4uvb - Revision history

OCA at 10:37, 10 January 2024

2024-01-10T10:37:03Z

← Older revision		Revision as of 10:37, 10 January 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4uvb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UVB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UVB FirstGlance]. <br>		<table><tr><td colspan='2'>[[4uvb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UVB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UVB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D51:[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL+(2R,3S,4S)-5-[(1R,3S,3AS,7AS)-1-AMINO-1,10,11-TRIMETHYL-4,6-DIOXO-3-PHENYL-2,3,5,6,7,7A-HEXAHYDRO-1H-BENZO[G]PYRROLO[2,1-E]PTERIDIN-8(4H)-YL]-2,3,4-TRIHYDROXYPENTYL+DIHYDROGEN+DIPHOSPHATE'>D51</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D51:[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL+(2R,3S,4S)-5-[(1R,3S,3AS,7AS)-1-AMINO-1,10,11-TRIMETHYL-4,6-DIOXO-3-PHENYL-2,3,5,6,7,7A-HEXAHYDRO-1H-BENZO[G]PYRROLO[2,1-E]PTERIDIN-8(4H)-YL]-2,3,4-TRIHYDROXYPENTYL+DIHYDROGEN+DIPHOSPHATE'>D51</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uvb OCA], [https://pdbe.org/4uvb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uvb RCSB], [https://www.ebi.ac.uk/pdbsum/4uvb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uvb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uvb OCA], [https://pdbe.org/4uvb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uvb RCSB], [https://www.ebi.ac.uk/pdbsum/4uvb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uvb ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:41, 29 March 2023

2023-03-29T07:41:57Z

← Older revision		Revision as of 07:41, 29 March 2023
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	<StructureSection load='4uvb' size='340' side='right'caption='[[4uvb]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='4uvb' size='340' side='right'caption='[[4uvb]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4uvb]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UVB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4UVB FirstGlance]. <br>		<table><tr><td colspan='2'>[[4uvb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UVB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UVB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=D51:[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL+(2R,3S,4S)-5-[(1R,3S,3AS,7AS)-1-AMINO-1,10,11-TRIMETHYL-4,6-DIOXO-3-PHENYL-2,3,5,6,7,7A-HEXAHYDRO-1H-BENZO[G]PYRROLO[2,1-E]PTERIDIN-8(4H)-YL]-2,3,4-TRIHYDROXYPENTYL+DIHYDROGEN+DIPHOSPHATE'>D51</scene>~~</td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D51:[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL+(2R,3S,4S)-5-[(1R,3S,3AS,7AS)-1-AMINO-1,10,11-TRIMETHYL-4,6-DIOXO-3-PHENYL-2,3,5,6,7,7A-HEXAHYDRO-1H-BENZO[G]PYRROLO[2,1-E]PTERIDIN-8(4H)-YL]-2,3,4-TRIHYDROXYPENTYL+DIHYDROGEN+DIPHOSPHATE'>D51</scene></td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uv8\|4uv8]], [[4uv9\|4uv9]], [[4uva\|4uva]], [[4uvc\|4uvc]]~~</td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uvb OCA], [https://pdbe.org/4uvb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uvb RCSB], [https://www.ebi.ac.uk/pdbsum/4uvb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uvb ProSAT]</span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4uvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uvb OCA], [~~http~~://pdbe.org/4uvb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4uvb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4uvb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4uvb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/KDM1A_HUMAN KDM1A_HUMAN]] Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. Also acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in ANDR-containing complexes, which mediates phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag that prevents demethylation H3K4me, prevents H3K4me demethylase activity of KDM1A. Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation. Demethylates and stabilizes the DNA methylase DNMT1. Required for gastrulation during embryogenesis. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development.<ref>PMID:12032298</ref> <ref>PMID:15620353</ref> <ref>PMID:16079795</ref> <ref>PMID:17805299</ref> <ref>PMID:20228790</ref> [[http://www.uniprot.org/uniprot/RCOR1_HUMAN RCOR1_HUMAN]] Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation.<ref>PMID:11516394</ref> <ref>PMID:11171972</ref> <ref>PMID:12032298</ref> <ref>PMID:12399542</ref> <ref>PMID:12493763</ref> <ref>PMID:16140033</ref> <ref>PMID:16079794</ref>		[https://www.uniprot.org/uniprot/KDM1A_HUMAN KDM1A_HUMAN] Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. Also acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in ANDR-containing complexes, which mediates phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag that prevents demethylation H3K4me, prevents H3K4me demethylase activity of KDM1A. Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation. Demethylates and stabilizes the DNA methylase DNMT1. Required for gastrulation during embryogenesis. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development.<ref>PMID:12032298</ref> <ref>PMID:15620353</ref> <ref>PMID:16079795</ref> <ref>PMID:17805299</ref> <ref>PMID:20228790</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	==See Also==		==See Also==
	*[[Lysine-specific histone demethylase\|Lysine-specific histone demethylase]]		*[[Lysine-specific histone demethylase 3D structures\|Lysine-specific histone demethylase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Botrugno, O]]		[[Category: Botrugno O]]
	[[Category: Cappa, A]]		[[Category: Cappa A]]
	[[Category: Ciossani, G]]		[[Category: Ciossani G]]
	[[Category: Dessanti, P]]		[[Category: Dessanti P]]
	[[Category: Mai, A]]		[[Category: Mai A]]
	[[Category: Mattevi, A]]		[[Category: Mattevi A]]
	[[Category: Mercurio, C]]		[[Category: Mercurio C]]
	[[Category: Meroni, G]]		[[Category: Meroni G]]
	[[Category: Minucci, S]]		[[Category: Minucci S]]
	[[Category: Thaler, F]]		[[Category: Thaler F]]
	[[Category: Tortorici, M]]		[[Category: Tortorici M]]
	[[Category: Trifiro, P]]		[[Category: Trifiro P]]
	[[Category: Valente, S]]		[[Category: Valente S]]
	[[Category: Varasi, M]]		[[Category: Varasi M]]
	[[Category: Vianello, P]]		[[Category: Vianello P]]
	[[Category: Villa, M]]		[[Category: Villa M]]
	~~[[Category: Covalent inhibitor]]~~
	~~[[Category: Transcription~~]]

