4opy - Revision history

OCA at 03:23, 21 November 2024

2024-11-21T03:23:31Z

← Older revision		Revision as of 03:23, 21 November 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4opy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OPY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OPY FirstGlance]. <br>		<table><tr><td colspan='2'>[[4opy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OPY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OPY FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.75Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4opy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4opy OCA], [https://pdbe.org/4opy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4opy RCSB], [https://www.ebi.ac.uk/pdbsum/4opy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4opy ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4opy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4opy OCA], [https://pdbe.org/4opy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4opy RCSB], [https://www.ebi.ac.uk/pdbsum/4opy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4opy ProSAT]</span></td></tr>
	</table>		</table>
	~~== Function ==~~
	~~[https://www.uniprot.org/uniprot/Q9AGJ5_ECOLX Q9AGJ5_ECOLX]~~
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:39, 25 January 2023

2023-01-25T07:39:17Z

← Older revision		Revision as of 07:39, 25 January 2023
Line 1:		Line 1:

	==Room temperature crystal structure of stabilized TEM-1 beta-lactamase variant v.13 carrying R164S mutation==		==Room temperature crystal structure of stabilized TEM-1 beta-lactamase variant v.13 carrying R164S mutation==
	<StructureSection load='4opy' size='340' side='right' caption='[[4opy]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='4opy' size='340' side='right'caption='[[4opy]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4opy]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OPY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4OPY FirstGlance]. <br>		<table><tr><td colspan='2'>[[4opy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OPY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OPY FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ibr\|4ibr]], [[4ibx\|4ibx]], [[4op5\|4op5]], [[4op8\|4op8]], [[4opq\|4opq]], [[4opr\|4opr]], [[4opz\|4opz]], [[4oq0\|4oq0]], [[4oqg\|4oqg]], [[4oqh\|4oqh]], [[4oqi\|4oqi]]</td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4opy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4opy OCA], [https://pdbe.org/4opy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4opy RCSB], [https://www.ebi.ac.uk/pdbsum/4opy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4opy ProSAT]</span></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">blaTEM-63 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4opy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4opy OCA], [~~http~~://pdbe.org/4opy PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4opy RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4opy PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4opy ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/Q9AGJ5_ECOLX Q9AGJ5_ECOLX]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 4opy" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4opy" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Beta-lactamase 3D structures\|Beta-lactamase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Bacillus~~ coli ~~migula 1895~~]]		[[Category: Escherichia coli]]
	[[Category: Dellus-Gur, E]]		[[Category: Large Structures]]
	[[Category: Elias, M]]		[[Category: Dellus-Gur E]]
	[[Category: Fraser~~, J S~~]]		[[Category: Elias M]]
	[[Category: Tawfik~~, D S]]~~		[[Category: Fraser JS]]
	~~[[Category: Beta-lactama]]~~		[[Category: Tawfik DS]]
	~~[[Category: Hydrolase~~]]

OCA at 07:53, 17 January 2018

2018-01-17T07:53:34Z

← Older revision		Revision as of 07:53, 17 January 2018
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	<StructureSection load='4opy' size='340' side='right' caption='[[4opy]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='4opy' size='340' side='right' caption='[[4opy]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4opy]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OPY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OPY FirstGlance]. <br>		<table><tr><td colspan='2'>[[4opy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OPY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OPY FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ibr\|4ibr]], [[4ibx\|4ibx]], [[4op5\|4op5]], [[4op8\|4op8]], [[4opq\|4opq]], [[4opr\|4opr]], [[4opz\|4opz]], [[4oq0\|4oq0]], [[4oqg\|4oqg]], [[4oqh\|4oqh]], [[4oqi\|4oqi]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ibr\|4ibr]], [[4ibx\|4ibx]], [[4op5\|4op5]], [[4op8\|4op8]], [[4opq\|4opq]], [[4opr\|4opr]], [[4opz\|4opz]], [[4oq0\|4oq0]], [[4oqg\|4oqg]], [[4oqh\|4oqh]], [[4oqi\|4oqi]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">blaTEM-63 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4opy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4opy OCA], [http://pdbe.org/4opy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4opy RCSB], [http://www.ebi.ac.uk/pdbsum/4opy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4opy ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4opy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4opy OCA], [http://pdbe.org/4opy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4opy RCSB], [http://www.ebi.ac.uk/pdbsum/4opy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4opy ProSAT]</span></td></tr>
	</table>		</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Epistasis is a key factor in evolution since it determines which combinations of mutations provide adaptive solutions and which mutational pathways toward these solutions are accessible by natural selection. There is growing evidence for the pervasiveness of sign epistasis--a complete reversion of mutational effects, particularly in protein evolution--yet its molecular basis remains poorly understood. We describe the structural basis of sign epistasis between G238S and R164S, two adaptive mutations in TEM-1 beta-lactamase--an enzyme that endows antibiotics resistance. Separated by 10 A, these mutations initiate two separate trajectories toward increased hydrolysis rates and resistance toward second and third-generation cephalosporins antibiotics. Both mutations allow the enzyme's active site to adopt alternative conformations and accommodate the new antibiotics. By solving the corresponding set of crystal structures, we found that R164S causes local disorder whereas G238S induces discrete conformations. When combined, the mutations in 238 and 164 induce local disorder whereby nonproductive conformations that perturb the enzyme's catalytic preorganization dominate. Specifically, Asn170 that coordinates the deacylating water molecule is misaligned, in both the free form and the inhibitor-bound double mutant. This local disorder is not restored by stabilizing global suppressor mutations and thus leads to an evolutionary cul-de-sac. Conformational dynamism therefore underlines the reshaping potential of protein's structures and functions but also limits protein evolvability because of the fragility of the interactions networks that maintain protein structures.

			Negative Epistasis and Evolvability in TEM-1 beta-Lactamase--The Thin Line between an Enzyme's Conformational Freedom and Disorder.,Dellus-Gur E, Elias M, Caselli E, Prati F, Salverda ML, de Visser JA, Fraser JS, Tawfik DS J Mol Biol. 2015 Jul 17;427(14):2396-409. doi: 10.1016/j.jmb.2015.05.011. Epub, 2015 May 22. PMID:26004540<ref>PMID:26004540</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 4opy" style="background-color:#fffaf0;"></div>
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Bacillus coli migula 1895]]
	[[Category: Dellus-Gur, E]]		[[Category: Dellus-Gur, E]]
	[[Category: Elias, M]]		[[Category: Elias, M]]

OCA at 17:32, 9 March 2017

2017-03-09T17:32:53Z

← Older revision		Revision as of 17:32, 9 March 2017
Line 1:		Line 1:

	==Room temperature crystal structure of stabilized TEM-1 beta-lactamase variant v.13 carrying R164S mutation==		==Room temperature crystal structure of stabilized TEM-1 beta-lactamase variant v.13 carrying R164S mutation==
	<StructureSection load='4opy' size='340' side='right' caption='[[4opy]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='4opy' size='340' side='right' caption='[[4opy]], [[Resolution\|resolution]] 1.75Å' scene=''>
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ibr\|4ibr]], [[4ibx\|4ibx]], [[4op5\|4op5]], [[4op8\|4op8]], [[4opq\|4opq]], [[4opr\|4opr]], [[4opz\|4opz]], [[4oq0\|4oq0]], [[4oqg\|4oqg]], [[4oqh\|4oqh]], [[4oqi\|4oqi]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ibr\|4ibr]], [[4ibx\|4ibx]], [[4op5\|4op5]], [[4op8\|4op8]], [[4opq\|4opq]], [[4opr\|4opr]], [[4opz\|4opz]], [[4oq0\|4oq0]], [[4oqg\|4oqg]], [[4oqh\|4oqh]], [[4oqi\|4oqi]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4opy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4opy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4opy RCSB], [http://www.ebi.ac.uk/pdbsum/4opy PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4opy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4opy OCA], [http://pdbe.org/4opy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4opy RCSB], [http://www.ebi.ac.uk/pdbsum/4opy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4opy ProSAT]</span></td></tr>
	</table>		</table>
	__TOC__		__TOC__

OCA at 12:14, 20 May 2015

2015-05-20T12:14:58Z

← Older revision		Revision as of 12:14, 20 May 2015
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	~~WITHDRAWN~~: ~~The PDB entry~~ 4OPY ~~was withdrawn~~.		==Room temperature crystal structure of stabilized TEM-1 beta-lactamase variant v.13 carrying R164S mutation==
			<StructureSection load='4opy' size='340' side='right' caption='[[4opy]], [[Resolution\|resolution]] 1.75Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[4opy]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OPY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OPY FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ibr\|4ibr]], [[4ibx\|4ibx]], [[4op5\|4op5]], [[4op8\|4op8]], [[4opq\|4opq]], [[4opr\|4opr]], [[4opz\|4opz]], [[4oq0\|4oq0]], [[4oqg\|4oqg]], [[4oqh\|4oqh]], [[4oqi\|4oqi]]</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4opy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4opy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4opy RCSB], [http://www.ebi.ac.uk/pdbsum/4opy PDBsum]</span></td></tr>
			</table>
			__TOC__
			</StructureSection>
			[[Category: Dellus-Gur, E]]
			[[Category: Elias, M]]
			[[Category: Fraser, J S]]
			[[Category: Tawfik, D S]]
			[[Category: Beta-lactama]]
			[[Category: Hydrolase]]

OCA at 11:01, 30 April 2015

2015-04-30T11:01:48Z

← Older revision		Revision as of 11:01, 30 April 2015
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	~~'''Unreleased structure'''~~		WITHDRAWN: The PDB entry 4OPY was withdrawn.

	The entry ~~4opy is ON HOLD until Oct 23 2016~~

	~~Authors: Dellus-Gur, E., Elias, M., Fraser, J.S., Tawfik, D.S.~~

	~~Description: Room temperature crystal structure of stabilized TEM-1 beta-lactamase variant v.13 carrying R164S mutation~~
	~~[[Category: Unreleased Structures]]~~
	~~[[Category: Elias, M]]~~
	~~[[Category: Fraser, J.S]]~~
	~~[[Category: Dellus-Gur, E]]~~
	~~[[Category: Tawfik, D~~.~~S]]~~

OCA at 07:52, 15 April 2015

2015-04-15T07:52:58Z

← Older revision		Revision as of 07:52, 15 April 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4opy is ON HOLD until ~~Apr 11~~ 2016		The entry 4opy is ON HOLD until Oct 23 2016

	Authors: Dellus-Gur, E., Elias, M., Fraser, J.S., Tawfik, D.S.		Authors: Dellus-Gur, E., Elias, M., Fraser, J.S., Tawfik, D.S.

OCA at 11:35, 7 February 2015

2015-02-07T11:35:46Z

← Older revision		Revision as of 11:35, 7 February 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4opy is ON HOLD until ~~Paper Publication~~		The entry 4opy is ON HOLD until Apr 11 2016

	Authors: Dellus-Gur, E., Elias, M., Fraser, J.S., Tawfik, D.S.		Authors: Dellus-Gur, E., Elias, M., Fraser, J.S., Tawfik, D.S.

OCA at 14:31, 24 December 2014

2014-12-24T14:31:32Z

← Older revision		Revision as of 14:31, 24 December 2014
Line 6:		Line 6:

	Description: Room temperature crystal structure of stabilized TEM-1 beta-lactamase variant v.13 carrying R164S mutation		Description: Room temperature crystal structure of stabilized TEM-1 beta-lactamase variant v.13 carrying R164S mutation
			[[Category: Unreleased Structures]]
			[[Category: Elias, M]]
			[[Category: Fraser, J.S]]
			[[Category: Dellus-Gur, E]]
			[[Category: Tawfik, D.S]]

OCA at 07:26, 19 March 2014

2014-03-19T07:26:04Z

← Older revision		Revision as of 07:26, 19 March 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4opy is ON HOLD		The entry 4opy is ON HOLD until Paper Publication

	Authors: Dellus-Gur, E., Elias, M., Fraser, J.S., Tawfik, D.S.		Authors: Dellus-Gur, E., Elias, M., Fraser, J.S., Tawfik, D.S.

	Description: Room temperature crystal structure of stabilized TEM-1 beta-lactamase variant v.13 carrying R164S mutation		Description: Room temperature crystal structure of stabilized TEM-1 beta-lactamase variant v.13 carrying R164S mutation