4tkf - Revision history

OCA at 00:46, 28 December 2023

2023-12-28T00:46:14Z

← Older revision		Revision as of 00:46, 28 December 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4tkf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TKF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TKF FirstGlance]. <br>		<table><tr><td colspan='2'>[[4tkf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TKF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TKF FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=33C:4-[(3AR,4R,7S,7AS)-1,3-DIOXOOCTAHYDRO-2H-4,7-METHANOISOINDOL-2-YL]-N-(QUINOLIN-8-YL)BENZAMIDE'>33C</scene>, <scene name='pdbligand=3AB:3-AMINOBENZAMIDE'>3AB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=33C:4-[(3AR,4R,7S,7AS)-1,3-DIOXOOCTAHYDRO-2H-4,7-METHANOISOINDOL-2-YL]-N-(QUINOLIN-8-YL)BENZAMIDE'>33C</scene>, <scene name='pdbligand=3AB:3-AMINOBENZAMIDE'>3AB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4tkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tkf OCA], [https://pdbe.org/4tkf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4tkf RCSB], [https://www.ebi.ac.uk/pdbsum/4tkf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4tkf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4tkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tkf OCA], [https://pdbe.org/4tkf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4tkf RCSB], [https://www.ebi.ac.uk/pdbsum/4tkf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4tkf ProSAT]</span></td></tr>
	</table>		</table>

OCA at 10:43, 15 March 2023

2023-03-15T10:43:50Z

← Older revision		Revision as of 10:43, 15 March 2023
Line 1:		Line 1:

	==Crystal Structure of human Tankyrase 2 in complex with IWR-1.==		==Crystal Structure of human Tankyrase 2 in complex with IWR-1.==
	<StructureSection load='4tkf' size='340' side='right' caption='[[4tkf]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='4tkf' size='340' side='right'caption='[[4tkf]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4tkf]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TKF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4TKF FirstGlance]. <br>		<table><tr><td colspan='2'>[[4tkf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TKF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TKF FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=33C:4-[(3AR,4R,7S,7AS)-1,3-DIOXOOCTAHYDRO-2H-4,7-METHANOISOINDOL-2-YL]-N-(QUINOLIN-8-YL)BENZAMIDE'>33C</scene>, <scene name='pdbligand=3AB:3-AMINOBENZAMIDE'>3AB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=33C:4-[(3AR,4R,7S,7AS)-1,3-DIOXOOCTAHYDRO-2H-4,7-METHANOISOINDOL-2-YL]-N-(QUINOLIN-8-YL)BENZAMIDE'>33C</scene>, <scene name='pdbligand=3AB:3-AMINOBENZAMIDE'>3AB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pml\|4pml]], [[4pnl\|4pnl]], [[4pnm\|4pnm]], [[4pnn\|4pnn]], [[4pnq\|4pnq]], [[4pnt\|4pnt]], [[4pnr\|4pnr]], [[4pns\|4pns]], [[4tju\|4tju]], [[4tjw\|4tjw]], [[4tjy\|4tjy]], [[4tk0\|4tk0]], [[4tk5\|4tk5]], [[4tkg\|4tkg]], [[4tki\|4tki]]</td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4tkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tkf OCA], [https://pdbe.org/4tkf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4tkf RCSB], [https://www.ebi.ac.uk/pdbsum/4tkf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4tkf ProSAT]</span></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TNKS2, PARP5B, TANK2, TNKL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4tkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tkf OCA], [~~http~~://pdbe.org/4tkf PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4tkf RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4tkf PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4tkf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/TNKS2_HUMAN TNKS2_HUMAN]] Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.<ref>PMID:11802774</ref> <ref>PMID:11739745</ref> <ref>PMID:19759537</ref> <ref>PMID:21478859</ref>		[https://www.uniprot.org/uniprot/TNKS2_HUMAN TNKS2_HUMAN] Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.<ref>PMID:11802774</ref> <ref>PMID:11739745</ref> <ref>PMID:19759537</ref> <ref>PMID:21478859</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4tkf" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4tkf" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Poly(ADP-ribose) polymerase 3D structures\|Poly(ADP-ribose) polymerase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Battaile~~, K P~~]]		[[Category: Large Structures]]
	[[Category: Beletskaya, I]]		[[Category: Battaile KP]]
	[[Category: Chirgadze~~, N Y~~]]		[[Category: Beletskaya I]]
	[[Category: Gebremeskel, S]]		[[Category: Chirgadze NY]]
	[[Category: Gordon, R]]		[[Category: Gebremeskel S]]
	[[Category: Lam, R]]		[[Category: Gordon R]]
	[[Category: Pai~~, E F~~]]		[[Category: Lam R]]
	[[Category: Qiu, W]]		[[Category: Pai EF]]
	[[Category: Romanov, V]]		[[Category: Qiu W]]
	[[Category: Thompson, C]]		[[Category: Romanov V]]
	[[Category: Vodsedalek, J]]		[[Category: Thompson C]]
	~~[[Category: Transferase~~]]		[[Category: Vodsedalek J]]

