4ugg - Revision history

OCA at 12:30, 20 December 2023

2023-12-20T12:30:08Z

← Older revision		Revision as of 12:30, 20 December 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ugg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis_subsp._subtilis_str._168 Bacillus subtilis subsp. subtilis str. 168]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UGG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UGG FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ugg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis_subsp._subtilis_str._168 Bacillus subtilis subsp. subtilis str. 168]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UGG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UGG FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=S5D:(R)-6-(2-AMINO-2-(3-(2-(6-AMINO-4-METHYLPYRIDIN-2-YL)ETHYL)PHENYL)ETHYL)-4-METHYLPYRIDIN-2-AMINE'>S5D</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.356Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=S5D:(R)-6-(2-AMINO-2-(3-(2-(6-AMINO-4-METHYLPYRIDIN-2-YL)ETHYL)PHENYL)ETHYL)-4-METHYLPYRIDIN-2-AMINE'>S5D</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ugg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ugg OCA], [https://pdbe.org/4ugg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ugg RCSB], [https://www.ebi.ac.uk/pdbsum/4ugg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ugg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ugg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ugg OCA], [https://pdbe.org/4ugg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ugg RCSB], [https://www.ebi.ac.uk/pdbsum/4ugg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ugg ProSAT]</span></td></tr>
	</table>		</table>

OCA at 08:23, 22 March 2023

2023-03-22T08:23:19Z

← Older revision		Revision as of 08:23, 22 March 2023
Line 3:		Line 3:
	<StructureSection load='4ugg' size='340' side='right'caption='[[4ugg]], [[Resolution\|resolution]] 2.36Å' scene=''>		<StructureSection load='4ugg' size='340' side='right'caption='[[4ugg]], [[Resolution\|resolution]] 2.36Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ugg]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Bacsu Bacsu~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UGG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=4UGG FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ugg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis_subsp._subtilis_str._168 Bacillus subtilis subsp. subtilis str. 168]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UGG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UGG FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=S5D:(R)-6-(2-AMINO-2-(3-(2-(6-AMINO-4-METHYLPYRIDIN-2-YL)ETHYL)PHENYL)ETHYL)-4-METHYLPYRIDIN-2-AMINE'>S5D</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=S5D:(R)-6-(2-AMINO-2-(3-(2-(6-AMINO-4-METHYLPYRIDIN-2-YL)ETHYL)PHENYL)ETHYL)-4-METHYLPYRIDIN-2-AMINE'>S5D</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ug5\|4ug5]], [[4ug6\|4ug6]], [[4ug7\|4ug7]], [[4ug8\|4ug8]], [[4ug9\|4ug9]], [[4uga\|4uga]], [[4ugb\|4ugb]], [[4ugc\|4ugc]], [[4ugd\|4ugd]], [[4uge\|4uge]], [[4ugf\|4ugf]], [[4ugh\|4ugh]], [[4ugi\|4ugi]], [[4ugj\|4ugj]], [[4ugk\|4ugk]], [[4ugl\|4ugl]], [[4ugm\|4ugm]], [[4ugn\|4ugn]], [[4ugo\|4ugo]], [[4ugp\|4ugp]], [[4ugq\|4ugq]], [[4ugr\|4ugr]], [[4ugs\|4ugs]], [[4ugt\|4ugt]], [[4ugu\|4ugu]], [[4ugv\|4ugv]], [[4ugw\|4ugw]], [[4ugx\|4ugx]], [[4ugy\|4ugy]]</td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ugg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ugg OCA], [https://pdbe.org/4ugg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ugg RCSB], [https://www.ebi.ac.uk/pdbsum/4ugg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ugg ProSAT]</span></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NAD(P)H-dependent) Nitric-oxide synthase (NAD(P)H-dependent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.165 1.14.13.165] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=4ugg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ugg OCA], [~~http~~://pdbe.org/4ugg PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4ugg RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4ugg PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4ugg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/NOSO_BACSU NOSO_BACSU]] Catalyzes the production of nitric oxide.		[https://www.uniprot.org/uniprot/NOSO_BACSU NOSO_BACSU] Catalyzes the production of nitric oxide.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Bacsu~~]]		[[Category: Bacillus subtilis subsp. subtilis str. 168]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Holden~~, J K~~]]		[[Category: Holden JK]]
	[[Category: Poulos~~, T L]]~~		[[Category: Poulos TL]]
	~~[[Category: Inhibitor]]~~
	~~[[Category: Nitric oxide synthase]]~~
	~~[[Category: Oxidoreductase~~]]

