4put - Revision history

OCA at 12:43, 1 March 2024

2024-03-01T12:43:09Z

← Older revision		Revision as of 12:43, 1 March 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4put]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PUT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PUT FirstGlance]. <br>		<table><tr><td colspan='2'>[[4put]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PUT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PUT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4put FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4put OCA], [https://pdbe.org/4put PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4put RCSB], [https://www.ebi.ac.uk/pdbsum/4put PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4put ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4put FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4put OCA], [https://pdbe.org/4put PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4put RCSB], [https://www.ebi.ac.uk/pdbsum/4put PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4put ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/COPDA_ARATH COPDA_ARATH] Oligopeptidase that may be involved in the degradation of proteasome-generated peptides (By similarity). Binds salicylic acid.<ref>PMID:24004003</ref> <ref>PMID:24043784</ref>		[https://www.uniprot.org/uniprot/COPDA_ARATH COPDA_ARATH] Oligopeptidase that may be involved in the degradation of proteasome-generated peptides (By similarity). Binds salicylic acid.<ref>PMID:24004003</ref> <ref>PMID:24043784</ref>
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	Thimet oligopeptidase (TOP) is a zinc-dependent metallopeptidase. Recent studies suggest that Arabidopsis thaliana TOP1 and TOP2 are targets for salicylic acid (SA) binding and participate in SA-mediated plant innate immunity. The crystal structure of A. thaliana TOP2 has been determined at 3.0 A resolution. Comparisons to the structure of human TOP revealed good overall structural conservation, especially in the active-site region, despite their weak sequence conservation. The protein sample was incubated with the photo-activated SA analog 4-azido-SA and exposed to UV irradiation before crystallization. However, there was no conclusive evidence for the binding of SA based on the X-ray diffraction data. Further studies are needed to elucidate the molecular mechanism of how SA regulates the activity of A. thaliana TOP1 and TOP2.

	Structure of the Arabidopsis thaliana TOP2 oligopeptidase.,Wang R, Rajagopalan K, Sadre-Bazzaz K, Moreau M, Klessig DF, Tong L Acta Crystallogr F Struct Biol Commun. 2014 May;70(Pt 5):555-9. doi:, 10.1107/S2053230X14006128. Epub 2014 Apr 15. PMID:24817709<ref>PMID:24817709</ref>

	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~<div class="pdbe-citations 4put" style="background-color:#fffaf0;"></div>~~
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:32, 8 February 2023

2023-02-08T07:32:19Z

← Older revision		Revision as of 07:32, 8 February 2023
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	<StructureSection load='4put' size='340' side='right'caption='[[4put]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='4put' size='340' side='right'caption='[[4put]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4put]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Arath Arath~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PUT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4PUT FirstGlance]. <br>		<table><tr><td colspan='2'>[[4put]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PUT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PUT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYOP, TOP2, At5g10540, F12B17.110 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4put FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4put OCA], [https://pdbe.org/4put PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4put RCSB], [https://www.ebi.ac.uk/pdbsum/4put PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4put ProSAT]</span></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Oligopeptidase_A Oligopeptidase A], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.70 3.4.24.70] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4put FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4put OCA], [~~http~~://pdbe.org/4put PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4put RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4put PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4put ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/COPDA_ARATH COPDA_ARATH]] Oligopeptidase that may be involved in the degradation of proteasome-generated peptides (By similarity). Binds salicylic acid.<ref>PMID:24004003</ref> <ref>PMID:24043784</ref>		[https://www.uniprot.org/uniprot/COPDA_ARATH COPDA_ARATH] Oligopeptidase that may be involved in the degradation of proteasome-generated peptides (By similarity). Binds salicylic acid.<ref>PMID:24004003</ref> <ref>PMID:24043784</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Arath~~]]		[[Category: Arabidopsis thaliana]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	~~[[Category: Oligopeptidase A]]~~		[[Category: Rajagopalan K]]
	[[Category: Rajagopalan, K]]		[[Category: Tong L]]
	[[Category: Tong, L]]		[[Category: Wang R]]
	[[Category: Wang, R]]
	~~[[Category: Hydrolase]]~~
	~~[[Category: Oligopeptidase~~]]

