4ria - Revision history

OCA at 12:52, 1 March 2024

2024-03-01T12:52:47Z

← Older revision		Revision as of 12:52, 1 March 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ria]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RIA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RIA FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ria]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RIA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RIA FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ria FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ria OCA], [https://pdbe.org/4ria PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ria RCSB], [https://www.ebi.ac.uk/pdbsum/4ria PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ria ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ria FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ria OCA], [https://pdbe.org/4ria PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ria RCSB], [https://www.ebi.ac.uk/pdbsum/4ria PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ria ProSAT]</span></td></tr>
	</table>		</table>
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	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/FAN1_HUMAN FAN1_HUMAN] Nuclease required for maintenance of chromosomal stability. Plays a key role in DNA repair of DNA interstrand cross-links (ICL) by being recruited to sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, possibly in the resolution of homologous recombination intermediates. Not involved in DNA double-strand breaks resection. Has both endonuclease activity toward 5'-flaps and 5'-exonuclease activity: may act in concert with the 3'-flap-specific enzymes to unhook the ICL by cleaving the lagging-strand template.<ref>PMID:20603015</ref> <ref>PMID:20603016</ref> <ref>PMID:20603073</ref> <ref>PMID:20671156</ref>		[https://www.uniprot.org/uniprot/FAN1_HUMAN FAN1_HUMAN] Nuclease required for maintenance of chromosomal stability. Plays a key role in DNA repair of DNA interstrand cross-links (ICL) by being recruited to sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, possibly in the resolution of homologous recombination intermediates. Not involved in DNA double-strand breaks resection. Has both endonuclease activity toward 5'-flaps and 5'-exonuclease activity: may act in concert with the 3'-flap-specific enzymes to unhook the ICL by cleaving the lagging-strand template.<ref>PMID:20603015</ref> <ref>PMID:20603016</ref> <ref>PMID:20603073</ref> <ref>PMID:20671156</ref>
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	DNA interstrand cross-links (ICLs) are highly toxic lesions associated with cancer and degenerative diseases. ICLs can be repaired by the Fanconi anemia (FA) pathway and through FA-independent processes involving the FAN1 nuclease. In this work, FAN1-DNA crystal structures and biochemical data reveal that human FAN1 cleaves DNA successively at every third nucleotide. In vitro, this exonuclease mechanism allows FAN1 to excise an ICL from one strand through flanking incisions. DNA access requires a 5'-terminal phosphate anchor at a nick or a 1- or 2-nucleotide flap and is augmented by a 3' flap, suggesting that FAN1 action is coupled to DNA synthesis or recombination. FAN1's mechanism of ICL excision is well suited for processing other localized DNA adducts as well.

	DNA repair. Mechanism of DNA interstrand cross-link processing by repair nuclease FAN1.,Wang R, Persky NS, Yoo B, Ouerfelli O, Smogorzewska A, Elledge SJ, Pavletich NP Science. 2014 Nov 28;346(6213):1127-30. doi: 10.1126/science.1258973. PMID:25430771<ref>PMID:25430771</ref>

	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~<div class="pdbe-citations 4ria" style="background-color:#fffaf0;"></div>~~

	==See Also==		==See Also==

OCA at 06:58, 2 March 2023

2023-03-02T06:58:07Z

← Older revision		Revision as of 06:58, 2 March 2023
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	<StructureSection load='4ria' size='340' side='right'caption='[[4ria]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='4ria' size='340' side='right'caption='[[4ria]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ria]] is a 10 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RIA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4RIA FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ria]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RIA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RIA FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene>~~</td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene></td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ri8\|4ri8]], [[4ri9\|4ri9]], [[4rib\|4rib]], [[4ric\|4ric]], [[4rid\|4rid]]</td></tr>~~		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ria FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ria OCA], [https://pdbe.org/4ria PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ria RCSB], [https://www.ebi.ac.uk/pdbsum/4ria PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ria ProSAT]</span></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FAN1, KIAA1018, MTMR15 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ria FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ria OCA], [~~http~~://pdbe.org/4ria PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4ria RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4ria PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4ria ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[~~[http~~://www.uniprot.org/uniprot/FAN1_HUMAN FAN1_HUMAN]] Karyomegalic interstitial nephritis. The disease is caused by mutations affecting the gene represented in this entry.		[https://www.uniprot.org/uniprot/FAN1_HUMAN FAN1_HUMAN] Karyomegalic interstitial nephritis. The disease is caused by mutations affecting the gene represented in this entry.
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/FAN1_HUMAN FAN1_HUMAN]] Nuclease required for maintenance of chromosomal stability. Plays a key role in DNA repair of DNA interstrand cross-links (ICL) by being recruited to sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, possibly in the resolution of homologous recombination intermediates. Not involved in DNA double-strand breaks resection. Has both endonuclease activity toward 5'-flaps and 5'-exonuclease activity: may act in concert with the 3'-flap-specific enzymes to unhook the ICL by cleaving the lagging-strand template.<ref>PMID:20603015</ref> <ref>PMID:20603016</ref> <ref>PMID:20603073</ref> <ref>PMID:20671156</ref>		[https://www.uniprot.org/uniprot/FAN1_HUMAN FAN1_HUMAN] Nuclease required for maintenance of chromosomal stability. Plays a key role in DNA repair of DNA interstrand cross-links (ICL) by being recruited to sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, possibly in the resolution of homologous recombination intermediates. Not involved in DNA double-strand breaks resection. Has both endonuclease activity toward 5'-flaps and 5'-exonuclease activity: may act in concert with the 3'-flap-specific enzymes to unhook the ICL by cleaving the lagging-strand template.<ref>PMID:20603015</ref> <ref>PMID:20603016</ref> <ref>PMID:20603073</ref> <ref>PMID:20671156</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 4ria" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4ria" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Dual specificity phosphatase 3D structures\|Dual specificity phosphatase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Pavletich~~, N P~~]]		[[Category: Pavletich NP]]
	[[Category: Wang, R]]		[[Category: Wang R]]
	~~[[Category: Hydrolase-dna complex]]~~
	~~[[Category: Nuclease~~]]

