4yzs - Revision history

OCA at 03:44, 21 November 2024

2024-11-21T03:44:30Z

← Older revision		Revision as of 03:44, 21 November 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4yzs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YZS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YZS FirstGlance]. <br>		<table><tr><td colspan='2'>[[4yzs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YZS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YZS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=W:TUNGSTEN+ION'>W</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.14Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=W:TUNGSTEN+ION'>W</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yzs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yzs OCA], [https://pdbe.org/4yzs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yzs RCSB], [https://www.ebi.ac.uk/pdbsum/4yzs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yzs ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yzs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yzs OCA], [https://pdbe.org/4yzs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yzs RCSB], [https://www.ebi.ac.uk/pdbsum/4yzs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yzs ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:33, 10 May 2023

2023-05-10T07:33:10Z

← Older revision		Revision as of 07:33, 10 May 2023
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	<StructureSection load='4yzs' size='340' side='right'caption='[[4yzs]], [[Resolution\|resolution]] 3.14Å' scene=''>		<StructureSection load='4yzs' size='340' side='right'caption='[[4yzs]], [[Resolution\|resolution]] 3.14Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4yzs]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YZS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4YZS FirstGlance]. <br>		<table><tr><td colspan='2'>[[4yzs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YZS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YZS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=W:TUNGSTEN+ION'>W</scene~~></td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=W:TUNGSTEN+ION'>W</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yzs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yzs OCA], [https://pdbe.org/4yzs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yzs RCSB], [https://www.ebi.ac.uk/pdbsum/4yzs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yzs ProSAT]</span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4yzs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yzs OCA], [~~http~~://pdbe.org/4yzs PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4yzs RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4yzs PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4yzs ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[~~[http~~://www.uniprot.org/uniprot/E2AK3_HUMAN E2AK3_HUMAN]] Wolcott-Rallison syndrome. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:10932183</ref>		[https://www.uniprot.org/uniprot/E2AK3_HUMAN E2AK3_HUMAN] Wolcott-Rallison syndrome. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:10932183</ref>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/E2AK3_HUMAN E2AK3_HUMAN]] Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1) (By similarity).		[https://www.uniprot.org/uniprot/E2AK3_HUMAN E2AK3_HUMAN] Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1) (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	~~[[Category: Non-specific serine/threonine protein kinase]]~~		[[Category: Ali MMU]]
	[[Category: Ali~~, M M.U~~]]		[[Category: Carrara M]]
	[[Category: Carrara, M]]		[[Category: Prischi F]]
	[[Category: Prischi, F]]
	~~[[Category: Er stress]]~~
	~~[[Category: Perk]]~~
	~~[[Category: Proteostasis]]~~
	~~[[Category: Signaling protein]]~~
	~~[[Category: Tetramer]]~~
	~~[[Category: Unfolded protein]]~~
	~~[[Category: Upr]]~~
	~~[[Category: Upr activation]]~~
	~~[[Category: Upr sensor~~]]

OCA at 06:57, 10 July 2019

2019-07-10T06:57:47Z

← Older revision		Revision as of 06:57, 10 July 2019
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	==Crystal structures reveal transient PERK luminal domain tetramerization in ER stress signaling==		==Crystal structures reveal transient PERK luminal domain tetramerization in ER stress signaling==
	<StructureSection load='4yzs' size='340' side='right' caption='[[4yzs]], [[Resolution\|resolution]] 3.14Å' scene=''>		<StructureSection load='4yzs' size='340' side='right'caption='[[4yzs]], [[Resolution\|resolution]] 3.14Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4yzs]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YZS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YZS FirstGlance]. <br>		<table><tr><td colspan='2'>[[4yzs]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YZS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YZS FirstGlance]. <br>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]
	[[Category: Ali, M M.U]]		[[Category: Ali, M M.U]]

OCA at 17:08, 22 March 2017

2017-03-22T17:08:42Z

← Older revision		Revision as of 17:08, 22 March 2017
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	==Crystal structures reveal transient PERK luminal domain tetramerization in ER stress signaling==		==Crystal structures reveal transient PERK luminal domain tetramerization in ER stress signaling==
	<StructureSection load='4yzs' size='340' side='right' caption='[[4yzs]], [[Resolution\|resolution]] 3.14Å' scene=''>		<StructureSection load='4yzs' size='340' side='right' caption='[[4yzs]], [[Resolution\|resolution]] 3.14Å' scene=''>
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=W:TUNGSTEN+ION'>W</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=W:TUNGSTEN+ION'>W</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yzs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yzs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4yzs RCSB], [http://www.ebi.ac.uk/pdbsum/4yzs PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yzs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yzs OCA], [http://pdbe.org/4yzs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yzs RCSB], [http://www.ebi.ac.uk/pdbsum/4yzs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4yzs ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4yzs" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:20, 13 May 2015

2015-05-13T12:20:07Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Crystal structures reveal transient PERK luminal domain tetramerization in ER stress signaling==
-The entry 4yzs is ON HOLD  until Paper Publication
+Crystal structures reveal transient PERK luminal domain tetramerization in endoplasmic reticulum stress signaling.,Carrara M, Prischi F, Nowak PR, Ali MM EMBO J. 2015 Apr 28. pii: e201489183. PMID:25925385<ref>PMID:25925385</ref>
-Authors: Carrara, M., Prischi, F., Ali, M.M.U.
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-Description: Crystal structures reveal transient PERK luminal domain tetramerization in ER stress signaling
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
 [[Category: Carrara, M]]
 [[Category: Prischi, F]]
-[[Category: Ali, M.M.U]]
+[[Category: Er stress]]

OCA at 09:58, 8 April 2015

2015-04-08T09:58:03Z

← Older revision		Revision as of 09:58, 8 April 2015
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4yzs is ON HOLD		The entry 4yzs is ON HOLD until Paper Publication

	Authors: Carrara, M., Prischi, F., Ali, M.M.U.		Authors: Carrara, M., Prischi, F., Ali, M.M.U.

OCA: Protected "4yzs" [edit=sysop:move=sysop]

2015-04-01T12:07:02Z

Protected "4yzs" [edit=sysop:move=sysop]

← Older revision	Revision as of 12:07, 1 April 2015
(No difference)

OCA: New page: '''Unreleased structure''' The entry 4yzs is ON HOLD Authors: Carrara, M., Prischi, F., Ali, M.M.U. Description: Crystal structures reveal transient PERK luminal domain tetramerization...

2015-04-01T12:07:00Z

New page: '''Unreleased structure''' The entry 4yzs is ON HOLD Authors: Carrara, M., Prischi, F., Ali, M.M.U. Description: Crystal structures reveal transient PERK luminal domain tetramerization...

New page

'''Unreleased structure'''

The entry 4yzs is ON HOLD

Authors: Carrara, M., Prischi, F., Ali, M.M.U.

Description: Crystal structures reveal transient PERK luminal domain tetramerization in ER stress signaling
[[Category: Unreleased Structures]]
[[Category: Carrara, M]]
[[Category: Prischi, F]]
[[Category: Ali, M.M.U]]