OCA at 09:14, 22 November 2017

2017-11-22T09:14:45Z

← Older revision		Revision as of 09:14, 22 November 2017
Line 3:		Line 3:
	<StructureSection load='4tkf' size='340' side='right' caption='[[4tkf]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='4tkf' size='340' side='right' caption='[[4tkf]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4tkf]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TKF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TKF FirstGlance]. <br>		<table><tr><td colspan='2'>[[4tkf]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TKF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TKF FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=33C:4-[(3AR,4R,7S,7AS)-1,3-DIOXOOCTAHYDRO-2H-4,7-METHANOISOINDOL-2-YL]-N-(QUINOLIN-8-YL)BENZAMIDE'>33C</scene>, <scene name='pdbligand=3AB:3-AMINOBENZAMIDE'>3AB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=33C:4-[(3AR,4R,7S,7AS)-1,3-DIOXOOCTAHYDRO-2H-4,7-METHANOISOINDOL-2-YL]-N-(QUINOLIN-8-YL)BENZAMIDE'>33C</scene>, <scene name='pdbligand=3AB:3-AMINOBENZAMIDE'>3AB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pml\|4pml]], [[4pnl\|4pnl]], [[4pnm\|4pnm]], [[4pnn\|4pnn]], [[4pnq\|4pnq]], [[4pnt\|4pnt]], [[4pnr\|4pnr]], [[4pns\|4pns]], [[4tju\|4tju]], [[4tjw\|4tjw]], [[4tjy\|4tjy]], [[4tk0\|4tk0]], [[4tk5\|4tk5]], [[4tkg\|4tkg]], [[4tki\|4tki]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pml\|4pml]], [[4pnl\|4pnl]], [[4pnm\|4pnm]], [[4pnn\|4pnn]], [[4pnq\|4pnq]], [[4pnt\|4pnt]], [[4pnr\|4pnr]], [[4pns\|4pns]], [[4tju\|4tju]], [[4tjw\|4tjw]], [[4tjy\|4tjy]], [[4tk0\|4tk0]], [[4tk5\|4tk5]], [[4tkg\|4tkg]], [[4tki\|4tki]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TNKS2, PARP5B, TANK2, TNKL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tkf OCA], [http://pdbe.org/4tkf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4tkf RCSB], [http://www.ebi.ac.uk/pdbsum/4tkf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4tkf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tkf OCA], [http://pdbe.org/4tkf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4tkf RCSB], [http://www.ebi.ac.uk/pdbsum/4tkf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4tkf ProSAT]</span></td></tr>
Line 20:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 4tkf" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4tkf" style="background-color:#fffaf0;"></div>

	~~==See Also==~~
	*[[Poly (ADP-ribose) polymerase\|Poly (ADP-ribose) polymerase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Human]]
	[[Category: Battaile, K P]]		[[Category: Battaile, K P]]
	[[Category: Beletskaya, I]]		[[Category: Beletskaya, I]]

OCA at 18:46, 11 August 2016

2016-08-11T18:46:09Z

← Older revision		Revision as of 18:46, 11 August 2016
Line 1:		Line 1:

	==Crystal Structure of human Tankyrase 2 in complex with IWR-1.==		==Crystal Structure of human Tankyrase 2 in complex with IWR-1.==
	<StructureSection load='4tkf' size='340' side='right' caption='[[4tkf]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='4tkf' size='340' side='right' caption='[[4tkf]], [[Resolution\|resolution]] 2.60Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pml\|4pml]], [[4pnl\|4pnl]], [[4pnm\|4pnm]], [[4pnn\|4pnn]], [[4pnq\|4pnq]], [[4pnt\|4pnt]], [[4pnr\|4pnr]], [[4pns\|4pns]], [[4tju\|4tju]], [[4tjw\|4tjw]], [[4tjy\|4tjy]], [[4tk0\|4tk0]], [[4tk5\|4tk5]], [[4tkg\|4tkg]], [[4tki\|4tki]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pml\|4pml]], [[4pnl\|4pnl]], [[4pnm\|4pnm]], [[4pnn\|4pnn]], [[4pnq\|4pnq]], [[4pnt\|4pnt]], [[4pnr\|4pnr]], [[4pns\|4pns]], [[4tju\|4tju]], [[4tjw\|4tjw]], [[4tjy\|4tjy]], [[4tk0\|4tk0]], [[4tk5\|4tk5]], [[4tkg\|4tkg]], [[4tki\|4tki]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tkf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tkf RCSB], [http://www.ebi.ac.uk/pdbsum/4tkf PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tkf OCA], [http://pdbe.org/4tkf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4tkf RCSB], [http://www.ebi.ac.uk/pdbsum/4tkf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4tkf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4tkf" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Poly (ADP-ribose) polymerase\|Poly (ADP-ribose) polymerase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:12, 7 January 2015

2015-01-07T11:12:16Z

← Older revision		Revision as of 11:12, 7 January 2015
Line 10:		Line 10:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/TNKS2_HUMAN TNKS2_HUMAN]] Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.<ref>PMID:11802774</ref> <ref>PMID:11739745</ref> <ref>PMID:19759537</ref> <ref>PMID:21478859</ref>		[[http://www.uniprot.org/uniprot/TNKS2_HUMAN TNKS2_HUMAN]] Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.<ref>PMID:11802774</ref> <ref>PMID:11739745</ref> <ref>PMID:19759537</ref> <ref>PMID:21478859</ref>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The poly(ADP-ribose) polymerase (PARP) family represents a new class of therapeutic targets with diverse potential disease indications. PARP1 and PARP2 inhibitors have been developed for breast and ovarian tumors manifesting double-stranded DNA-repair defects, whereas tankyrase 1 and 2 (TNKS1 and TNKS2, also known as PARP5a and PARP5b, respectively) inhibitors have been developed for tumors with elevated beta-catenin activity. As the clinical relevance of PARP inhibitors continues to be actively explored, there is heightened interest in the design of selective inhibitors based on the detailed structural features of how small-molecule inhibitors bind to each of the PARP family members. Here, the high-resolution crystal structures of the human TNKS2 PARP domain in complex with 16 various PARP inhibitors are reported, including the compounds BSI-201, AZD-2281 and ABT-888, which are currently in Phase 2 or 3 clinical trials. These structures provide insight into the inhibitor-binding modes for the tankyrase PARP domain and valuable information to guide the rational design of future tankyrase-specific inhibitors.

			Insights into the binding of PARP inhibitors to the catalytic domain of human tankyrase-2.,Qiu W, Lam R, Voytyuk O, Romanov V, Gordon R, Gebremeskel S, Vodsedalek J, Thompson C, Beletskaya I, Battaile KP, Pai EF, Rottapel R, Chirgadze NY Acta Crystallogr D Biol Crystallogr. 2014 Oct;70(Pt 10):2740-53. doi:, 10.1107/S1399004714017660. Epub 2014 Sep 27. PMID:25286857<ref>PMID:25286857</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 20:23, 24 December 2014

2014-12-24T20:23:40Z

← Older revision		Revision as of 20:23, 24 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tkf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tkf RCSB], [http://www.ebi.ac.uk/pdbsum/4tkf PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tkf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tkf RCSB], [http://www.ebi.ac.uk/pdbsum/4tkf PDBsum]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/TNKS2_HUMAN TNKS2_HUMAN]] Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.<ref>PMID:11802774</ref> <ref>PMID:11739745</ref> <ref>PMID:19759537</ref> <ref>PMID:21478859</ref>
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Battaile, K P.]]		[[Category: Battaile, K P]]
	[[Category: Beletskaya, I.]]		[[Category: Beletskaya, I]]
	[[Category: Chirgadze, N Y.]]		[[Category: Chirgadze, N Y]]
	[[Category: Gebremeskel, S.]]		[[Category: Gebremeskel, S]]
	[[Category: Gordon, R.]]		[[Category: Gordon, R]]
	[[Category: Lam, R.]]		[[Category: Lam, R]]
	[[Category: Pai, E F.]]		[[Category: Pai, E F]]
	[[Category: Qiu, W.]]		[[Category: Qiu, W]]
	[[Category: Romanov, V.]]		[[Category: Romanov, V]]
	[[Category: Thompson, C.]]		[[Category: Thompson, C]]
	[[Category: Vodsedalek, J.]]		[[Category: Vodsedalek, J]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 09:02, 5 November 2014

2014-11-05T09:02:14Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Crystal Structure of human Tankyrase 2 in complex with IWR-1.==
+<StructureSection load='4tkf' size='340' side='right' caption='[[4tkf]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
-The entry 4tkf is ON HOLD
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4tkf]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TKF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TKF FirstGlance]. <br>
-Authors: Qiu, W., Lam, R., Romanov, V., Gordon, R., Gebremeskel, S., Vodsedalek, J., Thompson, C., Beletskaya, I., Battaile, K.P., Pai, E.F., Chirgadze, N.Y.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=33C:4-[(3AR,4R,7S,7AS)-1,3-DIOXOOCTAHYDRO-2H-4,7-METHANOISOINDOL-2-YL]-N-(QUINOLIN-8-YL)BENZAMIDE'>33C</scene>, <scene name='pdbligand=3AB:3-AMINOBENZAMIDE'>3AB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4pml|4pml]], [[4pnl|4pnl]], [[4pnm|4pnm]], [[4pnn|4pnn]], [[4pnq|4pnq]], [[4pnt|4pnt]], [[4pnr|4pnr]], [[4pns|4pns]], [[4tju|4tju]], [[4tjw|4tjw]], [[4tjy|4tjy]], [[4tk0|4tk0]], [[4tk5|4tk5]], [[4tkg|4tkg]], [[4tki|4tki]]</td></tr>
-Description: Crystal Structure of human Tankyrase 2 in complex with IWR-1.
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>

OCA: Protected "4tkf" [edit=sysop:move=sysop]

2014-06-04T04:59:36Z

Protected "4tkf" [edit=sysop:move=sysop]

← Older revision	Revision as of 04:59, 4 June 2014
(No difference)

OCA: New page: '''Unreleased structure''' The entry 4tkf is ON HOLD Authors: Qiu, W., Lam, R., Romanov, V., Gordon, R., Gebremeskel, S., Vodsedalek, J., Thompson, C., Beletskaya, I., Battaile, K.P., P...

2014-06-04T04:59:35Z

New page: '''Unreleased structure''' The entry 4tkf is ON HOLD Authors: Qiu, W., Lam, R., Romanov, V., Gordon, R., Gebremeskel, S., Vodsedalek, J., Thompson, C., Beletskaya, I., Battaile, K.P., P...

New page

'''Unreleased structure'''

The entry 4tkf is ON HOLD

Authors: Qiu, W., Lam, R., Romanov, V., Gordon, R., Gebremeskel, S., Vodsedalek, J., Thompson, C., Beletskaya, I., Battaile, K.P., Pai, E.F., Chirgadze, N.Y.

Description: Crystal Structure of human Tankyrase 2 in complex with IWR-1.