4tk2 - Revision history

OCA at 07:19, 27 September 2023

2023-09-27T07:19:05Z

← Older revision		Revision as of 07:19, 27 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4tk2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TK2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TK2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4tk2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TK2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TK2 FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4tk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tk2 OCA], [https://pdbe.org/4tk2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4tk2 RCSB], [https://www.ebi.ac.uk/pdbsum/4tk2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4tk2 ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 4.1Å</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4tk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tk2 OCA], [https://pdbe.org/4tk2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4tk2 RCSB], [https://www.ebi.ac.uk/pdbsum/4tk2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4tk2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 10:43, 15 March 2023

2023-03-15T10:43:38Z

← Older revision		Revision as of 10:43, 15 March 2023
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	<StructureSection load='4tk2' size='340' side='right'caption='[[4tk2]], [[Resolution\|resolution]] 4.10Å' scene=''>		<StructureSection load='4tk2' size='340' side='right'caption='[[4tk2]], [[Resolution\|resolution]] 4.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4tk2]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TK2 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4TK2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4tk2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TK2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TK2 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fu3\|2fu3]], [[2fts\|2fts]], [[4pdo\|4pdo]], [[4pd1\|4pd1]], [[4tk1\|4tk1]], [[4tk3\|4tk3]], [[4tk4\|4tk4]]</td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4tk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tk2 OCA], [https://pdbe.org/4tk2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4tk2 RCSB], [https://www.ebi.ac.uk/pdbsum/4tk2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4tk2 ProSAT]</span></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Gphn, Gph ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4tk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tk2 OCA], [~~http~~://pdbe.org/4tk2 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4tk2 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4tk2 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4tk2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/GEPH_RAT GEPH_RAT]] Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.<ref>PMID:8264797</ref> <ref>PMID:9990024</ref> [[http://www.uniprot.org/uniprot/GBRA3_RAT GBRA3_RAT]] GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.		[https://www.uniprot.org/uniprot/GEPH_RAT GEPH_RAT] Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.<ref>PMID:8264797</ref> <ref>PMID:9990024</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	==See Also==		==See Also==
	*[[GABA receptor 3D structures\|GABA receptor 3D structures]]
	*[[Gephyrin\|Gephyrin]]		*[[Gephyrin\|Gephyrin]]
	== References ==		== References ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Buffalo rat]]~~
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Kasaragod, V B~~]]		[[Category: Rattus norvegicus]]
	[[Category: ~~Maric, H M~~]]		[[Category: Kasaragod VB]]
	[[Category: ~~Schindelin, H~~]]		[[Category: Maric HM]]
	[[Category: ~~Biosynthetic protein]]~~		[[Category: Schindelin H]]
	~~[[Category: Molybdenum co factor biosynthesis]]~~
	~~[[Category: Neurotransmitter receptor anchoring]]~~
	~~[[Category: Scaffolding protein]]~~
	~~[[Category: Structural protein~~]]

OCA at 07:47, 8 January 2020

2020-01-08T07:47:28Z

← Older revision		Revision as of 07:47, 8 January 2020
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	==Geph E in complex with a GABA receptor alpha3 subunit derived peptide in space group P61==		==Geph E in complex with a GABA receptor alpha3 subunit derived peptide in space group P61==
	<StructureSection load='4tk2' size='340' side='right' caption='[[4tk2]], [[Resolution\|resolution]] 4.10Å' scene=''>		<StructureSection load='4tk2' size='340' side='right'caption='[[4tk2]], [[Resolution\|resolution]] 4.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4tk2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TK2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TK2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4tk2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TK2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TK2 FirstGlance]. <br>
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	</div>		</div>
	<div class="pdbe-citations 4tk2" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4tk2" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[GABA receptor 3D structures\|GABA receptor 3D structures]]
			*[[Gephyrin\|Gephyrin]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Buffalo rat]]		[[Category: Buffalo rat]]
			[[Category: Large Structures]]
	[[Category: Kasaragod, V B]]		[[Category: Kasaragod, V B]]
	[[Category: Maric, H M]]		[[Category: Maric, H M]]

OCA at 12:02, 6 November 2017

2017-11-06T12:02:52Z

← Older revision		Revision as of 12:02, 6 November 2017
Line 3:		Line 3:
	<StructureSection load='4tk2' size='340' side='right' caption='[[4tk2]], [[Resolution\|resolution]] 4.10Å' scene=''>		<StructureSection load='4tk2' size='340' side='right' caption='[[4tk2]], [[Resolution\|resolution]] 4.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4tk2]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TK2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TK2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4tk2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TK2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TK2 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fu3\|2fu3]], [[2fts\|2fts]], [[4pdo\|4pdo]], [[4pd1\|4pd1]], [[4tk1\|4tk1]], [[4tk3\|4tk3]], [[4tk4\|4tk4]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fu3\|2fu3]], [[2fts\|2fts]], [[4pdo\|4pdo]], [[4pd1\|4pd1]], [[4tk1\|4tk1]], [[4tk3\|4tk3]], [[4tk4\|4tk4]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Gphn, Gph ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tk2 OCA], [http://pdbe.org/4tk2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4tk2 RCSB], [http://www.ebi.ac.uk/pdbsum/4tk2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4tk2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tk2 OCA], [http://pdbe.org/4tk2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4tk2 RCSB], [http://www.ebi.ac.uk/pdbsum/4tk2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4tk2 ProSAT]</span></td></tr>
	</table>		</table>
Line 22:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Buffalo rat]]
	[[Category: Kasaragod, V B]]		[[Category: Kasaragod, V B]]
	[[Category: Maric, H M]]		[[Category: Maric, H M]]
	[[Category: Schindelin, H]]		[[Category: Schindelin, H]]
			[[Category: Biosynthetic protein]]
	[[Category: Molybdenum co factor biosynthesis]]		[[Category: Molybdenum co factor biosynthesis]]
	[[Category: Neurotransmitter receptor anchoring]]		[[Category: Neurotransmitter receptor anchoring]]
	[[Category: Scaffolding protein]]		[[Category: Scaffolding protein]]
	[[Category: Structural protein]]		[[Category: Structural protein]]

OCA at 14:25, 11 August 2016

2016-08-11T14:25:29Z

← Older revision		Revision as of 14:25, 11 August 2016
Line 1:		Line 1:

	==Geph E in complex with a GABA receptor alpha3 subunit derived peptide in space group P61==		==Geph E in complex with a GABA receptor alpha3 subunit derived peptide in space group P61==
	<StructureSection load='4tk2' size='340' side='right' caption='[[4tk2]], [[Resolution\|resolution]] 4.10Å' scene=''>		<StructureSection load='4tk2' size='340' side='right' caption='[[4tk2]], [[Resolution\|resolution]] 4.10Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[4tk2]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TK2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TK2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4tk2]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TK2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TK2 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fu3\|2fu3]], [[2fts\|2fts]], [[4pdo\|4pdo]], [[4pd1\|4pd1]], [[4tk1\|4tk1]], [[4tk3\|4tk3]], [[4tk4\|4tk4]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fu3\|2fu3]], [[2fts\|2fts]], [[4pdo\|4pdo]], [[4pd1\|4pd1]], [[4tk1\|4tk1]], [[4tk3\|4tk3]], [[4tk4\|4tk4]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tk2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tk2 RCSB], [http://www.ebi.ac.uk/pdbsum/4tk2 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tk2 OCA], [http://pdbe.org/4tk2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4tk2 RCSB], [http://www.ebi.ac.uk/pdbsum/4tk2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4tk2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4tk2" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:16, 7 February 2015

2015-02-07T10:16:05Z

← Older revision		Revision as of 10:16, 7 February 2015
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	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/GEPH_RAT GEPH_RAT]] Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.<ref>PMID:8264797</ref> <ref>PMID:9990024</ref> [[http://www.uniprot.org/uniprot/GBRA3_RAT GBRA3_RAT]] GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.		[[http://www.uniprot.org/uniprot/GEPH_RAT GEPH_RAT]] Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.<ref>PMID:8264797</ref> <ref>PMID:9990024</ref> [[http://www.uniprot.org/uniprot/GBRA3_RAT GBRA3_RAT]] GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			gamma-Aminobutyric acid type A and glycine receptors (GABAARs, GlyRs) are the major inhibitory neurotransmitter receptors and contribute to many synaptic functions, dysfunctions and human diseases. GABAARs are important drug targets regulated by direct interactions with the scaffolding protein gephyrin. Here we deduce the molecular basis of this interaction by chemical, biophysical and structural studies of the gephyrin-GABAAR alpha3 complex, revealing that the N-terminal region of the alpha3 peptide occupies the same binding site as the GlyR beta subunit, whereas the C-terminal moiety, which is conserved among all synaptic GABAAR alpha subunits, engages in unique interactions. Thermodynamic dissections of the gephyrin-receptor interactions identify two residues as primary determinants for gephyrin's subunit preference. This first structural evidence for the gephyrin-mediated synaptic accumulation of GABAARs offers a framework for future investigations into the regulation of inhibitory synaptic strength and for the development of mechanistically and therapeutically relevant compounds targeting the gephyrin-GABAAR interaction.

			Molecular basis of the alternative recruitment of GABAA versus glycine receptors through gephyrin.,Maric HM, Kasaragod VB, Hausrat TJ, Kneussel M, Tretter V, Stromgaard K, Schindelin H Nat Commun. 2014 Dec 22;5:5767. doi: 10.1038/ncomms6767. PMID:25531214<ref>PMID:25531214</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:12, 24 December 2014

2014-12-24T11:12:01Z

← Older revision		Revision as of 11:12, 24 December 2014
Line 1:		Line 1:
	'''~~Unreleased~~ structure'''		==Geph E in complex with a GABA receptor alpha3 subunit derived peptide in space group P61==
			<StructureSection load='4tk2' size='340' side='right' caption='[[4tk2]], [[Resolution\|resolution]] 4.10Å' scene=''>
	~~The entry 4tk2~~ is ~~ON HOLD~~ ~~until Paper Publication~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[4tk2]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TK2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TK2 FirstGlance]. <br>
	~~Authors~~: Kasaragod, V.B., Maric, H.M., Schindelin, H.		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fu3\|2fu3]], [[2fts\|2fts]], [[4pdo\|4pdo]], [[4pd1\|4pd1]], [[4tk1\|4tk1]], [[4tk3\|4tk3]], [[4tk4\|4tk4]]</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tk2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tk2 RCSB], [http://www.ebi.ac.uk/pdbsum/4tk2 PDBsum]</span></td></tr>
	~~Description~~:		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/GEPH_RAT GEPH_RAT]] Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.<ref>PMID:8264797</ref> <ref>PMID:9990024</ref> [[http://www.uniprot.org/uniprot/GBRA3_RAT GBRA3_RAT]] GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
			== References ==
			<references/>
			__TOC__
			</StructureSection>
			[[Category: Kasaragod, V B]]
			[[Category: Maric, H M]]
			[[Category: Schindelin, H]]
			[[Category: Molybdenum co factor biosynthesis]]
			[[Category: Neurotransmitter receptor anchoring]]
			[[Category: Scaffolding protein]]
			[[Category: Structural protein]]

OCA at 07:29, 2 July 2014

2014-07-02T07:29:02Z

← Older revision		Revision as of 07:29, 2 July 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4tk2 is ON HOLD		The entry 4tk2 is ON HOLD until Paper Publication

	Authors: Kasaragod, V.B., Maric, H.M., Schindelin, H.		Authors: Kasaragod, V.B., Maric, H.M., Schindelin, H.

	Description:		Description:

OCA at 08:10, 11 June 2014

2014-06-11T08:10:40Z

← Older revision		Revision as of 08:10, 11 June 2014
Line 5:		Line 5:
	Authors: Kasaragod, V.B., Maric, H.M., Schindelin, H.		Authors: Kasaragod, V.B., Maric, H.M., Schindelin, H.

	Description: ~~Geph E in complex with GABA receptor alpha3 subunit derived peptide in space group P61~~		Description:

OCA: Protected "4tk2" [edit=sysop:move=sysop]

2014-06-04T04:59:24Z

Protected "4tk2" [edit=sysop:move=sysop]

← Older revision	Revision as of 04:59, 4 June 2014
(No difference)