4wt2 - Revision history

OCA at 07:36, 27 September 2023

2023-09-27T07:36:23Z

← Older revision		Revision as of 07:36, 27 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4wt2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WT2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WT2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4wt2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WT2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WT2 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3UD:4-({[(3R,5R,6S)-1-[(1S)-2-(TERT-BUTYLSULFONYL)-1-CYCLOPROPYLETHYL]-6-(4-CHLORO-3-FLUOROPHENYL)-5-(3-CHLOROPHENYL)-3-METHYL-2-OXOPIPERIDIN-3-YL]ACETYL}AMINO)-2-METHOXYBENZOIC+ACID'>3UD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.42Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3UD:4-({[(3R,5R,6S)-1-[(1S)-2-(TERT-BUTYLSULFONYL)-1-CYCLOPROPYLETHYL]-6-(4-CHLORO-3-FLUOROPHENYL)-5-(3-CHLOROPHENYL)-3-METHYL-2-OXOPIPERIDIN-3-YL]ACETYL}AMINO)-2-METHOXYBENZOIC+ACID'>3UD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wt2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wt2 OCA], [https://pdbe.org/4wt2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wt2 RCSB], [https://www.ebi.ac.uk/pdbsum/4wt2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wt2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wt2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wt2 OCA], [https://pdbe.org/4wt2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wt2 RCSB], [https://www.ebi.ac.uk/pdbsum/4wt2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wt2 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:24, 7 April 2023

2023-04-07T07:24:50Z

← Older revision		Revision as of 07:24, 7 April 2023
Line 1:		Line 1:

	==Co-crystal Structure of MDM2 in Complex with AM-7209==		==Co-crystal Structure of MDM2 in Complex with AM-7209==
	<StructureSection load='4wt2' size='340' side='right' caption='[[4wt2]], [[Resolution\|resolution]] 1.42Å' scene=''>		<StructureSection load='4wt2' size='340' side='right'caption='[[4wt2]], [[Resolution\|resolution]] 1.42Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4wt2]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WT2 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4WT2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4wt2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WT2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WT2 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3UD:4-({[(3R,5R,6S)-1-[(1S)-2-(TERT-BUTYLSULFONYL)-1-CYCLOPROPYLETHYL]-6-(4-CHLORO-3-FLUOROPHENYL)-5-(3-CHLOROPHENYL)-3-METHYL-2-OXOPIPERIDIN-3-YL]ACETYL}AMINO)-2-METHOXYBENZOIC+ACID'>3UD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3UD:4-({[(3R,5R,6S)-1-[(1S)-2-(TERT-BUTYLSULFONYL)-1-CYCLOPROPYLETHYL]-6-(4-CHLORO-3-FLUOROPHENYL)-5-(3-CHLOROPHENYL)-3-METHYL-2-OXOPIPERIDIN-3-YL]ACETYL}AMINO)-2-METHOXYBENZOIC+ACID'>3UD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MDM2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wt2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wt2 OCA], [https://pdbe.org/4wt2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wt2 RCSB], [https://www.ebi.ac.uk/pdbsum/4wt2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wt2 ProSAT]</span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4wt2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wt2 OCA], [~~http~~://pdbe.org/4wt2 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4wt2 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4wt2 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4wt2 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[~~[http~~://www.uniprot.org/uniprot/MDM2_HUMAN MDM2_HUMAN]] Note=Seems to be amplified in certain tumors (including soft tissue sarcomas, osteosarcomas and gliomas). A higher frequency of splice variants lacking p53 binding domain sequences was found in late-stage and high-grade ovarian and bladder carcinomas. Four of the splice variants show loss of p53 binding.		[https://www.uniprot.org/uniprot/MDM2_HUMAN MDM2_HUMAN] Note=Seems to be amplified in certain tumors (including soft tissue sarcomas, osteosarcomas and gliomas). A higher frequency of splice variants lacking p53 binding domain sequences was found in late-stage and high-grade ovarian and bladder carcinomas. Four of the splice variants show loss of p53 binding.
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/MDM2_HUMAN MDM2_HUMAN]] E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as an ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and promotes it to proteasomal degradation.<ref>PMID:12821780</ref> <ref>PMID:15053880</ref> <ref>PMID:15195100</ref> <ref>PMID:16337594</ref> <ref>PMID:15632057</ref> <ref>PMID:17290220</ref> <ref>PMID:19098711</ref> <ref>PMID:19219073</ref> <ref>PMID:19965871</ref> <ref>PMID:20858735</ref> <ref>PMID:20173098</ref>		[https://www.uniprot.org/uniprot/MDM2_HUMAN MDM2_HUMAN] E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as an ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and promotes it to proteasomal degradation.<ref>PMID:12821780</ref> <ref>PMID:15053880</ref> <ref>PMID:15195100</ref> <ref>PMID:16337594</ref> <ref>PMID:15632057</ref> <ref>PMID:17290220</ref> <ref>PMID:19098711</ref> <ref>PMID:19219073</ref> <ref>PMID:19965871</ref> <ref>PMID:20858735</ref> <ref>PMID:20173098</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 4wt2" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4wt2" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[MDM2 3D structures\|MDM2 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: ~~Huang, X~~]]		[[Category: Large Structures]]
	[[Category: ~~Long, A M~~]]		[[Category: Huang X]]
	[[Category: ~~Shaffer, P L~~]]		[[Category: Long AM]]
	[[Category: ~~Yakowec, P~~]]		[[Category: Shaffer PL]]
	[[Category: ~~Ligase-ligase inhibitor complex]]~~		[[Category: Yakowec P]]
	~~[[Category: P53]]~~
	~~[[Category: Protein-protein interaction~~]]