OCA at 10:06, 1 May 2019

2019-05-01T10:06:27Z

← Older revision		Revision as of 10:06, 1 May 2019
Line 1:		Line 1:

	==FAN1 Nuclease bound to 5' phosphorylated nicked DNA==		==FAN1 Nuclease bound to 5' phosphorylated nicked DNA==
	<StructureSection load='4ria' size='340' side='right' caption='[[4ria]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='4ria' size='340' side='right'caption='[[4ria]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ria]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RIA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RIA FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ria]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RIA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RIA FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ri8\|4ri8]], [[4ri9\|4ri9]], [[4rib\|4rib]], [[4ric\|4ric]], [[4rid\|4rid]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ri8\|4ri8]], [[4ri9\|4ri9]], [[4rib\|4rib]], [[4ric\|4ric]], [[4rid\|4rid]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FAN1, KIAA1018, MTMR15 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ria FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ria OCA], [http://pdbe.org/4ria PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ria RCSB], [http://www.ebi.ac.uk/pdbsum/4ria PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ria ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ria FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ria OCA], [http://pdbe.org/4ria PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ria RCSB], [http://www.ebi.ac.uk/pdbsum/4ria PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ria ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Pavletich, N P]]		[[Category: Pavletich, N P]]
	[[Category: Wang, R]]		[[Category: Wang, R]]
	[[Category: Hydrolase-dna complex]]		[[Category: Hydrolase-dna complex]]
	[[Category: Nuclease]]		[[Category: Nuclease]]

OCA at 17:33, 18 January 2017

2017-01-18T17:33:31Z

← Older revision		Revision as of 17:33, 18 January 2017
Line 1:		Line 1:

	==FAN1 Nuclease bound to 5' phosphorylated nicked DNA==		==FAN1 Nuclease bound to 5' phosphorylated nicked DNA==
	<StructureSection load='4ria' size='340' side='right' caption='[[4ria]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='4ria' size='340' side='right' caption='[[4ria]], [[Resolution\|resolution]] 3.00Å' scene=''>
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ri8\|4ri8]], [[4ri9\|4ri9]], [[4rib\|4rib]], [[4ric\|4ric]], [[4rid\|4rid]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ri8\|4ri8]], [[4ri9\|4ri9]], [[4rib\|4rib]], [[4ric\|4ric]], [[4rid\|4rid]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ria FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ria OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ria RCSB], [http://www.ebi.ac.uk/pdbsum/4ria PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ria FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ria OCA], [http://pdbe.org/4ria PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ria RCSB], [http://www.ebi.ac.uk/pdbsum/4ria PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ria ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4ria" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 16:13, 10 December 2014

2014-12-10T16:13:47Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==FAN1 Nuclease bound to 5' phosphorylated nicked DNA==
-The entry 4ria is ON HOLD  until Paper Publication
+DNA repair. Mechanism of DNA interstrand cross-link processing by repair nuclease FAN1.,Wang R, Persky NS, Yoo B, Ouerfelli O, Smogorzewska A, Elledge SJ, Pavletich NP Science. 2014 Nov 28;346(6213):1127-30. doi: 10.1126/science.1258973. PMID:25430771<ref>PMID:25430771</ref>
-Authors: Pavletich, N.P., Wang, R.
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-Description: FAN1 Nuclease bound to 5' phosphorylated nicked DNA
+== References ==

OCA at 08:16, 3 December 2014

2014-12-03T08:16:21Z

← Older revision		Revision as of 08:16, 3 December 2014
Line 5:		Line 5:
	Authors: Pavletich, N.P., Wang, R.		Authors: Pavletich, N.P., Wang, R.

	Description: ~~Repair Enzyme1 Structure~~		Description: FAN1 Nuclease bound to 5' phosphorylated nicked DNA

OCA at 06:42, 26 November 2014

2014-11-26T06:42:32Z

← Older revision		Revision as of 06:42, 26 November 2014
Line 5:		Line 5:
	Authors: Pavletich, N.P., Wang, R.		Authors: Pavletich, N.P., Wang, R.

	Description:		Description: Repair Enzyme1 Structure

OCA at 07:38, 5 November 2014

2014-11-05T07:38:08Z

← Older revision		Revision as of 07:38, 5 November 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4ria is ON HOLD		The entry 4ria is ON HOLD until Paper Publication

	Authors: Pavletich, N.P., Wang, R.		Authors: Pavletich, N.P., Wang, R.

	Description:		Description:

OCA: Protected "4ria" [edit=sysop:move=sysop]

2014-10-20T09:29:39Z

Protected "4ria" [edit=sysop:move=sysop]

← Older revision	Revision as of 09:29, 20 October 2014
(No difference)

OCA: New page: '''Unreleased structure''' The entry 4ria is ON HOLD Authors: Pavletich, N.P., Wang, R. Description:

2014-10-20T09:29:38Z

New page: '''Unreleased structure''' The entry 4ria is ON HOLD Authors: Pavletich, N.P., Wang, R. Description:

New page

'''Unreleased structure'''

The entry 4ria is ON HOLD

Authors: Pavletich, N.P., Wang, R.

Description: