4two - Revision history

OCA at 12:25, 20 December 2023

2023-12-20T12:25:24Z

← Older revision		Revision as of 12:25, 20 December 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4two]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TWO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TWO FirstGlance]. <br>		<table><tr><td colspan='2'>[[4two]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TWO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TWO FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=37W:5-{[3-CARBAMOYL-4-(3,4-DIMETHYLPHENYL)-5-METHYLTHIOPHEN-2-YL]AMINO}-5-OXOPENTANOIC+ACID'>37W</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.047Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=37W:5-{[3-CARBAMOYL-4-(3,4-DIMETHYLPHENYL)-5-METHYLTHIOPHEN-2-YL]AMINO}-5-OXOPENTANOIC+ACID'>37W</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4two FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4two OCA], [https://pdbe.org/4two PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4two RCSB], [https://www.ebi.ac.uk/pdbsum/4two PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4two ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4two FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4two OCA], [https://pdbe.org/4two PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4two RCSB], [https://www.ebi.ac.uk/pdbsum/4two PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4two ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:49, 22 March 2023

2023-03-22T07:49:45Z

← Older revision		Revision as of 07:49, 22 March 2023
Line 3:		Line 3:
	<StructureSection load='4two' size='340' side='right'caption='[[4two]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='4two' size='340' side='right'caption='[[4two]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4two]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TWO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4TWO FirstGlance]. <br>		<table><tr><td colspan='2'>[[4two]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TWO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TWO FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=37W:5-{[3-CARBAMOYL-4-(3,4-DIMETHYLPHENYL)-5-METHYLTHIOPHEN-2-YL]AMINO}-5-OXOPENTANOIC+ACID'>37W</scene~~></td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=37W:5-{[3-CARBAMOYL-4-(3,4-DIMETHYLPHENYL)-5-METHYLTHIOPHEN-2-YL]AMINO}-5-OXOPENTANOIC+ACID'>37W</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EPHA3, ETK, ETK1, HEK, TYRO4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4two FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4two OCA], [https://pdbe.org/4two PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4two RCSB], [https://www.ebi.ac.uk/pdbsum/4two PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4two ProSAT]</span></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4two FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4two OCA], [~~http~~://pdbe.org/4two PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4two RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4two PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4two ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[~~[http~~://www.uniprot.org/uniprot/EPHA3_HUMAN EPHA3_HUMAN]] Defects in EPHA3 may be a cause of colorectal cancer (CRC) [MIM:[~~http~~://omim.org/entry/114500 114500]].		[https://www.uniprot.org/uniprot/EPHA3_HUMAN EPHA3_HUMAN] Defects in EPHA3 may be a cause of colorectal cancer (CRC) [MIM:[https://omim.org/entry/114500 114500].
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/EPHA3_HUMAN EPHA3_HUMAN]] Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development.<ref>PMID:11870224</ref>		[https://www.uniprot.org/uniprot/EPHA3_HUMAN EPHA3_HUMAN] Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development.<ref>PMID:11870224</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	==See Also==		==See Also==
	*[[Ephrin receptor\|Ephrin receptor]]		*[[Ephrin receptor 3D structures\|Ephrin receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	~~[[Category: Receptor protein-tyrosine kinase]]~~		[[Category: Caflisch A]]
	[[Category: Caflisch, A]]		[[Category: Dong J]]
	[[Category: Dong, J]]
	~~[[Category: Transferase]]~~
	~~[[Category: Transferase/transferase inhibitor~~]]

OCA at 14:08, 10 May 2019

2019-05-10T14:08:07Z

← Older revision		Revision as of 14:08, 10 May 2019
Line 1:		Line 1:

	==Human EphA3 Kinase domain in complex with compound 164==		==Human EphA3 Kinase domain in complex with compound 164==
	<StructureSection load='4two' size='340' side='right' caption='[[4two]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='4two' size='340' side='right'caption='[[4two]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4two]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TWO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TWO FirstGlance]. <br>		<table><tr><td colspan='2'>[[4two]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TWO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TWO FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=37W:5-{[3-CARBAMOYL-4-(3,4-DIMETHYLPHENYL)-5-METHYLTHIOPHEN-2-YL]AMINO}-5-OXOPENTANOIC+ACID'>37W</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=37W:5-{[3-CARBAMOYL-4-(3,4-DIMETHYLPHENYL)-5-METHYLTHIOPHEN-2-YL]AMINO}-5-OXOPENTANOIC+ACID'>37W</scene></td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EPHA3, ETK, ETK1, HEK, TYRO4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4two FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4two OCA], [http://pdbe.org/4two PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4two RCSB], [http://www.ebi.ac.uk/pdbsum/4two PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4two ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4two FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4two OCA], [http://pdbe.org/4two PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4two RCSB], [http://www.ebi.ac.uk/pdbsum/4two PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4two ProSAT]</span></td></tr>
Line 21:		Line 22:
	</div>		</div>
	<div class="pdbe-citations 4two" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4two" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Ephrin receptor\|Ephrin receptor]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Receptor protein-tyrosine kinase]]		[[Category: Receptor protein-tyrosine kinase]]
	[[Category: Caflisch, A]]		[[Category: Caflisch, A]]

OCA at 01:50, 10 March 2017

2017-03-10T01:50:51Z

← Older revision		Revision as of 01:50, 10 March 2017
Line 1:		Line 1:

