4rox - Revision history

OCA at 12:54, 1 March 2024

2024-03-01T12:54:21Z

← Older revision		Revision as of 12:54, 1 March 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4rox]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Norovirus_Hu/GII.1/7EK/Hawaii/1971/USA Norovirus Hu/GII.1/7EK/Hawaii/1971/USA]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ROX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ROX FirstGlance]. <br>		<table><tr><td colspan='2'>[[4rox]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Norovirus_Hu/GII.1/7EK/Hawaii/1971/USA Norovirus Hu/GII.1/7EK/Hawaii/1971/USA]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ROX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ROX FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.89Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rox FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rox OCA], [https://pdbe.org/4rox PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rox RCSB], [https://www.ebi.ac.uk/pdbsum/4rox PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rox ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rox FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rox OCA], [https://pdbe.org/4rox PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rox RCSB], [https://www.ebi.ac.uk/pdbsum/4rox PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rox ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/J9XXB7_9CALI J9XXB7_9CALI]		[https://www.uniprot.org/uniprot/J9XXB7_9CALI J9XXB7_9CALI]
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	Human norovirus interacts with the polymorphic human histo-blood group antigens (HBGAs), and this interaction is thought to be important for infection. The genogroup II genotype 4 (GII.4) noroviruses are the dominant cluster, evolve every other year, and are thought to modify their binding interactions with different HBGA types. Most human noroviruses bind HBGAs, while some strains were found to have minimal or no HBGA interactions. Here, we explain some possible structural constraints for several noroviruses that were found to bind poorly to HBGAs by using X-ray crystallography. We showed that one aspartic acid was flexible or positioned away from the fucose moiety of the HBGAs and this likely hindered binding, although other fucose-interacting residues were perfectly oriented. Interestingly, a neighboring loop also appeared to influence the loop hosting the aspartic acid. These new findings might explain why some human noroviruses bound HBGAs poorly, although further studies are required.

	Structural Constraints on Human Norovirus Binding to Histo-Blood Group Antigens.,Singh BK, Leuthold MM, Hansman GS mSphere. 2016 Mar 30;1(2). pii: e00049-16. doi: 10.1128/mSphere.00049-16., eCollection 2016 Mar-Apr. PMID:27303720<ref>PMID:27303720</ref>

	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~<div class="pdbe-citations 4rox" style="background-color:#fffaf0;"></div>~~

	==See Also==		==See Also==
	*[[Virus coat proteins 3D structures\|Virus coat proteins 3D structures]]		*[[Virus coat proteins 3D structures\|Virus coat proteins 3D structures]]
	~~== References ==~~
	~~<references/>~~
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 08:22, 8 March 2023

2023-03-08T08:22:45Z

← Older revision		Revision as of 08:22, 8 March 2023
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	<StructureSection load='4rox' size='340' side='right'caption='[[4rox]], [[Resolution\|resolution]] 1.89Å' scene=''>		<StructureSection load='4rox' size='340' side='right'caption='[[4rox]], [[Resolution\|resolution]] 1.89Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4rox]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Norovirus_hu~~/~~gii~~.1/~~7ek~~/~~hawaii~~/1971/~~usa~~ Norovirus hu/~~gii~~.1/~~7ek~~/~~hawaii~~/1971/~~usa~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ROX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ROX FirstGlance]. <br>		<table><tr><td colspan='2'>[[4rox]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Norovirus_Hu/GII.1/7EK/Hawaii/1971/USA Norovirus Hu/GII.1/7EK/Hawaii/1971/USA]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ROX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ROX FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>~~</td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VP1, U07611 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1208060 Norovirus Hu/GII.1/7EK/Hawaii/1971/USA])</td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rox FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rox OCA], [https://pdbe.org/4rox PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rox RCSB], [https://www.ebi.ac.uk/pdbsum/4rox PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rox ProSAT]</span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4rox FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rox OCA], [~~http~~://pdbe.org/4rox PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4rox RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4rox PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4rox ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/J9XXB7_9CALI J9XXB7_9CALI]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 17:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4rox" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4rox" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Virus coat proteins 3D structures\|Virus coat proteins 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 22:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Norovirus hu/~~gii~~ 1/~~7ek~~/~~hawaii~~/1971/~~usa~~]]		[[Category: Norovirus Hu/GII 1/7EK/Hawaii/1971/USA]]
	[[Category: Hansman~~, G S~~]]		[[Category: Hansman GS]]
	[[Category: Singh~~, B K]]~~		[[Category: Singh BK]]
	~~[[Category: Hbga]]~~
	~~[[Category: Protruding domain]]~~
	~~[[Category: Surface domain]]~~
	~~[[Category: Viral protein]]~~
	~~[[Category: Virus binding]]~~
	~~[[Category: Virus surface~~]]

OCA at 10:04, 1 May 2019

2019-05-01T10:04:02Z

← Older revision		Revision as of 10:04, 1 May 2019
Line 1:		Line 1:

	==Crystal Structure of P Domain of Hawaii Norovirus (GII.1)==		==Crystal Structure of P Domain of Hawaii Norovirus (GII.1)==
	<StructureSection load='4rox' size='340' side='right' caption='[[4rox]], [[Resolution\|resolution]] 1.89Å' scene=''>		<StructureSection load='4rox' size='340' side='right'caption='[[4rox]], [[Resolution\|resolution]] 1.89Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4rox]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ROX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ROX FirstGlance]. <br>		<table><tr><td colspan='2'>[[4rox]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Norovirus_hu/gii.1/7ek/hawaii/1971/usa Norovirus hu/gii.1/7ek/hawaii/1971/usa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ROX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ROX FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VP1, U07611 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1208060 Norovirus Hu/GII.1/7EK/Hawaii/1971/USA])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rox FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rox OCA], [http://pdbe.org/4rox PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rox RCSB], [http://www.ebi.ac.uk/pdbsum/4rox PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4rox ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rox FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rox OCA], [http://pdbe.org/4rox PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rox RCSB], [http://www.ebi.ac.uk/pdbsum/4rox PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4rox ProSAT]</span></td></tr>
	</table>		</table>
Line 20:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
			[[Category: Norovirus hu/gii 1/7ek/hawaii/1971/usa]]
	[[Category: Hansman, G S]]		[[Category: Hansman, G S]]
	[[Category: Singh, B K]]		[[Category: Singh, B K]]

OCA at 18:36, 12 July 2016

2016-07-12T18:36:57Z

← Older revision		Revision as of 18:36, 12 July 2016
Line 5:		Line 5:
	<table><tr><td colspan='2'>[[4rox]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ROX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ROX FirstGlance]. <br>		<table><tr><td colspan='2'>[[4rox]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ROX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ROX FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rox FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rox OCA], [http://pdbe.org/4rox PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rox RCSB], [http://www.ebi.ac.uk/pdbsum/4rox PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rox FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rox OCA], [http://pdbe.org/4rox PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rox RCSB], [http://www.ebi.ac.uk/pdbsum/4rox PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4rox ProSAT]</span></td></tr>
	</table>		</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Human norovirus interacts with the polymorphic human histo-blood group antigens (HBGAs), and this interaction is thought to be important for infection. The genogroup II genotype 4 (GII.4) noroviruses are the dominant cluster, evolve every other year, and are thought to modify their binding interactions with different HBGA types. Most human noroviruses bind HBGAs, while some strains were found to have minimal or no HBGA interactions. Here, we explain some possible structural constraints for several noroviruses that were found to bind poorly to HBGAs by using X-ray crystallography. We showed that one aspartic acid was flexible or positioned away from the fucose moiety of the HBGAs and this likely hindered binding, although other fucose-interacting residues were perfectly oriented. Interestingly, a neighboring loop also appeared to influence the loop hosting the aspartic acid. These new findings might explain why some human noroviruses bound HBGAs poorly, although further studies are required.

