4rt4 - Revision history

OCA at 15:15, 8 November 2023

2023-11-08T15:15:57Z

← Older revision		Revision as of 15:15, 8 November 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4rt4]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RT4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RT4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4rt4]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RT4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RT4 FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rt4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rt4 OCA], [https://pdbe.org/4rt4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rt4 RCSB], [https://www.ebi.ac.uk/pdbsum/4rt4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rt4 ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.997Å</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rt4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rt4 OCA], [https://pdbe.org/4rt4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rt4 RCSB], [https://www.ebi.ac.uk/pdbsum/4rt4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rt4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 08:27, 8 March 2023

2023-03-08T08:27:38Z

← Older revision		Revision as of 08:27, 8 March 2023
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	<StructureSection load='4rt4' size='340' side='right'caption='[[4rt4]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='4rt4' size='340' side='right'caption='[[4rt4]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4rt4]] is a 5 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RT4 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4RT4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4rt4]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RT4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RT4 FirstGlance]. <br>
	</td></tr>~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DPY30 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rt4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rt4 OCA], [https://pdbe.org/4rt4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rt4 RCSB], [https://www.ebi.ac.uk/pdbsum/4rt4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rt4 ProSAT]</span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4rt4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rt4 OCA], [~~http~~://pdbe.org/4rt4 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4rt4 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4rt4 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4rt4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/DPY30_HUMAN DPY30_HUMAN]] As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport.<ref>PMID:19556245</ref> <ref>PMID:19651892</ref> <ref>PMID:21335234</ref> [[http://www.uniprot.org/uniprot/BRE2_YEAST BRE2_YEAST]] The COMPASS (Set1C) complex specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.<ref>PMID:11742990</ref> <ref>PMID:11805083</ref>		[https://www.uniprot.org/uniprot/DPY30_HUMAN DPY30_HUMAN] As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport.<ref>PMID:19556245</ref> <ref>PMID:19651892</ref> <ref>PMID:21335234</ref>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Chang, W R~~]]		[[Category: Saccharomyces cerevisiae S288C]]
	[[Category: ~~Li, M~~]]		[[Category: Chang WR]]
	[[Category: ~~Zhang, H~~ M]]		[[Category: Li M]]
	[[Category: ~~H3k4 methylation]]~~		[[Category: Zhang HM]]
	~~[[Category: Protein binding]]~~
	~~[[Category: X-type helix~~]]

OCA at 09:57, 1 May 2019

2019-05-01T09:57:59Z

← Older revision		Revision as of 09:57, 1 May 2019
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	==Crystal structure of Dpy30 complexed with Bre2==		==Crystal structure of Dpy30 complexed with Bre2==
	<StructureSection load='4rt4' size='340' side='right' caption='[[4rt4]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='4rt4' size='340' side='right'caption='[[4rt4]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4rt4]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RT4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RT4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4rt4]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RT4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RT4 FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rt4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rt4 OCA], [http://pdbe.org/4rt4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rt4 RCSB], [http://www.ebi.ac.uk/pdbsum/4rt4 PDBsum]</span></td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DPY30 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rt4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rt4 OCA], [http://pdbe.org/4rt4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rt4 RCSB], [http://www.ebi.ac.uk/pdbsum/4rt4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4rt4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Chang, W R]]		[[Category: Chang, W R]]
	[[Category: Li, M]]		[[Category: Li, M]]

OCA at 13:42, 7 October 2015

2015-10-07T13:42:57Z

← Older revision		Revision as of 13:42, 7 October 2015
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	'''~~Unreleased structure~~'''		==Crystal structure of Dpy30 complexed with Bre2==
			<StructureSection load='4rt4' size='340' side='right' caption='[[4rt4]], [[Resolution\|resolution]] 2.00Å' scene=''>
	~~The entry~~ 4rt4 is ~~ON HOLD until Paper Publication~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[4rt4]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RT4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RT4 FirstGlance]. <br>
	~~Authors~~: ~~Zhang~~, H.M., Li, M., ~~Chang, W~~.R.		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rt4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rt4 OCA], [http://pdbe.org/4rt4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rt4 RCSB], [http://www.ebi.ac.uk/pdbsum/4rt4 PDBsum]</span></td></tr>
			</table>
	~~Description~~: ~~Crystal structure~~ of ~~Dpy30 complexed with Bre2~~		== Function ==
	[[~~Category~~: ~~Unreleased Structures~~]]		[[http://www.uniprot.org/uniprot/DPY30_HUMAN DPY30_HUMAN]] As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport.<ref>PMID:19556245</ref> <ref>PMID:19651892</ref> <ref>PMID:21335234</ref> [[http://www.uniprot.org/uniprot/BRE2_YEAST BRE2_YEAST]] The COMPASS (Set1C) complex specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.<ref>PMID:11742990</ref> <ref>PMID:11805083</ref>
	[[Category: ~~Zhang~~, ~~H.M~~]]		== References ==
			<references/>
			__TOC__
			</StructureSection>
			[[Category: Chang, W R]]
	[[Category: Li, M]]		[[Category: Li, M]]
	[[Category: ~~Chang~~, ~~W.R~~]]		[[Category: Zhang, H M]]
			[[Category: H3k4 methylation]]
			[[Category: Protein binding]]
			[[Category: X-type helix]]

OCA at 17:19, 24 December 2014

2014-12-24T17:19:53Z

← Older revision		Revision as of 17:19, 24 December 2014
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	Description: Crystal structure of Dpy30 complexed with Bre2		Description: Crystal structure of Dpy30 complexed with Bre2
			[[Category: Unreleased Structures]]
			[[Category: Zhang, H.M]]
			[[Category: Li, M]]
			[[Category: Chang, W.R]]

OCA at 08:18, 3 December 2014

2014-12-03T08:18:29Z

← Older revision		Revision as of 08:18, 3 December 2014
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4rt4 is ON HOLD		The entry 4rt4 is ON HOLD until Paper Publication

	Authors: Zhang, H.M., Li, M., Chang, W.R.		Authors: Zhang, H.M., Li, M., Chang, W.R.

	Description: Crystal structure of Dpy30 complexed with Bre2		Description: Crystal structure of Dpy30 complexed with Bre2

OCA at 06:46, 26 November 2014

2014-11-26T06:46:28Z

← Older revision		Revision as of 06:46, 26 November 2014
Line 3:		Line 3:
	The entry 4rt4 is ON HOLD		The entry 4rt4 is ON HOLD

	Authors: Zhang H.M., Li M., Chang W.R.		Authors: Zhang, H.M., Li, M., Chang, W.R.

	Description: ~~crystal~~ structure of Dpy30 complexed with Bre2		Description: Crystal structure of Dpy30 complexed with Bre2

OCA: Protected "4rt4" [edit=sysop:move=sysop]

2014-11-19T11:33:53Z

Protected "4rt4" [edit=sysop:move=sysop]

← Older revision	Revision as of 11:33, 19 November 2014
(No difference)

OCA: New page: '''Unreleased structure''' The entry 4rt4 is ON HOLD Authors: Zhang H.M., Li M., Chang W.R. Description: crystal structure of Dpy30 complexed with Bre2

2014-11-19T11:33:52Z

New page: '''Unreleased structure''' The entry 4rt4 is ON HOLD Authors: Zhang H.M., Li M., Chang W.R. Description: crystal structure of Dpy30 complexed with Bre2

New page

'''Unreleased structure'''

The entry 4rt4 is ON HOLD

Authors: Zhang H.M., Li M., Chang W.R.

Description: crystal structure of Dpy30 complexed with Bre2