4ppo - Revision history

OCA at 17:20, 20 September 2023

2023-09-20T17:20:17Z

← Older revision		Revision as of 17:20, 20 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ppo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PPO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PPO FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ppo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PPO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PPO FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PT:CYCLOHEXANE-1(R),2(R)-DIAMINE-PLATINUM(II)'>1PT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.73Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PT:CYCLOHEXANE-1(R),2(R)-DIAMINE-PLATINUM(II)'>1PT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ppo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ppo OCA], [https://pdbe.org/4ppo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ppo RCSB], [https://www.ebi.ac.uk/pdbsum/4ppo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ppo ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ppo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ppo OCA], [https://pdbe.org/4ppo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ppo RCSB], [https://www.ebi.ac.uk/pdbsum/4ppo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ppo ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:23, 8 February 2023

2023-02-08T07:23:48Z

← Older revision		Revision as of 07:23, 8 February 2023
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	<StructureSection load='4ppo' size='340' side='right'caption='[[4ppo]], [[Resolution\|resolution]] 1.73Å' scene=''>		<StructureSection load='4ppo' size='340' side='right'caption='[[4ppo]], [[Resolution\|resolution]] 1.73Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ppo]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Chick Chick~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PPO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4PPO FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ppo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PPO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PPO FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PT:CYCLOHEXANE-1(R),2(R)-DIAMINE-PLATINUM(II)'>1PT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene~~></td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PT:CYCLOHEXANE-1(R),2(R)-DIAMINE-PLATINUM(II)'>1PT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LYZ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK])</td></tr>~~		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ppo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ppo OCA], [https://pdbe.org/4ppo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ppo RCSB], [https://www.ebi.ac.uk/pdbsum/4ppo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ppo ProSAT]</span></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ppo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ppo OCA], [~~http~~://pdbe.org/4ppo PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4ppo RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4ppo PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4ppo ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/LYSC_CHICK LYSC_CHICK]] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.<ref>PMID:22044478</ref>		[https://www.uniprot.org/uniprot/LYSC_CHICK LYSC_CHICK] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.<ref>PMID:22044478</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Chick~~]]		[[Category: Gallus gallus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	~~[[Category: Lysozyme]]~~		[[Category: Merlino A]]
	[[Category: Merlino, A]]		[[Category: Messori L]]
	[[Category: Messori, L]]
	~~[[Category: Hydrolase]]~~
	~~[[Category: Lysozyme fold~~]]

OCA at 07:30, 17 April 2019

2019-04-17T07:30:40Z

← Older revision		Revision as of 07:30, 17 April 2019
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	==First Crystal Structure for an Oxaliplatin-Protein Complex==		==First Crystal Structure for an Oxaliplatin-Protein Complex==
	<StructureSection load='4ppo' size='340' side='right' caption='[[4ppo]], [[Resolution\|resolution]] 1.73Å' scene=''>		<StructureSection load='4ppo' size='340' side='right'caption='[[4ppo]], [[Resolution\|resolution]] 1.73Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ppo]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PPO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PPO FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ppo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PPO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PPO FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PT:CYCLOHEXANE-1(R),2(R)-DIAMINE-PLATINUM(II)'>1PT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PT:CYCLOHEXANE-1(R),2(R)-DIAMINE-PLATINUM(II)'>1PT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LYZ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ppo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ppo OCA], [http://pdbe.org/4ppo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ppo RCSB], [http://www.ebi.ac.uk/pdbsum/4ppo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ppo ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ppo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ppo OCA], [http://pdbe.org/4ppo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ppo RCSB], [http://www.ebi.ac.uk/pdbsum/4ppo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ppo ProSAT]</span></td></tr>
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	</div>		</div>
	<div class="pdbe-citations 4ppo" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4ppo" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Lysozyme 3D structures\|Lysozyme 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Chick]]
			[[Category: Large Structures]]
	[[Category: Lysozyme]]		[[Category: Lysozyme]]
	[[Category: Merlino, A]]		[[Category: Merlino, A]]

OCA at 20:40, 11 August 2016

2016-08-11T20:40:27Z

← Older revision		Revision as of 20:40, 11 August 2016
Line 1:		Line 1:

	==First Crystal Structure for an Oxaliplatin-Protein Complex==		==First Crystal Structure for an Oxaliplatin-Protein Complex==
	<StructureSection load='4ppo' size='340' side='right' caption='[[4ppo]], [[Resolution\|resolution]] 1.73Å' scene=''>		<StructureSection load='4ppo' size='340' side='right' caption='[[4ppo]], [[Resolution\|resolution]] 1.73Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PT:CYCLOHEXANE-1(R),2(R)-DIAMINE-PLATINUM(II)'>1PT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PT:CYCLOHEXANE-1(R),2(R)-DIAMINE-PLATINUM(II)'>1PT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ppo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ppo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ppo RCSB], [http://www.ebi.ac.uk/pdbsum/4ppo PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ppo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ppo OCA], [http://pdbe.org/4ppo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ppo RCSB], [http://www.ebi.ac.uk/pdbsum/4ppo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ppo ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4ppo" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:36, 14 January 2015

2015-01-14T13:36:14Z

← Older revision		Revision as of 13:36, 14 January 2015
Line 1:		Line 1:
	'''~~Unreleased~~ structure'''		==First Crystal Structure for an Oxaliplatin-Protein Complex==
			<StructureSection load='4ppo' size='340' side='right' caption='[[4ppo]], [[Resolution\|resolution]] 1.73Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[4ppo]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PPO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PPO FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PT:CYCLOHEXANE-1(R),2(R)-DIAMINE-PLATINUM(II)'>1PT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
			<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ppo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ppo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ppo RCSB], [http://www.ebi.ac.uk/pdbsum/4ppo PDBsum]</span></td></tr>
			</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/LYSC_CHICK LYSC_CHICK]] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.<ref>PMID:22044478</ref>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The X-ray structure of the adduct formed between oxaliplatin and the model protein hen egg white lysozyme is reported here. The structure is compared with those of cisplatin and carboplatin derivatives, previously solved. Relevant changes are highlighted among these crystal structures that are suggestive of significant differences in the reactivity of platinum drugs with this protein; possible biological implications are discussed.

	The ~~entry 4ppo is ON HOLD until Paper Publication~~		The X-ray structure of the complex formed in the reaction between oxaliplatin and lysozyme.,Messori L, Marzo T, Merlino A Chem Commun (Camb). 2014 Aug 7;50(61):8360-2. doi: 10.1039/c4cc02254h. PMID:24943911<ref>PMID:24943911</ref>

	~~Authors: Messori~~, L.~~, Merlino, A~~.		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~Description~~: ~~First Crystal Structure for an Oxaliplatin-Protein Complex~~		== References ==
	[[Category: ~~Unreleased Structures~~]]		<references/>
			__TOC__
			</StructureSection>
			[[Category: Lysozyme]]
			[[Category: Merlino, A]]
	[[Category: Messori, L]]		[[Category: Messori, L]]
	[[Category: ~~Merlino, A~~]]		[[Category: Hydrolase]]
			[[Category: Lysozyme fold]]

OCA at 15:10, 24 December 2014

2014-12-24T15:10:43Z

← Older revision		Revision as of 15:10, 24 December 2014
Line 6:		Line 6:

	Description: First Crystal Structure for an Oxaliplatin-Protein Complex		Description: First Crystal Structure for an Oxaliplatin-Protein Complex
			[[Category: Unreleased Structures]]
			[[Category: Messori, L]]
			[[Category: Merlino, A]]

OCA at 06:18, 8 October 2014

2014-10-08T06:18:09Z

← Older revision		Revision as of 06:18, 8 October 2014
Line 3:		Line 3:
	The entry 4ppo is ON HOLD until Paper Publication		The entry 4ppo is ON HOLD until Paper Publication

	Authors: Messori, L., Merlino, A:		Authors: Messori, L., Merlino, A.

	Description: First Crystal Structure for an Oxaliplatin-Protein Complex		Description: First Crystal Structure for an Oxaliplatin-Protein Complex

OCA at 08:32, 2 April 2014

2014-04-02T08:32:09Z

← Older revision		Revision as of 08:32, 2 April 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4ppo is ON HOLD		The entry 4ppo is ON HOLD until Paper Publication

	Authors: Messori, L., Merlino, A:		Authors: Messori, L., Merlino, A:

	Description: First Crystal Structure for an Oxaliplatin-Protein Complex		Description: First Crystal Structure for an Oxaliplatin-Protein Complex

OCA: Protected "4ppo" [edit=sysop:move=sysop]

2014-03-12T12:34:13Z

Protected "4ppo" [edit=sysop:move=sysop]

← Older revision	Revision as of 12:34, 12 March 2014
(No difference)

OCA: New page: '''Unreleased structure''' The entry 4ppo is ON HOLD Authors: Messori, L., Merlino, A: Description: First Crystal Structure for an Oxaliplatin-Protein Complex

2014-03-12T12:34:11Z

New page: '''Unreleased structure''' The entry 4ppo is ON HOLD Authors: Messori, L., Merlino, A: Description: First Crystal Structure for an Oxaliplatin-Protein Complex

New page

'''Unreleased structure'''

The entry 4ppo is ON HOLD

Authors: Messori, L., Merlino, A:

Description: First Crystal Structure for an Oxaliplatin-Protein Complex