			Structural Constraints on Human Norovirus Binding to Histo-Blood Group Antigens.,Singh BK, Leuthold MM, Hansman GS mSphere. 2016 Mar 30;1(2). pii: e00049-16. doi: 10.1128/mSphere.00049-16., eCollection 2016 Mar-Apr. PMID:27303720<ref>PMID:27303720</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 4rox" style="background-color:#fffaf0;"></div>
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 22:51, 1 June 2016

2016-06-01T22:51:34Z

← Older revision		Revision as of 22:51, 1 June 2016
Line 1:		Line 1:
	~~'''Unreleased structure'''~~

	~~The entry 4rox is ON HOLD until Paper Publication~~		==Crystal Structure of P Domain of Hawaii Norovirus (GII.1)==
			<StructureSection load='4rox' size='340' side='right' caption='[[4rox]], [[Resolution\|resolution]] 1.89Å' scene=''>
	~~Authors: Singh, B.K., Hansman, G.S.~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[4rox]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ROX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ROX FirstGlance]. <br>
	~~Description:~~ Crystal Structure of P Domain of Hawaii Norovirus (GII.1)		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
	[[~~Category~~: ~~Unreleased Structures~~]]		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rox FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rox OCA], [http://pdbe.org/4rox PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rox RCSB], [http://www.ebi.ac.uk/pdbsum/4rox PDBsum]</span></td></tr>
	[[Category: Hansman, G.S]]		</table>
	[[Category: Singh, B.K]]		__TOC__
			</StructureSection>
			[[Category: Hansman, G S]]
			[[Category: Singh, B K]]
			[[Category: Hbga]]
			[[Category: Protruding domain]]
			[[Category: Surface domain]]
			[[Category: Viral protein]]
			[[Category: Virus binding]]
			[[Category: Virus surface]]

OCA at 06:55, 23 December 2015

2015-12-23T06:55:12Z

← Older revision		Revision as of 06:55, 23 December 2015
Line 3:		Line 3:
	The entry 4rox is ON HOLD until Paper Publication		The entry 4rox is ON HOLD until Paper Publication

	Authors: ~~Avvaru~~, B.S., Hansman, G.S.		Authors: Singh, B.K., Hansman, G.S.

	Description: Crystal Structure of P Domain of Hawaii Norovirus (GII.1)		Description: Crystal Structure of P Domain of Hawaii Norovirus (GII.1)
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	~~[[Category: Avvaru, B.S]]~~
	[[Category: Hansman, G.S]]		[[Category: Hansman, G.S]]
			[[Category: Singh, B.K]]

OCA at 12:01, 31 December 2014

2014-12-31T12:01:52Z

← Older revision		Revision as of 12:01, 31 December 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4rox is ON HOLD		The entry 4rox is ON HOLD until Paper Publication

	Authors: Avvaru, B.S., Hansman, G.S.		Authors: Avvaru, B.S., Hansman, G.S.

OCA at 17:09, 24 December 2014

2014-12-24T17:09:06Z

← Older revision		Revision as of 17:09, 24 December 2014
Line 6:		Line 6:

	Description: Crystal Structure of P Domain of Hawaii Norovirus (GII.1)		Description: Crystal Structure of P Domain of Hawaii Norovirus (GII.1)
			[[Category: Unreleased Structures]]
			[[Category: Avvaru, B.S]]
			[[Category: Hansman, G.S]]

OCA: Protected "4rox" [edit=sysop:move=sysop]

2014-11-05T07:42:34Z

Protected "4rox" [edit=sysop:move=sysop]

← Older revision	Revision as of 07:42, 5 November 2014
(No difference)

OCA: New page: '''Unreleased structure''' The entry 4rox is ON HOLD Authors: Avvaru, B.S., Hansman, G.S. Description: Crystal Structure of P Domain of Hawaii Norovirus (GII.1)

2014-11-05T07:42:32Z

New page: '''Unreleased structure''' The entry 4rox is ON HOLD Authors: Avvaru, B.S., Hansman, G.S. Description: Crystal Structure of P Domain of Hawaii Norovirus (GII.1)

New page

'''Unreleased structure'''

The entry 4rox is ON HOLD

Authors: Avvaru, B.S., Hansman, G.S.

Description: Crystal Structure of P Domain of Hawaii Norovirus (GII.1)