OCA at 09:07, 23 May 2019

2019-05-23T09:07:19Z

← Older revision		Revision as of 09:07, 23 May 2019
Line 1:		Line 1:

	==LSD1(KDM1A)-CoREST in complex with 1-Methyl-Tranylcypromine (1S,2R)==		==LSD1(KDM1A)-CoREST in complex with 1-Methyl-Tranylcypromine (1S,2R)==
	<StructureSection load='4uvb' size='340' side='right' caption='[[4uvb]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='4uvb' size='340' side='right'caption='[[4uvb]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4uvb]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UVB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UVB FirstGlance]. <br>		<table><tr><td colspan='2'>[[4uvb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UVB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UVB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=D51:[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL+(2R,3S,4S)-5-[(1R,3S,3AS,7AS)-1-AMINO-1,10,11-TRIMETHYL-4,6-DIOXO-3-PHENYL-2,3,5,6,7,7A-HEXAHYDRO-1H-BENZO[G]PYRROLO[2,1-E]PTERIDIN-8(4H)-YL]-2,3,4-TRIHYDROXYPENTYL+DIHYDROGEN+DIPHOSPHATE'>D51</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=D51:[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL+(2R,3S,4S)-5-[(1R,3S,3AS,7AS)-1-AMINO-1,10,11-TRIMETHYL-4,6-DIOXO-3-PHENYL-2,3,5,6,7,7A-HEXAHYDRO-1H-BENZO[G]PYRROLO[2,1-E]PTERIDIN-8(4H)-YL]-2,3,4-TRIHYDROXYPENTYL+DIHYDROGEN+DIPHOSPHATE'>D51</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uv8\|4uv8]], [[4uv9\|4uv9]], [[4uva\|4uva]], [[4uvc\|4uvc]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uv8\|4uv8]], [[4uv9\|4uv9]], [[4uva\|4uva]], [[4uvc\|4uvc]]</td></tr>
Line 26:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Botrugno, O]]		[[Category: Botrugno, O]]
	[[Category: Cappa, A]]		[[Category: Cappa, A]]

OCA at 06:26, 5 August 2016

2016-08-05T06:26:18Z

← Older revision		Revision as of 06:26, 5 August 2016
Line 1:		Line 1:

	==LSD1(KDM1A)-CoREST in complex with 1-Methyl-Tranylcypromine (1S,2R)==		==LSD1(KDM1A)-CoREST in complex with 1-Methyl-Tranylcypromine (1S,2R)==
	<StructureSection load='4uvb' size='340' side='right' caption='[[4uvb]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='4uvb' size='340' side='right' caption='[[4uvb]], [[Resolution\|resolution]] 2.80Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=D51:[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL+(2R,3S,4S)-5-[(1R,3S,3AS,7AS)-1-AMINO-1,10,11-TRIMETHYL-4,6-DIOXO-3-PHENYL-2,3,5,6,7,7A-HEXAHYDRO-1H-BENZO[G]PYRROLO[2,1-E]PTERIDIN-8(4H)-YL]-2,3,4-TRIHYDROXYPENTYL+DIHYDROGEN+DIPHOSPHATE'>D51</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=D51:[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL+(2R,3S,4S)-5-[(1R,3S,3AS,7AS)-1-AMINO-1,10,11-TRIMETHYL-4,6-DIOXO-3-PHENYL-2,3,5,6,7,7A-HEXAHYDRO-1H-BENZO[G]PYRROLO[2,1-E]PTERIDIN-8(4H)-YL]-2,3,4-TRIHYDROXYPENTYL+DIHYDROGEN+DIPHOSPHATE'>D51</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uv8\|4uv8]], [[4uv9\|4uv9]], [[4uva\|4uva]], [[4uvc\|4uvc]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uv8\|4uv8]], [[4uv9\|4uv9]], [[4uva\|4uva]], [[4uvc\|4uvc]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uvb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4uvb RCSB], [http://www.ebi.ac.uk/pdbsum/4uvb PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uvb OCA], [http://pdbe.org/4uvb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uvb RCSB], [http://www.ebi.ac.uk/pdbsum/4uvb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4uvb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4uvb" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Lysine-specific histone demethylase\|Lysine-specific histone demethylase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 16:30, 25 December 2014

2014-12-25T16:30:37Z

← Older revision		Revision as of 16:30, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4uvb]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UVB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UVB FirstGlance]. <br>		<table><tr><td colspan='2'>[[4uvb]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UVB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UVB FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=D51:[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL+(2R,3S,4S)-5-[(1R,3S,3AS,7AS)-1-AMINO-1,10,11-TRIMETHYL-4,6-DIOXO-3-PHENYL-2,3,5,6,7,7A-HEXAHYDRO-1H-BENZO[G]PYRROLO[2,1-E]PTERIDIN-8(4H)-YL]-2,3,4-TRIHYDROXYPENTYL+DIHYDROGEN+DIPHOSPHATE'>D51</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=D51:[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL+(2R,3S,4S)-5-[(1R,3S,3AS,7AS)-1-AMINO-1,10,11-TRIMETHYL-4,6-DIOXO-3-PHENYL-2,3,5,6,7,7A-HEXAHYDRO-1H-BENZO[G]PYRROLO[2,1-E]PTERIDIN-8(4H)-YL]-2,3,4-TRIHYDROXYPENTYL+DIHYDROGEN+DIPHOSPHATE'>D51</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uv8\|4uv8]], [[4uv9\|4uv9]], [[4uva\|4uva]], [[4uvc\|4uvc]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uv8\|4uv8]], [[4uv9\|4uv9]], [[4uva\|4uva]], [[4uvc\|4uvc]]</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uvb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4uvb RCSB], [http://www.ebi.ac.uk/pdbsum/4uvb PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uvb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4uvb RCSB], [http://www.ebi.ac.uk/pdbsum/4uvb PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/KDM1A_HUMAN KDM1A_HUMAN]] Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. Also acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in ANDR-containing complexes, which mediates phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag that prevents demethylation H3K4me, prevents H3K4me demethylase activity of KDM1A. Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation. Demethylates and stabilizes the DNA methylase DNMT1. Required for gastrulation during embryogenesis. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development.<ref>PMID:12032298</ref> <ref>PMID:15620353</ref> <ref>PMID:16079795</ref> <ref>PMID:17805299</ref> <ref>PMID:20228790</ref> [[http://www.uniprot.org/uniprot/RCOR1_HUMAN RCOR1_HUMAN]] Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation.<ref>PMID:11516394</ref> <ref>PMID:11171972</ref> <ref>PMID:12032298</ref> <ref>PMID:12399542</ref> <ref>PMID:12493763</ref> <ref>PMID:16140033</ref> <ref>PMID:16079794</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Botrugno, O.]]		[[Category: Botrugno, O]]
	[[Category: Cappa, A.]]		[[Category: Cappa, A]]
	[[Category: Ciossani, G.]]		[[Category: Ciossani, G]]
	[[Category: Dessanti, P.]]		[[Category: Dessanti, P]]
	[[Category: Mai, A.]]		[[Category: Mai, A]]
	[[Category: Mattevi, A.]]		[[Category: Mattevi, A]]
	[[Category: Mercurio, C.]]		[[Category: Mercurio, C]]
	[[Category: Meroni, G.]]		[[Category: Meroni, G]]
	[[Category: Minucci, S.]]		[[Category: Minucci, S]]
	[[Category: Thaler, F.]]		[[Category: Thaler, F]]
	[[Category: Tortorici, M.]]		[[Category: Tortorici, M]]
	[[Category: Trifiro, P.]]		[[Category: Trifiro, P]]
	[[Category: Valente, S.]]		[[Category: Valente, S]]
	[[Category: Varasi, M.]]		[[Category: Varasi, M]]
	[[Category: Vianello, P.]]		[[Category: Vianello, P]]
	[[Category: Villa, M.]]		[[Category: Villa, M]]
	[[Category: Covalent inhibitor]]		[[Category: Covalent inhibitor]]
	[[Category: Transcription]]		[[Category: Transcription]]

OCA at 09:58, 10 September 2014

2014-09-10T09:58:29Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==LSD1(KDM1A)-CoREST in complex with 1-Methyl-Tranylcypromine (1S,2R)==
-The entry 4uvb is ON HOLD  until Paper Publication
+Synthesis, biological activity and mechanistic insights of 1-substituted cyclopropylamine derivatives: A novel class of irreversible inhibitors of histone demethylase KDM1A.,Vianello P, Botrugno OA, Cappa A, Ciossani G, Dessanti P, Mai A, Mattevi A, Meroni G, Minucci S, Thaler F, Tortorici M, Trifiro P, Valente S, Villa M, Varasi M, Mercurio C Eur J Med Chem. 2014 Aug 27;86C:352-363. doi: 10.1016/j.ejmech.2014.08.068. PMID:25173853<ref>PMID:25173853</ref>
-Authors: Vianello, P., Botrugno, O., Cappa, A., Ciossani, G., Dessanti, P., Mai, A., Mattevi, A., Meroni, G., Minucci, S., Thaler, F., Tortorici, M., Trifiro, P., Valente, S., Villa, M., Varasi, M., Mercurio, C.
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-Description: LSD1(KDM1A)-CoREST in complex with 1-Methyl-Tranylcypromine (1S,2R)
+== References ==

OCA: Protected "4uvb" [edit=sysop:move=sysop]

2014-08-13T08:15:12Z

Protected "4uvb" [edit=sysop:move=sysop]

← Older revision	Revision as of 08:15, 13 August 2014
(No difference)

OCA: New page: '''Unreleased structure''' The entry 4uvb is ON HOLD until Paper Publication Authors: Vianello, P., Botrugno, O., Cappa, A., Ciossani, G., Dessanti, P., Mai, A., Mattevi, A., Meroni, G....

2014-08-13T08:15:10Z

New page: '''Unreleased structure''' The entry 4uvb is ON HOLD until Paper Publication Authors: Vianello, P., Botrugno, O., Cappa, A., Ciossani, G., Dessanti, P., Mai, A., Mattevi, A., Meroni, G....

New page

'''Unreleased structure'''

The entry 4uvb is ON HOLD until Paper Publication

Authors: Vianello, P., Botrugno, O., Cappa, A., Ciossani, G., Dessanti, P., Mai, A., Mattevi, A., Meroni, G., Minucci, S., Thaler, F., Tortorici, M., Trifiro, P., Valente, S., Villa, M., Varasi, M., Mercurio, C.

Description: LSD1(KDM1A)-CoREST in complex with 1-Methyl-Tranylcypromine (1S,2R)