4zyk - Revision history

OCA at 08:26, 27 September 2023

2023-09-27T08:26:13Z

← Older revision		Revision as of 08:26, 27 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4zyk]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZYK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZYK FirstGlance]. <br>		<table><tr><td colspan='2'>[[4zyk]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZYK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZYK FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zyk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zyk OCA], [https://pdbe.org/4zyk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zyk RCSB], [https://www.ebi.ac.uk/pdbsum/4zyk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zyk ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zyk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zyk OCA], [https://pdbe.org/4zyk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zyk RCSB], [https://www.ebi.ac.uk/pdbsum/4zyk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zyk ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:46, 18 May 2023

2023-05-18T07:46:50Z

← Older revision		Revision as of 07:46, 18 May 2023
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	<StructureSection load='4zyk' size='340' side='right'caption='[[4zyk]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='4zyk' size='340' side='right'caption='[[4zyk]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4zyk]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZYK OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ZYK FirstGlance]. <br>		<table><tr><td colspan='2'>[[4zyk]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZYK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZYK FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4zyp\|4zyp]]~~</td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zyk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zyk OCA], [https://pdbe.org/4zyk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zyk RCSB], [https://www.ebi.ac.uk/pdbsum/4zyk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zyk ProSAT]</span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4zyk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zyk OCA], [~~http~~://pdbe.org/4zyk PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4zyk RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4zyk PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4zyk ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Gilman~~, M S.A~~]]		[[Category: Gilman MSA]]
	[[Category: McLellan~~, J S]]~~		[[Category: McLellan JS]]
	~~[[Category: Fab]]~~
	~~[[Category: Ig domain]]~~
	~~[[Category: Immune system~~]]

OCA at 15:57, 11 December 2019

2019-12-11T15:57:24Z

← Older revision		Revision as of 15:57, 11 December 2019
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	==Crystal Structure of Quaternary-Specific RSV-Neutralizing Human Antibody AM14==		==Crystal Structure of Quaternary-Specific RSV-Neutralizing Human Antibody AM14==
	<StructureSection load='4zyk' size='340' side='right' caption='[[4zyk]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='4zyk' size='340' side='right'caption='[[4zyk]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4zyk]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZYK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZYK FirstGlance]. <br>		<table><tr><td colspan='2'>[[4zyk]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZYK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZYK FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Gilman, M S.A]]		[[Category: Gilman, M S.A]]
	[[Category: McLellan, J S]]		[[Category: McLellan, J S]]

OCA at 12:22, 6 November 2017

2017-11-06T12:22:34Z

← Older revision		Revision as of 12:22, 6 November 2017
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	<StructureSection load='4zyk' size='340' side='right' caption='[[4zyk]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='4zyk' size='340' side='right' caption='[[4zyk]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4zyk]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZYK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZYK FirstGlance]. <br>		<table><tr><td colspan='2'>[[4zyk]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZYK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZYK FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4zyp\|4zyp]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4zyp\|4zyp]]</td></tr>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Human]]
	[[Category: Gilman, M S.A]]		[[Category: Gilman, M S.A]]
	[[Category: McLellan, J S]]		[[Category: McLellan, J S]]

OCA at 13:31, 4 May 2017

2017-05-04T13:31:37Z

← Older revision		Revision as of 13:31, 4 May 2017
Line 1:		Line 1:

	==Crystal Structure of Quaternary-Specific RSV-Neutralizing Human Antibody AM14==		==Crystal Structure of Quaternary-Specific RSV-Neutralizing Human Antibody AM14==
	<StructureSection load='4zyk' size='340' side='right' caption='[[4zyk]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='4zyk' size='340' side='right' caption='[[4zyk]], [[Resolution\|resolution]] 2.00Å' scene=''>
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4zyp\|4zyp]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4zyp\|4zyp]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zyk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zyk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4zyk RCSB], [http://www.ebi.ac.uk/pdbsum/4zyk PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zyk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zyk OCA], [http://pdbe.org/4zyk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zyk RCSB], [http://www.ebi.ac.uk/pdbsum/4zyk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zyk ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4zyk" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 14:44, 29 July 2015

