https://proteopedia.org/index.php?action=history&feed=atom&title=4pg3 4pg3 - Revision history 2026-09-26T05:05:45Z Revision history for this page on the wiki MediaWiki 1.43.8 https://proteopedia.org/index.php?title=4pg3&diff=3883684&oldid=prev OCA at 07:16, 27 September 2023 2023-09-27T07:16:42Z <p></p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 07:16, 27 September 2023</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l4">Line 4:</td> <td colspan="2" class="diff-lineno">Line 4:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Structural highlights ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Structural highlights ==</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>&lt;table&gt;&lt;tr&gt;&lt;td colspan=&#039;2&#039;&gt;[[4pg3]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PG3 OCA]. For a &lt;b&gt;guided tour on the structure components&lt;/b&gt; use [https://proteopedia.org/fgij/fg.htm?mol=4PG3 FirstGlance]. &lt;br&gt;</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>&lt;table&gt;&lt;tr&gt;&lt;td colspan=&#039;2&#039;&gt;[[4pg3]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PG3 OCA]. For a &lt;b&gt;guided tour on the structure components&lt;/b&gt; use [https://proteopedia.org/fgij/fg.htm?mol=4PG3 FirstGlance]. &lt;br&gt;</div></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>&lt;/td&gt;&lt;/tr&gt;&lt;tr id='ligand'&gt;&lt;td class="sblockLbl"&gt;&lt;b&gt;[[Ligand|Ligands:]]&lt;/b&gt;&lt;/td&gt;&lt;td class="sblockDat" id="ligandDat"&gt;&lt;scene name='pdbligand=KRS:CLADOSPORIN'&gt;KRS&lt;/scene&gt;, &lt;scene name='pdbligand=LYS:LYSINE'&gt;LYS&lt;/scene&gt;&lt;/td&gt;&lt;/tr&gt;</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>&lt;/td&gt;&lt;/tr&gt;<ins style="font-weight: bold; text-decoration: none;">&lt;tr id='method'&gt;&lt;td class="sblockLbl"&gt;&lt;b&gt;[[Empirical_models|Method:]]&lt;/b&gt;&lt;/td&gt;&lt;td class="sblockDat" id="methodDat"&gt;X-ray diffraction, [[Resolution|Resolution]] 2.696&amp;#8491;&lt;/td&gt;&lt;/tr&gt;</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>&lt;tr id='ligand'&gt;&lt;td class="sblockLbl"&gt;&lt;b&gt;[[Ligand|Ligands:]]&lt;/b&gt;&lt;/td&gt;&lt;td class="sblockDat" id="ligandDat"&gt;&lt;scene name='pdbligand=KRS:CLADOSPORIN'&gt;KRS&lt;/scene&gt;, &lt;scene name='pdbligand=LYS:LYSINE'&gt;LYS&lt;/scene&gt;&lt;/td&gt;&lt;/tr&gt;</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>&lt;tr id=&#039;resources&#039;&gt;&lt;td class=&quot;sblockLbl&quot;&gt;&lt;b&gt;Resources:&lt;/b&gt;&lt;/td&gt;&lt;td class=&quot;sblockDat&quot;&gt;&lt;span class=&#039;plainlinks&#039;&gt;[https://proteopedia.org/fgij/fg.htm?mol=4pg3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pg3 OCA], [https://pdbe.org/4pg3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pg3 RCSB], [https://www.ebi.ac.uk/pdbsum/4pg3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pg3 ProSAT]&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>&lt;tr id=&#039;resources&#039;&gt;&lt;td class=&quot;sblockLbl&quot;&gt;&lt;b&gt;Resources:&lt;/b&gt;&lt;/td&gt;&lt;td class=&quot;sblockDat&quot;&gt;&lt;span class=&#039;plainlinks&#039;&gt;[https://proteopedia.org/fgij/fg.htm?mol=4pg3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pg3 OCA], [https://pdbe.org/4pg3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pg3 RCSB], [https://www.ebi.ac.uk/pdbsum/4pg3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pg3 ProSAT]&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>&lt;/table&gt;</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>&lt;/table&gt;</div></td></tr> </table> OCA https://proteopedia.org/index.php?title=4pg3&diff=3710399&oldid=prev OCA at 13:00, 1 February 2023 2023-02-01T13:00:38Z <p></p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 13:00, 1 February 2023</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l3">Line 3:</td> <td colspan="2" class="diff-lineno">Line 3:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>&lt;StructureSection load=&#039;4pg3&#039; size=&#039;340&#039; side=&#039;right&#039;caption=&#039;[[4pg3]], [[Resolution|resolution]] 2.70&amp;Aring;&#039; scene=&#039;&#039;&gt;</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>&lt;StructureSection load=&#039;4pg3&#039; size=&#039;340&#039; side=&#039;right&#039;caption=&#039;[[4pg3]], [[Resolution|resolution]] 2.70&amp;Aring;&#039; scene=&#039;&#039;&gt;</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Structural highlights ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Structural highlights ==</div></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>&lt;table&gt;&lt;tr&gt;&lt;td colspan='2'&gt;[[4pg3]] is a 4 chain structure with sequence from [<del style="font-weight: bold; text-decoration: none;">http</del>://en.wikipedia.org/wiki/<del style="font-weight: bold; text-decoration: none;">Plaf7 Plaf7</del>]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PG3 OCA]. For a &lt;b&gt;guided tour on the structure components&lt;/b&gt; use [<del style="font-weight: bold; text-decoration: none;">http</del>://<del style="font-weight: bold; text-decoration: none;">oca</del>.<del style="font-weight: bold; text-decoration: none;">weizmann.ac.il/oca-docs</del>/fgij/fg.htm?mol=4PG3 FirstGlance]. &lt;br&gt;</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>&lt;table&gt;&lt;tr&gt;&lt;td colspan='2'&gt;[[4pg3]] is a 4 chain structure with sequence from [<ins style="font-weight: bold; text-decoration: none;">https</ins>://en.wikipedia.org/wiki/<ins style="font-weight: bold; text-decoration: none;">Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7</ins>]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PG3 OCA]. For a &lt;b&gt;guided tour on the structure components&lt;/b&gt; use [<ins style="font-weight: bold; text-decoration: none;">https</ins>://<ins style="font-weight: bold; text-decoration: none;">proteopedia</ins>.<ins style="font-weight: bold; text-decoration: none;">org</ins>/fgij/fg.htm?mol=4PG3 FirstGlance]. &lt;br&gt;</div></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>&lt;/td&gt;&lt;/tr&gt;&lt;tr id='ligand'&gt;&lt;td class="sblockLbl"&gt;&lt;b&gt;[[Ligand|Ligands:]]&lt;/b&gt;&lt;/td&gt;&lt;td class="sblockDat"&gt;&lt;scene name='pdbligand=KRS:CLADOSPORIN'&gt;KRS&lt;/scene&gt;, &lt;scene name='pdbligand=LYS:LYSINE'&gt;LYS&lt;/scene<del style="font-weight: bold; text-decoration: none;">&gt;&lt;/td&gt;&lt;/tr&gt;</del></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>&lt;/td&gt;&lt;/tr&gt;&lt;tr id='ligand'&gt;&lt;td class="sblockLbl"&gt;&lt;b&gt;[[Ligand|Ligands:]]&lt;/b&gt;&lt;/td&gt;&lt;td class="sblockDat<ins style="font-weight: bold; text-decoration: none;">" id="ligandDat</ins>"&gt;&lt;scene name='pdbligand=KRS:CLADOSPORIN'&gt;KRS&lt;/scene&gt;, &lt;scene name='pdbligand=LYS:LYSINE'&gt;LYS&lt;/scene&gt;&lt;/td&gt;&lt;/tr&gt;</div></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">&lt;tr id='gene'&gt;&lt;td class="sblockLbl"&gt;&lt;b&gt;[[Gene|Gene:]]&lt;/b&gt;&lt;/td&gt;&lt;td class="sblockDat"&gt;PF13_0262 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&amp;srchmode=5&amp;id=36329 PLAF7])&lt;/td&gt;&lt;/tr&gt;</del></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>&lt;tr id='resources'&gt;&lt;td class="sblockLbl"&gt;&lt;b&gt;Resources:&lt;/b&gt;&lt;/td&gt;&lt;td class="sblockDat"&gt;&lt;span class='plainlinks'&gt;[<ins style="font-weight: bold; text-decoration: none;">https</ins>://<ins style="font-weight: bold; text-decoration: none;">proteopedia</ins>.<ins style="font-weight: bold; text-decoration: none;">org</ins>/fgij/fg.htm?mol=4pg3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pg3 OCA], [<ins style="font-weight: bold; text-decoration: none;">https</ins>://pdbe.org/4pg3 PDBe], [<ins style="font-weight: bold; text-decoration: none;">https</ins>://www.rcsb.org/pdb/explore.do?structureId=4pg3 RCSB], [<ins style="font-weight: bold; text-decoration: none;">https</ins>://www.ebi.ac.uk/pdbsum/4pg3 PDBsum], [<ins style="font-weight: bold; text-decoration: none;">https</ins>://prosat.h-its.org/prosat/prosatexe?pdbcode=4pg3 ProSAT]&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;</div></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">&lt;tr id='activity'&gt;&lt;td class="sblockLbl"&gt;&lt;b&gt;Activity:&lt;/b&gt;&lt;/td&gt;&lt;td class="sblockDat"&gt;&lt;span class='plainlinks'&gt;[http://en.wikipedia.org/wiki/Lysine--tRNA_ligase Lysine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.6 6.1.1.6] &lt;/span</del>&gt;&lt;/td&gt;&lt;/tr&gt;</div></td><td colspan="2" class="diff-side-added"></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>&lt;tr id='resources'&gt;&lt;td class="sblockLbl"&gt;&lt;b&gt;Resources:&lt;/b&gt;&lt;/td&gt;&lt;td class="sblockDat"&gt;&lt;span class='plainlinks'&gt;[<del style="font-weight: bold; text-decoration: none;">http</del>://<del style="font-weight: bold; text-decoration: none;">oca</del>.<del style="font-weight: bold; text-decoration: none;">weizmann.ac.il/oca-docs</del>/fgij/fg.htm?mol=4pg3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pg3 OCA], [<del style="font-weight: bold; text-decoration: none;">http</del>://pdbe.org/4pg3 PDBe], [<del style="font-weight: bold; text-decoration: none;">http</del>://www.rcsb.org/pdb/explore.do?structureId=4pg3 RCSB], [<del style="font-weight: bold; text-decoration: none;">http</del>://www.ebi.ac.uk/pdbsum/4pg3 PDBsum], [<del style="font-weight: bold; text-decoration: none;">http</del>://prosat.h-its.org/prosat/prosatexe?pdbcode=4pg3 ProSAT]&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;</div></td><td colspan="2" class="diff-side-added"></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>&lt;/table&gt;</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>&lt;/table&gt;</div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">== Function ==</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">[https://www.uniprot.org/uniprot/Q8IDJ8_PLAF7 Q8IDJ8_PLAF7] </ins></div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>&lt;div style=&quot;background-color:#fffaf0;&quot;&gt;</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>&lt;div style=&quot;background-color:#fffaf0;&quot;&gt;</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Publication Abstract from PubMed ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Publication Abstract from PubMed ==</div></td></tr> <tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l26">Line 26:</td> <td colspan="2" class="diff-lineno">Line 26:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>&lt;/StructureSection&gt;</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>&lt;/StructureSection&gt;</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Category: Large Structures]]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Category: Large Structures]]</div></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>[[Category: <del style="font-weight: bold; text-decoration: none;">Lysine--tRNA ligase]]</del></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>[[Category: <ins style="font-weight: bold; text-decoration: none;">Plasmodium falciparum 3D7</ins>]]</div></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">[[Category: Plaf7</del>]]</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>[[Category: Belrhali H]]</div></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>[[Category: Belrhali<del style="font-weight: bold; text-decoration: none;">, </del>H]]</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>[[Category: Khan S]]</div></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>[[Category: Khan<del style="font-weight: bold; text-decoration: none;">, </del>S]]</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>[[Category: Sharma A]]</div></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>[[Category: Sharma<del style="font-weight: bold; text-decoration: none;">, </del>A]]</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>[[Category: Yogavel M]]</div></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>[[Category: Yogavel<del style="font-weight: bold; text-decoration: none;">, </del>M<del style="font-weight: bold; text-decoration: none;">]]</del></div></td><td colspan="2" class="diff-side-added"></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">[[Category: Complex]]</del></div></td><td colspan="2" class="diff-side-added"></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">[[Category: Inhibitor]]</del></div></td><td colspan="2" class="diff-side-added"></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">[[Category: Kr]]</del></div></td><td colspan="2" class="diff-side-added"></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">[[Category: Ligase-ligase inhibitor complex</del>]]</div></td><td colspan="2" class="diff-side-added"></td></tr> </table> OCA https://proteopedia.org/index.php?title=4pg3&diff=3029345&oldid=prev OCA at 07:47, 17 April 2019 2019-04-17T07:47:46Z <p></p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 07:47, 17 April 2019</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l1">Line 1:</td> <td colspan="2" class="diff-lineno">Line 1:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Crystal structure of KRS complexed with inhibitor==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Crystal structure of KRS complexed with inhibitor==</div></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>&lt;StructureSection load='4pg3' size='340' side='right' caption='[[4pg3]], [[Resolution|resolution]] 2.70&amp;Aring;' scene=''&gt;</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>&lt;StructureSection load='4pg3' size='340' side='right'caption='[[4pg3]], [[Resolution|resolution]] 2.70&amp;Aring;' scene=''&gt;</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Structural highlights ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Structural highlights ==</div></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>&lt;table&gt;&lt;tr&gt;&lt;td colspan='2'&gt;[[4pg3]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PG3 OCA]. For a &lt;b&gt;guided tour on the structure components&lt;/b&gt; use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PG3 FirstGlance]. &lt;br&gt;</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>&lt;table&gt;&lt;tr&gt;&lt;td colspan='2'&gt;[[4pg3]] is a 4 chain structure <ins style="font-weight: bold; text-decoration: none;">with sequence from [http://en.wikipedia.org/wiki/Plaf7 Plaf7]</ins>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PG3 OCA]. For a &lt;b&gt;guided tour on the structure components&lt;/b&gt; use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PG3 FirstGlance]. &lt;br&gt;</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>&lt;/td&gt;&lt;/tr&gt;&lt;tr id=&#039;ligand&#039;&gt;&lt;td class=&quot;sblockLbl&quot;&gt;&lt;b&gt;[[Ligand|Ligands:]]&lt;/b&gt;&lt;/td&gt;&lt;td class=&quot;sblockDat&quot;&gt;&lt;scene name=&#039;pdbligand=KRS:CLADOSPORIN&#039;&gt;KRS&lt;/scene&gt;, &lt;scene name=&#039;pdbligand=LYS:LYSINE&#039;&gt;LYS&lt;/scene&gt;&lt;/td&gt;&lt;/tr&gt;</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>&lt;/td&gt;&lt;/tr&gt;&lt;tr id=&#039;ligand&#039;&gt;&lt;td class=&quot;sblockLbl&quot;&gt;&lt;b&gt;[[Ligand|Ligands:]]&lt;/b&gt;&lt;/td&gt;&lt;td class=&quot;sblockDat&quot;&gt;&lt;scene name=&#039;pdbligand=KRS:CLADOSPORIN&#039;&gt;KRS&lt;/scene&gt;, &lt;scene name=&#039;pdbligand=LYS:LYSINE&#039;&gt;LYS&lt;/scene&gt;&lt;/td&gt;&lt;/tr&gt;</div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">&lt;tr id='gene'&gt;&lt;td class="sblockLbl"&gt;&lt;b&gt;[[Gene|Gene:]]&lt;/b&gt;&lt;/td&gt;&lt;td class="sblockDat"&gt;PF13_0262 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&amp;srchmode=5&amp;id=36329 PLAF7])&lt;/td&gt;&lt;/tr&gt;</ins></div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>&lt;tr id=&#039;activity&#039;&gt;&lt;td class=&quot;sblockLbl&quot;&gt;&lt;b&gt;Activity:&lt;/b&gt;&lt;/td&gt;&lt;td class=&quot;sblockDat&quot;&gt;&lt;span class=&#039;plainlinks&#039;&gt;[http://en.wikipedia.org/wiki/Lysine--tRNA_ligase Lysine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.6 6.1.1.6] &lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>&lt;tr id=&#039;activity&#039;&gt;&lt;td class=&quot;sblockLbl&quot;&gt;&lt;b&gt;Activity:&lt;/b&gt;&lt;/td&gt;&lt;td class=&quot;sblockDat&quot;&gt;&lt;span class=&#039;plainlinks&#039;&gt;[http://en.wikipedia.org/wiki/Lysine--tRNA_ligase Lysine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.6 6.1.1.6] &lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>&lt;tr id=&#039;resources&#039;&gt;&lt;td class=&quot;sblockLbl&quot;&gt;&lt;b&gt;Resources:&lt;/b&gt;&lt;/td&gt;&lt;td class=&quot;sblockDat&quot;&gt;&lt;span class=&#039;plainlinks&#039;&gt;[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pg3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pg3 OCA], [http://pdbe.org/4pg3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pg3 RCSB], [http://www.ebi.ac.uk/pdbsum/4pg3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pg3 ProSAT]&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>&lt;tr id=&#039;resources&#039;&gt;&lt;td class=&quot;sblockLbl&quot;&gt;&lt;b&gt;Resources:&lt;/b&gt;&lt;/td&gt;&lt;td class=&quot;sblockDat&quot;&gt;&lt;span class=&#039;plainlinks&#039;&gt;[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pg3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pg3 OCA], [http://pdbe.org/4pg3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pg3 RCSB], [http://www.ebi.ac.uk/pdbsum/4pg3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pg3 ProSAT]&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;</div></td></tr> <tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l17">Line 17:</td> <td colspan="2" class="diff-lineno">Line 18:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>&lt;/div&gt;</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>&lt;/div&gt;</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>&lt;div class=&quot;pdbe-citations 4pg3&quot; style=&quot;background-color:#fffaf0;&quot;&gt;&lt;/div&gt;</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>&lt;div class=&quot;pdbe-citations 4pg3&quot; style=&quot;background-color:#fffaf0;&quot;&gt;&lt;/div&gt;</div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">==See Also==</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">*[[Aminoacyl tRNA synthetase 3D structures|Aminoacyl tRNA synthetase 3D structures]]</ins></div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== References ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== References ==</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>&lt;references/&gt;</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>&lt;references/&gt;</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>__TOC__</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>__TOC__</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>&lt;/StructureSection&gt;</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>&lt;/StructureSection&gt;</div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">[[Category: Large Structures]]</ins></div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Category: Lysine--tRNA ligase]]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Category: Lysine--tRNA ligase]]</div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">[[Category: Plaf7]]</ins></div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Category: Belrhali, H]]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Category: Belrhali, H]]</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Category: Khan, S]]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Category: Khan, S]]</div></td></tr> </table> OCA https://proteopedia.org/index.php?title=4pg3&diff=2704527&oldid=prev OCA at 16:58, 4 January 2017 2017-01-04T16:58:36Z <p></p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 16:58, 4 January 2017</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l1">Line 1:</td> <td colspan="2" class="diff-lineno">Line 1:</td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Crystal structure of KRS complexed with inhibitor==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Crystal structure of KRS complexed with inhibitor==</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>&lt;StructureSection load=&#039;4pg3&#039; size=&#039;340&#039; side=&#039;right&#039; caption=&#039;[[4pg3]], [[Resolution|resolution]] 2.70&amp;Aring;&#039; scene=&#039;&#039;&gt;</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>&lt;StructureSection load=&#039;4pg3&#039; size=&#039;340&#039; side=&#039;right&#039; caption=&#039;[[4pg3]], [[Resolution|resolution]] 2.70&amp;Aring;&#039; scene=&#039;&#039;&gt;</div></td></tr> <tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l5">Line 5:</td> <td colspan="2" class="diff-lineno">Line 6:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>&lt;/td&gt;&lt;/tr&gt;&lt;tr id=&#039;ligand&#039;&gt;&lt;td class=&quot;sblockLbl&quot;&gt;&lt;b&gt;[[Ligand|Ligands:]]&lt;/b&gt;&lt;/td&gt;&lt;td class=&quot;sblockDat&quot;&gt;&lt;scene name=&#039;pdbligand=KRS:CLADOSPORIN&#039;&gt;KRS&lt;/scene&gt;, &lt;scene name=&#039;pdbligand=LYS:LYSINE&#039;&gt;LYS&lt;/scene&gt;&lt;/td&gt;&lt;/tr&gt;</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>&lt;/td&gt;&lt;/tr&gt;&lt;tr id=&#039;ligand&#039;&gt;&lt;td class=&quot;sblockLbl&quot;&gt;&lt;b&gt;[[Ligand|Ligands:]]&lt;/b&gt;&lt;/td&gt;&lt;td class=&quot;sblockDat&quot;&gt;&lt;scene name=&#039;pdbligand=KRS:CLADOSPORIN&#039;&gt;KRS&lt;/scene&gt;, &lt;scene name=&#039;pdbligand=LYS:LYSINE&#039;&gt;LYS&lt;/scene&gt;&lt;/td&gt;&lt;/tr&gt;</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>&lt;tr id=&#039;activity&#039;&gt;&lt;td class=&quot;sblockLbl&quot;&gt;&lt;b&gt;Activity:&lt;/b&gt;&lt;/td&gt;&lt;td class=&quot;sblockDat&quot;&gt;&lt;span class=&#039;plainlinks&#039;&gt;[http://en.wikipedia.org/wiki/Lysine--tRNA_ligase Lysine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.6 6.1.1.6] &lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>&lt;tr id=&#039;activity&#039;&gt;&lt;td class=&quot;sblockLbl&quot;&gt;&lt;b&gt;Activity:&lt;/b&gt;&lt;/td&gt;&lt;td class=&quot;sblockDat&quot;&gt;&lt;span class=&#039;plainlinks&#039;&gt;[http://en.wikipedia.org/wiki/Lysine--tRNA_ligase Lysine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.6 6.1.1.6] &lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;</div></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>&lt;tr id='resources'&gt;&lt;td class="sblockLbl"&gt;&lt;b&gt;Resources:&lt;/b&gt;&lt;/td&gt;&lt;td class="sblockDat"&gt;&lt;span class='plainlinks'&gt;[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pg3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pg3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pg3 RCSB], [http://www.ebi.ac.uk/pdbsum/4pg3 PDBsum]&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>&lt;tr id='resources'&gt;&lt;td class="sblockLbl"&gt;&lt;b&gt;Resources:&lt;/b&gt;&lt;/td&gt;&lt;td class="sblockDat"&gt;&lt;span class='plainlinks'&gt;[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pg3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pg3 OCA<ins style="font-weight: bold; text-decoration: none;">], [http://pdbe.org/4pg3 PDBe</ins>], [http://www.rcsb.org/pdb/explore.do?structureId=4pg3 RCSB], [http://www.ebi.ac.uk/pdbsum/4pg3 PDBsum<ins style="font-weight: bold; text-decoration: none;">], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pg3 ProSAT</ins>]&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>&lt;/table&gt;</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>&lt;/table&gt;</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>&lt;div style=&quot;background-color:#fffaf0;&quot;&gt;</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>&lt;div style=&quot;background-color:#fffaf0;&quot;&gt;</div></td></tr> <tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l15">Line 15:</td> <td colspan="2" class="diff-lineno">Line 16:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>From MEDLINE&amp;reg;/PubMed&amp;reg;, a database of the U.S. National Library of Medicine.&lt;br&gt;</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>From MEDLINE&amp;reg;/PubMed&amp;reg;, a database of the U.S. National Library of Medicine.&lt;br&gt;</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>&lt;/div&gt;</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>&lt;/div&gt;</div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">&lt;div class="pdbe-citations 4pg3" style="background-color:#fffaf0;"&gt;&lt;/div&gt;</ins></div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== References ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== References ==</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>&lt;references/&gt;</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>&lt;references/&gt;</div></td></tr> </table> OCA https://proteopedia.org/index.php?title=4pg3&diff=2386454&oldid=prev OCA at 07:14, 26 March 2015 2015-03-26T07:14:29Z <p></p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 07:14, 26 March 2015</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l3">Line 3:</td> <td colspan="2" class="diff-lineno">Line 3:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Structural highlights ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Structural highlights ==</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>&lt;table&gt;&lt;tr&gt;&lt;td colspan=&#039;2&#039;&gt;[[4pg3]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PG3 OCA]. For a &lt;b&gt;guided tour on the structure components&lt;/b&gt; use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PG3 FirstGlance]. &lt;br&gt;</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>&lt;table&gt;&lt;tr&gt;&lt;td colspan=&#039;2&#039;&gt;[[4pg3]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PG3 OCA]. For a &lt;b&gt;guided tour on the structure components&lt;/b&gt; use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PG3 FirstGlance]. &lt;br&gt;</div></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>&lt;/td&gt;&lt;/tr&gt;&lt;tr id='ligand'&gt;&lt;td class="sblockLbl"&gt;&lt;b&gt;[[Ligand|Ligands:]]&lt;/b&gt;&lt;/td&gt;&lt;td class="sblockDat"&gt;&lt;scene name='pdbligand=KRS:<del style="font-weight: bold; text-decoration: none;">(3R)-3-[[(2R,6S)-6-METHYLOXAN-2-YL]METHYL]-6,8-BIS(OXIDANYL)-3,4-DIHYDROISOCHROMEN-1-ONE</del>'&gt;KRS&lt;/scene&gt;, &lt;scene name='pdbligand=LYS:LYSINE'&gt;LYS&lt;/scene&gt;&lt;/td&gt;&lt;/tr&gt;</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>&lt;/td&gt;&lt;/tr&gt;&lt;tr id='ligand'&gt;&lt;td class="sblockLbl"&gt;&lt;b&gt;[[Ligand|Ligands:]]&lt;/b&gt;&lt;/td&gt;&lt;td class="sblockDat"&gt;&lt;scene name='pdbligand=KRS:<ins style="font-weight: bold; text-decoration: none;">CLADOSPORIN</ins>'&gt;KRS&lt;/scene&gt;, &lt;scene name='pdbligand=LYS:LYSINE'&gt;LYS&lt;/scene&gt;&lt;/td&gt;&lt;/tr&gt;</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>&lt;tr id=&#039;activity&#039;&gt;&lt;td class=&quot;sblockLbl&quot;&gt;&lt;b&gt;Activity:&lt;/b&gt;&lt;/td&gt;&lt;td class=&quot;sblockDat&quot;&gt;&lt;span class=&#039;plainlinks&#039;&gt;[http://en.wikipedia.org/wiki/Lysine--tRNA_ligase Lysine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.6 