4tle - Revision history

OCA at 09:00, 20 March 2024

2024-03-20T09:00:26Z

← Older revision		Revision as of 09:00, 20 March 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4tle]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Synechococcus_elongatus_PCC_7942_=_FACHB-805 Synechococcus elongatus PCC 7942 = FACHB-805]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TLE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TLE FirstGlance]. <br>		<table><tr><td colspan='2'>[[4tle]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Synechococcus_elongatus_PCC_7942_=_FACHB-805 Synechococcus elongatus PCC 7942 = FACHB-805]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TLE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TLE FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.936Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4tle FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tle OCA], [https://pdbe.org/4tle PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4tle RCSB], [https://www.ebi.ac.uk/pdbsum/4tle PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4tle ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4tle FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tle OCA], [https://pdbe.org/4tle PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4tle RCSB], [https://www.ebi.ac.uk/pdbsum/4tle PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4tle ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/KAIC_SYNE7 KAIC_SYNE7] Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction.<ref>PMID:9727980</ref> <ref>PMID:14709675</ref>		[https://www.uniprot.org/uniprot/KAIC_SYNE7 KAIC_SYNE7] Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction.<ref>PMID:9727980</ref> <ref>PMID:14709675</ref>
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	Circadian clocks generate slow and ordered cellular dynamics, but consist of fast-moving bio-macromolecules; consequently, the origins of the overall slowness remain unclear. We identified the adenosine triphosphate catalytic region (ATPase) in the N-terminal half of the clock protein KaiC as the minimal pacemaker that controls the in vivo frequency of the cyanobacterial clock. Crystal structures of the ATPase revealed that the slowness of this ATPase arises from sequestration of a lytic water molecule in an unfavorable position and coupling of ATP hydrolysis to a peptide isomerization with high activation energy. The slow ATPase is coupled with another ATPase catalyzing autodephosphorylation in the C-terminal half of KaiC, yielding the circadian response frequency of intermolecular interactions with other clock-related proteins that influences the transcription and translation cycle.

	Atomic-scale origins of slowness in the cyanobacterial circadian clock.,Abe J, Hiyama TB, Mukaiyama A, Son S, Mori T, Saito S, Osako M, Wolanin J, Yamashita E, Kondo T, Akiyama S Science. 2015 Jun 25. pii: 1261040. PMID:26113637<ref>PMID:26113637</ref>

	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~<div class="pdbe-citations 4tle" style="background-color:#fffaf0;"></div>~~

	==See Also==		==See Also==

OCA at 10:45, 15 March 2023

2023-03-15T10:45:14Z

← Older revision		Revision as of 10:45, 15 March 2023
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	<StructureSection load='4tle' size='340' side='right'caption='[[4tle]], [[Resolution\|resolution]] 1.94Å' scene=''>		<StructureSection load='4tle' size='340' side='right'caption='[[4tle]], [[Resolution\|resolution]] 1.94Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4tle]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Anacystis_nidulans_r2 Anacystis nidulans r2~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TLE OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4TLE FirstGlance]. <br>		<table><tr><td colspan='2'>[[4tle]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Synechococcus_elongatus_PCC_7942_=_FACHB-805 Synechococcus elongatus PCC 7942 = FACHB-805]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TLE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TLE FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene~~></td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4tl6\|4tl6]], [[4tl7\|4tl7]], [[4tl8\|4tl8]], [[4tl9\|4tl9]], [[4tla\|4tla]], [[4tlb\|4tlb]], [[4tlc\|4tlc]], [[4tld\|4tld]]</td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4tle FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tle OCA], [https://pdbe.org/4tle PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4tle RCSB], [https://www.ebi.ac.uk/pdbsum/4tle PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4tle ProSAT]</span></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">kaiC, Synpcc7942_1216, see0011 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1140 Anacystis nidulans R2])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4tle FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tle OCA], [~~http~~://pdbe.org/4tle PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4tle RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4tle PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4tle ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/KAIC_SYNE7 KAIC_SYNE7]] Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction.<ref>PMID:9727980</ref> <ref>PMID:14709675</ref>		[https://www.uniprot.org/uniprot/KAIC_SYNE7 KAIC_SYNE7] Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction.<ref>PMID:9727980</ref> <ref>PMID:14709675</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Anacystis nidulans r2]]~~
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Non~~-~~specific serine/threonine protein kinase~~]]		[[Category: Synechococcus elongatus PCC 7942 = FACHB-805]]
	[[Category: Abe, J]]		[[Category: Abe J]]
	[[Category: Akiyama, S]]		[[Category: Akiyama S]]
	[[Category: Hiyama~~, T B~~]]		[[Category: Hiyama TB]]
	[[Category: Mukaiyama, A]]		[[Category: Mukaiyama A]]
	[[Category: Son, S]]		[[Category: Son S]]
	~~[[Category: Serine/threonine-protein kinase]]~~
	~~[[Category: Transferase~~]]