2015-07-29T14:44:51Z

← Older revision		Revision as of 14:44, 29 July 2015
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	'''~~Unreleased~~ structure'''		==Crystal Structure of Quaternary-Specific RSV-Neutralizing Human Antibody AM14==
			<StructureSection load='4zyk' size='340' side='right' caption='[[4zyk]], [[Resolution\|resolution]] 2.00Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[4zyk]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZYK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZYK FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4zyp\|4zyp]]</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zyk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zyk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4zyk RCSB], [http://www.ebi.ac.uk/pdbsum/4zyk PDBsum]</span></td></tr>
			</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Prevention efforts for respiratory syncytial virus (RSV) have been advanced due to the recent isolation and characterization of antibodies that specifically recognize the prefusion conformation of the RSV fusion (F) glycoprotein. These potently neutralizing antibodies are in clinical development for passive prophylaxis and have also aided the design of vaccine antigens that display prefusion-specific epitopes. To date, prefusion-specific antibodies have been shown to target two antigenic sites on RSV F, but both of these sites are also present on monomeric forms of F. Here we present a structural and functional characterization of human antibody AM14, which potently neutralized laboratory strains and clinical isolates of RSV from both A and B subtypes. The crystal structure and location of escape mutations revealed that AM14 recognizes a quaternary epitope that spans two protomers and includes a region that undergoes extensive conformational changes in the pre- to postfusion F transition. Binding assays demonstrated that AM14 is unique in its specific recognition of trimeric furin-cleaved prefusion F, which is the mature form of F on infectious virions. These results demonstrate that the prefusion F trimer contains potent neutralizing epitopes not present on monomers and that AM14 should be particularly useful for characterizing the conformational state of RSV F-based vaccine antigens.

	~~The entry 4zyk is ON HOLD until Paper Publication~~		Characterization of a Prefusion-Specific Antibody That Recognizes a Quaternary, Cleavage-Dependent Epitope on the RSV Fusion Glycoprotein.,Gilman MS, Moin SM, Mas V, Chen M, Patel NK, Kramer K, Zhu Q, Kabeche SC, Kumar A, Palomo C, Beaumont T, Baxa U, Ulbrandt ND, Melero JA, Graham BS, McLellan JS PLoS Pathog. 2015 Jul 10;11(7):e1005035. doi: 10.1371/journal.ppat.1005035., eCollection 2015 Jul. PMID:26161532<ref>PMID:26161532</ref>

	~~Authors~~: Gilman, M.S.A., McLellan, J.S.		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~Description: Crystal Structure of Quaternary-Specific RSV-Neutralizing Human Antibody AM14~~		== References ==
	[[Category: ~~Unreleased Structures~~]]		<references/>
	[[Category: ~~Mclellan, J.S~~]]		__TOC__
	[[Category: ~~Gilman, M.S.A~~]]		</StructureSection>
			[[Category: Gilman, M S.A]]
			[[Category: McLellan, J S]]
			[[Category: Fab]]
			[[Category: Ig domain]]
			[[Category: Immune system]]

OCA at 11:19, 15 July 2015

2015-07-15T11:19:01Z

← Older revision		Revision as of 11:19, 15 July 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4zyk is ON HOLD		The entry 4zyk is ON HOLD until Paper Publication

	Authors: Gilman, M.S.A., McLellan, J.S.		Authors: Gilman, M.S.A., McLellan, J.S.

OCA: Protected "4zyk" [edit=sysop:move=sysop]

2015-05-27T14:54:50Z

Protected "4zyk" [edit=sysop:move=sysop]

← Older revision	Revision as of 14:54, 27 May 2015
(No difference)

OCA: New page: '''Unreleased structure''' The entry 4zyk is ON HOLD Authors: Gilman, M.S.A., McLellan, J.S. Description: Crystal Structure of Quaternary-Specific RSV-Neutralizing Human Antibody AM14 ...

2015-05-27T14:54:49Z

New page: '''Unreleased structure''' The entry 4zyk is ON HOLD Authors: Gilman, M.S.A., McLellan, J.S. Description: Crystal Structure of Quaternary-Specific RSV-Neutralizing Human Antibody AM14 ...

New page

'''Unreleased structure'''

The entry 4zyk is ON HOLD

Authors: Gilman, M.S.A., McLellan, J.S.

Description: Crystal Structure of Quaternary-Specific RSV-Neutralizing Human Antibody AM14
[[Category: Unreleased Structures]]
[[Category: Mclellan, J.S]]
[[Category: Gilman, M.S.A]]