4zhy - Revision history

OCA at 07:28, 18 May 2023

2023-05-18T07:28:32Z

← Older revision		Revision as of 07:28, 18 May 2023
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	<StructureSection load='4zhy' size='340' side='right'caption='[[4zhy]], [[Resolution\|resolution]] 1.97Å' scene=''>		<StructureSection load='4zhy' size='340' side='right'caption='[[4zhy]], [[Resolution\|resolution]] 1.97Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4zhy]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Pseae Pseae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZHY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ZHY FirstGlance]. <br>		<table><tr><td colspan='2'>[[4zhy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZHY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZHY FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4zhu\|4zhu]], [[4zhv\|4zhv]], [[4zhw\|4zhw]]</td></tr>~~		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zhy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zhy OCA], [https://pdbe.org/4zhy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zhy RCSB], [https://www.ebi.ac.uk/pdbsum/4zhy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zhy ProSAT]</span></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">yfiR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 PSEAE]), yfiB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 PSEAE])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4zhy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zhy OCA], [~~http~~://pdbe.org/4zhy PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4zhy RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4zhy PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4zhy ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/Q9I4L4_PSEAE Q9I4L4_PSEAE]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Pseae~~]]		[[Category: Pseudomonas aeruginosa PAO1]]
	[[Category: Bartlam, M]]		[[Category: Bartlam M]]
	[[Category: Li, S]]		[[Category: Li S]]
	[[Category: Li, T]]		[[Category: Li T]]
	[[Category: Wang, Y]]		[[Category: Wang Y]]
	~~[[Category: Outer membrane protein]]~~
	~~[[Category: Periplasmic binding protein]]~~
	~~[[Category: Repressor]]~~
	~~[[Category: Signalling complex]]~~
	~~[[Category: Transcription-signaling protein complex~~]]

OCA at 07:14, 19 June 2019

2019-06-19T07:14:04Z

← Older revision		Revision as of 07:14, 19 June 2019
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	==Crystal structure of a bacterial signalling complex==		==Crystal structure of a bacterial signalling complex==
	<StructureSection load='4zhy' size='340' side='right' caption='[[4zhy]], [[Resolution\|resolution]] 1.97Å' scene=''>		<StructureSection load='4zhy' size='340' side='right'caption='[[4zhy]], [[Resolution\|resolution]] 1.97Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4zhy]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZHY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZHY FirstGlance]. <br>		<table><tr><td colspan='2'>[[4zhy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZHY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZHY FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4zhu\|4zhu]], [[4zhv\|4zhv]], [[4zhw\|4zhw]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4zhu\|4zhu]], [[4zhv\|4zhv]], [[4zhw\|4zhw]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zhy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zhy OCA], [http://pdbe.org/4zhy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zhy RCSB], [http://www.ebi.ac.uk/pdbsum/4zhy PDBsum]</span></td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">yfiR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 PSEAE]), yfiB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 PSEAE])</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zhy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zhy OCA], [http://pdbe.org/4zhy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zhy RCSB], [http://www.ebi.ac.uk/pdbsum/4zhy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zhy ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
			[[Category: Pseae]]
	[[Category: Bartlam, M]]		[[Category: Bartlam, M]]
	[[Category: Li, S]]		[[Category: Li, S]]

OCA at 11:58, 13 May 2016

2016-05-13T11:58:41Z

← Older revision		Revision as of 11:58, 13 May 2016
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	~~'''Unreleased structure'''~~

	~~The entry~~ 4zhy is ~~ON HOLD until Paper~~ Publication		==Crystal structure of a bacterial signalling complex==
			<StructureSection load='4zhy' size='340' side='right' caption='[[4zhy]], [[Resolution\|resolution]] 1.97Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[4zhy]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZHY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZHY FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4zhu\|4zhu]], [[4zhv\|4zhv]], [[4zhw\|4zhw]]</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zhy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zhy OCA], [http://pdbe.org/4zhy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zhy RCSB], [http://www.ebi.ac.uk/pdbsum/4zhy PDBsum]</span></td></tr>
			</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			YfiBNR is a tripartite signalling system in Pseudomonas aeruginosa that modulates intracellular c-di-GMP levels in response to signals received in the periplasm. YfiB is an outer membrane lipoprotein and presumed sensor protein that sequesters the repressor protein YfiR. To provide insights into YfiBNR function, we have determined three-dimensional crystal structures of YfiB and YfiR from P. aeruginosa PAO1 alone and as a 1:1 complex. A YfiB(27-168) construct is predominantly dimeric, whereas a YfiB(59-168) is monomeric, indicating that YfiB can dimerize via its N-terminal region. YfiR forms a stable complex with YfiB(59-168), while the YfiR binding interface is obstructed by the N-terminal region in YfiB(27-168). The YfiB-YfiR complex reveals a conserved interaction surface on YfiR that overlaps with residues predicted to interact with the periplasmic PAS domain of YfiN. Comparison of native and YfiR-bound structures of YfiB suggests unwinding of the N-terminal linker region for attachment to the outer membrane. A model is thus proposed for YfiR sequestration at the outer membrane by YfiB. Our work provides the first detailed insights into the interaction between YfiB and YfiR at the molecular level and is a valuable starting point for further functional and mechanistic studies of the YfiBNR signalling system.

	~~Authors:~~ Li, S., Li, T., Wang, Y., Bartlam, M.		Structural insights into YfiR sequestering by YfiB in Pseudomonas aeruginosa PAO1.,Li S, Li T, Xu Y, Zhang Q, Zhang W, Che S, Liu R, Wang Y, Bartlam M Sci Rep. 2015 Nov 23;5:16915. doi: 10.1038/srep16915. PMID:26593397<ref>PMID:26593397</ref>

	~~Description~~:		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	[[Category: ~~Unreleased Structures~~]]		</div>
			<div class="pdbe-citations 4zhy" style="background-color:#fffaf0;"></div>
			== References ==
			<references/>
			__TOC__
			</StructureSection>
			[[Category: Bartlam, M]]
	[[Category: Li, S]]		[[Category: Li, S]]
	[[Category: Li, T]]		[[Category: Li, T]]
	[[Category: Wang, Y]]		[[Category: Wang, Y]]
	[[Category: ~~Bartlam, M~~]]		[[Category: Outer membrane protein]]
			[[Category: Periplasmic binding protein]]
			[[Category: Repressor]]
			[[Category: Signalling complex]]
			[[Category: Transcription-signaling protein complex]]

OCA at 09:09, 9 December 2015

2015-12-09T09:09:48Z

← Older revision		Revision as of 09:09, 9 December 2015
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4zhy is ON HOLD		The entry 4zhy is ON HOLD until Paper Publication

	Authors: Li, S., Li, T., Wang, Y., Bartlam, M.		Authors: Li, S., Li, T., Wang, Y., Bartlam, M.

OCA: Protected "4zhy" [edit=sysop:move=sysop]

2015-05-06T11:45:11Z

Protected "4zhy" [edit=sysop:move=sysop]

← Older revision	Revision as of 11:45, 6 May 2015
(No difference)

OCA: New page: '''Unreleased structure''' The entry 4zhy is ON HOLD Authors: Li, S., Li, T., Wang, Y., Bartlam, M. Description: Category: Unreleased Structures Category: Li, S [[Category: Li...

2015-05-06T11:45:10Z

New page: '''Unreleased structure''' The entry 4zhy is ON HOLD Authors: Li, S., Li, T., Wang, Y., Bartlam, M. Description: Category: Unreleased Structures Category: Li, S [[Category: Li...

New page

'''Unreleased structure'''

The entry 4zhy is ON HOLD

Authors: Li, S., Li, T., Wang, Y., Bartlam, M.

Description:
[[Category: Unreleased Structures]]
[[Category: Li, S]]
[[Category: Li, T]]
[[Category: Wang, Y]]
[[Category: Bartlam, M]]