4oth - Revision history

OCA at 07:17, 27 November 2024

2024-11-27T07:17:23Z

← Older revision		Revision as of 07:17, 27 November 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4oth]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OTH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OTH FirstGlance]. <br>		<table><tr><td colspan='2'>[[4oth]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OTH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OTH FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DRN:BISINDOLYLMALEIMIDE+IX'>DRN</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DRN:BISINDOLYLMALEIMIDE+IX'>DRN</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4oth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oth OCA], [https://pdbe.org/4oth PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4oth RCSB], [https://www.ebi.ac.uk/pdbsum/4oth PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4oth ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4oth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oth OCA], [https://pdbe.org/4oth PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4oth RCSB], [https://www.ebi.ac.uk/pdbsum/4oth PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4oth ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:45, 25 January 2023

2023-01-25T07:45:03Z

← Older revision		Revision as of 07:45, 25 January 2023
Line 1:		Line 1:

	==Crystal Structure of PRK1 Catalytic Domain in Complex with Ro-31-8220==		==Crystal Structure of PRK1 Catalytic Domain in Complex with Ro-31-8220==
	<StructureSection load='4oth' size='340' side='right' caption='[[4oth]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='4oth' size='340' side='right'caption='[[4oth]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4oth]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OTH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4OTH FirstGlance]. <br>		<table><tr><td colspan='2'>[[4oth]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OTH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OTH FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DRN:BISINDOLYLMALEIMIDE+IX'>DRN</scene>~~</td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DRN:BISINDOLYLMALEIMIDE+IX'>DRN</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene~~></td></tr>~~		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4oth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oth OCA], [https://pdbe.org/4oth PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4oth RCSB], [https://www.ebi.ac.uk/pdbsum/4oth PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4oth ProSAT]</span></td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4otd\|4otd]], [[4otg\|4otg]], [[4oti\|4oti]]</td></tr>~~
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PKN1, PAK1, PKN, PRK1, PRKCL1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein_kinase_C Protein kinase C], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.13 2.7.11.13] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4oth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oth OCA], [~~http~~://pdbe.org/4oth PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4oth RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4oth PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4oth ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/PKN1_HUMAN PKN1_HUMAN]] PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Phosphorylates 'Thr-38' of PPP1R14A, 'Ser-159', 'Ser-163' and 'Ser-170' of MARCKS, and GFAP. Able to phosphorylate RPS6 in vitro.<ref>PMID:8557118</ref> <ref>PMID:8621664</ref> <ref>PMID:9175763</ref> <ref>PMID:11104762</ref> <ref>PMID:12514133</ref> <ref>PMID:17332740</ref> <ref>PMID:18066052</ref> <ref>PMID:20188095</ref> <ref>PMID:21754995</ref>		[https://www.uniprot.org/uniprot/PKN1_HUMAN PKN1_HUMAN] PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Phosphorylates 'Thr-38' of PPP1R14A, 'Ser-159', 'Ser-163' and 'Ser-170' of MARCKS, and GFAP. Able to phosphorylate RPS6 in vitro.<ref>PMID:8557118</ref> <ref>PMID:8621664</ref> <ref>PMID:9175763</ref> <ref>PMID:11104762</ref> <ref>PMID:12514133</ref> <ref>PMID:17332740</ref> <ref>PMID:18066052</ref> <ref>PMID:20188095</ref> <ref>PMID:21754995</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	==See Also==		==See Also==
	*[[~~Student Project 1 for UMass Chemistry 423 Spring 2015~~\|~~Student Project 1 for UMass Chemistry 423 Spring 2015~~]]		*[[Serine/threonine protein kinase 3D structures\|Serine/threonine protein kinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: ~~Protein kinase C~~]]		[[Category: Large Structures]]
	[[Category: Abbassian, M]]		[[Category: Abbassian M]]
	[[Category: Cathers, B]]		[[Category: Cathers B]]
	[[Category: Chamberlain~~, P P~~]]		[[Category: Chamberlain PP]]
	[[Category: Delker, S]]		[[Category: Delker S]]
	[[Category: Jackson, P]]		[[Category: Jackson P]]
	[[Category: Mahmoudi, A]]		[[Category: Mahmoudi A]]
	[[Category: Muir, J]]		[[Category: Muir J]]
	[[Category: Pagarigan, B]]		[[Category: Pagarigan B]]
	[[Category: Raheja, N]]		[[Category: Raheja N]]
	~~[[Category: Atp binding]]~~
	~~[[Category: Kinase]]~~
	~~[[Category: Phosphorylation]]~~
	~~[[Category: Pkn1]]~~
	~~[[Category: Prk1]]~~
	~~[[Category: Protein kinase]]~~
	~~[[Category: Protein kinase c related kinase 1]]~~
	~~[[Category: Transferase-transferase inhibitor complex~~]]

OCA at 20:16, 24 January 2018

2018-01-24T20:16:07Z

← Older revision		Revision as of 20:16, 24 January 2018
Line 3:		Line 3:
	<StructureSection load='4oth' size='340' side='right' caption='[[4oth]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='4oth' size='340' side='right' caption='[[4oth]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4oth]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OTH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OTH FirstGlance]. <br>		<table><tr><td colspan='2'>[[4oth]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OTH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OTH FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DRN:BISINDOLYLMALEIMIDE+IX'>DRN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DRN:BISINDOLYLMALEIMIDE+IX'>DRN</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4otd\|4otd]], [[4otg\|4otg]], [[4oti\|4oti]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4otd\|4otd]], [[4otg\|4otg]], [[4oti\|4oti]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PKN1, PAK1, PKN, PRK1, PRKCL1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein_kinase_C Protein kinase C], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.13 2.7.11.13] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein_kinase_C Protein kinase C], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.13 2.7.11.13] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oth OCA], [http://pdbe.org/4oth PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4oth RCSB], [http://www.ebi.ac.uk/pdbsum/4oth PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4oth ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oth OCA], [http://pdbe.org/4oth PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4oth RCSB], [http://www.ebi.ac.uk/pdbsum/4oth PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4oth ProSAT]</span></td></tr>
Line 23:		Line 24:

	==See Also==		==See Also==
	*[[Serine/threonine protein kinase\|Serine/threonine protein kinase]]
	*[[Student Project 1 for UMass Chemistry 423 Spring 2015\|Student Project 1 for UMass Chemistry 423 Spring 2015]]		*[[Student Project 1 for UMass Chemistry 423 Spring 2015\|Student Project 1 for UMass Chemistry 423 Spring 2015]]
	== References ==		== References ==
Line 29:		Line 29:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Human]]
	[[Category: Protein kinase C]]		[[Category: Protein kinase C]]
	[[Category: Abbassian, M]]		[[Category: Abbassian, M]]
	~~[[Category: B., Pagarigan]]~~
	[[Category: Cathers, B]]		[[Category: Cathers, B]]
	[[Category: Chamberlain, P P]]		[[Category: Chamberlain, P P]]
Line 38:		Line 38:
	[[Category: Mahmoudi, A]]		[[Category: Mahmoudi, A]]
	[[Category: Muir, J]]		[[Category: Muir, J]]
			[[Category: Pagarigan, B]]
	[[Category: Raheja, N]]		[[Category: Raheja, N]]
	[[Category: Atp binding]]		[[Category: Atp binding]]

OCA at 10:16, 5 August 2016

2016-08-05T10:16:28Z

← Older revision		Revision as of 10:16, 5 August 2016
Line 1:		Line 1:

	==Crystal Structure of PRK1 Catalytic Domain in Complex with Ro-31-8220==		==Crystal Structure of PRK1 Catalytic Domain in Complex with Ro-31-8220==
	<StructureSection load='4oth' size='340' side='right' caption='[[4oth]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='4oth' size='340' side='right' caption='[[4oth]], [[Resolution\|resolution]] 1.80Å' scene=''>
Line 7:		Line 8:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4otd\|4otd]], [[4otg\|4otg]], [[4oti\|4oti]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4otd\|4otd]], [[4otg\|4otg]], [[4oti\|4oti]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein_kinase_C Protein kinase C], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.13 2.7.11.13] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein_kinase_C Protein kinase C], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.13 2.7.11.13] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oth OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4oth RCSB], [http://www.ebi.ac.uk/pdbsum/4oth PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oth OCA], [http://pdbe.org/4oth PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4oth RCSB], [http://www.ebi.ac.uk/pdbsum/4oth PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4oth ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4oth" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Serine/threonine protein kinase\|Serine/threonine protein kinase]]
			*[[Student Project 1 for UMass Chemistry 423 Spring 2015\|Student Project 1 for UMass Chemistry 423 Spring 2015]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 01:32, 25 December 2014

2014-12-25T01:32:02Z

← Older revision		Revision as of 01:32, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4oth]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OTH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OTH FirstGlance]. <br>		<table><tr><td colspan='2'>[[4oth]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OTH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OTH FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DRN:BISINDOLYLMALEIMIDE+IX'>DRN</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DRN:BISINDOLYLMALEIMIDE+IX'>DRN</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4otd\|4otd]], [[4otg\|4otg]], [[4oti\|4oti]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4otd\|4otd]], [[4otg\|4otg]], [[4oti\|4oti]]</td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein_kinase_C Protein kinase C], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.13 2.7.11.13] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein_kinase_C Protein kinase C], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.13 2.7.11.13] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oth OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4oth RCSB], [http://www.ebi.ac.uk/pdbsum/4oth PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oth OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4oth RCSB], [http://www.ebi.ac.uk/pdbsum/4oth PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/PKN1_HUMAN PKN1_HUMAN]] PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Phosphorylates 'Thr-38' of PPP1R14A, 'Ser-159', 'Ser-163' and 'Ser-170' of MARCKS, and GFAP. Able to phosphorylate RPS6 in vitro.<ref>PMID:8557118</ref> <ref>PMID:8621664</ref> <ref>PMID:9175763</ref> <ref>PMID:11104762</ref> <ref>PMID:12514133</ref> <ref>PMID:17332740</ref> <ref>PMID:18066052</ref> <ref>PMID:20188095</ref> <ref>PMID:21754995</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Protein kinase C]]		[[Category: Protein kinase C]]
	[[Category: Abbassian, M.]]		[[Category: Abbassian, M]]
	[[Category: B., Pagarigan.]]		[[Category: B., Pagarigan]]
	[[Category: Cathers, B.]]		[[Category: Cathers, B]]
	[[Category: Chamberlain, P P.]]		[[Category: Chamberlain, P P]]
	[[Category: Delker, S.]]		[[Category: Delker, S]]
	[[Category: Jackson, P.]]		[[Category: Jackson, P]]
	[[Category: Mahmoudi, A.]]		[[Category: Mahmoudi, A]]
	[[Category: Muir, J.]]		[[Category: Muir, J]]
	[[Category: Raheja, N.]]		[[Category: Raheja, N]]
	[[Category: Atp binding]]		[[Category: Atp binding]]
	[[Category: Kinase]]		[[Category: Kinase]]

OCA at 08:37, 27 August 2014

2014-08-27T08:37:33Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Crystal Structure of PRK1 Catalytic Domain in Complex with Ro-31-8220==
-The entry 4oth is ON HOLD
+Crystal Structures of PRK1 in Complex with the Clinical Compounds Lestaurtinib and Tofacitinib Reveal Ligand Induced Conformational Changes.,Chamberlain P, Delker S, Pagarigan B, Mahmoudi A, Jackson P, Abbasian M, Muir J, Raheja N, Cathers B PLoS One. 2014 Aug 11;9(8):e103638. doi: 10.1371/journal.pone.0103638., eCollection 2014. PMID:25111382<ref>PMID:25111382</ref>
-Authors: Chamberlain, P.P., Delker, S., Pagarigan B., Mahmoudi, A., Jackson, P., Abbassian, M., Muir, J., Raheja, N., Cathers, B.
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-Description: Crystal Structure of PRK1 Catalytic Domain in Complex with Ro-31-8220
+== References ==

OCA: Protected "4oth" [edit=sysop:move=sysop]

2014-02-19T16:23:58Z

Protected "4oth" [edit=sysop:move=sysop]

← Older revision	Revision as of 16:23, 19 February 2014
(No difference)

OCA: New page: '''Unreleased structure''' The entry 4oth is ON HOLD Authors: Chamberlain, P.P., Delker, S., Pagarigan B., Mahmoudi, A., Jackson, P., Abbassian, M., Muir, J., Raheja, N., Cathers, B. D...

2014-02-19T16:23:57Z

New page: '''Unreleased structure''' The entry 4oth is ON HOLD Authors: Chamberlain, P.P., Delker, S., Pagarigan B., Mahmoudi, A., Jackson, P., Abbassian, M., Muir, J., Raheja, N., Cathers, B. D...

New page

'''Unreleased structure'''

The entry 4oth is ON HOLD

Authors: Chamberlain, P.P., Delker, S., Pagarigan B., Mahmoudi, A., Jackson, P., Abbassian, M., Muir, J., Raheja, N., Cathers, B.

Description: Crystal Structure of PRK1 Catalytic Domain in Complex with Ro-31-8220