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mo8 OCA], [~~http~~://pdbe.org/4mo8 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4mo8 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4mo8 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4mo8 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[~~[http~~://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[~~http~~://omim.org/entry/259730 259730]]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref>		[https://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[https://omim.org/entry/259730 259730]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>		[https://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	==See Also==		==See Also==
	*[[Carbonic anhydrase\|Carbonic anhydrase]]		*[[Carbonic anhydrase 3D structures\|Carbonic anhydrase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Carbonate dehydratase~~]]		[[Category: Homo sapiens]]
	[[Category: ~~Human~~]]		[[Category: Large Structures]]
	[[Category: Alterio, V]]		[[Category: Alterio V]]
	[[Category: Simone, G ~~De]]~~		[[Category: De Simone G]]
	~~[[Category: Lyase-lyase inhibitor complex]]~~
	~~[[Category: Sulfamide]]~~
	~~[[Category: Zinc binding~~]]

OCA at 09:34, 11 August 2016

2016-08-11T09:34:50Z

← Older revision		Revision as of 09:34, 11 August 2016
Line 1:		Line 1:

	==The crystal structure of the human carbonic anhydrase II in complex with N-[2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl]sulfamide==		==The crystal structure of the human carbonic anhydrase II in complex with N-[2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl]sulfamide==
	<StructureSection load='4mo8' size='340' side='right' caption='[[4mo8]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='4mo8' size='340' side='right' caption='[[4mo8]], [[Resolution\|resolution]] 1.85Å' scene=''>
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	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CA2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CA2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mo8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mo8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mo8 RCSB], [http://www.ebi.ac.uk/pdbsum/4mo8 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mo8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mo8 OCA], [http://pdbe.org/4mo8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4mo8 RCSB], [http://www.ebi.ac.uk/pdbsum/4mo8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4mo8 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4mo8" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 10:40, 20 January 2015

2015-01-20T10:40:58Z

← Older revision		Revision as of 10:40, 20 January 2015
Line 1:		Line 1:
	~~{{STRUCTURE_4mo8\| PDB=4mo8 \| SCENE= }}~~		==The crystal structure of the human carbonic anhydrase II in complex with N-[2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl]sulfamide==
	===The crystal structure of the human carbonic anhydrase II in complex with N-[2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl]sulfamide===		<StructureSection load='4mo8' size='340' side='right' caption='[[4mo8]], [[Resolution\|resolution]] 1.85Å' scene=''>
	~~{{ABSTRACT_PUBMED_24128000}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[4mo8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MO8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MO8 FirstGlance]. <br>
	==Disease==		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2VQ:N-[2-(2-METHYL-5-NITRO-1H-IMIDAZOL-1-YL)ETHYL]SULFAMIDE'>2VQ</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4l84\|4l84]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CA2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
			<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mo8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mo8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mo8 RCSB], [http://www.ebi.ac.uk/pdbsum/4mo8 PDBsum]</span></td></tr>
			</table>
			== Disease ==
	[[http://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[http://omim.org/entry/259730 259730]]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref>		[[http://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[http://omim.org/entry/259730 259730]]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref>
			== Function ==
			[[http://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			A series of nitroimidazoles incorporating sulfonamide/sulfamide/sulfamate moieties were designed and synthesized as radio/chemosensitizing agent targeting the tumor-associated carbonic anhydrase (CA) isoforms IX and XII. Most of the new compounds were nanomolar inhibitors of these isoforms. Crystallographic studies on the complex of hCA II with the lead sulfamide derivative of this series, clarified the binding mode of this type of inhibitors in the enzyme active site cavity. Some of the best nitroimidazole CA IX inhibitors showed significant activity in vitro by reducing hypoxia-induced extracellular acidosis in HT-29 and HeLa cell lines. In vivo testing of the lead molecule in the sulfamide series, in co-treatment with doxorubicin, demonstrated a chemosensitization of CA IX containing tumors. Such CA inhibitors, specifically targeting the tumor-associated isoforms, are candidates for novel treatment strategies against hypoxic tumors overexpressing extracellular CA isozymes.

	~~==Function==~~		Hypoxia-targeting Carbonic Anhydrase IX inhibitors by a new series of nitroimidazole-sulfonamides /sulfamides/ sulfamates.,Rami M, Dubois L, Parvathaneni NK, Alterio V, van Kuijk S, Monti SM, Lambin P, De Simone G, Supuran CT, Winum JY J Med Chem. 2013 Oct 15. PMID:24128000<ref>PMID:24128000</ref>
	~~[[http:~~//~~www~~.~~uniprot~~.~~org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Essential for bone resorption and osteoclast differentiation (By similarity)~~. ~~Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>~~PMID:~~10550681</ref>~~ <ref>PMID:~~11831900~~</ref>

	~~==About this Structure==~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~[[4mo8]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Human Human]~~. ~~Full crystallographic information is available from [http:/~~/~~oca.weizmann.ac.il/oca-bin/ocashort?id=4MO8 OCA].~~		</div>