OCA at 07:54, 17 April 2019

2019-04-17T07:54:04Z

← Older revision		Revision as of 07:54, 17 April 2019
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	==Crystal structure of the Arabidopsis thaliana TOP2 oligopeptidase==		==Crystal structure of the Arabidopsis thaliana TOP2 oligopeptidase==
	<StructureSection load='4put' size='340' side='right' caption='[[4put]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='4put' size='340' side='right'caption='[[4put]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4put]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PUT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PUT FirstGlance]. <br>		<table><tr><td colspan='2'>[[4put]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PUT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PUT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYOP, TOP2, At5g10540, F12B17.110 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Oligopeptidase_A Oligopeptidase A], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.70 3.4.24.70] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Oligopeptidase_A Oligopeptidase A], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.70 3.4.24.70] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4put FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4put OCA], [http://pdbe.org/4put PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4put RCSB], [http://www.ebi.ac.uk/pdbsum/4put PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4put ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4put FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4put OCA], [http://pdbe.org/4put PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4put RCSB], [http://www.ebi.ac.uk/pdbsum/4put PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4put ProSAT]</span></td></tr>
Line 23:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Arath]]
			[[Category: Large Structures]]
	[[Category: Oligopeptidase A]]		[[Category: Oligopeptidase A]]
	[[Category: Rajagopalan, K]]		[[Category: Rajagopalan, K]]

OCA at 12:27, 5 August 2016

2016-08-05T12:27:54Z

← Older revision		Revision as of 12:27, 5 August 2016
Line 1:		Line 1:

	==Crystal structure of the Arabidopsis thaliana TOP2 oligopeptidase==		==Crystal structure of the Arabidopsis thaliana TOP2 oligopeptidase==
	<StructureSection load='4put' size='340' side='right' caption='[[4put]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='4put' size='340' side='right' caption='[[4put]], [[Resolution\|resolution]] 3.00Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Oligopeptidase_A Oligopeptidase A], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.70 3.4.24.70] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Oligopeptidase_A Oligopeptidase A], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.70 3.4.24.70] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4put FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4put OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4put RCSB], [http://www.ebi.ac.uk/pdbsum/4put PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4put FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4put OCA], [http://pdbe.org/4put PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4put RCSB], [http://www.ebi.ac.uk/pdbsum/4put PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4put ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4put" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 02:26, 25 December 2014

2014-12-25T02:26:59Z

← Older revision		Revision as of 02:26, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4put]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PUT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PUT FirstGlance]. <br>		<table><tr><td colspan='2'>[[4put]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PUT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PUT FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Oligopeptidase_A Oligopeptidase A], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.70 3.4.24.70] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Oligopeptidase_A Oligopeptidase A], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.70 3.4.24.70] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4put FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4put OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4put RCSB], [http://www.ebi.ac.uk/pdbsum/4put PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4put FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4put OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4put RCSB], [http://www.ebi.ac.uk/pdbsum/4put PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/COPDA_ARATH COPDA_ARATH]] Oligopeptidase that may be involved in the degradation of proteasome-generated peptides (By similarity). Binds salicylic acid.<ref>PMID:24004003</ref> <ref>PMID:24043784</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Oligopeptidase A]]		[[Category: Oligopeptidase A]]
	[[Category: Rajagopalan, K.]]		[[Category: Rajagopalan, K]]
	[[Category: Tong, L.]]		[[Category: Tong, L]]
	[[Category: Wang, R.]]		[[Category: Wang, R]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Oligopeptidase]]		[[Category: Oligopeptidase]]

OCA at 05:15, 25 June 2014

2014-06-25T05:15:26Z

← Older revision		Revision as of 05:15, 25 June 2014
Line 2:		Line 2:
	<StructureSection load='4put' size='340' side='right' caption='[[4put]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='4put' size='340' side='right' caption='[[4put]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4put]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PUT OCA]. <br>		<table><tr><td colspan='2'>[[4put]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PUT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PUT FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>		</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/~~Glucokinase Glucokinase~~], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.~~2 2~~.7.1.2] </span></td></tr>		<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Oligopeptidase_A Oligopeptidase A], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.70 3.4.24.70] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4put FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4put OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4put RCSB], [http://www.ebi.ac.uk/pdbsum/4put PDBsum]</span></td></tr>		<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4put FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4put OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4put RCSB], [http://www.ebi.ac.uk/pdbsum/4put PDBsum]</span></td></tr>
	<table>		<table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Thimet oligopeptidase (TOP) is a zinc-dependent metallopeptidase. Recent studies suggest that Arabidopsis thaliana TOP1 and TOP2 are targets for salicylic acid (SA) binding and participate in SA-mediated plant innate immunity. The crystal structure of A. thaliana TOP2 has been determined at 3.0 A resolution. Comparisons to the structure of human TOP revealed good overall structural conservation, especially in the active-site region, despite their weak sequence conservation. The protein sample was incubated with the photo-activated SA analog 4-azido-SA and exposed to UV irradiation before crystallization. However, there was no conclusive evidence for the binding of SA based on the X-ray diffraction data. Further studies are needed to elucidate the molecular mechanism of how SA regulates the activity of A. thaliana TOP1 and TOP2.

			Structure of the Arabidopsis thaliana TOP2 oligopeptidase.,Wang R, Rajagopalan K, Sadre-Bazzaz K, Moreau M, Klessig DF, Tong L Acta Crystallogr F Struct Biol Commun. 2014 May;70(Pt 5):555-9. doi:, 10.1107/S2053230X14006128. Epub 2014 Apr 15. PMID:24817709<ref>PMID:24817709</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 07:29, 14 May 2014

2014-05-14T07:29:08Z

← Older revision		Revision as of 07:29, 14 May 2014
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	'''~~Unreleased structure~~'''		==Crystal structure of the Arabidopsis thaliana TOP2 oligopeptidase==
			<StructureSection load='4put' size='340' side='right' caption='[[4put]], [[Resolution\|resolution]] 3.00Å' scene=''>
	~~The entry~~ 4put is ~~ON HOLD~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[4put]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PUT OCA]. <br>
	~~Authors~~: ~~Wang~~, R., Rajagopalan, K., Tong, L.		</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
			<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
	~~Description~~: ~~Crystal structure of the Arabidopsis thaliana TOP2 oligopeptidase~~		<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4put FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4put OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4put RCSB], [http://www.ebi.ac.uk/pdbsum/4put PDBsum]</span></td></tr>
			<table>
			__TOC__
			</StructureSection>
			[[Category: Oligopeptidase A]]
			[[Category: Rajagopalan, K.]]
			[[Category: Tong, L.]]
			[[Category: Wang, R.]]
			[[Category: Hydrolase]]
			[[Category: Oligopeptidase]]

OCA: Protected "4put" [edit=sysop:move=sysop]

2014-03-19T07:45:45Z

Protected "4put" [edit=sysop:move=sysop]

← Older revision	Revision as of 07:45, 19 March 2014
(No difference)

OCA: New page: '''Unreleased structure''' The entry 4put is ON HOLD Authors: Wang, R., Rajagopalan, K., Tong, L. Description: Crystal structure of the Arabidopsis thaliana TOP2 oligopeptidase

2014-03-19T07:45:43Z

New page: '''Unreleased structure''' The entry 4put is ON HOLD Authors: Wang, R., Rajagopalan, K., Tong, L. Description: Crystal structure of the Arabidopsis thaliana TOP2 oligopeptidase

New page

'''Unreleased structure'''

The entry 4put is ON HOLD

Authors: Wang, R., Rajagopalan, K., Tong, L.

Description: Crystal structure of the Arabidopsis thaliana TOP2 oligopeptidase