6.1.1.6] &lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>&lt;tr id=&#039;activity&#039;&gt;&lt;td class=&quot;sblockLbl&quot;&gt;&lt;b&gt;Activity:&lt;/b&gt;&lt;/td&gt;&lt;td class=&quot;sblockDat&quot;&gt;&lt;span class=&#039;plainlinks&#039;&gt;[http://en.wikipedia.org/wiki/Lysine--tRNA_ligase Lysine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.6 6.1.1.6] &lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>&lt;tr id=&#039;resources&#039;&gt;&lt;td class=&quot;sblockLbl&quot;&gt;&lt;b&gt;Resources:&lt;/b&gt;&lt;/td&gt;&lt;td class=&quot;sblockDat&quot;&gt;&lt;span class=&#039;plainlinks&#039;&gt;[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pg3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pg3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pg3 RCSB], [http://www.ebi.ac.uk/pdbsum/4pg3 PDBsum]&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>&lt;tr id=&#039;resources&#039;&gt;&lt;td class=&quot;sblockLbl&quot;&gt;&lt;b&gt;Resources:&lt;/b&gt;&lt;/td&gt;&lt;td class=&quot;sblockDat&quot;&gt;&lt;span class=&#039;plainlinks&#039;&gt;[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pg3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pg3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pg3 RCSB], [http://www.ebi.ac.uk/pdbsum/4pg3 PDBsum]&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;</div></td></tr> </table> OCA https://proteopedia.org/index.php?title=4pg3&diff=2321321&oldid=prev OCA at 12:49, 5 January 2015 2015-01-05T12:49:45Z <p></p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 12:49, 5 January 2015</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l3">Line 3:</td> <td colspan="2" class="diff-lineno">Line 3:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Structural highlights ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Structural highlights ==</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>&lt;table&gt;&lt;tr&gt;&lt;td colspan=&#039;2&#039;&gt;[[4pg3]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PG3 OCA]. For a &lt;b&gt;guided tour on the structure components&lt;/b&gt; use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PG3 FirstGlance]. &lt;br&gt;</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>&lt;table&gt;&lt;tr&gt;&lt;td colspan=&#039;2&#039;&gt;[[4pg3]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PG3 OCA]. For a &lt;b&gt;guided tour on the structure components&lt;/b&gt; use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PG3 FirstGlance]. &lt;br&gt;</div></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td class="sblockLbl"&gt;&lt;b&gt;[[Ligand|Ligands:]]&lt;/b&gt;&lt;/td&gt;&lt;td class="sblockDat"&gt;&lt;scene name='pdbligand=KRS:(3R)-3-[[(2R,6S)-6-METHYLOXAN-2-YL]METHYL]-6,8-BIS(OXIDANYL)-3,4-DIHYDROISOCHROMEN-1-ONE'&gt;KRS&lt;/scene&gt;, &lt;scene name='pdbligand=LYS:LYSINE'&gt;LYS&lt;/scene&gt;&lt;<del style="font-weight: bold; text-decoration: none;">br</del>&gt;</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>&lt;/td&gt;&lt;/tr&gt;&lt;tr <ins style="font-weight: bold; text-decoration: none;">id='ligand'</ins>&gt;&lt;td class="sblockLbl"&gt;&lt;b&gt;[[Ligand|Ligands:]]&lt;/b&gt;&lt;/td&gt;&lt;td class="sblockDat"&gt;&lt;scene name='pdbligand=KRS:(3R)-3-[[(2R,6S)-6-METHYLOXAN-2-YL]METHYL]-6,8-BIS(OXIDANYL)-3,4-DIHYDROISOCHROMEN-1-ONE'&gt;KRS&lt;/scene&gt;, &lt;scene name='pdbligand=LYS:LYSINE'&gt;LYS&lt;/scene&gt;&lt;<ins style="font-weight: bold; text-decoration: none;">/td&gt;&lt;/tr</ins>&gt;</div></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>&lt;tr&gt;&lt;td class="sblockLbl"&gt;&lt;b&gt;Activity:&lt;/b&gt;&lt;/td&gt;&lt;td class="sblockDat"&gt;&lt;span class='plainlinks'&gt;[http://en.wikipedia.org/wiki/Lysine--tRNA_ligase Lysine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.6 6.1.1.6] &lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>&lt;tr <ins style="font-weight: bold; text-decoration: none;">id='activity'</ins>&gt;&lt;td class="sblockLbl"&gt;&lt;b&gt;Activity:&lt;/b&gt;&lt;/td&gt;&lt;td class="sblockDat"&gt;&lt;span class='plainlinks'&gt;[http://en.wikipedia.org/wiki/Lysine--tRNA_ligase Lysine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.6 6.1.1.6] &lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;</div></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>&lt;tr&gt;&lt;td class="sblockLbl"&gt;&lt;b&gt;Resources:&lt;/b&gt;&lt;/td&gt;&lt;td class="sblockDat"&gt;&lt;span class='plainlinks'&gt;[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pg3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pg3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pg3 RCSB], [http://www.ebi.ac.uk/pdbsum/4pg3 PDBsum]&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>&lt;tr <ins style="font-weight: bold; text-decoration: none;">id='resources'</ins>&gt;&lt;td class="sblockLbl"&gt;&lt;b&gt;Resources:&lt;/b&gt;&lt;/td&gt;&lt;td class="sblockDat"&gt;&lt;span class='plainlinks'&gt;[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pg3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pg3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pg3 RCSB], [http://www.ebi.ac.uk/pdbsum/4pg3 PDBsum]&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;</div></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>&lt;table&gt;</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>&lt;<ins style="font-weight: bold; text-decoration: none;">/</ins>table&gt;</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>&lt;div style=&quot;background-color:#fffaf0;&quot;&gt;</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>&lt;div style=&quot;background-color:#fffaf0;&quot;&gt;</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Publication Abstract from PubMed ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Publication Abstract from PubMed ==</div></td></tr> <tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l20">Line 20:</td> <td colspan="2" class="diff-lineno">Line 20:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>&lt;/StructureSection&gt;</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>&lt;/StructureSection&gt;</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Category: Lysine--tRNA ligase]]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Category: Lysine--tRNA ligase]]</div></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>[[Category: Belrhali, H<del style="font-weight: bold; text-decoration: none;">.</del>]]</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>[[Category: Belrhali, H]]</div></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>[[Category: Khan, S<del style="font-weight: bold; text-decoration: none;">.</del>]]</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>[[Category: Khan, S]]</div></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>[[Category: Sharma, A<del style="font-weight: bold; text-decoration: none;">.</del>]]</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>[[Category: Sharma, A]]</div></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>[[Category: Yogavel, M<del style="font-weight: bold; text-decoration: none;">.</del>]]</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>[[Category: Yogavel, M]]</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Category: Complex]]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Category: Complex]]</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Category: Inhibitor]]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Category: Inhibitor]]</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Category: Kr]]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Category: Kr]]</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Category: Ligase-ligase inhibitor complex]]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Category: Ligase-ligase inhibitor complex]]</div></td></tr> </table> OCA https://proteopedia.org/index.php?title=4pg3&diff=1961459&oldid=prev OCA at 10:14, 16 July 2014 2014-07-16T10:14:42Z <p></p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 10:14, 16 July 2014</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l1">Line 1:</td> <td colspan="2" class="diff-lineno">Line 1:</td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>'''<del style="font-weight: bold; text-decoration: none;">Unreleased </del>structure'''</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">==Crystal structure of KRS complexed with inhibitor==</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">&lt;StructureSection load='4pg3' size='340' side='right</ins>' <ins style="font-weight: bold; text-decoration: none;">caption=</ins>'<ins style="font-weight: bold; text-decoration: none;">[[4pg3]], [[Resolution|resolution]] 2.70&amp;Aring;</ins>' <ins style="font-weight: bold; text-decoration: none;">scene=''&gt;</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">== Structural highlights ==</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">&lt;table&gt;&lt;tr&gt;&lt;td colspan='2'&gt;[[4pg3]] is a 4 chain </ins>structure<ins style="font-weight: bold; text-decoration: none;">. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PG3 OCA]. For a &lt;b&gt;guided tour on the structure components&lt;/b&gt; use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PG3 FirstGlance]. &lt;br&gt;</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td class="sblockLbl"&gt;&lt;b&gt;[[Ligand|Ligands:]]&lt;/b&gt;&lt;/td&gt;&lt;td class="sblockDat"&gt;&lt;scene name=</ins>'<ins style="font-weight: bold; text-decoration: none;">pdbligand=KRS:(3R)-3-[[(2R,6S)-6-METHYLOXAN-2-YL]METHYL]-6,8-BIS(OXIDANYL)-3,4-DIHYDROISOCHROMEN-1-ONE</ins>'<ins style="font-weight: bold; text-decoration: none;">&gt;KRS&lt;/scene&gt;, &lt;scene name=</ins>'<ins style="font-weight: bold; text-decoration: none;">pdbligand=LYS:LYSINE'&gt;LYS&lt;/scene&gt;&lt;br&gt;</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">&lt;tr&gt;&lt;td class="sblockLbl"&gt;&lt;b&gt;Activity:&lt;/b&gt;&lt;/td&gt;&lt;td class="sblockDat"&gt;&lt;span class='plainlinks'&gt;[http://en.wikipedia.org/wiki/Lysine--tRNA_ligase Lysine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.6 6.1.1.6] &lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">&lt;tr&gt;&lt;td class="sblockLbl"&gt;&lt;b&gt;Resources:&lt;/b&gt;&lt;/td&gt;&lt;td class="sblockDat"&gt;&lt;span class='plainlinks'&gt;[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pg3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pg3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pg3 RCSB], [http://www.ebi.ac.uk/pdbsum/4pg3 PDBsum]&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">&lt;table&gt;</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">&lt;div style="background-color:#fffaf0;"&gt;</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">== Publication Abstract from PubMed ==</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">Malaria parasites inevitably develop drug resistance to anti-malarials over time. Hence the immediacy for discovering new chemical scaffolds to include in combination malaria drug therapy. The desirable attributes of new chemotherapeutic agents currently include activity against both liver and blood stage malaria parasites. One such recently discovered compound called cladosporin abrogates parasite growth via inhibition of Plasmodium falciparum lysyl-tRNA synthetase (PfKRS), an enzyme central to protein translation. Here, we present crystal structure of ternary PfKRS-lysine-cladosporin (PfKRS-K-C) complex that reveals cladosporin's remarkable ability to mimic the natural substrate adenosine and thereby colonize PfKRS active site. The isocoumarin fragment of cladosporin sandwiches between critical adenine-recognizing residues while its pyran ring fits snugly in the ribose-recognizing cavity. PfKRS-K-C structure highlights ample space within PfKRS active site for further chemical derivatization of cladosporin. Such derivatives may be useful against additional human pathogens that retain high conservation in cladosporin chelating residues within their lysyl-tRNA synthetase.</ins></div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">The entry 4pg3 is ON HOLD </del></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">Structural basis of malaria parasite lysyl-tRNA synthetase inhibition by cladosporin.,Khan S, Sharma A, Belrhali H, Yogavel M, Sharma A J Struct Funct Genomics. 2014 Jun;15(2):63-71. doi: 10.1007/s10969-014-9182-1., Epub 2014 Jun 17. PMID:24935905&lt;ref&gt;PMID:24935905&lt;/ref&gt;</ins></div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">Authors: Sharma</del>, <del style="font-weight: bold; text-decoration: none;">A</del>., <del style="font-weight: bold; text-decoration: none;">Yogavel, M</del>.<del style="font-weight: bold; text-decoration: none;">, </del>Khan, S.<del style="font-weight: bold; text-decoration: none;">, </del>Sharma, A., <del style="font-weight: bold; text-decoration: none;">Belrhali, H</del>.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">From MEDLINE&amp;reg;/PubMed&amp;reg;</ins>, <ins style="font-weight: bold; text-decoration: none;">a database of the U.S. National Library of Medicine</ins>.<ins style="font-weight: bold; text-decoration: none;">&lt;br&gt;</ins></div></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">&lt;/div&gt;</ins></div></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">Description</del>: <del style="font-weight: bold; text-decoration: none;">Crystal structure of KRS complexed with </del>inhibitor</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">== References ==</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">&lt;references/&gt;</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">__TOC__</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">&lt;/StructureSection&gt;</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">[[Category: Lysine--tRNA ligase]]</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">[[Category: Belrhali</ins>, <ins style="font-weight: bold; text-decoration: none;">H</ins>.<ins style="font-weight: bold; text-decoration: none;">]]</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">[[Category: </ins>Khan, S.<ins style="font-weight: bold; text-decoration: none;">]]</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">[[Category: </ins>Sharma, A.<ins style="font-weight: bold; text-decoration: none;">]]</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">[[Category: Yogavel</ins>, <ins style="font-weight: bold; text-decoration: none;">M</ins>.<ins style="font-weight: bold; text-decoration: none;">]]</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">[[Category: Complex]]</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">[[Category: Inhibitor]]</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">[[Category</ins>: <ins style="font-weight: bold; text-decoration: none;">Kr]]</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">[[Category: Ligase-ligase </ins>inhibitor <ins style="font-weight: bold; text-decoration: none;">complex]]</ins></div></td></tr> </table> OCA https://proteopedia.org/index.php?title=4pg3&diff=1924536&oldid=prev OCA: Protected "4pg3" [edit=sysop:move=sysop] 2014-05-07T07:45:01Z <p>Protected &quot;<a href="/4pg3" title="4pg3">4pg3</a>&quot; [edit=sysop:move=sysop]</p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <tr class="diff-title" lang="en"> <td colspan="1" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="1" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 07:45, 7 May 2014</td> </tr><tr><td colspan="2" class="diff-notice" lang="en"><div class="mw-diff-empty">(No difference)</div> </td></tr></table> OCA https://proteopedia.org/index.php?title=4pg3&diff=1924535&oldid=prev OCA: New page: '''Unreleased structure''' The entry 4pg3 is ON HOLD Authors: Sharma, A., Yogavel, M., Khan, S., Sharma, A., Belrhali, H. Description: Crystal structure of KRS complexed with inhibitor 2014-05-07T07:45:00Z <p>New page: &#039;&#039;&#039;Unreleased structure&#039;&#039;&#039; The entry 4pg3 is ON HOLD Authors: Sharma, A., Yogavel, M., Khan, S., Sharma, A., Belrhali, H. Description: Crystal structure of KRS complexed with inhibitor</p> <p><b>New page</b></p><div>&#039;&#039;&#039;Unreleased structure&#039;&#039;&#039;<br /> <br /> The entry 4pg3 is ON HOLD <br /> <br /> Authors: Sharma, A., Yogavel, M., Khan, S., Sharma, A., Belrhali, H.<br /> <br /> Description: Crystal structure of KRS complexed with inhibitor</div> OCA