4mvb - Revision history

OCA at 11:10, 6 November 2024

2024-11-06T11:10:20Z

← Older revision		Revision as of 11:10, 6 November 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4mvb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MVB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MVB FirstGlance]. <br>		<table><tr><td colspan='2'>[[4mvb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MVB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MVB FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mvb OCA], [https://pdbe.org/4mvb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mvb RCSB], [https://www.ebi.ac.uk/pdbsum/4mvb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mvb ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.088Å</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mvb OCA], [https://pdbe.org/4mvb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mvb RCSB], [https://www.ebi.ac.uk/pdbsum/4mvb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mvb ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==

OCA at 10:12, 28 December 2022

2022-12-28T10:12:12Z

← Older revision		Revision as of 10:12, 28 December 2022
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	==42F3 pCPB7/H-2Ld Complex==		==42F3 pCPB7/H-2Ld Complex==
	<StructureSection load='4mvb' size='340' side='right' caption='[[4mvb]], [[Resolution\|resolution]] 3.09Å' scene=''>		<StructureSection load='4mvb' size='340' side='right'caption='[[4mvb]], [[Resolution\|resolution]] 3.09Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4mvb]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~] and [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MVB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4MVB FirstGlance]. <br>		<table><tr><td colspan='2'>[[4mvb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MVB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MVB FirstGlance]. <br>
	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3tf7\|3tf7]], [[3tfk\|3tfk]], [[3tjh\|3tjh]], [[3tpu\|3tpu]], [[4ms8\|4ms8]]</td></tr>~~		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mvb OCA], [https://pdbe.org/4mvb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mvb RCSB], [https://www.ebi.ac.uk/pdbsum/4mvb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mvb ProSAT]</span></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">H2-L ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4mvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mvb OCA], [~~http~~://pdbe.org/4mvb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4mvb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4mvb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4mvb ProSAT]</span></td></tr>
	</table>		</table>
			== Disease ==
			[https://www.uniprot.org/uniprot/TRAC_HUMAN TRAC_HUMAN] TCR-alpha-beta-positive T-cell deficiency. The disease is caused by variants affecting the gene represented in this entry.
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/~~HA1L_MOUSE HA1L_MOUSE~~]~~] Involved~~ in the ~~presentation~~ of ~~foreign antigens to~~ the ~~immune system~~.		[https://www.uniprot.org/uniprot/TRAC_HUMAN TRAC_HUMAN] Constant region of T cell receptor (TR) alpha chain (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).<ref>PMID:15040585</ref> <ref>PMID:23524462</ref> <ref>PMID:24600447</ref> <ref>PMID:25493333</ref> [https://www.uniprot.org/uniprot/A0A0G2JFA3_MOUSE A0A0G2JFA3_MOUSE] [https://www.uniprot.org/uniprot/TVA1_MOUSE TVA1_MOUSE]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: ~~Lk3 transgenic mice~~]]		[[Category: Large Structures]]
	[[Category: ~~Adams, J J~~]]		[[Category: Mus musculus]]
	[[Category: ~~Birnbaum, M E~~]]		[[Category: Adams JJ]]
	[[Category: ~~Garcia, K C~~]]		[[Category: Birnbaum ME]]
	[[Category: ~~Ig]]~~		[[Category: Garcia KC]]
	~~[[Category: Immune system]]~~
	~~[[Category: Mhc]]~~
	~~[[Category: Tcr~~]]

OCA at 08:32, 26 September 2018

2018-09-26T08:32:07Z

← Older revision		Revision as of 08:32, 26 September 2018
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	<StructureSection load='4mvb' size='340' side='right' caption='[[4mvb]], [[Resolution\|resolution]] 3.09Å' scene=''>		<StructureSection load='4mvb' size='340' side='right' caption='[[4mvb]], [[Resolution\|resolution]] 3.09Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4mvb]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MVB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MVB FirstGlance]. <br>		<table><tr><td colspan='2'>[[4mvb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MVB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MVB FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3tf7\|3tf7]], [[3tfk\|3tfk]], [[3tjh\|3tjh]], [[3tpu\|3tpu]], [[4ms8\|4ms8]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3tf7\|3tf7]], [[3tfk\|3tfk]], [[3tjh\|3tjh]], [[3tpu\|3tpu]], [[4ms8\|4ms8]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">H2-L ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mvb OCA], [http://pdbe.org/4mvb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4mvb RCSB], [http://www.ebi.ac.uk/pdbsum/4mvb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4mvb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mvb OCA], [http://pdbe.org/4mvb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4mvb RCSB], [http://www.ebi.ac.uk/pdbsum/4mvb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4mvb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/HA1L_MOUSE HA1L_MOUSE]] Involved in the presentation of foreign antigens to the immune system.		[[http://www.uniprot.org/uniprot/HA1L_MOUSE HA1L_MOUSE]] Involved in the presentation of foreign antigens to the immune system.
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The T cell antigen receptor (TCR)-peptide-major histocompatibility complex (MHC) interface is composed of conserved and diverse regions, yet the relative contribution of each in shaping recognition by T cells remains unclear. Here we isolated cross-reactive peptides with limited homology, which allowed us to compare the structural properties of nine peptides for a single TCR-MHC pair. The TCR's cross-reactivity was rooted in highly similar recognition of an apical 'hot-spot' position in the peptide with tolerance of sequence variation at ancillary positions. Furthermore, we found a striking structural convergence onto a germline-mediated interaction between the TCR CDR1alpha region and the MHC alpha2 helix in twelve TCR-peptide-MHC complexes. Our studies suggest that TCR-MHC germline-mediated constraints, together with a focus on a small peptide hot spot, might place limits on peptide antigen cross-reactivity.

