4py2 - Revision history

OCA at 17:24, 20 September 2023

2023-09-20T17:24:31Z

← Older revision		Revision as of 17:24, 20 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4py2]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Brucella_abortus_2308 Brucella abortus 2308]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PY2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PY2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4py2]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Brucella_abortus_2308 Brucella abortus 2308]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PY2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PY2 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=43E:1-{3-[(3,5-DICHLOROBENZYL)AMINO]PROPYL}-3-THIOPHEN-3-YLUREA'>43E</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.15Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=43E:1-{3-[(3,5-DICHLOROBENZYL)AMINO]PROPYL}-3-THIOPHEN-3-YLUREA'>43E</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4py2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4py2 OCA], [https://pdbe.org/4py2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4py2 RCSB], [https://www.ebi.ac.uk/pdbsum/4py2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4py2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4py2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4py2 OCA], [https://pdbe.org/4py2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4py2 RCSB], [https://www.ebi.ac.uk/pdbsum/4py2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4py2 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:36, 8 February 2023

2023-02-08T07:36:48Z

← Older revision		Revision as of 07:36, 8 February 2023
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	==Crystal structure of methionyl-tRNA synthetase MetRS from Brucella melitensis in complex with inhibitor 1-{3-[(3,5-DICHLOROBENZYL)AMINO]PROPYL}-3-THIOPHEN-3-YLUREA==		==Crystal structure of methionyl-tRNA synthetase MetRS from Brucella melitensis in complex with inhibitor 1-{3-[(3,5-DICHLOROBENZYL)AMINO]PROPYL}-3-THIOPHEN-3-YLUREA==
	<StructureSection load='4py2' size='340' side='right' caption='[[4py2]], [[Resolution\|resolution]] 2.15Å' scene=''>		<StructureSection load='4py2' size='340' side='right'caption='[[4py2]], [[Resolution\|resolution]] 2.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4py2]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Brua2 Brua2~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PY2 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4PY2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4py2]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Brucella_abortus_2308 Brucella abortus 2308]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PY2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PY2 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=43E:1-{3-[(3,5-DICHLOROBENZYL)AMINO]PROPYL}-3-THIOPHEN-3-YLUREA'>43E</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene~~></td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=43E:1-{3-[(3,5-DICHLOROBENZYL)AMINO]PROPYL}-3-THIOPHEN-3-YLUREA'>43E</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4dlp\|4dlp]], [[4lne\|4lne]], [[4ppw\|4ppw]]</td></tr>~~		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4py2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4py2 OCA], [https://pdbe.org/4py2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4py2 RCSB], [https://www.ebi.ac.uk/pdbsum/4py2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4py2 ProSAT]</span></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">metG, BAB1_1014 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=359391 BRUA2])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methionine--tRNA_ligase Methionine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.10 6.1.1.10] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4py2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4py2 OCA], [~~http~~://pdbe.org/4py2 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4py2 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4py2 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4py2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/Q2YQ76_BRUA2 Q2YQ76_BRUA2]] Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity).[HAMAP-Rule:MF_01228][SAAS:SAAS023457_004_015657]		[https://www.uniprot.org/uniprot/Q2YQ76_BRUA2 Q2YQ76_BRUA2] Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity).[HAMAP-Rule:MF_01228][SAAS:SAAS023457_004_015657]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 4py2" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4py2" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Aminoacyl tRNA synthetase 3D structures\|Aminoacyl tRNA synthetase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Brua2~~]]		[[Category: Brucella abortus 2308]]
	[[Category: ~~Methionine--tRNA ligase~~]]		[[Category: Large Structures]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	~~[[Category: Ligase]]~~
	~~[[Category: Ligase-ligase inhibitor complex]]~~
	~~[[Category: Methionyl-trna synthetase]]~~
	~~[[Category: National institute of allergy and infectious disease]]~~
	~~[[Category: Niaid]]~~
	~~[[Category: Ssgcid]]~~

OCA at 08:46, 22 November 2017

2017-11-22T08:46:31Z

← Older revision		Revision as of 08:46, 22 November 2017
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	<StructureSection load='4py2' size='340' side='right' caption='[[4py2]], [[Resolution\|resolution]] 2.15Å' scene=''>		<StructureSection load='4py2' size='340' side='right' caption='[[4py2]], [[Resolution\|resolution]] 2.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4py2]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PY2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PY2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4py2]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Brua2 Brua2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PY2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PY2 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=43E:1-{3-[(3,5-DICHLOROBENZYL)AMINO]PROPYL}-3-THIOPHEN-3-YLUREA'>43E</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=43E:1-{3-[(3,5-DICHLOROBENZYL)AMINO]PROPYL}-3-THIOPHEN-3-YLUREA'>43E</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4dlp\|4dlp]], [[4lne\|4lne]], [[4ppw\|4ppw]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4dlp\|4dlp]], [[4lne\|4lne]], [[4ppw\|4ppw]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">metG, BAB1_1014 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=359391 BRUA2])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methionine--tRNA_ligase Methionine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.10 6.1.1.10] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methionine--tRNA_ligase Methionine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.10 6.1.1.10] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4py2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4py2 OCA], [http://pdbe.org/4py2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4py2 RCSB], [http://www.ebi.ac.uk/pdbsum/4py2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4py2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4py2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4py2 OCA], [http://pdbe.org/4py2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4py2 RCSB], [http://www.ebi.ac.uk/pdbsum/4py2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4py2 ProSAT]</span></td></tr>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Brua2]]
	[[Category: Methionine--tRNA ligase]]		[[Category: Methionine--tRNA ligase]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]

OCA at 04:28, 9 September 2016

2016-09-09T04:28:51Z

← Older revision		Revision as of 04:28, 9 September 2016
Line 1:		Line 1:

	==Crystal structure of methionyl-tRNA synthetase MetRS from Brucella melitensis in complex with inhibitor 1-{3-[(3,5-DICHLOROBENZYL)AMINO]PROPYL}-3-THIOPHEN-3-YLUREA==		==Crystal structure of methionyl-tRNA synthetase MetRS from Brucella melitensis in complex with inhibitor 1-{3-[(3,5-DICHLOROBENZYL)AMINO]PROPYL}-3-THIOPHEN-3-YLUREA==
	<StructureSection load='4py2' size='340' side='right' caption='[[4py2]], [[Resolution\|resolution]] 2.15Å' scene=''>		<StructureSection load='4py2' size='340' side='right' caption='[[4py2]], [[Resolution\|resolution]] 2.15Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4dlp\|4dlp]], [[4lne\|4lne]], [[4ppw\|4ppw]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4dlp\|4dlp]], [[4lne\|4lne]], [[4ppw\|4ppw]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methionine--tRNA_ligase Methionine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.10 6.1.1.10] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methionine--tRNA_ligase Methionine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.10 6.1.1.10] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4py2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4py2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4py2 RCSB], [http://www.ebi.ac.uk/pdbsum/4py2 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4py2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4py2 OCA], [http://pdbe.org/4py2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4py2 RCSB], [http://www.ebi.ac.uk/pdbsum/4py2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4py2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/Q2YQ76_BRUA2 Q2YQ76_BRUA2]] Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity).[HAMAP-Rule:MF_01228][SAAS:SAAS023457_004_015657]		[[http://www.uniprot.org/uniprot/Q2YQ76_BRUA2 Q2YQ76_BRUA2]] Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity).[HAMAP-Rule:MF_01228][SAAS:SAAS023457_004_015657]
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			We investigated Brucella melitensis methionyl-tRNA-synthetase (BmMetRS) with molecular, structural and phenotypic methods to learn if BmMetRS is a promising target for brucellosis drug development. Recombinant BmMetRS was expressed, purified from wild type Brucella melitensis biovar Abortus 2308 strain ATCC/CRP #DD-156 and screened by a thermal melt assay against a focused library of one hundred previously classified methionyl-tRNA-synthetase inhibitors of the blood stage form of Trypanosoma brucei. Three compounds showed appreciable shift of denaturation temperature and were selected for further studies on inhibition of the recombinant enzyme activity and cell viability against wild type B. melitensis strain 16M. BmMetRS protein complexed with these three inhibitors resolved into three-dimensional crystal structures and was analyzed. All three selected methionyl-tRNA-synthetase compounds inhibit recombinant BmMetRS enzymatic functions in an aminoacylation assay at varying concentrations. Furthermore, growth inhibition of B. melitensis strain 16M by the compounds was shown. Inhibitor-BmMetRS crystal structure models were used to illustrate the molecular basis of the enzyme inhibition. Our current data suggests that BmMetRS is a promising target for brucellosis drug development. However, further studies are needed to optimize lead compound potency, efficacy and safety as well as determine the pharmacokinetics, optimal dosage, and duration for effective treatment.

			Brucella melitensis Methionyl-tRNA-Synthetase (MetRS), a Potential Drug Target for Brucellosis.,Ojo KK, Ranade RM, Zhang Z, Dranow DM, Myers JB, Choi R, Nakazawa Hewitt S, Edwards TE, Davies DR, Lorimer D, Boyle SM, Barrett LK, Buckner FS, Fan E, Van Voorhis WC PLoS One. 2016 Aug 8;11(8):e0160350. doi: 10.1371/journal.pone.0160350., eCollection 2016. PMID:27500735<ref>PMID:27500735</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 4py2" style="background-color:#fffaf0;"></div>
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 12:58, 15 April 2015

2015-04-15T12:58:35Z

← Older revision		Revision as of 12:58, 15 April 2015
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	'''~~Unreleased~~ structure'''		==Crystal structure of methionyl-tRNA synthetase MetRS from Brucella melitensis in complex with inhibitor 1-{3-[(3,5-DICHLOROBENZYL)AMINO]PROPYL}-3-THIOPHEN-3-YLUREA==
			<StructureSection load='4py2' size='340' side='right' caption='[[4py2]], [[Resolution\|resolution]] 2.15Å' scene=''>
	~~The entry~~ 4py2 ~~is ON HOLD until Paper Publication~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[4py2]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PY2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PY2 FirstGlance]. <br>
	~~Authors~~: ~~Seattle Structural Genomics Center~~ for ~~Infectious Disease, Seattle Structural Genomics Center~~ for ~~Infectious Disease~~ (~~SSGCID~~)		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=43E:1-{3-[(3,5-DICHLOROBENZYL)AMINO]PROPYL}-3-THIOPHEN-3-YLUREA'>43E</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4dlp\|4dlp]], [[4lne\|4lne]], [[4ppw\|4ppw]]</td></tr>
	~~Description~~:		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methionine--tRNA_ligase Methionine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.10 6.1.1.10] </span></td></tr>
	[[Category: ~~Unreleased Structures~~]]		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4py2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4py2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4py2 RCSB], [http://www.ebi.ac.uk/pdbsum/4py2 PDBsum]</span></td></tr>
	[[Category: ~~Seattle Structural Genomics Center For Infectious Disease, Seattle Structural Genomics Center For Infectious Disease (~~Ssgcid)]]		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/Q2YQ76_BRUA2 Q2YQ76_BRUA2]] Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity).[HAMAP-Rule:MF_01228][SAAS:SAAS023457_004_015657]
			__TOC__
			</StructureSection>
			[[Category: Methionine--tRNA ligase]]
			[[Category: Structural genomic]]
			[[Category: Ligase]]
			[[Category: Ligase-ligase inhibitor complex]]
			[[Category: Methionyl-trna synthetase]]
			[[Category: National institute of allergy and infectious disease]]
			[[Category: Niaid]]
			[[Category: Ssgcid]]

OCA at 15:19, 24 December 2014

2014-12-24T15:19:21Z

← Older revision		Revision as of 15:19, 24 December 2014
Line 5:		Line 5:
	Authors: Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)		Authors: Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)

	Description:		Description:
			[[Category: Unreleased Structures]]
			[[Category: Seattle Structural Genomics Center For Infectious Disease, Seattle Structural Genomics Center For Infectious Disease (Ssgcid)]]

OCA at 05:57, 9 April 2014

2014-04-09T05:57:56Z

← Older revision		Revision as of 05:57, 9 April 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4py2 is ON HOLD		The entry 4py2 is ON HOLD until Paper Publication

	Authors: Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)		Authors: Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)

	Description: ~~Crystal structure of methionyl-tRNA synthetase MetRS from Brucella melitensis in complex with inhibitor Chem 1433~~		Description:

OCA: Protected "4py2" [edit=sysop:move=sysop]

2014-04-02T08:35:45Z

Protected "4py2" [edit=sysop:move=sysop]

← Older revision	Revision as of 08:35, 2 April 2014
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OCA: New page: '''Unreleased structure''' The entry 4py2 is ON HOLD Authors: Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCI...

2014-04-02T08:35:43Z

New page: '''Unreleased structure''' The entry 4py2 is ON HOLD Authors: Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCI...

New page

'''Unreleased structure'''

The entry 4py2 is ON HOLD

Authors: Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)

Description: Crystal structure of methionyl-tRNA synthetase MetRS from Brucella melitensis in complex with inhibitor Chem 1433