	==~~Reference~~==		==See Also==
	~~<ref group~~=~~"xtra">PMID:024128000</ref>~~<references ~~group="xtra"~~/><~~references~~/>		*[[Carbonic anhydrase\|Carbonic anhydrase]]
			== References ==
			<references/>
			__TOC__
			</StructureSection>
	[[Category: Carbonate dehydratase]]		[[Category: Carbonate dehydratase]]
	[[Category: Human]]		[[Category: Human]]
	[[Category: Alterio, V.]]		[[Category: Alterio, V]]
	[[Category: Simone, G De.]]		[[Category: Simone, G De]]
	[[Category: Lyase-lyase inhibitor complex]]		[[Category: Lyase-lyase inhibitor complex]]
	[[Category: Sulfamide]]		[[Category: Sulfamide]]
	[[Category: Zinc binding]]		[[Category: Zinc binding]]

OCA at 06:55, 15 January 2014

2014-01-15T06:55:50Z

← Older revision		Revision as of 06:55, 15 January 2014
Line 10:		Line 10:

	==About this Structure==		==About this Structure==
	[[4mo8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MO8 OCA].		[[4mo8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MO8 OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:024128000</ref><references group="xtra"/><references/>		<ref group="xtra">PMID:024128000</ref><references group="xtra"/><references/>
	[[Category: Carbonate dehydratase]]		[[Category: Carbonate dehydratase]]
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Alterio, V.]]		[[Category: Alterio, V.]]
	[[Category: Simone, G De.]]		[[Category: Simone, G De.]]

OCA at 09:35, 30 October 2013

2013-10-30T09:35:57Z

← Older revision		Revision as of 09:35, 30 October 2013
Line 1:		Line 1:
	~~'''Unreleased~~ structure~~'''~~		{{STRUCTURE_4mo8\| PDB=4mo8 \| SCENE= }}
			===The crystal structure of the human carbonic anhydrase II in complex with N-[2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl]sulfamide===
			{{ABSTRACT_PUBMED_24128000}}

	The ~~entry 4mo8~~ is ~~ON HOLD~~		==Disease==
			[[http://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[http://omim.org/entry/259730 259730]]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref>

	~~Authors~~: ~~Alterio, V~~.~~, De Simone, G~~.		==Function==
			[[http://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>

	~~Description: The crystal~~ structure ~~of the human carbonic anhydrase II in complex~~ with N-[2-~~(2-methyl-5-nitro-imidazol-1-yl)ethyl~~]~~sulfamide~~		==About this Structure==
			[[4mo8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MO8 OCA].

			==Reference==
			<ref group="xtra">PMID:024128000</ref><references group="xtra"/><references/>
			[[Category: Carbonate dehydratase]]
			[[Category: Homo sapiens]]
			[[Category: Alterio, V.]]
			[[Category: Simone, G De.]]
			[[Category: Lyase-lyase inhibitor complex]]
			[[Category: Sulfamide]]
			[[Category: Zinc binding]]

OCA at 07:39, 29 September 2013

2013-09-29T07:39:35Z

← Older revision		Revision as of 07:39, 29 September 2013
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	The entry 4mo8 is ON HOLD		The entry 4mo8 is ON HOLD

	Authors: ~~ALTERIO~~,V., ~~DE SIMONE~~, G.		Authors: Alterio, V., De Simone, G.

	Description: ~~THE CRYSTAL STRUCTURE OF THE HUMAN CARBONIC ANHYDRASE~~ II ~~IN COMPLEX WITH~~ N-[2-(2-~~METHYL~~-5-~~NITRO~~-~~IMIDAZOL~~-1-YL)~~ETHYL~~]~~SULFAMIDE~~		Description: The crystal structure of the human carbonic anhydrase II in complex with N-[2-(2-methyl-5-nitro-imidazol-1-yl)ethyl]sulfamide

OCA: Protected "4mo8" [edit=sysop:move=sysop]

2013-09-20T03:44:24Z

Protected "4mo8" [edit=sysop:move=sysop]

← Older revision	Revision as of 03:44, 20 September 2013
(No difference)

OCA: New page: '''Unreleased structure''' The entry 4mo8 is ON HOLD Authors: ALTERIO,V., DE SIMONE, G. Description: THE CRYSTAL STRUCTURE OF THE HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH N-[2-(2-ME...

2013-09-20T03:44:23Z

New page: '''Unreleased structure''' The entry 4mo8 is ON HOLD Authors: ALTERIO,V., DE SIMONE, G. Description: THE CRYSTAL STRUCTURE OF THE HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH N-[2-(2-ME...

New page

'''Unreleased structure'''

The entry 4mo8 is ON HOLD

Authors: ALTERIO,V., DE SIMONE, G.

Description: THE CRYSTAL STRUCTURE OF THE HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH N-[2-(2-METHYL-5-NITRO-IMIDAZOL-1-YL)ETHYL]SULFAMIDE