4tkd - Revision history

OCA at 00:46, 28 December 2023

2023-12-28T00:46:14Z

← Older revision		Revision as of 00:46, 28 December 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4tkd]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus_P2 Saccharolobus solfataricus P2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TKD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TKD FirstGlance]. <br>		<table><tr><td colspan='2'>[[4tkd]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus_P2 Saccharolobus solfataricus P2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TKD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TKD FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4tkd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tkd OCA], [https://pdbe.org/4tkd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4tkd RCSB], [https://www.ebi.ac.uk/pdbsum/4tkd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4tkd ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.01Å</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4tkd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tkd OCA], [https://pdbe.org/4tkd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4tkd RCSB], [https://www.ebi.ac.uk/pdbsum/4tkd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4tkd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 10:43, 15 March 2023

2023-03-15T10:43:47Z

← Older revision		Revision as of 10:43, 15 March 2023
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	<StructureSection load='4tkd' size='340' side='right'caption='[[4tkd]], [[Resolution\|resolution]] 2.01Å' scene=''>		<StructureSection load='4tkd' size='340' side='right'caption='[[4tkd]], [[Resolution\|resolution]] 2.01Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4tkd]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Sacs2 Sacs2~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TKD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4TKD FirstGlance]. <br>		<table><tr><td colspan='2'>[[4tkd]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus_P2 Saccharolobus solfataricus P2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TKD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TKD FirstGlance]. <br>
	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4tkk\|4tkk]]</td></tr>~~		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4tkd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tkd OCA], [https://pdbe.org/4tkd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4tkd RCSB], [https://www.ebi.ac.uk/pdbsum/4tkd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4tkd ProSAT]</span></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hjc, SSO0575, ORF-c21_024 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=273057 SACS2])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Crossover_junction_endodeoxyribonuclease Crossover junction endodeoxyribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.22.4 3.1.22.4] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4tkd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tkd OCA], [~~http~~://pdbe.org/4tkd PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4tkd RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4tkd PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4tkd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/~~HJC_SULSO HJC_SULSO]~~] A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination; may have some degree of sequence preference in a mobile junction. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products. Can cleave all 4 strands 3 bases 3' of the junction center. Cleaves both mobile and immobile junctions. Modifies the structure of the 4-way DNA junction, a model Holliday junction structure. The protein forms multiple complexes with 4-way DNA, suggesting more than 1 homodimer can bind to each junction.<ref>PMID:10701121</ref> <ref>PMID:10736227</ref> <ref>PMID:10940317</ref> <ref>PMID:11709558</ref> <ref>PMID:17011573</ref>		[https://www.uniprot.org/uniprot/HJC_SACS2 HJC_SACS2] A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination; may have some degree of sequence preference in a mobile junction. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products. Can cleave all 4 strands 3 bases 3' of the junction center. Cleaves both mobile and immobile junctions. Modifies the structure of the 4-way DNA junction, a model Holliday junction structure. The protein forms multiple complexes with 4-way DNA, suggesting more than 1 homodimer can bind to each junction.<ref>PMID:10701121</ref> <ref>PMID:10736227</ref> <ref>PMID:10940317</ref> <ref>PMID:11709558</ref> <ref>PMID:17011573</ref>

	==See Also==		==See Also==
	*[[Resolvase\|Resolvase]]		*[[Resolvase 3D structures\|Resolvase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Crossover junction endodeoxyribonuclease]]~~
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Sacs2~~]]		[[Category: Saccharolobus solfataricus P2]]
	[[Category: Bond~~, C S]]~~		[[Category: Bond CS]]
	~~[[Category: Hydrolase~~]]

OCA at 10:04, 1 May 2019

2019-05-01T10:04:25Z

← Older revision		Revision as of 10:04, 1 May 2019
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	==Sulfolobus solfataricus HJC mutants==		==Sulfolobus solfataricus HJC mutants==
	<StructureSection load='4tkd' size='340' side='right' caption='[[4tkd]], [[Resolution\|resolution]] 2.01Å' scene=''>		<StructureSection load='4tkd' size='340' side='right'caption='[[4tkd]], [[Resolution\|resolution]] 2.01Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4tkd]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TKD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TKD FirstGlance]. <br>		<table><tr><td colspan='2'>[[4tkd]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Sacs2 Sacs2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TKD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TKD FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4tkk\|4tkk]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4tkk\|4tkk]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hjc, SSO0575, ORF-c21_024 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=273057 SACS2])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Crossover_junction_endodeoxyribonuclease Crossover junction endodeoxyribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.22.4 3.1.22.4] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Crossover_junction_endodeoxyribonuclease Crossover junction endodeoxyribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.22.4 3.1.22.4] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tkd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tkd OCA], [http://pdbe.org/4tkd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4tkd RCSB], [http://www.ebi.ac.uk/pdbsum/4tkd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4tkd ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tkd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tkd OCA], [http://pdbe.org/4tkd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4tkd RCSB], [http://www.ebi.ac.uk/pdbsum/4tkd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4tkd ProSAT]</span></td></tr>
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	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/HJC_SULSO HJC_SULSO]] A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination; may have some degree of sequence preference in a mobile junction. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products. Can cleave all 4 strands 3 bases 3' of the junction center. Cleaves both mobile and immobile junctions. Modifies the structure of the 4-way DNA junction, a model Holliday junction structure. The protein forms multiple complexes with 4-way DNA, suggesting more than 1 homodimer can bind to each junction.<ref>PMID:10701121</ref> <ref>PMID:10736227</ref> <ref>PMID:10940317</ref> <ref>PMID:11709558</ref> <ref>PMID:17011573</ref>		[[http://www.uniprot.org/uniprot/HJC_SULSO HJC_SULSO]] A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination; may have some degree of sequence preference in a mobile junction. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products. Can cleave all 4 strands 3 bases 3' of the junction center. Cleaves both mobile and immobile junctions. Modifies the structure of the 4-way DNA junction, a model Holliday junction structure. The protein forms multiple complexes with 4-way DNA, suggesting more than 1 homodimer can bind to each junction.<ref>PMID:10701121</ref> <ref>PMID:10736227</ref> <ref>PMID:10940317</ref> <ref>PMID:11709558</ref> <ref>PMID:17011573</ref>

			==See Also==
			*[[Resolvase\|Resolvase]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Crossover junction endodeoxyribonuclease]]		[[Category: Crossover junction endodeoxyribonuclease]]
			[[Category: Large Structures]]
			[[Category: Sacs2]]
	[[Category: Bond, C S]]		[[Category: Bond, C S]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 16:09, 17 May 2017

2017-05-17T16:09:56Z

← Older revision		Revision as of 16:09, 17 May 2017
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	==Sulfolobus solfataricus HJC mutants==		==Sulfolobus solfataricus HJC mutants==
	<StructureSection load='4tkd' size='340' side='right' caption='[[4tkd]], [[Resolution\|resolution]] 2.01Å' scene=''>		<StructureSection load='4tkd' size='340' side='right' caption='[[4tkd]], [[Resolution\|resolution]] 2.01Å' scene=''>
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	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4tkk\|4tkk]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4tkk\|4tkk]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Crossover_junction_endodeoxyribonuclease Crossover junction endodeoxyribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.22.4 3.1.22.4] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Crossover_junction_endodeoxyribonuclease Crossover junction endodeoxyribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.22.4 3.1.22.4] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tkd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tkd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tkd RCSB], [http://www.ebi.ac.uk/pdbsum/4tkd PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tkd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tkd OCA], [http://pdbe.org/4tkd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4tkd RCSB], [http://www.ebi.ac.uk/pdbsum/4tkd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4tkd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 14:47, 12 August 2015

2015-08-12T14:47:00Z

← Older revision		Revision as of 14:47, 12 August 2015
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	'''~~Unreleased structure~~'''		==Sulfolobus solfataricus HJC mutants==
			<StructureSection load='4tkd' size='340' side='right' caption='[[4tkd]], [[Resolution\|resolution]] 2.01Å' scene=''>
	~~The entry~~ 4tkd is ~~ON HOLD until Paper Publication~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[4tkd]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TKD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TKD FirstGlance]. <br>
	~~Authors~~: ~~Bond~~, C.S.		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4tkk\|4tkk]]</td></tr>
			<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Crossover_junction_endodeoxyribonuclease Crossover junction endodeoxyribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.22.4 3.1.22.4] </span></td></tr>
	~~Description~~: ~~Sulfolobus solfataricus HJC mutants~~		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tkd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tkd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tkd RCSB], [http://www.ebi.ac.uk/pdbsum/4tkd PDBsum]</span></td></tr>
	[[Category: ~~Unreleased Structures~~]]		</table>
	[[Category: Bond, C.S]]		== Function ==
			[[http://www.uniprot.org/uniprot/HJC_SULSO HJC_SULSO]] A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination; may have some degree of sequence preference in a mobile junction. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products. Can cleave all 4 strands 3 bases 3' of the junction center. Cleaves both mobile and immobile junctions. Modifies the structure of the 4-way DNA junction, a model Holliday junction structure. The protein forms multiple complexes with 4-way DNA, suggesting more than 1 homodimer can bind to each junction.<ref>PMID:10701121</ref> <ref>PMID:10736227</ref> <ref>PMID:10940317</ref> <ref>PMID:11709558</ref> <ref>PMID:17011573</ref>
			== References ==
			<references/>
			__TOC__
			</StructureSection>
			[[Category: Crossover junction endodeoxyribonuclease]]
			[[Category: Bond, C S]]
			[[Category: Hydrolase]]

OCA at 17:40, 24 December 2014

2014-12-24T17:40:04Z

← Older revision		Revision as of 17:40, 24 December 2014
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	Description: Sulfolobus solfataricus HJC mutants		Description: Sulfolobus solfataricus HJC mutants
			[[Category: Unreleased Structures]]
			[[Category: Bond, C.S]]

OCA at 07:44, 5 November 2014

2014-11-05T07:44:00Z

← Older revision		Revision as of 07:44, 5 November 2014
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4tkd is ON HOLD		The entry 4tkd is ON HOLD until Paper Publication

	Authors: Bond, C.S.		Authors: Bond, C.S.

	Description: Sulfolobus solfataricus HJC mutants		Description: Sulfolobus solfataricus HJC mutants

OCA: Protected "4tkd" [edit=sysop:move=sysop]

2014-06-04T04:59:34Z

Protected "4tkd" [edit=sysop:move=sysop]

← Older revision	Revision as of 04:59, 4 June 2014
(No difference)

OCA: New page: '''Unreleased structure''' The entry 4tkd is ON HOLD Authors: Bond, C.S. Description: Sulfolobus solfataricus HJC mutants

2014-06-04T04:59:33Z

New page: '''Unreleased structure''' The entry 4tkd is ON HOLD Authors: Bond, C.S. Description: Sulfolobus solfataricus HJC mutants

New page

'''Unreleased structure'''

The entry 4tkd is ON HOLD

Authors: Bond, C.S.

Description: Sulfolobus solfataricus HJC mutants