OCA at 15:55, 29 January 2020

2020-01-29T15:55:29Z

← Older revision		Revision as of 15:55, 29 January 2020
Line 23:		Line 23:

	==See Also==		==See Also==
	*[[Circadian clock protein\|Circadian clock protein]]		*[[Circadian clock protein 3D structures\|Circadian clock protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:57, 10 May 2019

2019-05-10T13:57:27Z

← Older revision		Revision as of 13:57, 10 May 2019
Line 1:		Line 1:

	==Crystal structure of N-terminal C1 domain of KaiC==		==Crystal structure of N-terminal C1 domain of KaiC==
	<StructureSection load='4tle' size='340' side='right' caption='[[4tle]], [[Resolution\|resolution]] 1.94Å' scene=''>		<StructureSection load='4tle' size='340' side='right'caption='[[4tle]], [[Resolution\|resolution]] 1.94Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4tle]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TLE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TLE FirstGlance]. <br>		<table><tr><td colspan='2'>[[4tle]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Anacystis_nidulans_r2 Anacystis nidulans r2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TLE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TLE FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4tl6\|4tl6]], [[4tl7\|4tl7]], [[4tl8\|4tl8]], [[4tl9\|4tl9]], [[4tla\|4tla]], [[4tlb\|4tlb]], [[4tlc\|4tlc]], [[4tld\|4tld]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4tl6\|4tl6]], [[4tl7\|4tl7]], [[4tl8\|4tl8]], [[4tl9\|4tl9]], [[4tla\|4tla]], [[4tlb\|4tlb]], [[4tlc\|4tlc]], [[4tld\|4tld]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">kaiC, Synpcc7942_1216, see0011 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1140 Anacystis nidulans R2])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tle FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tle OCA], [http://pdbe.org/4tle PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4tle RCSB], [http://www.ebi.ac.uk/pdbsum/4tle PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4tle ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tle FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tle OCA], [http://pdbe.org/4tle PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4tle RCSB], [http://www.ebi.ac.uk/pdbsum/4tle PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4tle ProSAT]</span></td></tr>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Anacystis nidulans r2]]
			[[Category: Large Structures]]
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]
	[[Category: Abe, J]]		[[Category: Abe, J]]

OCA at 13:28, 4 May 2017

2017-05-04T13:28:05Z

← Older revision		Revision as of 13:28, 4 May 2017
Line 1:		Line 1:

	==Crystal structure of N-terminal C1 domain of KaiC==		==Crystal structure of N-terminal C1 domain of KaiC==
	<StructureSection load='4tle' size='340' side='right' caption='[[4tle]], [[Resolution\|resolution]] 1.94Å' scene=''>		<StructureSection load='4tle' size='340' side='right' caption='[[4tle]], [[Resolution\|resolution]] 1.94Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4tl6\|4tl6]], [[4tl7\|4tl7]], [[4tl8\|4tl8]], [[4tl9\|4tl9]], [[4tla\|4tla]], [[4tlb\|4tlb]], [[4tlc\|4tlc]], [[4tld\|4tld]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4tl6\|4tl6]], [[4tl7\|4tl7]], [[4tl8\|4tl8]], [[4tl9\|4tl9]], [[4tla\|4tla]], [[4tlb\|4tlb]], [[4tlc\|4tlc]], [[4tld\|4tld]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tle FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tle OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tle RCSB], [http://www.ebi.ac.uk/pdbsum/4tle PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tle FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tle OCA], [http://pdbe.org/4tle PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4tle RCSB], [http://www.ebi.ac.uk/pdbsum/4tle PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4tle ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4tle" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Circadian clock protein\|Circadian clock protein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:06, 8 July 2015