OCA at 08:20, 4 November 2020

2020-11-04T08:20:49Z

← Older revision		Revision as of 08:20, 4 November 2020
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	==Structure of Bacillus subtilis Nitric Oxide Synthase in complex with (R)-6-(2-Amino-2-(3-(2-(6-amino-4-methylpyridin-2-yl)ethyl)phenyl) ethyl)-4-methylpyridin-2-amine==		==Structure of Bacillus subtilis Nitric Oxide Synthase in complex with (R)-6-(2-Amino-2-(3-(2-(6-amino-4-methylpyridin-2-yl)ethyl)phenyl) ethyl)-4-methylpyridin-2-amine==
	<StructureSection load='4ugg' size='340' side='right' caption='[[4ugg]], [[Resolution\|resolution]] 2.36Å' scene=''>		<StructureSection load='4ugg' size='340' side='right'caption='[[4ugg]], [[Resolution\|resolution]] 2.36Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ugg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacsu Bacsu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UGG OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4UGG FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ugg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacsu Bacsu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UGG OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=4UGG FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=S5D:(R)-6-(2-AMINO-2-(3-(2-(6-AMINO-4-METHYLPYRIDIN-2-YL)ETHYL)PHENYL)ETHYL)-4-METHYLPYRIDIN-2-AMINE'>S5D</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=S5D:(R)-6-(2-AMINO-2-(3-(2-(6-AMINO-4-METHYLPYRIDIN-2-YL)ETHYL)PHENYL)ETHYL)-4-METHYLPYRIDIN-2-AMINE'>S5D</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ug5\|4ug5]], [[4ug6\|4ug6]], [[4ug7\|4ug7]], [[4ug8\|4ug8]], [[4ug9\|4ug9]], [[4uga\|4uga]], [[4ugb\|4ugb]], [[4ugc\|4ugc]], [[4ugd\|4ugd]], [[4uge\|4uge]], [[4ugf\|4ugf]], [[4ugh\|4ugh]], [[4ugi\|4ugi]], [[4ugj\|4ugj]], [[4ugk\|4ugk]], [[4ugl\|4ugl]], [[4ugm\|4ugm]], [[4ugn\|4ugn]], [[4ugo\|4ugo]], [[4ugp\|4ugp]], [[4ugq\|4ugq]], [[4ugr\|4ugr]], [[4ugs\|4ugs]], [[4ugt\|4ugt]], [[4ugu\|4ugu]], [[4ugv\|4ugv]], [[4ugw\|4ugw]], [[4ugx\|4ugx]], [[4ugy\|4ugy]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ug5\|4ug5]], [[4ug6\|4ug6]], [[4ug7\|4ug7]], [[4ug8\|4ug8]], [[4ug9\|4ug9]], [[4uga\|4uga]], [[4ugb\|4ugb]], [[4ugc\|4ugc]], [[4ugd\|4ugd]], [[4uge\|4uge]], [[4ugf\|4ugf]], [[4ugh\|4ugh]], [[4ugi\|4ugi]], [[4ugj\|4ugj]], [[4ugk\|4ugk]], [[4ugl\|4ugl]], [[4ugm\|4ugm]], [[4ugn\|4ugn]], [[4ugo\|4ugo]], [[4ugp\|4ugp]], [[4ugq\|4ugq]], [[4ugr\|4ugr]], [[4ugs\|4ugs]], [[4ugt\|4ugt]], [[4ugu\|4ugu]], [[4ugv\|4ugv]], [[4ugw\|4ugw]], [[4ugx\|4ugx]], [[4ugy\|4ugy]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NAD(P)H-dependent) Nitric-oxide synthase (NAD(P)H-dependent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.165 1.14.13.165] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NAD(P)H-dependent) Nitric-oxide synthase (NAD(P)H-dependent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.165 1.14.13.165] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ugg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ugg OCA], [http://pdbe.org/4ugg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ugg RCSB], [http://www.ebi.ac.uk/pdbsum/4ugg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ugg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=4ugg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ugg OCA], [http://pdbe.org/4ugg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ugg RCSB], [http://www.ebi.ac.uk/pdbsum/4ugg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ugg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	==See Also==		==See Also==
	*[[Nitric Oxide Synthase\|Nitric Oxide Synthase]]		*[[Nitric Oxide Synthase 3D structures\|Nitric Oxide Synthase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Bacsu]]		[[Category: Bacsu]]
			[[Category: Large Structures]]
	[[Category: Holden, J K]]		[[Category: Holden, J K]]
	[[Category: Poulos, T L]]		[[Category: Poulos, T L]]

OCA at 09:13, 30 January 2019

2019-01-30T09:13:31Z

← Older revision		Revision as of 09:13, 30 January 2019
Line 3:		Line 3:
	<StructureSection load='4ugg' size='340' side='right' caption='[[4ugg]], [[Resolution\|resolution]] 2.36Å' scene=''>		<StructureSection load='4ugg' size='340' side='right' caption='[[4ugg]], [[Resolution\|resolution]] 2.36Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ugg]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UGG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UGG FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ugg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacsu Bacsu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UGG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UGG FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=S5D:(R)-6-(2-AMINO-2-(3-(2-(6-AMINO-4-METHYLPYRIDIN-2-YL)ETHYL)PHENYL)ETHYL)-4-METHYLPYRIDIN-2-AMINE'>S5D</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=S5D:(R)-6-(2-AMINO-2-(3-(2-(6-AMINO-4-METHYLPYRIDIN-2-YL)ETHYL)PHENYL)ETHYL)-4-METHYLPYRIDIN-2-AMINE'>S5D</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ug5\|4ug5]], [[4ug6\|4ug6]], [[4ug7\|4ug7]], [[4ug8\|4ug8]], [[4ug9\|4ug9]], [[4uga\|4uga]], [[4ugb\|4ugb]], [[4ugc\|4ugc]], [[4ugd\|4ugd]], [[4uge\|4uge]], [[4ugf\|4ugf]], [[4ugh\|4ugh]], [[4ugi\|4ugi]], [[4ugj\|4ugj]], [[4ugk\|4ugk]], [[4ugl\|4ugl]], [[4ugm\|4ugm]], [[4ugn\|4ugn]], [[4ugo\|4ugo]], [[4ugp\|4ugp]], [[4ugq\|4ugq]], [[4ugr\|4ugr]], [[4ugs\|4ugs]], [[4ugt\|4ugt]], [[4ugu\|4ugu]], [[4ugv\|4ugv]], [[4ugw\|4ugw]], [[4ugx\|4ugx]], [[4ugy\|4ugy]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ug5\|4ug5]], [[4ug6\|4ug6]], [[4ug7\|4ug7]], [[4ug8\|4ug8]], [[4ug9\|4ug9]], [[4uga\|4uga]], [[4ugb\|4ugb]], [[4ugc\|4ugc]], [[4ugd\|4ugd]], [[4uge\|4uge]], [[4ugf\|4ugf]], [[4ugh\|4ugh]], [[4ugi\|4ugi]], [[4ugj\|4ugj]], [[4ugk\|4ugk]], [[4ugl\|4ugl]], [[4ugm\|4ugm]], [[4ugn\|4ugn]], [[4ugo\|4ugo]], [[4ugp\|4ugp]], [[4ugq\|4ugq]], [[4ugr\|4ugr]], [[4ugs\|4ugs]], [[4ugt\|4ugt]], [[4ugu\|4ugu]], [[4ugv\|4ugv]], [[4ugw\|4ugw]], [[4ugx\|4ugx]], [[4ugy\|4ugy]]</td></tr>
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	</div>		</div>
	<div class="pdbe-citations 4ugg" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4ugg" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Nitric Oxide Synthase\|Nitric Oxide Synthase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Bacsu]]
	[[Category: Holden, J K]]		[[Category: Holden, J K]]
	[[Category: Poulos, T L]]		[[Category: Poulos, T L]]

OCA at 14:20, 27 April 2017

2017-04-27T14:20:58Z

← Older revision		Revision as of 14:20, 27 April 2017
Line 1:		Line 1:

	==Structure of Bacillus subtilis Nitric Oxide Synthase in complex with (R)-6-(2-Amino-2-(3-(2-(6-amino-4-methylpyridin-2-yl)ethyl)phenyl) ethyl)-4-methylpyridin-2-amine==		==Structure of Bacillus subtilis Nitric Oxide Synthase in complex with (R)-6-(2-Amino-2-(3-(2-(6-amino-4-methylpyridin-2-yl)ethyl)phenyl) ethyl)-4-methylpyridin-2-amine==
	<StructureSection load='4ugg' size='340' side='right' caption='[[4ugg]], [[Resolution\|resolution]] 2.36Å' scene=''>		<StructureSection load='4ugg' size='340' side='right' caption='[[4ugg]], [[Resolution\|resolution]] 2.36Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ug5\|4ug5]], [[4ug6\|4ug6]], [[4ug7\|4ug7]], [[4ug8\|4ug8]], [[4ug9\|4ug9]], [[4uga\|4uga]], [[4ugb\|4ugb]], [[4ugc\|4ugc]], [[4ugd\|4ugd]], [[4uge\|4uge]], [[4ugf\|4ugf]], [[4ugh\|4ugh]], [[4ugi\|4ugi]], [[4ugj\|4ugj]], [[4ugk\|4ugk]], [[4ugl\|4ugl]], [[4ugm\|4ugm]], [[4ugn\|4ugn]], [[4ugo\|4ugo]], [[4ugp\|4ugp]], [[4ugq\|4ugq]], [[4ugr\|4ugr]], [[4ugs\|4ugs]], [[4ugt\|4ugt]], [[4ugu\|4ugu]], [[4ugv\|4ugv]], [[4ugw\|4ugw]], [[4ugx\|4ugx]], [[4ugy\|4ugy]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ug5\|4ug5]], [[4ug6\|4ug6]], [[4ug7\|4ug7]], [[4ug8\|4ug8]], [[4ug9\|4ug9]], [[4uga\|4uga]], [[4ugb\|4ugb]], [[4ugc\|4ugc]], [[4ugd\|4ugd]], [[4uge\|4uge]], [[4ugf\|4ugf]], [[4ugh\|4ugh]], [[4ugi\|4ugi]], [[4ugj\|4ugj]], [[4ugk\|4ugk]], [[4ugl\|4ugl]], [[4ugm\|4ugm]], [[4ugn\|4ugn]], [[4ugo\|4ugo]], [[4ugp\|4ugp]], [[4ugq\|4ugq]], [[4ugr\|4ugr]], [[4ugs\|4ugs]], [[4ugt\|4ugt]], [[4ugu\|4ugu]], [[4ugv\|4ugv]], [[4ugw\|4ugw]], [[4ugx\|4ugx]], [[4ugy\|4ugy]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NAD(P)H-dependent) Nitric-oxide synthase (NAD(P)H-dependent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.165 1.14.13.165] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NAD(P)H-dependent) Nitric-oxide synthase (NAD(P)H-dependent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.165 1.14.13.165] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ugg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ugg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ugg RCSB], [http://www.ebi.ac.uk/pdbsum/4ugg PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ugg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ugg OCA], [http://pdbe.org/4ugg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ugg RCSB], [http://www.ebi.ac.uk/pdbsum/4ugg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ugg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4ugg" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:55, 24 June 2015

2015-06-24T12:55:21Z

← Older revision		Revision as of 12:55, 24 June 2015
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	'''~~Unreleased~~ structure'''		==Structure of Bacillus subtilis Nitric Oxide Synthase in complex with (R)-6-(2-Amino-2-(3-(2-(6-amino-4-methylpyridin-2-yl)ethyl)phenyl) ethyl)-4-methylpyridin-2-amine==
			<StructureSection load='4ugg' size='340' side='right' caption='[[4ugg]], [[Resolution\|resolution]] 2.36Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[4ugg]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UGG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UGG FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=S5D:(R)-6-(2-AMINO-2-(3-(2-(6-AMINO-4-METHYLPYRIDIN-2-YL)ETHYL)PHENYL)ETHYL)-4-METHYLPYRIDIN-2-AMINE'>S5D</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ug5\|4ug5]], [[4ug6\|4ug6]], [[4ug7\|4ug7]], [[4ug8\|4ug8]], [[4ug9\|4ug9]], [[4uga\|4uga]], [[4ugb\|4ugb]], [[4ugc\|4ugc]], [[4ugd\|4ugd]], [[4uge\|4uge]], [[4ugf\|4ugf]], [[4ugh\|4ugh]], [[4ugi\|4ugi]], [[4ugj\|4ugj]], [[4ugk\|4ugk]], [[4ugl\|4ugl]], [[4ugm\|4ugm]], [[4ugn\|4ugn]], [[4ugo\|4ugo]], [[4ugp\|4ugp]], [[4ugq\|4ugq]], [[4ugr\|4ugr]], [[4ugs\|4ugs]], [[4ugt\|4ugt]], [[4ugu\|4ugu]], [[4ugv\|4ugv]], [[4ugw\|4ugw]], [[4ugx\|4ugx]], [[4ugy\|4ugy]]</td></tr>
			<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NAD(P)H-dependent) Nitric-oxide synthase (NAD(P)H-dependent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.165 1.14.13.165] </span></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ugg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ugg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ugg RCSB], [http://www.ebi.ac.uk/pdbsum/4ugg PDBsum]</span></td></tr>
			</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/NOSO_BACSU NOSO_BACSU]] Catalyzes the production of nitric oxide.
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Nitric oxide generated by bacterial nitric oxide synthase (NOS) increases the susceptibility of Gram-positive pathogens Staphylococcus aureus and Bacillus anthracis to oxidative stress, including antibiotic-induced oxidative stress. Not surprisingly, NOS inhibitors also improve the effectiveness of antimicrobials. Development of potent and selective bacterial NOS inhibitors is complicated by the high active site sequence and structural conservation shared with the mammalian NOS isoforms. To exploit bacterial NOS for the development of new therapeutics, recognition of alternative NOS surfaces and pharmacophores suitable for drug binding is required. Here, we report on a wide number of inhibitor-bound bacterial NOS crystal structures to identify several compounds that interact with surfaces unique to the bacterial NOS. Although binding studies indicate that these inhibitors weakly interact with the NOS active site, many of the inhibitors reported here provide a revised structural framework for the development of new antimicrobials that target bacterial NOS. In addition, mutagenesis studies reveal several key residues that unlock access to bacterial NOS surfaces that could provide the selectivity required to develop potent bacterial NOS inhibitors.

