4rt3 - Revision history

OCA at 17:55, 20 September 2023

2023-09-20T17:55:07Z

← Older revision		Revision as of 17:55, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4rt3]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RT3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RT3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4rt3]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RT3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RT3 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C6T:2-DEOXY-5-O-[(S)-HYDROXY{[(R)-HYDROXY(PHOSPHONOMETHYL)PHOSPHORYL]AMINO}PHOSPHORYL]-3,4-DIHYDROTHYMIDINE'>C6T</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DOC:2,3-DIDEOXYCYTIDINE-5-MONOPHOSPHATE'>DOC</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.92Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C6T:2-DEOXY-5-O-[(S)-HYDROXY{[(R)-HYDROXY(PHOSPHONOMETHYL)PHOSPHORYL]AMINO}PHOSPHORYL]-3,4-DIHYDROTHYMIDINE'>C6T</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DOC:2,3-DIDEOXYCYTIDINE-5-MONOPHOSPHATE'>DOC</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rt3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rt3 OCA], [https://pdbe.org/4rt3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rt3 RCSB], [https://www.ebi.ac.uk/pdbsum/4rt3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rt3 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rt3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rt3 OCA], [https://pdbe.org/4rt3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rt3 RCSB], [https://www.ebi.ac.uk/pdbsum/4rt3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rt3 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 08:27, 8 March 2023

2023-03-08T08:27:34Z

← Older revision		Revision as of 08:27, 8 March 2023
Line 3:		Line 3:
	<StructureSection load='4rt3' size='340' side='right'caption='[[4rt3]], [[Resolution\|resolution]] 1.92Å' scene=''>		<StructureSection load='4rt3' size='340' side='right'caption='[[4rt3]], [[Resolution\|resolution]] 1.92Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4rt3]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RT3 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4RT3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4rt3]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RT3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RT3 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C6T:2-DEOXY-5-O-[(S)-HYDROXY{[(R)-HYDROXY(PHOSPHONOMETHYL)PHOSPHORYL]AMINO}PHOSPHORYL]-3,4-DIHYDROTHYMIDINE'>C6T</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:~~MAGNESIUM+ION~~'>MG</scene>, <scene name='pdbligand=NA:~~SODIUM~~+ION'>NA</scene>~~</td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C6T:2-DEOXY-5-O-[(S)-HYDROXY{[(R)-HYDROXY(PHOSPHONOMETHYL)PHOSPHORYL]AMINO}PHOSPHORYL]-3,4-DIHYDROTHYMIDINE'>C6T</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DOC:2,3-DIDEOXYCYTIDINE-5-MONOPHOSPHATE'>DOC</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=~~DOC~~:~~2,3-DIDEOXYCYTIDINE-5-MONOPHOSPHATE~~'>~~DOC~~</scene>~~</td></tr>~~		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rt3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rt3 OCA], [https://pdbe.org/4rt3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rt3 RCSB], [https://www.ebi.ac.uk/pdbsum/4rt3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rt3 ProSAT]</span></td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4rt2\|4rt2]]</td></tr>~~
	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">POLB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4rt3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rt3 OCA], [~~http~~://pdbe.org/4rt3 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4rt3 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4rt3 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4rt3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/DPOLB_HUMAN DPOLB_HUMAN]] Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.<ref>PMID:9207062</ref> <ref>PMID:9572863</ref> <ref>PMID:11805079</ref> <ref>PMID:21362556</ref>		[https://www.uniprot.org/uniprot/DPOLB_HUMAN DPOLB_HUMAN] Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.<ref>PMID:9207062</ref> <ref>PMID:9572863</ref> <ref>PMID:11805079</ref> <ref>PMID:21362556</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 20:

	==See Also==		==See Also==
	*[[DNA polymerase\|DNA polymerase]]		*[[DNA polymerase 3D structures\|DNA polymerase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Batra, V K~~]]		[[Category: Synthetic construct]]
	[[Category: ~~Wilson, S H~~]]		[[Category: Batra VK]]
	[[Category: ~~Dna polymerase beta]]~~		[[Category: Wilson SH]]
	~~[[Category: Ternary complex]]~~
	~~[[Category: Transferase-dna complex~~]]

OCA at 09:47, 1 May 2019

2019-05-01T09:47:46Z

← Older revision		Revision as of 09:47, 1 May 2019
Line 1:		Line 1:

	==Ternary complex crystal structure of DNA polymerase Beta with (alpha, beta)-NH-(beta,gamma)-CH2-dTTP==		==Ternary complex crystal structure of DNA polymerase Beta with (alpha, beta)-NH-(beta,gamma)-CH2-dTTP==
	<StructureSection load='4rt3' size='340' side='right' caption='[[4rt3]], [[Resolution\|resolution]] 1.92Å' scene=''>		<StructureSection load='4rt3' size='340' side='right'caption='[[4rt3]], [[Resolution\|resolution]] 1.92Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4rt3]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RT3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RT3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4rt3]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RT3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RT3 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C6T:2-DEOXY-5-O-[(S)-HYDROXY{[(R)-HYDROXY(PHOSPHONOMETHYL)PHOSPHORYL]AMINO}PHOSPHORYL]-3,4-DIHYDROTHYMIDINE'>C6T</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C6T:2-DEOXY-5-O-[(S)-HYDROXY{[(R)-HYDROXY(PHOSPHONOMETHYL)PHOSPHORYL]AMINO}PHOSPHORYL]-3,4-DIHYDROTHYMIDINE'>C6T</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DOC:2,3-DIDEOXYCYTIDINE-5-MONOPHOSPHATE'>DOC</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DOC:2,3-DIDEOXYCYTIDINE-5-MONOPHOSPHATE'>DOC</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4rt2\|4rt2]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4rt2\|4rt2]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">POLB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rt3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rt3 OCA], [http://pdbe.org/4rt3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rt3 RCSB], [http://www.ebi.ac.uk/pdbsum/4rt3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4rt3 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rt3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rt3 OCA], [http://pdbe.org/4rt3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rt3 RCSB], [http://www.ebi.ac.uk/pdbsum/4rt3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4rt3 ProSAT]</span></td></tr>
	</table>		</table>
Line 20:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 4rt3" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4rt3" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[DNA polymerase\|DNA polymerase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Batra, V K]]		[[Category: Batra, V K]]
	[[Category: Wilson, S H]]		[[Category: Wilson, S H]]

OCA at 13:47, 5 April 2017

2017-04-05T13:47:48Z

← Older revision		Revision as of 13:47, 5 April 2017
Line 1:		Line 1:

	==Ternary complex crystal structure of DNA polymerase Beta with (alpha, beta)-NH-(beta,gamma)-CH2-dTTP==		==Ternary complex crystal structure of DNA polymerase Beta with (alpha, beta)-NH-(beta,gamma)-CH2-dTTP==
	<StructureSection load='4rt3' size='340' side='right' caption='[[4rt3]], [[Resolution\|resolution]] 1.92Å' scene=''>		<StructureSection load='4rt3' size='340' side='right' caption='[[4rt3]], [[Resolution\|resolution]] 1.92Å' scene=''>
Line 6:		Line 7:
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DOC:2,3-DIDEOXYCYTIDINE-5-MONOPHOSPHATE'>DOC</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DOC:2,3-DIDEOXYCYTIDINE-5-MONOPHOSPHATE'>DOC</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4rt2\|4rt2]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4rt2\|4rt2]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rt3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rt3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4rt3 RCSB], [http://www.ebi.ac.uk/pdbsum/4rt3 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rt3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rt3 OCA], [http://pdbe.org/4rt3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rt3 RCSB], [http://www.ebi.ac.uk/pdbsum/4rt3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4rt3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4rt3" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:12, 1 July 2015

2015-07-01T12:12:31Z

← Older revision		Revision as of 12:12, 1 July 2015
Line 1:		Line 1:
	'''~~Unreleased~~ structure'''		==Ternary complex crystal structure of DNA polymerase Beta with (alpha, beta)-NH-(beta,gamma)-CH2-dTTP==
			<StructureSection load='4rt3' size='340' side='right' caption='[[4rt3]], [[Resolution\|resolution]] 1.92Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[4rt3]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RT3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RT3 FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C6T:2-DEOXY-5-O-[(S)-HYDROXY{[(R)-HYDROXY(PHOSPHONOMETHYL)PHOSPHORYL]AMINO}PHOSPHORYL]-3,4-DIHYDROTHYMIDINE'>C6T</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
			<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DOC:2,3-DIDEOXYCYTIDINE-5-MONOPHOSPHATE'>DOC</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4rt2\|4rt2]]</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rt3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rt3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4rt3 RCSB], [http://www.ebi.ac.uk/pdbsum/4rt3 PDBsum]</span></td></tr>
			</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/DPOLB_HUMAN DPOLB_HUMAN]] Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.<ref>PMID:9207062</ref> <ref>PMID:9572863</ref> <ref>PMID:11805079</ref> <ref>PMID:21362556</ref>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Novel alpha,beta-CH2 and beta,gamma-NH (1a) or alpha,beta-NH and beta,gamma-CH2 (1b) "Met-Im" dTTPs were synthesized via monodemethylation of triethyl-dimethyl phosphorimido-bisphosphonate synthons (4a, 4b), formed via a base-induced [1,3]-rearrangement of precursors (3a, 3b) in a reaction with dimethyl or diethyl phosphochloridate. Anomerization during final bromotrimethylsilane (BTMS) deprotection after Mitsunobu conjugation with dT was avoided by microwave conditions. 1a was 9-fold more potent in inhibiting DNA polymerase beta, attributed to an NH-group interaction with R183 in the active site.

	~~The entry 4rt3 is ON HOLD until Paper Publication~~		Two Scaffolds from Two Flips: (alpha,beta)/(beta,gamma) CH2/NH "Met-Im" Analogues of dTTP.,Kadina AP, Kashemirov BA, Oertell K, Batra VK, Wilson SH, Goodman MF, McKenna CE Org Lett. 2015 Jun 5;17(11):2586-9. doi: 10.1021/acs.orglett.5b00799. Epub 2015, May 13. PMID:25970636<ref>PMID:25970636</ref>

	~~Authors: Batra~~, ~~V.K~~.~~, Wilson,~~ S.H.		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~Description: Ternary complex crystal structure of DNA polymerase Beta with (alpha, beta)-NH-(beta,gamma)-CH2-dTTP~~		== References ==
	[[Category: ~~Unreleased Structures~~]]		<references/>
	[[Category: Wilson, S.H]]		__TOC__
	[[Category: ~~Batra, V.K~~]]		</StructureSection>
			[[Category: Batra, V K]]
			[[Category: Wilson, S H]]
			[[Category: Dna polymerase beta]]
			[[Category: Ternary complex]]
			[[Category: Transferase-dna complex]]

OCA at 17:19, 24 December 2014

2014-12-24T17:19:51Z

← Older revision		Revision as of 17:19, 24 December 2014
Line 6:		Line 6:

	Description: Ternary complex crystal structure of DNA polymerase Beta with (alpha, beta)-NH-(beta,gamma)-CH2-dTTP		Description: Ternary complex crystal structure of DNA polymerase Beta with (alpha, beta)-NH-(beta,gamma)-CH2-dTTP
			[[Category: Unreleased Structures]]
			[[Category: Wilson, S.H]]
			[[Category: Batra, V.K]]

OCA at 06:46, 26 November 2014

2014-11-26T06:46:25Z

← Older revision		Revision as of 06:46, 26 November 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4rt3 is ON HOLD		The entry 4rt3 is ON HOLD until Paper Publication

	Authors: Batra, V.K., Wilson, S.H.		Authors: Batra, V.K., Wilson, S.H.

	Description: Ternary complex crystal structure of DNA polymerase Beta with (alpha, beta)-NH-(beta,gamma)-CH2-dTTP		Description: Ternary complex crystal structure of DNA polymerase Beta with (alpha, beta)-NH-(beta,gamma)-CH2-dTTP

OCA: Protected "4rt3" [edit=sysop:move=sysop]

2014-11-19T11:33:51Z

Protected "4rt3" [edit=sysop:move=sysop]

← Older revision	Revision as of 11:33, 19 November 2014
(No difference)

OCA: New page: '''Unreleased structure''' The entry 4rt3 is ON HOLD Authors: Batra, V.K., Wilson, S.H. Description: Ternary complex crystal structure of DNA polymerase Beta with (alpha, beta)-NH-(bet...

2014-11-19T11:33:50Z

New page: '''Unreleased structure''' The entry 4rt3 is ON HOLD Authors: Batra, V.K., Wilson, S.H. Description: Ternary complex crystal structure of DNA polymerase Beta with (alpha, beta)-NH-(bet...

New page

'''Unreleased structure'''

The entry 4rt3 is ON HOLD

Authors: Batra, V.K., Wilson, S.H.

Description: Ternary complex crystal structure of DNA polymerase Beta with (alpha, beta)-NH-(beta,gamma)-CH2-dTTP