4oos - Revision history

OCA at 12:41, 1 March 2024

2024-03-01T12:41:21Z

← Older revision		Revision as of 12:41, 1 March 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4oos]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Norovirus_Hu/GII.4/Sydney/NSW0514/2012/AU Norovirus Hu/GII.4/Sydney/NSW0514/2012/AU]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OOS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OOS FirstGlance]. <br>		<table><tr><td colspan='2'>[[4oos]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Norovirus_Hu/GII.4/Sydney/NSW0514/2012/AU Norovirus Hu/GII.4/Sydney/NSW0514/2012/AU]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OOS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OOS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.64Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4oos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oos OCA], [https://pdbe.org/4oos PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4oos RCSB], [https://www.ebi.ac.uk/pdbsum/4oos PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4oos ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4oos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oos OCA], [https://pdbe.org/4oos PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4oos RCSB], [https://www.ebi.ac.uk/pdbsum/4oos PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4oos ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/K4LM89_9CALI K4LM89_9CALI]		[https://www.uniprot.org/uniprot/K4LM89_9CALI K4LM89_9CALI]
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	Human noroviruses are the dominant cause of outbreaks of gastroenteritis around the world. Human norovirus interacts with the polymorphic human histo-blood group antigens (HBGAs) and this interaction is thought to be important for infection. Indeed, synthetic HBGAs or HBGA-expressing enteric bacteria were shown to enhance norovirus infection in B cells. A number of studies have found a possible relationship between HBGA type and norovirus susceptibility. The genogroup II genotype 4 (GII.4) noroviruses are the dominant cluster, evolve every other year, and are thought to modify their binding interactions to different HBGA types. Here, we show the high-resolution X-ray crystal structures of the capsid protruding (P) domains from epidemic GII.4 variants in 2004, 2006, and 2012, co-crystallized with a panel of HBGA types (H type 2, Lewis Y, Lewis B, Lewis A, Lewis X, A-type, and B-type). Many of the HBGA binding interactions were found to be complex, involving capsid loop movements, alternative HBGA conformations, and HBGA rotations. We showed that a loop (residues 391-395) was elegantly repositioned in order to allow for Lewis Y binding. This loop was also slightly shifted to provide direct hydrogen and water-mediated bonds with Lewis B. We considered that the flexible loop modulated Lewis HBGA binding. The GII.4 noroviruses have dominated outbreaks over the past decade, which may be explained by their exquisite HBGA binding mechanisms, their fondness for Lewis HBGAs, and their temporal amino acid modifications. IMPORTANCE: Our data provides a comprehensive picture of GII.4 P domain and HBGA binding interactions. The exceptionally high resolutions of our X-ray crystal structures allowed us to accurately recognize novel GII.4 P domain interactions with numerous HBGA types. We showed that the GII.4 P domain HBGA interactions involved complex binding mechanisms that were not previously observed in norovirus structural studies. Many of the GII.4 P domain HBGA interactions we identified were negative in earlier ELISA-based studies. Altogether, we showed that the GII.4 norovirus P domains could accommodate numerous HBGA types.

	~~Human Noroviruses' Fondness of Histo-Blood Group Antigens.,Singh BK, Leuthold MM, Hansman GS J Virol. 2014 Nov 26. pii: JVI.02968-14. PMID:25428879<ref>PMID:25428879</ref>~~

	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~<div class="pdbe-citations 4oos" style="background-color:#fffaf0;"></div>~~

	==See Also==		==See Also==
	*[[Virus coat proteins 3D structures\|Virus coat proteins 3D structures]]		*[[Virus coat proteins 3D structures\|Virus coat proteins 3D structures]]
	~~== References ==~~
	~~<references/>~~
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 07:36, 25 January 2023

2023-01-25T07:36:36Z

← Older revision		Revision as of 07:36, 25 January 2023
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	<StructureSection load='4oos' size='340' side='right'caption='[[4oos]], [[Resolution\|resolution]] 1.64Å' scene=''>		<StructureSection load='4oos' size='340' side='right'caption='[[4oos]], [[Resolution\|resolution]] 1.64Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4oos]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Norovirus_hu~~/~~gii~~.4/~~sydney~~/~~nsw0514~~/2012/au Norovirus hu/~~gii~~.4/~~sydney~~/~~nsw0514~~/2012/au]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OOS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4OOS FirstGlance]. <br>		<table><tr><td colspan='2'>[[4oos]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Norovirus_Hu/GII.4/Sydney/NSW0514/2012/AU Norovirus Hu/GII.4/Sydney/NSW0514/2012/AU]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OOS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OOS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>~~</td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4op7\|4op7]], [[4opo\|4opo]]</td></tr>~~		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4oos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oos OCA], [https://pdbe.org/4oos PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4oos RCSB], [https://www.ebi.ac.uk/pdbsum/4oos PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4oos ProSAT]</span></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">JX459908 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1241973 Norovirus Hu/GII.4/Sydney/NSW0514/2012/AU])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4oos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oos OCA], [~~http~~://pdbe.org/4oos PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4oos RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4oos PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4oos ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/K4LM89_9CALI K4LM89_9CALI]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 4oos" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4oos" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Virus coat proteins 3D structures\|Virus coat proteins 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Norovirus hu/~~gii~~ 4/~~sydney~~/~~nsw0514~~/2012/au]]		[[Category: Norovirus Hu/GII 4/Sydney/NSW0514/2012/AU]]
	[[Category: Hansman~~, G S~~]]		[[Category: Hansman GS]]
	[[Category: Singh~~, B K]]~~		[[Category: Singh BK]]
	~~[[Category: Viral capsid protein]]~~
	~~[[Category: Viral protein~~]]

OCA at 07:44, 17 April 2019

2019-04-17T07:44:08Z

← Older revision		Revision as of 07:44, 17 April 2019
Line 1:		Line 1:

	==Crystal structure of P domain from norovirus strain NSW0514==		==Crystal structure of P domain from norovirus strain NSW0514==
	<StructureSection load='4oos' size='340' side='right' caption='[[4oos]], [[Resolution\|resolution]] 1.64Å' scene=''>		<StructureSection load='4oos' size='340' side='right'caption='[[4oos]], [[Resolution\|resolution]] 1.64Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4oos]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OOS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OOS FirstGlance]. <br>		<table><tr><td colspan='2'>[[4oos]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Norovirus_hu/gii.4/sydney/nsw0514/2012/au Norovirus hu/gii.4/sydney/nsw0514/2012/au]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OOS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OOS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4op7\|4op7]], [[4opo\|4opo]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4op7\|4op7]], [[4opo\|4opo]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">JX459908 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1241973 Norovirus Hu/GII.4/Sydney/NSW0514/2012/AU])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oos OCA], [http://pdbe.org/4oos PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4oos RCSB], [http://www.ebi.ac.uk/pdbsum/4oos PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4oos ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oos OCA], [http://pdbe.org/4oos PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4oos RCSB], [http://www.ebi.ac.uk/pdbsum/4oos PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4oos ProSAT]</span></td></tr>
	</table>		</table>
Line 21:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
			[[Category: Norovirus hu/gii 4/sydney/nsw0514/2012/au]]
	[[Category: Hansman, G S]]		[[Category: Hansman, G S]]
	[[Category: Singh, B K]]		[[Category: Singh, B K]]
	[[Category: Viral capsid protein]]		[[Category: Viral capsid protein]]
	[[Category: Viral protein]]		[[Category: Viral protein]]

OCA at 17:08, 2 January 2017

2017-01-02T17:08:00Z

← Older revision		Revision as of 17:08, 2 January 2017
Line 1:		Line 1:

	==Crystal structure of P domain from norovirus strain NSW0514==		==Crystal structure of P domain from norovirus strain NSW0514==
	<StructureSection load='4oos' size='340' side='right' caption='[[4oos]], [[Resolution\|resolution]] 1.64Å' scene=''>		<StructureSection load='4oos' size='340' side='right' caption='[[4oos]], [[Resolution\|resolution]] 1.64Å' scene=''>
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4op7\|4op7]], [[4opo\|4opo]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4op7\|4op7]], [[4opo\|4opo]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oos OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4oos RCSB], [http://www.ebi.ac.uk/pdbsum/4oos PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oos OCA], [http://pdbe.org/4oos PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4oos RCSB], [http://www.ebi.ac.uk/pdbsum/4oos PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4oos ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4oos" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:46, 17 December 2014

2014-12-17T12:46:50Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Crystal structure of P domain from norovirus strain NSW0514==
-The entry 4oos is ON HOLD  until Paper Publication
+Human Noroviruses' Fondness of Histo-Blood Group Antigens.,Singh BK, Leuthold MM, Hansman GS J Virol. 2014 Nov 26. pii: JVI.02968-14. PMID:25428879<ref>PMID:25428879</ref>
-Authors: Singh, B.K., Hansman, G.S.
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-Description: Crystal structure of P domain from norovirus strain NSW0514
+== References ==

OCA at 12:18, 12 March 2014

2014-03-12T12:18:21Z

← Older revision		Revision as of 12:18, 12 March 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4oos is ON HOLD		The entry 4oos is ON HOLD until Paper Publication

	Authors: Singh, B.K., Hansman, G.S.		Authors: Singh, B.K., Hansman, G.S.

	Description: Crystal structure of P domain from norovirus strain NSW0514		Description: Crystal structure of P domain from norovirus strain NSW0514

OCA: Protected "4oos" [edit=sysop:move=sysop]

2014-02-13T04:51:59Z

Protected "4oos" [edit=sysop:move=sysop]

← Older revision	Revision as of 04:51, 13 February 2014
(No difference)

OCA: New page: '''Unreleased structure''' The entry 4oos is ON HOLD Authors: Singh, B.K., Hansman, G.S. Description: Crystal structure of P domain from norovirus strain NSW0514

2014-02-13T04:51:59Z

New page: '''Unreleased structure''' The entry 4oos is ON HOLD Authors: Singh, B.K., Hansman, G.S. Description: Crystal structure of P domain from norovirus strain NSW0514

New page

'''Unreleased structure'''

The entry 4oos is ON HOLD

Authors: Singh, B.K., Hansman, G.S.

Description: Crystal structure of P domain from norovirus strain NSW0514