OCA at 09:29, 22 November 2017

2017-11-22T09:29:15Z

← Older revision		Revision as of 09:29, 22 November 2017
Line 3:		Line 3:
	<StructureSection load='4wt2' size='340' side='right' caption='[[4wt2]], [[Resolution\|resolution]] 1.42Å' scene=''>		<StructureSection load='4wt2' size='340' side='right' caption='[[4wt2]], [[Resolution\|resolution]] 1.42Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4wt2]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WT2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WT2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4wt2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WT2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WT2 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3UD:4-({[(3R,5R,6S)-1-[(1S)-2-(TERT-BUTYLSULFONYL)-1-CYCLOPROPYLETHYL]-6-(4-CHLORO-3-FLUOROPHENYL)-5-(3-CHLOROPHENYL)-3-METHYL-2-OXOPIPERIDIN-3-YL]ACETYL}AMINO)-2-METHOXYBENZOIC+ACID'>3UD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3UD:4-({[(3R,5R,6S)-1-[(1S)-2-(TERT-BUTYLSULFONYL)-1-CYCLOPROPYLETHYL]-6-(4-CHLORO-3-FLUOROPHENYL)-5-(3-CHLOROPHENYL)-3-METHYL-2-OXOPIPERIDIN-3-YL]ACETYL}AMINO)-2-METHOXYBENZOIC+ACID'>3UD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MDM2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wt2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wt2 OCA], [http://pdbe.org/4wt2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4wt2 RCSB], [http://www.ebi.ac.uk/pdbsum/4wt2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4wt2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wt2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wt2 OCA], [http://pdbe.org/4wt2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4wt2 RCSB], [http://www.ebi.ac.uk/pdbsum/4wt2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4wt2 ProSAT]</span></td></tr>
	</table>		</table>
Line 20:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 4wt2" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4wt2" style="background-color:#fffaf0;"></div>

	~~==See Also==~~
	*[[MDM2\|MDM2]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Human]]
	[[Category: Huang, X]]		[[Category: Huang, X]]
	[[Category: Long, A M]]		[[Category: Long, A M]]

OCA at 11:26, 11 August 2016

2016-08-11T11:26:39Z

← Older revision		Revision as of 11:26, 11 August 2016
Line 1:		Line 1:

	==Co-crystal Structure of MDM2 in Complex with AM-7209==		==Co-crystal Structure of MDM2 in Complex with AM-7209==
	<StructureSection load='4wt2' size='340' side='right' caption='[[4wt2]], [[Resolution\|resolution]] 1.42Å' scene=''>		<StructureSection load='4wt2' size='340' side='right' caption='[[4wt2]], [[Resolution\|resolution]] 1.42Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[4wt2]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WT2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WT2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4wt2]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WT2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WT2 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3UD:4-({[(3R,5R,6S)-1-[(1S)-2-(TERT-BUTYLSULFONYL)-1-CYCLOPROPYLETHYL]-6-(4-CHLORO-3-FLUOROPHENYL)-5-(3-CHLOROPHENYL)-3-METHYL-2-OXOPIPERIDIN-3-YL]ACETYL}AMINO)-2-METHOXYBENZOIC+ACID'>3UD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3UD:4-({[(3R,5R,6S)-1-[(1S)-2-(TERT-BUTYLSULFONYL)-1-CYCLOPROPYLETHYL]-6-(4-CHLORO-3-FLUOROPHENYL)-5-(3-CHLOROPHENYL)-3-METHYL-2-OXOPIPERIDIN-3-YL]ACETYL}AMINO)-2-METHOXYBENZOIC+ACID'>3UD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wt2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wt2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wt2 RCSB], [http://www.ebi.ac.uk/pdbsum/4wt2 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wt2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wt2 OCA], [http://pdbe.org/4wt2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4wt2 RCSB], [http://www.ebi.ac.uk/pdbsum/4wt2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4wt2 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4wt2" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[MDM2\|MDM2]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:31, 3 December 2014

2014-12-03T09:31:38Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Co-crystal Structure of MDM2 in Complex with AM-7209==
-The entry 4wt2 is ON HOLD  until Paper Publication
+Discovery of AM-7209, a Potent and Selective 4-Amidobenzoic Acid Inhibitor of the MDM2-p53 Interaction.,Rew Y, Sun D, Yan X, Beck HP, Canon J, Ada C, Duquette J, Eksterowicz J, Fox BM, Fu J, Gonzalez AZ, Houze JB, Huang X, Jiang B, Jin L, Li Y, Li Z, Ling Y, Lo MC, Long AM, McGee LR, McIntosh J, Oliner J, Osgood T, Saiki A, Shaffer P, Wortman S, Yakowec P, Ye Q, Yu D, Medina JC, Olson SH J Med Chem. 2014 Nov 10. PMID:25384157<ref>PMID:25384157</ref>
-Authors: Shaffer, P.L., Huang, X., Yakowec, P., Long, A.M.
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-Description: Co-crystal Structure of MDM2 in Complex with AM-7209
+== References ==

OCA at 07:08, 26 November 2014

2014-11-26T07:08:26Z

← Older revision		Revision as of 07:08, 26 November 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4wt2 is ON HOLD		The entry 4wt2 is ON HOLD until Paper Publication

	Authors: Shaffer, P.L., Huang, X., Yakowec, P., Long, A.M.		Authors: Shaffer, P.L., Huang, X., Yakowec, P., Long, A.M.

	Description: Co-crystal Structure of MDM2 in Complex with AM-7209		Description: Co-crystal Structure of MDM2 in Complex with AM-7209

OCA: Protected "4wt2" [edit=sysop:move=sysop]

2014-11-05T08:08:14Z

Protected "4wt2" [edit=sysop:move=sysop]

← Older revision	Revision as of 08:08, 5 November 2014
(No difference)

OCA: New page: '''Unreleased structure''' The entry 4wt2 is ON HOLD Authors: Shaffer, P.L., Huang, X., Yakowec, P., Long, A.M. Description: Co-crystal Structure of MDM2 in Complex with AM-7209

2014-11-05T08:08:13Z

New page: '''Unreleased structure''' The entry 4wt2 is ON HOLD Authors: Shaffer, P.L., Huang, X., Yakowec, P., Long, A.M. Description: Co-crystal Structure of MDM2 in Complex with AM-7209

New page

'''Unreleased structure'''

The entry 4wt2 is ON HOLD

Authors: Shaffer, P.L., Huang, X., Yakowec, P., Long, A.M.

Description: Co-crystal Structure of MDM2 in Complex with AM-7209