4odd - Revision history

OCA at 03:22, 21 November 2024

2024-11-21T03:22:16Z

← Older revision		Revision as of 03:22, 21 November 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4odd]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ODD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ODD FirstGlance]. <br>		<table><tr><td colspan='2'>[[4odd]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ODD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ODD FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4odd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4odd OCA], [https://pdbe.org/4odd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4odd RCSB], [https://www.ebi.ac.uk/pdbsum/4odd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4odd ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6Å</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4odd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4odd OCA], [https://pdbe.org/4odd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4odd RCSB], [https://www.ebi.ac.uk/pdbsum/4odd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4odd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 07:18, 25 January 2023

2023-01-25T07:18:34Z

← Older revision		Revision as of 07:18, 25 January 2023
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	<StructureSection load='4odd' size='340' side='right'caption='[[4odd]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='4odd' size='340' side='right'caption='[[4odd]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4odd]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Canlf Canlf~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ODD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ODD FirstGlance]. <br>		<table><tr><td colspan='2'>[[4odd]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ODD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ODD FirstGlance]. <br>
	</td></tr>~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">OBP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9615 CANLF])</td></tr>~~		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4odd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4odd OCA], [https://pdbe.org/4odd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4odd RCSB], [https://www.ebi.ac.uk/pdbsum/4odd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4odd ProSAT]</span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4odd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4odd OCA], [~~http~~://pdbe.org/4odd PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4odd RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4odd PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4odd ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/J9P950_CANLF J9P950_CANLF]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Canlf~~]]		[[Category: Canis lupus familiaris]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Niemi~~, M H~~]]		[[Category: Niemi MH]]
	[[Category: Rouvinen, J]]		[[Category: Rouvinen J]]
	~~[[Category: Allergen~~]]

OCA at 09:10, 10 April 2019

2019-04-10T09:10:34Z

← Older revision		Revision as of 09:10, 10 April 2019
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	==Crystal structure of a dog lipocalin allergen==		==Crystal structure of a dog lipocalin allergen==
	<StructureSection load='4odd' size='340' side='right' caption='[[4odd]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='4odd' size='340' side='right'caption='[[4odd]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4odd]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ODD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ODD FirstGlance]. <br>		<table><tr><td colspan='2'>[[4odd]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Canlf Canlf]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ODD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ODD FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4odd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4odd OCA], [http://pdbe.org/4odd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4odd RCSB], [http://www.ebi.ac.uk/pdbsum/4odd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4odd ProSAT]</span></td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">OBP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9615 CANLF])</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4odd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4odd OCA], [http://pdbe.org/4odd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4odd RCSB], [http://www.ebi.ac.uk/pdbsum/4odd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4odd ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Canlf]]
			[[Category: Large Structures]]
	[[Category: Niemi, M H]]		[[Category: Niemi, M H]]
	[[Category: Rouvinen, J]]		[[Category: Rouvinen, J]]
	[[Category: Allergen]]		[[Category: Allergen]]

OCA at 10:40, 11 August 2016

2016-08-11T10:40:42Z

← Older revision		Revision as of 10:40, 11 August 2016
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	==Crystal structure of a dog lipocalin allergen==		==Crystal structure of a dog lipocalin allergen==
	<StructureSection load='4odd' size='340' side='right' caption='[[4odd]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='4odd' size='340' side='right' caption='[[4odd]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4odd]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ODD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ODD FirstGlance]. <br>		<table><tr><td colspan='2'>[[4odd]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ODD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ODD FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4odd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4odd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4odd RCSB], [http://www.ebi.ac.uk/pdbsum/4odd PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4odd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4odd OCA], [http://pdbe.org/4odd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4odd RCSB], [http://www.ebi.ac.uk/pdbsum/4odd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4odd ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4odd" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:51, 5 January 2015

2015-01-05T09:51:50Z

← Older revision		Revision as of 09:51, 5 January 2015
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4odd]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ODD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ODD FirstGlance]. <br>		<table><tr><td colspan='2'>[[4odd]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ODD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ODD FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4odd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4odd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4odd RCSB], [http://www.ebi.ac.uk/pdbsum/4odd PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4odd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4odd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4odd RCSB], [http://www.ebi.ac.uk/pdbsum/4odd PDBsum]</span></td></tr>
	<table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	Structural aspects of dog allergies: The crystal structure of a dog dander allergen Can f 4.,Niemi MH, Rytkonen-Nissinen M, Janis J, Virtanen T, Rouvinen J Mol Immunol. 2014 Sep;61(1):7-15. doi: 10.1016/j.molimm.2014.04.003. Epub 2014, May 21. PMID:24859823<ref>PMID:24859823</ref>		Structural aspects of dog allergies: The crystal structure of a dog dander allergen Can f 4.,Niemi MH, Rytkonen-Nissinen M, Janis J, Virtanen T, Rouvinen J Mol Immunol. 2014 Sep;61(1):7-15. doi: 10.1016/j.molimm.2014.04.003. Epub 2014, May 21. PMID:24859823<ref>PMID:24859823</ref>

	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Niemi, M H.]]		[[Category: Niemi, M H]]
	[[Category: Rouvinen, J.]]		[[Category: Rouvinen, J]]
	[[Category: Allergen]]		[[Category: Allergen]]

OCA at 05:09, 4 June 2014

2014-06-04T05:09:38Z

← Older revision		Revision as of 05:09, 4 June 2014
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	'''~~Unreleased~~ structure'''		==Crystal structure of a dog lipocalin allergen==
			<StructureSection load='4odd' size='340' side='right' caption='[[4odd]], [[Resolution\|resolution]] 2.60Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[4odd]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ODD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ODD FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4odd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4odd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4odd RCSB], [http://www.ebi.ac.uk/pdbsum/4odd PDBsum]</span></td></tr>
			<table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Four out of six officially recognized dog allergens are members of the lipocalin protein family. So far, a three-dimensional structure has been determined for only one dog allergen, Can f 2, which is a lipocalin protein. We present here the crystal structure of a second lipocalin allergen from dog, a variant of Can f 4. Moreover, we have compared and analyzed the structures of these two weakly homologous (amino acid identity 21%) dog allergens. The size and the amino acid composition of the ligand-binding pocket indicate that Can f 4 is capable of binding only relatively small hydrophobic molecules which are different from those that Can f 2 is able to bind. The crystal structure of Can f 4 contained both monomeric and dimeric forms of the allergen, suggesting that Can f 4 is able to form transient (weak) dimers. The existence of transient dimers in solution was confirmed by use of native mass spectrometry. The dimeric structure of Can f 4 is formed when the ends of four beta-strands are packed against the same strands from the second monomer. The residues in the interface are mainly hydrophobic and the formation of the dimer is similar to the major horse allergen Equ c 1. Interestingly, the crystal structure of dog Can f 2 has been reported to show a different type of dimer formation. The capability of these allergens to form dimers may be important for the development of immediate allergic reaction (mast cell activation) because oligomeric allergens can effectively present multivalent epitopes.

	The ~~entry 4odd is ON HOLD until Paper Publication~~		Structural aspects of dog allergies: The crystal structure of a dog dander allergen Can f 4.,Niemi MH, Rytkonen-Nissinen M, Janis J, Virtanen T, Rouvinen J Mol Immunol. 2014 Sep;61(1):7-15. doi: 10.1016/j.molimm.2014.04.003. Epub 2014, May 21. PMID:24859823<ref>PMID:24859823</ref>

	~~Authors~~: Niemi, M.H., Rouvinen, J.		From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~Description~~: ~~Crystal structure of a dog lipocalin allergen~~		== References ==
			<references/>
			__TOC__
			</StructureSection>
			[[Category: Niemi, M H.]]
			[[Category: Rouvinen, J.]]
			[[Category: Allergen]]

OCA at 05:48, 9 April 2014

2014-04-09T05:48:08Z

← Older revision		Revision as of 05:48, 9 April 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4odd is ON HOLD		The entry 4odd is ON HOLD until Paper Publication

	Authors: Niemi, M.H., Rouvinen, J.		Authors: Niemi, M.H., Rouvinen, J.

	Description: Crystal structure of a dog lipocalin allergen		Description: Crystal structure of a dog lipocalin allergen

OCA: Protected "4odd" [edit=sysop:move=sysop]

2014-01-22T06:47:18Z

Protected "4odd" [edit=sysop:move=sysop]

← Older revision	Revision as of 06:47, 22 January 2014
(No difference)

OCA: New page: '''Unreleased structure''' The entry 4odd is ON HOLD Authors: Niemi, M.H., Rouvinen, J. Description: Crystal structure of a dog lipocalin allergen

2014-01-22T06:47:18Z

New page: '''Unreleased structure''' The entry 4odd is ON HOLD Authors: Niemi, M.H., Rouvinen, J. Description: Crystal structure of a dog lipocalin allergen

New page

'''Unreleased structure'''

The entry 4odd is ON HOLD

Authors: Niemi, M.H., Rouvinen, J.

Description: Crystal structure of a dog lipocalin allergen