2015-07-08T08:06:13Z

← Older revision		Revision as of 08:06, 8 July 2015
Line 10:		Line 10:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/KAIC_SYNE7 KAIC_SYNE7]] Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction.<ref>PMID:9727980</ref> <ref>PMID:14709675</ref>		[[http://www.uniprot.org/uniprot/KAIC_SYNE7 KAIC_SYNE7]] Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction.<ref>PMID:9727980</ref> <ref>PMID:14709675</ref>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Circadian clocks generate slow and ordered cellular dynamics, but consist of fast-moving bio-macromolecules; consequently, the origins of the overall slowness remain unclear. We identified the adenosine triphosphate catalytic region (ATPase) in the N-terminal half of the clock protein KaiC as the minimal pacemaker that controls the in vivo frequency of the cyanobacterial clock. Crystal structures of the ATPase revealed that the slowness of this ATPase arises from sequestration of a lytic water molecule in an unfavorable position and coupling of ATP hydrolysis to a peptide isomerization with high activation energy. The slow ATPase is coupled with another ATPase catalyzing autodephosphorylation in the C-terminal half of KaiC, yielding the circadian response frequency of intermolecular interactions with other clock-related proteins that influences the transcription and translation cycle.

			Atomic-scale origins of slowness in the cyanobacterial circadian clock.,Abe J, Hiyama TB, Mukaiyama A, Son S, Mori T, Saito S, Osako M, Wolanin J, Yamashita E, Kondo T, Akiyama S Science. 2015 Jun 25. pii: 1261040. PMID:26113637<ref>PMID:26113637</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:20, 1 July 2015

2015-07-01T12:20:38Z

← Older revision		Revision as of 12:20, 1 July 2015
Line 1:		Line 1:
	'''~~Unreleased structure~~'''		==Crystal structure of N-terminal C1 domain of KaiC==
			<StructureSection load='4tle' size='340' side='right' caption='[[4tle]], [[Resolution\|resolution]] 1.94Å' scene=''>
	~~The entry~~ 4tle is ~~ON HOLD until Paper Publication~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[4tle]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TLE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TLE FirstGlance]. <br>
	~~Authors~~: ~~Abe~~, J., ~~Akiyama~~, S.		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4tl6\|4tl6]], [[4tl7\|4tl7]], [[4tl8\|4tl8]], [[4tl9\|4tl9]], [[4tla\|4tla]], [[4tlb\|4tlb]], [[4tlc\|4tlc]], [[4tld\|4tld]]</td></tr>
	~~Description~~:		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
	[[Category: ~~Unreleased Structures~~]]		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tle FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tle OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tle RCSB], [http://www.ebi.ac.uk/pdbsum/4tle PDBsum]</span></td></tr>
			</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/KAIC_SYNE7 KAIC_SYNE7]] Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction.<ref>PMID:9727980</ref> <ref>PMID:14709675</ref>
			== References ==
			<references/>
			__TOC__
			</StructureSection>
			[[Category: Non-specific serine/threonine protein kinase]]
	[[Category: Abe, J]]		[[Category: Abe, J]]
	[[Category: Akiyama, S]]		[[Category: Akiyama, S]]
			[[Category: Hiyama, T B]]
			[[Category: Mukaiyama, A]]
			[[Category: Son, S]]
			[[Category: Serine/threonine-protein kinase]]
			[[Category: Transferase]]

OCA at 17:41, 24 December 2014

2014-12-24T17:41:28Z

← Older revision		Revision as of 17:41, 24 December 2014
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	Authors: Abe, J., Akiyama, S.		Authors: Abe, J., Akiyama, S.

	Description:		Description:
			[[Category: Unreleased Structures]]
			[[Category: Abe, J]]
			[[Category: Akiyama, S]]

OCA at 09:51, 16 July 2014

2014-07-16T09:51:43Z

← Older revision		Revision as of 09:51, 16 July 2014
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4tle is ON HOLD		The entry 4tle is ON HOLD until Paper Publication

	Authors: Abe, J., Akiyama, S.		Authors: Abe, J., Akiyama, S.

	Description:		Description:

OCA at 06:41, 18 June 2014

2014-06-18T06:41:42Z

← Older revision		Revision as of 06:41, 18 June 2014
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	The entry 4tle is ON HOLD		The entry 4tle is ON HOLD

	Authors: Abe, J.		Authors: Abe, J., Akiyama, S.

	Description:		Description: