4qo7 - Revision history

OCA at 17:34, 20 September 2023

2023-09-20T17:34:10Z

← Older revision		Revision as of 17:34, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4qo7]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QO7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QO7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4qo7]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QO7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QO7 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2OP:(2S)-2-HYDROXYPROPANOIC+ACID'>2OP</scene>, <scene name='pdbligand=36V:TRANS-2-[(2-NITROPHENYL)SULFANYL]-5-PHENYLCYCLOHEXANE-1,3-DIONE'>36V</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.14Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2OP:(2S)-2-HYDROXYPROPANOIC+ACID'>2OP</scene>, <scene name='pdbligand=36V:TRANS-2-[(2-NITROPHENYL)SULFANYL]-5-PHENYLCYCLOHEXANE-1,3-DIONE'>36V</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qo7 OCA], [https://pdbe.org/4qo7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qo7 RCSB], [https://www.ebi.ac.uk/pdbsum/4qo7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qo7 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qo7 OCA], [https://pdbe.org/4qo7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qo7 RCSB], [https://www.ebi.ac.uk/pdbsum/4qo7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qo7 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 13:43, 22 February 2023

2023-02-22T13:43:40Z

← Older revision		Revision as of 13:43, 22 February 2023
Line 3:		Line 3:
	<StructureSection load='4qo7' size='340' side='right'caption='[[4qo7]], [[Resolution\|resolution]] 2.14Å' scene=''>		<StructureSection load='4qo7' size='340' side='right'caption='[[4qo7]], [[Resolution\|resolution]] 2.14Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4qo7]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QO7 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4QO7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4qo7]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QO7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QO7 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2OP:(2S)-2-HYDROXYPROPANOIC+ACID'>2OP</scene>, <scene name='pdbligand=36V:TRANS-2-[(2-NITROPHENYL)SULFANYL]-5-PHENYLCYCLOHEXANE-1,3-DIONE'>36V</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2OP:(2S)-2-HYDROXYPROPANOIC+ACID'>2OP</scene>, <scene name='pdbligand=36V:TRANS-2-[(2-NITROPHENYL)SULFANYL]-5-PHENYLCYCLOHEXANE-1,3-DIONE'>36V</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qo8\|4qo8]]</td></tr>~~		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qo7 OCA], [https://pdbe.org/4qo7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qo7 RCSB], [https://www.ebi.ac.uk/pdbsum/4qo7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qo7 ProSAT]</span></td></tr>
	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LDHA, PIG19 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4qo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qo7 OCA], [~~http~~://pdbe.org/4qo7 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4qo7 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4qo7 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4qo7 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[~~[http~~://www.uniprot.org/uniprot/LDHA_HUMAN LDHA_HUMAN]] Defects in LDHA are the cause of glycogen storage disease type 11 (GSD11) [MIM:[~~http~~://omim.org/entry/612933 612933]]. A metabolic disorder that results in exertional myoglobinuria, pain, cramps and easy fatigue.<ref>PMID:2334430</ref>		[https://www.uniprot.org/uniprot/LDHA_HUMAN LDHA_HUMAN] Defects in LDHA are the cause of glycogen storage disease type 11 (GSD11) [MIM:[https://omim.org/entry/612933 612933]. A metabolic disorder that results in exertional myoglobinuria, pain, cramps and easy fatigue.<ref>PMID:2334430</ref>
			== Function ==
			[https://www.uniprot.org/uniprot/LDHA_HUMAN LDHA_HUMAN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 22:

	==See Also==		==See Also==
	*[[Lactate ~~Dehydrogenase~~\|Lactate ~~Dehydrogenase~~]]		*[[Lactate dehydrogenase 3D structures\|Lactate dehydrogenase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human]]~~		[[Category: Homo sapiens]]
	~~[[Category: L-lactate dehydrogenase~~]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Eigenbrot, C]]		[[Category: Eigenbrot C]]
	[[Category: Ultsch, M]]		[[Category: Ultsch M]]
	~~[[Category: Nicotinamide adenine dinucleotide]]~~
	~~[[Category: Oxidoreductase]]~~
	~~[[Category: Oxidoreductase-oxidoreductase inhibitor complex~~]]

OCA at 08:42, 24 April 2019

2019-04-24T08:42:58Z

← Older revision		Revision as of 08:42, 24 April 2019
Line 1:		Line 1:

	==Lactate Dehydrogenase A in complex with substituted 3-Hydroxy-2-mercaptocyclohex-2-enone compound 7==		==Lactate Dehydrogenase A in complex with substituted 3-Hydroxy-2-mercaptocyclohex-2-enone compound 7==
	<StructureSection load='4qo7' size='340' side='right' caption='[[4qo7]], [[Resolution\|resolution]] 2.14Å' scene=''>		<StructureSection load='4qo7' size='340' side='right'caption='[[4qo7]], [[Resolution\|resolution]] 2.14Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4qo7]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QO7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QO7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4qo7]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QO7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QO7 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2OP:(2S)-2-HYDROXYPROPANOIC+ACID'>2OP</scene>, <scene name='pdbligand=36V:TRANS-2-[(2-NITROPHENYL)SULFANYL]-5-PHENYLCYCLOHEXANE-1,3-DIONE'>36V</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2OP:(2S)-2-HYDROXYPROPANOIC+ACID'>2OP</scene>, <scene name='pdbligand=36V:TRANS-2-[(2-NITROPHENYL)SULFANYL]-5-PHENYLCYCLOHEXANE-1,3-DIONE'>36V</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qo8\|4qo8]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qo8\|4qo8]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LDHA, PIG19 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qo7 OCA], [http://pdbe.org/4qo7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qo7 RCSB], [http://www.ebi.ac.uk/pdbsum/4qo7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qo7 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qo7 OCA], [http://pdbe.org/4qo7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qo7 RCSB], [http://www.ebi.ac.uk/pdbsum/4qo7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qo7 ProSAT]</span></td></tr>
Line 20:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 4qo7" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4qo7" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Lactate Dehydrogenase\|Lactate Dehydrogenase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Human]]
	[[Category: L-lactate dehydrogenase]]		[[Category: L-lactate dehydrogenase]]
			[[Category: Large Structures]]
	[[Category: Eigenbrot, C]]		[[Category: Eigenbrot, C]]
	[[Category: Ultsch, M]]		[[Category: Ultsch, M]]

OCA at 13:29, 4 August 2016

2016-08-04T13:29:45Z

← Older revision		Revision as of 13:29, 4 August 2016
Line 1:		Line 1:

	==Lactate Dehydrogenase A in complex with substituted 3-Hydroxy-2-mercaptocyclohex-2-enone compound 7==		==Lactate Dehydrogenase A in complex with substituted 3-Hydroxy-2-mercaptocyclohex-2-enone compound 7==
	<StructureSection load='4qo7' size='340' side='right' caption='[[4qo7]], [[Resolution\|resolution]] 2.14Å' scene=''>		<StructureSection load='4qo7' size='340' side='right' caption='[[4qo7]], [[Resolution\|resolution]] 2.14Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qo8\|4qo8]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qo8\|4qo8]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qo7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qo7 RCSB], [http://www.ebi.ac.uk/pdbsum/4qo7 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qo7 OCA], [http://pdbe.org/4qo7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qo7 RCSB], [http://www.ebi.ac.uk/pdbsum/4qo7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qo7 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4qo7" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 15:04, 24 December 2014

2014-12-24T15:04:01Z

← Older revision		Revision as of 15:04, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4qo7]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QO7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QO7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4qo7]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QO7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QO7 FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2OP:(2S)-2-HYDROXYPROPANOIC+ACID'>2OP</scene>, <scene name='pdbligand=36V:TRANS-2-[(2-NITROPHENYL)SULFANYL]-5-PHENYLCYCLOHEXANE-1,3-DIONE'>36V</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2OP:(2S)-2-HYDROXYPROPANOIC+ACID'>2OP</scene>, <scene name='pdbligand=36V:TRANS-2-[(2-NITROPHENYL)SULFANYL]-5-PHENYLCYCLOHEXANE-1,3-DIONE'>36V</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qo8\|4qo8]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qo8\|4qo8]]</td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qo7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qo7 RCSB], [http://www.ebi.ac.uk/pdbsum/4qo7 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qo7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qo7 RCSB], [http://www.ebi.ac.uk/pdbsum/4qo7 PDBsum]</span></td></tr>
	<table>		</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/LDHA_HUMAN LDHA_HUMAN]] Defects in LDHA are the cause of glycogen storage disease type 11 (GSD11) [MIM:[http://omim.org/entry/612933 612933]]. A metabolic disorder that results in exertional myoglobinuria, pain, cramps and easy fatigue.<ref>PMID:2334430</ref>		[[http://www.uniprot.org/uniprot/LDHA_HUMAN LDHA_HUMAN]] Defects in LDHA are the cause of glycogen storage disease type 11 (GSD11) [MIM:[http://omim.org/entry/612933 612933]]. A metabolic disorder that results in exertional myoglobinuria, pain, cramps and easy fatigue.<ref>PMID:2334430</ref>
	~~== Function ==~~

	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: L-lactate dehydrogenase]]		[[Category: L-lactate dehydrogenase]]
	[[Category: Eigenbrot, C.]]		[[Category: Eigenbrot, C]]
	[[Category: Ultsch, M.]]		[[Category: Ultsch, M]]
	[[Category: Nicotinamide adenine dinucleotide]]		[[Category: Nicotinamide adenine dinucleotide]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]		[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]

OCA at 06:35, 13 August 2014

2014-08-13T06:35:00Z

← Older revision		Revision as of 06:35, 13 August 2014
Line 12:		Line 12:
	== Function ==		== Function ==

			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			A novel class of 3-hydroxy-2-mercaptocyclohex-2-enone-containing inhibitors of human lactate dehydrogenase (LDH) was identified through a high-throughput screening approach. Biochemical and surface plasmon resonance experiments performed with a screening hit (LDHA IC50=1.7muM) indicated that the compound specifically associated with human LDHA in a manner that required simultaneous binding of the NADH co-factor. Structural variation of this screening hit resulted in significant improvements in LDHA biochemical inhibition activity (best IC50=0.18muM). Two crystal structures of optimized compounds bound to human LDHA were obtained and explained many of the observed structure-activity relationships. In addition, an optimized inhibitor exhibited good pharmacokinetic properties after oral administration to rats (F=45%).

			Identification of substituted 3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase.,Dragovich PS, Fauber BP, Boggs J, Chen J, Corson LB, Ding CZ, Eigenbrot C, Ge H, Giannetti AM, Hunsaker T, Labadie S, Li C, Liu Y, Liu Y, Ma S, Malek S, Peterson D, Pitts KE, Purkey HE, Robarge K, Salphati L, Sideris S, Ultsch M, VanderPorten E, Wang J, Wei B, Xu Q, Yen I, Yue Q, Zhang H, Zhang X, Zhou A Bioorg Med Chem Lett. 2014 Aug 15;24(16):3764-71. doi:, 10.1016/j.bmcl.2014.06.076. Epub 2014 Jul 1. PMID:25037916<ref>PMID:25037916</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:35, 16 July 2014

2014-07-16T10:35:31Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Lactate Dehydrogenase A in complex with substituted 3-Hydroxy-2-mercaptocyclohex-2-enone compound 7==
-The entry 4qo7 is ON HOLD  until Paper Publication
+== References ==
+<references/>
-Authors: Eigenbrot, C., Ultsch, M.
+__TOC__
+</StructureSection>
-Description: Lactate Dehydrogenase A in complex with substituted 3-Hydroxy-2-mercaptocyclohex-2-enone compound 7
+[[Category: L-lactate dehydrogenase]]

OCA at 06:51, 9 July 2014

2014-07-09T06:51:32Z

← Older revision		Revision as of 06:51, 9 July 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4qo7 is ON HOLD		The entry 4qo7 is ON HOLD until Paper Publication

	Authors: Eigenbrot, C., Ultsch, M.		Authors: Eigenbrot, C., Ultsch, M.

	Description: Lactate Dehydrogenase A in complex with substituted 3-Hydroxy-2-mercaptocyclohex-2-enone compound 7		Description: Lactate Dehydrogenase A in complex with substituted 3-Hydroxy-2-mercaptocyclohex-2-enone compound 7

OCA: Protected "4qo7" [edit=sysop:move=sysop]

2014-06-25T05:58:54Z

Protected "4qo7" [edit=sysop:move=sysop]

← Older revision	Revision as of 05:58, 25 June 2014
(No difference)

OCA: New page: '''Unreleased structure''' The entry 4qo7 is ON HOLD Authors: Eigenbrot, C., Ultsch, M. Description: Lactate Dehydrogenase A in complex with substituted 3-Hydroxy-2-mercaptocyclohex-2-...

2014-06-25T05:58:53Z

New page: '''Unreleased structure''' The entry 4qo7 is ON HOLD Authors: Eigenbrot, C., Ultsch, M. Description: Lactate Dehydrogenase A in complex with substituted 3-Hydroxy-2-mercaptocyclohex-2-...

New page

'''Unreleased structure'''

The entry 4qo7 is ON HOLD

Authors: Eigenbrot, C., Ultsch, M.

Description: Lactate Dehydrogenase A in complex with substituted 3-Hydroxy-2-mercaptocyclohex-2-enone compound 7