	~~The entry 4ugg is ON HOLD until Paper Publication~~		Inhibitor Bound Crystal Structures of Bacterial Nitric Oxide Synthase.,Holden JK, Dejam D, Lewis MC, Huang H, Kang S, Jing Q, Xue F, Silverman RB, Poulos TL Biochemistry. 2015 Jun 23. PMID:26062720<ref>PMID:26062720</ref>

	~~Authors: Holden~~, J.K.~~, Poulos, T.L~~.		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~Description: Structure of Bacillus subtilis Nitric Oxide Synthase in complex with ( R)-6-(2-Amino-2-(3-(2-(6-amino-4-methylpyridin-2-yl)ethyl)phenyl) ethyl)-4-methylpyridin-2-amine~~		== References ==
	[[Category: ~~Unreleased Structures~~]]		<references/>
	[[Category: Poulos, T.L]]		__TOC__
	[[Category: ~~Holden, J.K~~]]		</StructureSection>
			[[Category: Holden, J K]]
			[[Category: Poulos, T L]]
			[[Category: Inhibitor]]
			[[Category: Nitric oxide synthase]]
			[[Category: Oxidoreductase]]

OCA at 10:38, 17 June 2015

2015-06-17T10:38:50Z

← Older revision		Revision as of 10:38, 17 June 2015
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4ugg is ON HOLD		The entry 4ugg is ON HOLD until Paper Publication

	Authors: Holden, J.K., Poulos, T.L.		Authors: Holden, J.K., Poulos, T.L.

OCA: Protected "4ugg" [edit=sysop:move=sysop]

2015-04-01T09:42:18Z

Protected "4ugg" [edit=sysop:move=sysop]

← Older revision	Revision as of 09:42, 1 April 2015
(No difference)

OCA: New page: '''Unreleased structure''' The entry 4ugg is ON HOLD Authors: Holden, J.K., Poulos, T.L. Description: Structure of Bacillus subtilis Nitric Oxide Synthase in complex with ( R)-6-(2-Ami...

2015-04-01T09:42:16Z

New page: '''Unreleased structure''' The entry 4ugg is ON HOLD Authors: Holden, J.K., Poulos, T.L. Description: Structure of Bacillus subtilis Nitric Oxide Synthase in complex with ( R)-6-(2-Ami...

New page

'''Unreleased structure'''

The entry 4ugg is ON HOLD

Authors: Holden, J.K., Poulos, T.L.

Description: Structure of Bacillus subtilis Nitric Oxide Synthase in complex with ( R)-6-(2-Amino-2-(3-(2-(6-amino-4-methylpyridin-2-yl)ethyl)phenyl) ethyl)-4-methylpyridin-2-amine
[[Category: Unreleased Structures]]
[[Category: Poulos, T.L]]
[[Category: Holden, J.K]]