5a4e - Revision history

OCA at 11:03, 10 January 2024

2024-01-10T11:03:40Z

← Older revision		Revision as of 11:03, 10 January 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5a4e]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A4E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5A4E FirstGlance]. <br>		<table><tr><td colspan='2'>[[5a4e]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A4E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5A4E FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7QQ:N-(5-METHOXY-1,3-BENZOTHIAZOL-2-YL)ETHANAMIDE'>7QQ</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.68Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7QQ:N-(5-METHOXY-1,3-BENZOTHIAZOL-2-YL)ETHANAMIDE'>7QQ</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5a4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a4e OCA], [https://pdbe.org/5a4e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5a4e RCSB], [https://www.ebi.ac.uk/pdbsum/5a4e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5a4e ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5a4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a4e OCA], [https://pdbe.org/5a4e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5a4e RCSB], [https://www.ebi.ac.uk/pdbsum/5a4e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5a4e ProSAT]</span></td></tr>
	</table>		</table>

OCA at 04:38, 25 May 2023

2023-05-25T04:38:50Z

← Older revision		Revision as of 04:38, 25 May 2023
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	<StructureSection load='5a4e' size='340' side='right'caption='[[5a4e]], [[Resolution\|resolution]] 2.68Å' scene=''>		<StructureSection load='5a4e' size='340' side='right'caption='[[5a4e]], [[Resolution\|resolution]] 2.68Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5a4e]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A4E OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5A4E FirstGlance]. <br>		<table><tr><td colspan='2'>[[5a4e]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A4E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5A4E FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7QQ:N-(5-METHOXY-1,3-BENZOTHIAZOL-2-YL)ETHANAMIDE'>7QQ</scene>~~</td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7QQ:N-(5-METHOXY-1,3-BENZOTHIAZOL-2-YL)ETHANAMIDE'>7QQ</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene~~></td></tr>~~		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5a4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a4e OCA], [https://pdbe.org/5a4e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5a4e RCSB], [https://www.ebi.ac.uk/pdbsum/5a4e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5a4e ProSAT]</span></td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5a3x\|5a3x]], [[5a4l\|5a4l]], [[5a4q\|5a4q]], [[5a4t\|5a4t]], [[5a54\|5a54]]</td></tr>~~
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dual-specificity_kinase Dual-specificity kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.12.1 2.7.12.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5a4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a4e OCA], [~~http~~://pdbe.org/5a4e PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5a4e RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5a4e PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5a4e ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[~~[http~~://www.uniprot.org/uniprot/DYR1A_HUMAN DYR1A_HUMAN]] Defects in DYRK1A are the cause of mental retardation autosomal dominant type 7 (MRD7) [MIM:[~~http~~://omim.org/entry/614104 614104]]. A disease characterized by primary microcephaly, severe mental retardation without speech, anxious autistic behavior, and dysmorphic features, including bitemporal narrowing, deep-set eyes, large simple ears, and a pointed nasal tip. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period.<ref>PMID:21294719</ref>		[https://www.uniprot.org/uniprot/DYR1A_HUMAN DYR1A_HUMAN] Defects in DYRK1A are the cause of mental retardation autosomal dominant type 7 (MRD7) [MIM:[https://omim.org/entry/614104 614104]. A disease characterized by primary microcephaly, severe mental retardation without speech, anxious autistic behavior, and dysmorphic features, including bitemporal narrowing, deep-set eyes, large simple ears, and a pointed nasal tip. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period.<ref>PMID:21294719</ref>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/DYR1A_HUMAN DYR1A_HUMAN]] May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates.<ref>PMID:8769099</ref>		[https://www.uniprot.org/uniprot/DYR1A_HUMAN DYR1A_HUMAN] May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates.<ref>PMID:8769099</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 5a4e" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5a4e" style="background-color:#fffaf0;"></div>

	~~==See Also==~~
	*[[Dual specificity tyrosine-phosphorylation-regulated kinase\|Dual specificity tyrosine-phosphorylation-regulated kinase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Dual-specificity kinase]]~~		[[Category: Homo sapiens]]
	~~[[Category: Human~~]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Rothweiler, U]]		[[Category: Rothweiler U]]
	~~[[Category: Transferase~~]]

OCA at 08:23, 4 November 2020

2020-11-04T08:23:23Z

← Older revision		Revision as of 08:23, 4 November 2020
Line 1:		Line 1:

	==DYRK1A in complex with methoxy benzothiazole fragment==		==DYRK1A in complex with methoxy benzothiazole fragment==
	<StructureSection load='5a4e' size='340' side='right' caption='[[5a4e]], [[Resolution\|resolution]] 2.68Å' scene=''>		<StructureSection load='5a4e' size='340' side='right'caption='[[5a4e]], [[Resolution\|resolution]] 2.68Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5a4e]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A4E OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5A4E FirstGlance]. <br>		<table><tr><td colspan='2'>[[5a4e]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A4E OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5A4E FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7QQ:N-(5-METHOXY-1,3-BENZOTHIAZOL-2-YL)ETHANAMIDE'>7QQ</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7QQ:N-(5-METHOXY-1,3-BENZOTHIAZOL-2-YL)ETHANAMIDE'>7QQ</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5a3x\|5a3x]], [[5a4l\|5a4l]], [[5a4q\|5a4q]], [[5a4t\|5a4t]], [[5a54\|5a54]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5a3x\|5a3x]], [[5a4l\|5a4l]], [[5a4q\|5a4q]], [[5a4t\|5a4t]], [[5a54\|5a54]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dual-specificity_kinase Dual-specificity kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.12.1 2.7.12.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dual-specificity_kinase Dual-specificity kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.12.1 2.7.12.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5a4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a4e OCA], [http://pdbe.org/5a4e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5a4e RCSB], [http://www.ebi.ac.uk/pdbsum/5a4e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5a4e ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5a4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a4e OCA], [http://pdbe.org/5a4e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5a4e RCSB], [http://www.ebi.ac.uk/pdbsum/5a4e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5a4e ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	</div>		</div>
	<div class="pdbe-citations 5a4e" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5a4e" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Dual specificity tyrosine-phosphorylation-regulated kinase\|Dual specificity tyrosine-phosphorylation-regulated kinase]]
	== References ==		== References ==
	<references/>		<references/>
Line 29:		Line 32:
	[[Category: Dual-specificity kinase]]		[[Category: Dual-specificity kinase]]
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Rothweiler, U]]		[[Category: Rothweiler, U]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 09:16, 30 January 2019