	==Human EphA3 Kinase domain in complex with compound 164==		==Human EphA3 Kinase domain in complex with compound 164==
	<StructureSection load='4two' size='340' side='right' caption='[[4two]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='4two' size='340' side='right' caption='[[4two]], [[Resolution\|resolution]] 2.05Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=37W:5-{[3-CARBAMOYL-4-(3,4-DIMETHYLPHENYL)-5-METHYLTHIOPHEN-2-YL]AMINO}-5-OXOPENTANOIC+ACID'>37W</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=37W:5-{[3-CARBAMOYL-4-(3,4-DIMETHYLPHENYL)-5-METHYLTHIOPHEN-2-YL]AMINO}-5-OXOPENTANOIC+ACID'>37W</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4two FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4two OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4two RCSB], [http://www.ebi.ac.uk/pdbsum/4two PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4two FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4two OCA], [http://pdbe.org/4two PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4two RCSB], [http://www.ebi.ac.uk/pdbsum/4two PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4two ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4two" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:18, 13 May 2015

2015-05-13T12:18:02Z

← Older revision		Revision as of 12:18, 13 May 2015
Line 1:		Line 1:
	'''~~Unreleased~~ structure'''		==Human EphA3 Kinase domain in complex with compound 164==
			<StructureSection load='4two' size='340' side='right' caption='[[4two]], [[Resolution\|resolution]] 2.05Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[4two]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TWO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TWO FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=37W:5-{[3-CARBAMOYL-4-(3,4-DIMETHYLPHENYL)-5-METHYLTHIOPHEN-2-YL]AMINO}-5-OXOPENTANOIC+ACID'>37W</scene></td></tr>
			<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4two FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4two OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4two RCSB], [http://www.ebi.ac.uk/pdbsum/4two PDBsum]</span></td></tr>
			</table>
			== Disease ==
			[[http://www.uniprot.org/uniprot/EPHA3_HUMAN EPHA3_HUMAN]] Defects in EPHA3 may be a cause of colorectal cancer (CRC) [MIM:[http://omim.org/entry/114500 114500]].
			== Function ==
			[[http://www.uniprot.org/uniprot/EPHA3_HUMAN EPHA3_HUMAN]] Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development.<ref>PMID:11870224</ref>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			We have solved the crystal structures of the EphA3 tyrosine kinase in complex with nine small-molecule inhibitors, which represent five different chemotypes and three main binding modes, i.e., types I and I1/2 (DFG in) and type II (DFG out). The three structures with type I1/2 inhibitors show that the higher affinity with respect to type I is due to an additional polar group (hydroxyl or pyrazole ring of indazole) which is fully buried and is involved in the same hydrogen bonds as the (urea or amide) linker of the type II inhibitors. Overall, the type I and type II binding modes belong to the lock-and-key and induced fit mechanism, respectively. In the type II binding, the scaffold in contact with the hinge region influences the position of the Phe765 side chain of the DFG motif and the orientation of the Gly-rich loop. The binding mode of Birb796 in the EphA3 kinase does not involve any hydrogen bond with the hinge region, which is different from the Birb796/p38 MAP kinase complex. Our structural analysis emphasizes the importance of accounting for structural plasticity of the ATP binding site in the design of type II inhibitors of tyrosine kinases.

	~~The entry 4two is ON HOLD until Paper Publication~~		Structural Analysis of the Binding of Type I, I1/2, and II Inhibitors to Eph Tyrosine Kinases.,Dong J, Zhao H, Zhou T, Spiliotopoulos D, Rajendran C, Li XD, Huang D, Caflisch A ACS Med Chem Lett. 2014 Sep 29;6(1):79-83. doi: 10.1021/ml500355x. eCollection, 2015 Jan 8. PMID:25589935<ref>PMID:25589935</ref>

	~~Authors: Dong~~, J.~~, Caflisch, A~~.		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~Description~~: ~~Human EphA3 Kinase domain in complex with compound 164~~		== References ==
	[[Category: ~~Unreleased Structures~~]]		<references/>
			__TOC__
			</StructureSection>
			[[Category: Receptor protein-tyrosine kinase]]
			[[Category: Caflisch, A]]
	[[Category: Dong, J]]		[[Category: Dong, J]]
	[[Category: ~~Caflisch, A~~]]		[[Category: Transferase]]
			[[Category: Transferase/transferase inhibitor]]

OCA at 17:55, 24 December 2014

2014-12-24T17:55:06Z

← Older revision		Revision as of 17:55, 24 December 2014
Line 6:		Line 6:

	Description: Human EphA3 Kinase domain in complex with compound 164		Description: Human EphA3 Kinase domain in complex with compound 164
			[[Category: Unreleased Structures]]
			[[Category: Dong, J]]
			[[Category: Caflisch, A]]

OCA at 07:21, 23 July 2014

2014-07-23T07:21:34Z

← Older revision		Revision as of 07:21, 23 July 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4two is ON HOLD		The entry 4two is ON HOLD until Paper Publication

	Authors: Dong, J., Caflisch, A.		Authors: Dong, J., Caflisch, A.

	Description: Human EphA3 Kinase domain in complex with compound 164		Description: Human EphA3 Kinase domain in complex with compound 164

OCA: Protected "4two" [edit=sysop:move=sysop]

2014-07-09T07:00:27Z

Protected "4two" [edit=sysop:move=sysop]

← Older revision	Revision as of 07:00, 9 July 2014
(No difference)

OCA: New page: '''Unreleased structure''' The entry 4two is ON HOLD Authors: Dong, J., Caflisch, A. Description: Human EphA3 Kinase domain in complex with compound 164

2014-07-09T07:00:26Z

New page: '''Unreleased structure''' The entry 4two is ON HOLD Authors: Dong, J., Caflisch, A. Description: Human EphA3 Kinase domain in complex with compound 164

New page

'''Unreleased structure'''

The entry 4two is ON HOLD

Authors: Dong, J., Caflisch, A.

Description: Human EphA3 Kinase domain in complex with compound 164