4tkv - Revision history

OCA at 11:49, 13 August 2026

2026-08-13T11:49:01Z

← Older revision		Revision as of 11:49, 13 August 2026
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	<table><tr><td colspan='2'>[[4tkv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Azotobacter_vinelandii Azotobacter vinelandii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TKV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TKV FirstGlance]. <br>		<table><tr><td colspan='2'>[[4tkv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Azotobacter_vinelandii Azotobacter vinelandii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TKV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TKV FirstGlance]. <br>
	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.5Å</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.5Å</td></tr>
	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat">~~<scene name='pdbligand=CLF:FE(8)-S(7)+CLUSTER'>CLF</scene>,~~ <scene name='pdbligand=CMO:CARBON+MONOXIDE'>CMO</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=HCA:3-HYDROXY-3-CARBOXY-ADIPIC+ACID'>HCA~~</scene>, <scene name='pdbligand=ICE:IRON-SULFUR-MOLYBDENUM+CLUSTER+WITH+INTERSTITIAL+CARBON'>ICE~~</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CMO:CARBON+MONOXIDE'>CMO</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=HCA:3-HYDROXY-3-CARBOXY-ADIPIC+ACID'>HCA</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4tkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tkv OCA], [https://pdbe.org/4tkv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4tkv RCSB], [https://www.ebi.ac.uk/pdbsum/4tkv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4tkv ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4tkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tkv OCA], [https://pdbe.org/4tkv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4tkv RCSB], [https://www.ebi.ac.uk/pdbsum/4tkv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4tkv ProSAT]</span></td></tr>
	</table>		</table>

OCA at 00:46, 28 December 2023

2023-12-28T00:46:25Z

← Older revision		Revision as of 00:46, 28 December 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4tkv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Azotobacter_vinelandii Azotobacter vinelandii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TKV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TKV FirstGlance]. <br>		<table><tr><td colspan='2'>[[4tkv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Azotobacter_vinelandii Azotobacter vinelandii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TKV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TKV FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLF:FE(8)-S(7)+CLUSTER'>CLF</scene>, <scene name='pdbligand=CMO:CARBON+MONOXIDE'>CMO</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=HCA:3-HYDROXY-3-CARBOXY-ADIPIC+ACID'>HCA</scene>, <scene name='pdbligand=ICE:IRON-SULFUR-MOLYBDENUM+CLUSTER+WITH+INTERSTITIAL+CARBON'>ICE</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.5Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLF:FE(8)-S(7)+CLUSTER'>CLF</scene>, <scene name='pdbligand=CMO:CARBON+MONOXIDE'>CMO</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=HCA:3-HYDROXY-3-CARBOXY-ADIPIC+ACID'>HCA</scene>, <scene name='pdbligand=ICE:IRON-SULFUR-MOLYBDENUM+CLUSTER+WITH+INTERSTITIAL+CARBON'>ICE</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4tkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tkv OCA], [https://pdbe.org/4tkv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4tkv RCSB], [https://www.ebi.ac.uk/pdbsum/4tkv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4tkv ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4tkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tkv OCA], [https://pdbe.org/4tkv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4tkv RCSB], [https://www.ebi.ac.uk/pdbsum/4tkv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4tkv ProSAT]</span></td></tr>
	</table>		</table>

OCA at 10:44, 15 March 2023

2023-03-15T10:44:30Z

← Older revision		Revision as of 10:44, 15 March 2023
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	<StructureSection load='4tkv' size='340' side='right'caption='[[4tkv]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='4tkv' size='340' side='right'caption='[[4tkv]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4tkv]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Azotobacter_vinelandii Azotobacter vinelandii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TKV OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4TKV FirstGlance]. <br>		<table><tr><td colspan='2'>[[4tkv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Azotobacter_vinelandii Azotobacter vinelandii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TKV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TKV FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CLF:FE(8)-S(7)+CLUSTER'>CLF</scene>, <scene name='pdbligand=CMO:CARBON+MONOXIDE'>CMO</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=HCA:3-HYDROXY-3-CARBOXY-ADIPIC+ACID'>HCA</scene>, <scene name='pdbligand=ICE:IRON-SULFUR-MOLYBDENUM+CLUSTER+WITH+INTERSTITIAL+CARBON'>ICE</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene~~></td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLF:FE(8)-S(7)+CLUSTER'>CLF</scene>, <scene name='pdbligand=CMO:CARBON+MONOXIDE'>CMO</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=HCA:3-HYDROXY-3-CARBOXY-ADIPIC+ACID'>HCA</scene>, <scene name='pdbligand=ICE:IRON-SULFUR-MOLYBDENUM+CLUSTER+WITH+INTERSTITIAL+CARBON'>ICE</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m1n\|1m1n]], [[3u7q\|3u7q]], [[4tku\|4tku]]</td></tr>~~		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4tkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tkv OCA], [https://pdbe.org/4tkv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4tkv RCSB], [https://www.ebi.ac.uk/pdbsum/4tkv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4tkv ProSAT]</span></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitrogenase Nitrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.18.6.1 1.18.6.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4tkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tkv OCA], [~~http~~://pdbe.org/4tkv PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4tkv RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4tkv PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4tkv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/NIFD_AZOVI NIFD_AZOVI~~]] This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation. [[http://www.uniprot.org/uniprot/NIFK_AZOVI NIFK_AZOVI]~~] This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.		[https://www.uniprot.org/uniprot/NIFD_AZOVI NIFD_AZOVI] This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	==See Also==		==See Also==
	*[[Nitrogenase\|Nitrogenase]]		*[[Nitrogenase 3D structures\|Nitrogenase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	[[Category: Azotobacter vinelandii]]		[[Category: Azotobacter vinelandii]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	~~[[Category: Nitrogenase]]~~		[[Category: Einsle O]]
	[[Category: Einsle, O]]		[[Category: Howard JB]]
	[[Category: Howard~~, J B~~]]		[[Category: Perez K]]
	[[Category: Perez, K]]		[[Category: Rees DC]]
	[[Category: Rees~~, D C~~]]		[[Category: Spatzal T]]
	[[Category: Spatzal, T]]
	~~[[Category: Femo-cofactor]]~~
	~~[[Category: Inhibition]]~~
	~~[[Category: Oxidoreductase~~]]

OCA at 09:39, 1 May 2019

2019-05-01T09:39:23Z

← Older revision		Revision as of 09:39, 1 May 2019
Line 1:		Line 1:

	==CO-bound Nitrogenase MoFe-protein from A. vinelandii==		==CO-bound Nitrogenase MoFe-protein from A. vinelandii==
	<StructureSection load='4tkv' size='340' side='right' caption='[[4tkv]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='4tkv' size='340' side='right'caption='[[4tkv]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4tkv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Azotobacter_vinelandii Azotobacter vinelandii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TKV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TKV FirstGlance]. <br>		<table><tr><td colspan='2'>[[4tkv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Azotobacter_vinelandii Azotobacter vinelandii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TKV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TKV FirstGlance]. <br>
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Azotobacter vinelandii]]		[[Category: Azotobacter vinelandii]]
			[[Category: Large Structures]]
	[[Category: Nitrogenase]]		[[Category: Nitrogenase]]
	[[Category: Einsle, O]]		[[Category: Einsle, O]]

OCA at 16:58, 5 August 2016

2016-08-05T16:58:36Z

← Older revision		Revision as of 16:58, 5 August 2016
Line 1:		Line 1:

	==CO-bound Nitrogenase MoFe-protein from A. vinelandii==		==CO-bound Nitrogenase MoFe-protein from A. vinelandii==
	<StructureSection load='4tkv' size='340' side='right' caption='[[4tkv]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='4tkv' size='340' side='right' caption='[[4tkv]], [[Resolution\|resolution]] 1.50Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m1n\|1m1n]], [[3u7q\|3u7q]], [[4tku\|4tku]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m1n\|1m1n]], [[3u7q\|3u7q]], [[4tku\|4tku]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitrogenase Nitrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.18.6.1 1.18.6.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitrogenase Nitrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.18.6.1 1.18.6.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tkv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tkv RCSB], [http://www.ebi.ac.uk/pdbsum/4tkv PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tkv OCA], [http://pdbe.org/4tkv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4tkv RCSB], [http://www.ebi.ac.uk/pdbsum/4tkv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4tkv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4tkv" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Nitrogenase\|Nitrogenase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 04:13, 25 December 2014

2014-12-25T04:13:49Z

← Older revision		Revision as of 04:13, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tkv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tkv RCSB], [http://www.ebi.ac.uk/pdbsum/4tkv PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tkv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tkv RCSB], [http://www.ebi.ac.uk/pdbsum/4tkv PDBsum]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/NIFD_AZOVI NIFD_AZOVI]] This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation. [[http://www.uniprot.org/uniprot/NIFK_AZOVI NIFK_AZOVI]] This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	[[Category: Azotobacter vinelandii]]		[[Category: Azotobacter vinelandii]]
	[[Category: Nitrogenase]]		[[Category: Nitrogenase]]
	[[Category: Einsle, O.]]		[[Category: Einsle, O]]
	[[Category: Howard, J B.]]		[[Category: Howard, J B]]
	[[Category: Perez, K.]]		[[Category: Perez, K]]
	[[Category: Rees, D C.]]		[[Category: Rees, D C]]
	[[Category: Spatzal, T.]]		[[Category: Spatzal, T]]
	[[Category: Femo-cofactor]]		[[Category: Femo-cofactor]]
	[[Category: Inhibition]]		[[Category: Inhibition]]
	~~[[Category: Nitrogenase]]~~
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 08:38, 20 October 2014

2014-10-20T08:38:56Z

← Older revision		Revision as of 08:38, 20 October 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4tkv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Azotobacter_vinelandii Azotobacter vinelandii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TKV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TKV FirstGlance]. <br>		<table><tr><td colspan='2'>[[4tkv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Azotobacter_vinelandii Azotobacter vinelandii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TKV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TKV FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CLF:FE(8)-S(7)+CLUSTER'>CLF</scene>, <scene name='pdbligand=CMO:CARBON+MONOXIDE'>CMO</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=HCA:3-HYDROXY-3-CARBOXY-ADIPIC+ACID'>HCA</scene>, <scene name='pdbligand=ICE:IRON-SULFUR-MOLYBDENUM+CLUSTER+WITH+INTERSTITIAL+CARBON'>ICE</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CLF:FE(8)-S(7)+CLUSTER'>CLF</scene>, <scene name='pdbligand=CMO:CARBON+MONOXIDE'>CMO</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=HCA:3-HYDROXY-3-CARBOXY-ADIPIC+ACID'>HCA</scene>, <scene name='pdbligand=ICE:IRON-SULFUR-MOLYBDENUM+CLUSTER+WITH+INTERSTITIAL+CARBON'>ICE</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m1n\|1m1n]], [[3u7q\|3u7q]], [[4tku\|4tku]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m1n\|1m1n]], [[3u7q\|3u7q]], [[4tku\|4tku]]</td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitrogenase Nitrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.18.6.1 1.18.6.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitrogenase Nitrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.18.6.1 1.18.6.1] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tkv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tkv RCSB], [http://www.ebi.ac.uk/pdbsum/4tkv PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tkv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tkv RCSB], [http://www.ebi.ac.uk/pdbsum/4tkv PDBsum]</span></td></tr>
	<table>		</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The mechanism of nitrogenase remains enigmatic, with a major unresolved issue concerning how inhibitors and substrates bind to the active site. We report a crystal structure of carbon monoxide (CO)-inhibited nitrogenase molybdenum-iron (MoFe)-protein at 1.50 angstrom resolution, which reveals a CO molecule bridging Fe2 and Fe6 of the FeMo-cofactor. The mu2 binding geometry is achieved by replacing a belt-sulfur atom (S2B) and highlights the generation of a reactive iron species uncovered by the displacement of sulfur. The CO inhibition is fully reversible as established by regain of enzyme activity and reappearance of S2B in the 1.43 angstrom resolution structure of the reactivated enzyme. The substantial and reversible reorganization of the FeMo-cofactor accompanying CO binding was unanticipated and provides insights into a catalytically competent state of nitrogenase.

			Ligand binding to the FeMo-cofactor: structures of CO-bound and reactivated nitrogenase.,Spatzal T, Perez KA, Einsle O, Howard JB, Rees DC Science. 2014 Sep 26;345(6204):1620-3. doi: 10.1126/science.1256679. PMID:25258081<ref>PMID:25258081</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 00:28, 2 October 2014

2014-10-02T00:28:14Z

← Older revision		Revision as of 00:28, 2 October 2014
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	'''~~Unreleased structure~~'''		==CO-bound Nitrogenase MoFe-protein from A. vinelandii==
			<StructureSection load='4tkv' size='340' side='right' caption='[[4tkv]], [[Resolution\|resolution]] 1.50Å' scene=''>
	~~The entry~~ 4tkv is ~~ON HOLD~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[4tkv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Azotobacter_vinelandii Azotobacter vinelandii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TKV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TKV FirstGlance]. <br>
	~~Authors~~: ~~Spatzal~~, T., ~~Perez~~, K., Einsle, O., Howard, J.B., Rees, D.C.		</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CLF:FE(8)-S(7)+CLUSTER'>CLF</scene>, <scene name='pdbligand=CMO:CARBON+MONOXIDE'>CMO</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=HCA:3-HYDROXY-3-CARBOXY-ADIPIC+ACID'>HCA</scene>, <scene name='pdbligand=ICE:IRON-SULFUR-MOLYBDENUM+CLUSTER+WITH+INTERSTITIAL+CARBON'>ICE</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m1n\|1m1n]], [[3u7q\|3u7q]], [[4tku\|4tku]]</td></tr>
	~~Description~~:		<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitrogenase Nitrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.18.6.1 1.18.6.1] </span></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tkv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tkv RCSB], [http://www.ebi.ac.uk/pdbsum/4tkv PDBsum]</span></td></tr>
			<table>
			__TOC__
			</StructureSection>
			[[Category: Azotobacter vinelandii]]
			[[Category: Nitrogenase]]
			[[Category: Einsle, O.]]
			[[Category: Howard, J B.]]
			[[Category: Perez, K.]]
			[[Category: Rees, D C.]]
			[[Category: Spatzal, T.]]
			[[Category: Femo-cofactor]]
			[[Category: Inhibition]]
			[[Category: Nitrogenase]]
			[[Category: Oxidoreductase]]

OCA at 01:17, 7 August 2014

2014-08-07T01:17:46Z

← Older revision		Revision as of 01:17, 7 August 2014
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4tkv is ON HOLD ~~until sometime in the future~~		The entry 4tkv is ON HOLD

	Authors: Spatzal, T., Perez, K., Einsle, O., Howard, J.B., Rees, D.C.		Authors: Spatzal, T., Perez, K., Einsle, O., Howard, J.B., Rees, D.C.

	Description:		Description:

OCA at 07:07, 30 July 2014

2014-07-30T07:07:44Z

← Older revision		Revision as of 07:07, 30 July 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4tkv is ON HOLD		The entry 4tkv is ON HOLD until sometime in the future

	Authors: Spatzal, T., Perez, K., Einsle, O., Howard, J.B., Rees, D.C.		Authors: Spatzal, T., Perez, K., Einsle, O., Howard, J.B., Rees, D.C.

	Description:		Description: