4orb - Revision history

OCA at 14:58, 8 November 2023

2023-11-08T14:58:08Z

← Older revision		Revision as of 14:58, 8 November 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4orb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ORB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ORB FirstGlance]. <br>		<table><tr><td colspan='2'>[[4orb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ORB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ORB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.108Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4orb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4orb OCA], [https://pdbe.org/4orb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4orb RCSB], [https://www.ebi.ac.uk/pdbsum/4orb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4orb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4orb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4orb OCA], [https://pdbe.org/4orb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4orb RCSB], [https://www.ebi.ac.uk/pdbsum/4orb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4orb ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:42, 25 January 2023

2023-01-25T07:42:09Z

← Older revision		Revision as of 07:42, 25 January 2023
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	<StructureSection load='4orb' size='340' side='right'caption='[[4orb]], [[Resolution\|resolution]] 3.11Å' scene=''>		<StructureSection load='4orb' size='340' side='right'caption='[[4orb]], [[Resolution\|resolution]] 3.11Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4orb]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ORB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ORB FirstGlance]. <br>		<table><tr><td colspan='2'>[[4orb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ORB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ORB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4or9\|4or9]], [[4ora\|4ora]], [[4orc\|4orc]]</td></tr>~~		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4orb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4orb OCA], [https://pdbe.org/4orb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4orb RCSB], [https://www.ebi.ac.uk/pdbsum/4orb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4orb ProSAT]</span></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Calna, Ppp3ca ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), Cnb, Ppp3r1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4orb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4orb OCA], [~~http~~://pdbe.org/4orb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4orb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4orb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4orb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/PP2BA_MOUSE PP2BA_MOUSE]] Calcium-dependent, calmodulin-stimulated protein phosphatase. Many of the substrates contain a PxIxIT motif. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L and HSPB1 (By similarity). Dephosphorylates SSH1.<ref>PMID:1328240</ref> ~~[[http~~:/~~/www~~.~~uniprot~~.~~org/uniprot/CANB1_MOUSE CANB1_MOUSE]] Regulatory subunit~~ of ~~calcineurin~~, a ~~calcium~~-~~dependent~~, calmodulin ~~stimulated protein phosphatase~~. ~~Confers calcium sensitivity~~.		[https://www.uniprot.org/uniprot/PP2BA_MOUSE PP2BA_MOUSE] Calcium-dependent, calmodulin-stimulated protein phosphatase. Many of the substrates contain a PxIxIT motif. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L and HSPB1 (By similarity). Dephosphorylates SSH1.<ref>PMID:1328240</ref>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The Ca(2+)/calmodulin-dependent protein phosphatase calcineurin (CN), a heterodimer composed of a catalytic subunit A and an essential regulatory subunit B, plays critical functions in various cellular processes such as cardiac hypertrophy and T cell activation. It is the target of the most widely used immunosuppressants for transplantation, tacrolimus (FK506) and cyclosporin A. However, the structure of a large part of the CNA regulatory region remains to be determined, and there has been considerable debate concerning the regulation of CN activity. Here, we report the crystal structure of full-length CN (beta isoform), which revealed a novel autoinhibitory segment (AIS) in addition to the well-known autoinhibitory domain (AID). The AIS nestles in a hydrophobic intersubunit groove, which overlaps the recognition site for substrates and immunosuppressant-immunophilin complexes. Indeed, disruption of this AIS interaction results in partial stimulation of CN activity. More importantly, our biochemical studies demonstrate that calmodulin does not remove AID from the active site, but only regulates the orientation of AID with respect to the catalytic core, causing incomplete activation of CN. Our findings challenge the current model for CN activation, and provide a better understanding of molecular mechanisms of CN activity regulation.

			Cooperative autoinhibition and multi-level activation mechanisms of calcineurin.,Li SJ, Wang J, Ma L, Lu C, Wang J, Wu JW, Wang ZX Cell Res. 2016 Mar;26(3):336-49. doi: 10.1038/cr.2016.14. Epub 2016 Jan 22. PMID:26794871<ref>PMID:26794871</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 4orb" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Calcineurin\|Calcineurin]]		*[[Calcineurin 3D structures\|Calcineurin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Lk3 transgenic mice]]~~		[[Category: Mus musculus]]
	~~[[Category: Phosphoprotein phosphatase~~]]		[[Category: Li SJ]]
	[[Category: Li~~, S J~~]]		[[Category: Ma L]]
	[[Category: Ma, L]]		[[Category: Wang J]]
	[[Category: Wang, J]]		[[Category: Wang ZX]]
	[[Category: Wang~~, Z X~~]]		[[Category: Wu JW]]
	[[Category: Wu~~, J W]]~~
	~~[[Category: Calmodulin-binding]]~~
	~~[[Category: Hydrolase-metal binding protein complex~~]]

OCA at 08:06, 17 April 2019

2019-04-17T08:06:02Z

← Older revision		Revision as of 08:06, 17 April 2019
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	==Crystal structure of mouse calcineurin==		==Crystal structure of mouse calcineurin==
	<StructureSection load='4orb' size='340' side='right' caption='[[4orb]], [[Resolution\|resolution]] 3.11Å' scene=''>		<StructureSection load='4orb' size='340' side='right'caption='[[4orb]], [[Resolution\|resolution]] 3.11Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4orb]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ORB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ORB FirstGlance]. <br>		<table><tr><td colspan='2'>[[4orb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ORB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ORB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4or9\|4or9]], [[4ora\|4ora]], [[4orc\|4orc]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4or9\|4or9]], [[4ora\|4ora]], [[4orc\|4orc]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Calna, Ppp3ca ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), Cnb, Ppp3r1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4orb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4orb OCA], [http://pdbe.org/4orb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4orb RCSB], [http://www.ebi.ac.uk/pdbsum/4orb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4orb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4orb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4orb OCA], [http://pdbe.org/4orb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4orb RCSB], [http://www.ebi.ac.uk/pdbsum/4orb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4orb ProSAT]</span></td></tr>
Line 11:		Line 12:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/PP2BA_MOUSE PP2BA_MOUSE]] Calcium-dependent, calmodulin-stimulated protein phosphatase. Many of the substrates contain a PxIxIT motif. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L and HSPB1 (By similarity). Dephosphorylates SSH1.<ref>PMID:1328240</ref> [[http://www.uniprot.org/uniprot/CANB1_MOUSE CANB1_MOUSE]] Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.		[[http://www.uniprot.org/uniprot/PP2BA_MOUSE PP2BA_MOUSE]] Calcium-dependent, calmodulin-stimulated protein phosphatase. Many of the substrates contain a PxIxIT motif. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L and HSPB1 (By similarity). Dephosphorylates SSH1.<ref>PMID:1328240</ref> [[http://www.uniprot.org/uniprot/CANB1_MOUSE CANB1_MOUSE]] Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.

			==See Also==
			*[[Calcineurin\|Calcineurin]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
			[[Category: Lk3 transgenic mice]]
	[[Category: Phosphoprotein phosphatase]]		[[Category: Phosphoprotein phosphatase]]
	[[Category: Li, S J]]		[[Category: Li, S J]]

OCA at 14:41, 22 December 2016

2016-12-22T14:41:39Z

← Older revision		Revision as of 14:41, 22 December 2016
Line 1:		Line 1:
	==~~Crytal~~ structure of mouse calcineurin==
			==Crystal structure of mouse calcineurin==
	<StructureSection load='4orb' size='340' side='right' caption='[[4orb]], [[Resolution\|resolution]] 3.11Å' scene=''>		<StructureSection load='4orb' size='340' side='right' caption='[[4orb]], [[Resolution\|resolution]] 3.11Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4or9\|4or9]], [[4ora\|4ora]], [[4orc\|4orc]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4or9\|4or9]], [[4ora\|4ora]], [[4orc\|4orc]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4orb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4orb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4orb RCSB], [http://www.ebi.ac.uk/pdbsum/4orb PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4orb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4orb OCA], [http://pdbe.org/4orb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4orb RCSB], [http://www.ebi.ac.uk/pdbsum/4orb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4orb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 12:15, 20 May 2015

2015-05-20T12:15:23Z

← Older revision		Revision as of 12:15, 20 May 2015
Line 1:		Line 1:
	'''~~Unreleased structure~~'''		==Crytal structure of mouse calcineurin==
			<StructureSection load='4orb' size='340' side='right' caption='[[4orb]], [[Resolution\|resolution]] 3.11Å' scene=''>
	~~The entry~~ 4orb is ~~ON HOLD until Paper Publication~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[4orb]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ORB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ORB FirstGlance]. <br>
	~~Authors~~: Ma, L., Li, S.J., ~~Wang, J~~.~~, Wu, J~~.W., ~~Wang, Z~~.X.		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4or9\|4or9]], [[4ora\|4ora]], [[4orc\|4orc]]</td></tr>
	~~Description: Crytal structure of mouse calcineurin~~		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr>
	[[~~Category~~: ~~Unreleased Structures~~]]		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4orb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4orb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4orb RCSB], [http://www.ebi.ac.uk/pdbsum/4orb PDBsum]</span></td></tr>
	[[~~Category~~: ~~Wang, Z~~.X]]		</table>
	[[Category: ~~Wu, J.W~~]]		== Function ==
	[[Category: Li, S.J]]		[[http://www.uniprot.org/uniprot/PP2BA_MOUSE PP2BA_MOUSE]] Calcium-dependent, calmodulin-stimulated protein phosphatase. Many of the substrates contain a PxIxIT motif. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L and HSPB1 (By similarity). Dephosphorylates SSH1.<ref>PMID:1328240</ref> [[http://www.uniprot.org/uniprot/CANB1_MOUSE CANB1_MOUSE]] Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.
			== References ==
			<references/>
			__TOC__
			</StructureSection>
			[[Category: Phosphoprotein phosphatase]]
			[[Category: Li, S J]]
	[[Category: Ma, L]]		[[Category: Ma, L]]
	[[Category: Wang, J]]		[[Category: Wang, J]]
			[[Category: Wang, Z X]]
			[[Category: Wu, J W]]
			[[Category: Calmodulin-binding]]
			[[Category: Hydrolase-metal binding protein complex]]

OCA at 14:32, 24 December 2014

2014-12-24T14:32:36Z

← Older revision		Revision as of 14:32, 24 December 2014
Line 6:		Line 6:

	Description: Crytal structure of mouse calcineurin		Description: Crytal structure of mouse calcineurin
			[[Category: Unreleased Structures]]
			[[Category: Wang, Z.X]]
			[[Category: Wu, J.W]]
			[[Category: Li, S.J]]
			[[Category: Ma, L]]
			[[Category: Wang, J]]

OCA at 12:19, 12 March 2014

2014-03-12T12:19:46Z

← Older revision		Revision as of 12:19, 12 March 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4orb is ON HOLD		The entry 4orb is ON HOLD until Paper Publication

	Authors: Ma, L., Li, S.J., Wang, J., Wu, J.W., Wang, Z.X.		Authors: Ma, L., Li, S.J., Wang, J., Wu, J.W., Wang, Z.X.

	Description: Crytal structure of mouse calcineurin		Description: Crytal structure of mouse calcineurin

OCA: Protected "4orb" [edit=sysop:move=sysop]

2014-02-19T16:20:39Z

Protected "4orb" [edit=sysop:move=sysop]

← Older revision	Revision as of 16:20, 19 February 2014
(No difference)

OCA: New page: '''Unreleased structure''' The entry 4orb is ON HOLD Authors: Ma, L., Li, S.J., Wang, J., Wu, J.W., Wang, Z.X. Description: Crytal structure of mouse calcineurin

2014-02-19T16:20:38Z

New page: '''Unreleased structure''' The entry 4orb is ON HOLD Authors: Ma, L., Li, S.J., Wang, J., Wu, J.W., Wang, Z.X. Description: Crytal structure of mouse calcineurin

New page

'''Unreleased structure'''

The entry 4orb is ON HOLD

Authors: Ma, L., Li, S.J., Wang, J., Wu, J.W., Wang, Z.X.

Description: Crytal structure of mouse calcineurin