			Structural interplay between germline interactions and adaptive recognition determines the bandwidth of TCR-peptide-MHC cross-reactivity.,Adams JJ, Narayanan S, Birnbaum ME, Sidhu SS, Blevins SJ, Gee MH, Sibener LV, Baker BM, Kranz DM, Garcia KC Nat Immunol. 2016 Jan;17(1):87-94. doi: 10.1038/ni.3310. Epub 2015 Nov 2. PMID:26523866<ref>PMID:26523866</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 4mvb" style="background-color:#fffaf0;"></div>
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Human]]
			[[Category: Lk3 transgenic mice]]
	[[Category: Adams, J J]]		[[Category: Adams, J J]]
	[[Category: Birnbaum, M E]]		[[Category: Birnbaum, M E]]

OCA at 14:15, 24 May 2017

2017-05-24T14:15:29Z

← Older revision		Revision as of 14:15, 24 May 2017
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	==42F3 pCPB7/H-2Ld Complex==		==42F3 pCPB7/H-2Ld Complex==
	<StructureSection load='4mvb' size='340' side='right' caption='[[4mvb]], [[Resolution\|resolution]] 3.09Å' scene=''>		<StructureSection load='4mvb' size='340' side='right' caption='[[4mvb]], [[Resolution\|resolution]] 3.09Å' scene=''>
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	<table><tr><td colspan='2'>[[4mvb]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MVB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MVB FirstGlance]. <br>		<table><tr><td colspan='2'>[[4mvb]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MVB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MVB FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3tf7\|3tf7]], [[3tfk\|3tfk]], [[3tjh\|3tjh]], [[3tpu\|3tpu]], [[4ms8\|4ms8]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3tf7\|3tf7]], [[3tfk\|3tfk]], [[3tjh\|3tjh]], [[3tpu\|3tpu]], [[4ms8\|4ms8]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mvb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mvb RCSB], [http://www.ebi.ac.uk/pdbsum/4mvb PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mvb OCA], [http://pdbe.org/4mvb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4mvb RCSB], [http://www.ebi.ac.uk/pdbsum/4mvb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4mvb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 12:21, 20 August 2015

2015-08-20T12:21:41Z

← Older revision		Revision as of 12:21, 20 August 2015
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	'''~~Unreleased structure~~'''		==42F3 pCPB7/H-2Ld Complex==
			<StructureSection load='4mvb' size='340' side='right' caption='[[4mvb]], [[Resolution\|resolution]] 3.09Å' scene=''>
	~~The entry~~ 4mvb is ~~ON HOLD until Paper Publication~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[4mvb]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MVB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MVB FirstGlance]. <br>
	~~Authors~~: ~~Birnbaum~~, M.E., ~~Adams, J~~.J., ~~Garcia, K~~.C.		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3tf7\|3tf7]], [[3tfk\|3tfk]], [[3tjh\|3tjh]], [[3tpu\|3tpu]], [[4ms8\|4ms8]]</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mvb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mvb RCSB], [http://www.ebi.ac.uk/pdbsum/4mvb PDBsum]</span></td></tr>
	~~Description~~: ~~42F3 pCPB7~~/~~H-2Ld Complex~~		</table>
	[[Category: ~~Unreleased Structures~~]]		== Function ==
	[[Category: Garcia, K.C]]		[[http://www.uniprot.org/uniprot/HA1L_MOUSE HA1L_MOUSE]] Involved in the presentation of foreign antigens to the immune system.
	[[Category: ~~Adams, J.J~~]]		__TOC__
	[[Category: ~~Birnbaum, M.E~~]]		</StructureSection>
			[[Category: Adams, J J]]
			[[Category: Birnbaum, M E]]
			[[Category: Garcia, K C]]
			[[Category: Ig]]
			[[Category: Immune system]]
			[[Category: Mhc]]
			[[Category: Tcr]]

OCA at 14:08, 24 December 2014

2014-12-24T14:08:05Z

← Older revision		Revision as of 14:08, 24 December 2014
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	Description: 42F3 pCPB7/H-2Ld Complex		Description: 42F3 pCPB7/H-2Ld Complex
			[[Category: Unreleased Structures]]
			[[Category: Garcia, K.C]]
			[[Category: Adams, J.J]]
			[[Category: Birnbaum, M.E]]

OCA at 09:41, 27 November 2013

2013-11-27T09:41:38Z

← Older revision		Revision as of 09:41, 27 November 2013
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4mvb is ON HOLD		The entry 4mvb is ON HOLD until Paper Publication

	Authors: Birnbaum, M.E., Adams, J.J., Garcia, K.C.		Authors: Birnbaum, M.E., Adams, J.J., Garcia, K.C.

	Description: 42F3 pCPB7/H-2Ld Complex		Description: 42F3 pCPB7/H-2Ld Complex

OCA: Protected "4mvb" [edit=sysop:move=sysop]

2013-10-02T06:55:49Z

Protected "4mvb" [edit=sysop:move=sysop]

← Older revision	Revision as of 06:55, 2 October 2013
(No difference)

OCA: New page: '''Unreleased structure''' The entry 4mvb is ON HOLD Authors: Birnbaum, M.E., Adams, J.J., Garcia, K.C. Description: 42F3 pCPB7/H-2Ld Complex

2013-10-02T06:55:47Z

New page: '''Unreleased structure''' The entry 4mvb is ON HOLD Authors: Birnbaum, M.E., Adams, J.J., Garcia, K.C. Description: 42F3 pCPB7/H-2Ld Complex

New page

'''Unreleased structure'''

The entry 4mvb is ON HOLD

Authors: Birnbaum, M.E., Adams, J.J., Garcia, K.C.

Description: 42F3 pCPB7/H-2Ld Complex