2019-01-30T09:16:23Z

← Older revision		Revision as of 09:16, 30 January 2019
Line 1:		Line 1:

	==DYRK1A ~~IN COMPLEX WITH METHOXY BENZOTHIAZOL FRAGMENT~~==		==DYRK1A in complex with methoxy benzothiazole fragment==
	<StructureSection load='5a4e' size='340' side='right' caption='[[5a4e]], [[Resolution\|resolution]] 2.68Å' scene=''>		<StructureSection load='5a4e' size='340' side='right' caption='[[5a4e]], [[Resolution\|resolution]] 2.68Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5a4e]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A4E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A4E FirstGlance]. <br>		<table><tr><td colspan='2'>[[5a4e]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A4E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A4E FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7QQ:N-(5-METHOXY-1,3-BENZOTHIAZOL-2-YL)ETHANAMIDE'>7QQ</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7QQ:N-(5-METHOXY-1,3-BENZOTHIAZOL-2-YL)ETHANAMIDE'>7QQ</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Dual-specificity kinase]]		[[Category: Dual-specificity kinase]]
			[[Category: Human]]
	[[Category: Rothweiler, U]]		[[Category: Rothweiler, U]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 11:26, 15 December 2016

2016-12-15T11:26:43Z

← Older revision		Revision as of 11:26, 15 December 2016
Line 14:		Line 14:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/DYR1A_HUMAN DYR1A_HUMAN]] May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates.<ref>PMID:8769099</ref>		[[http://www.uniprot.org/uniprot/DYR1A_HUMAN DYR1A_HUMAN]] May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates.<ref>PMID:8769099</ref>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			DYRK1A has emerged as a potential target for therapies of Alzheimer's disease using small molecules. On the basis of the observation of selective DYRK1A inhibition by firefly d-luciferin, we have explored static and dynamic structural properties of fragment sized variants of the benzothiazole scaffold with respect to DYRK1A using X-ray crystallography and NMR techniques. The compounds have excellent ligand efficiencies and show a remarkable diversity of binding modes in dynamic equilibrium. Binding geometries are determined in part by interactions often considered "weak", including "orthogonal multipolar" types represented by, for example, F-CO, sulfur-aromatic, and halogen-aromatic interactions, together with hydrogen bonds that are modulated by variation of electron withdrawing groups. These studies show how the benzothiazole scaffold is highly promising for the development of therapeutic DYRK1A inhibitors. In addition, the subtleties of the binding interactions, including dynamics, show how full structural studies are required to fully interpret the essential physical determinants of binding.

			Probing the ATP-Binding Pocket of Protein Kinase DYRK1A with Benzothiazole Fragment Molecules.,Rothweiler U, Stensen W, Brandsdal BO, Isaksson J, Leeson FA, Engh RA, Svendsen JS J Med Chem. 2016 Nov 10;59(21):9814-9824. Epub 2016 Oct 21. PMID:27736065<ref>PMID:27736065</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 5a4e" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:16, 13 July 2016

2016-07-13T10:16:17Z

← Older revision		Revision as of 10:16, 13 July 2016
Line 1:		Line 1:
	~~'''Unreleased structure'''~~

	~~The entry~~ 5a4e is ~~ON HOLD until Paper Publication~~		==DYRK1A IN COMPLEX WITH METHOXY BENZOTHIAZOL FRAGMENT==
			<StructureSection load='5a4e' size='340' side='right' caption='[[5a4e]], [[Resolution\|resolution]] 2.68Å' scene=''>
	~~Authors~~: ~~Rothweiler~~, U.		== Structural highlights ==
			<table><tr><td colspan='2'>[[5a4e]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A4E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A4E FirstGlance]. <br>
	~~Description~~: DYRK1A ~~IN COMPLEX WITH METHOXY BENZOTHIAZOL FRAGMENT~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7QQ:N-(5-METHOXY-1,3-BENZOTHIAZOL-2-YL)ETHANAMIDE'>7QQ</scene></td></tr>
	[[Category: ~~Unreleased Structures~~]]		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5a3x\|5a3x]], [[5a4l\|5a4l]], [[5a4q\|5a4q]], [[5a4t\|5a4t]], [[5a54\|5a54]]</td></tr>
			<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dual-specificity_kinase Dual-specificity kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.12.1 2.7.12.1] </span></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a4e OCA], [http://pdbe.org/5a4e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5a4e RCSB], [http://www.ebi.ac.uk/pdbsum/5a4e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5a4e ProSAT]</span></td></tr>
			</table>
			== Disease ==
			[[http://www.uniprot.org/uniprot/DYR1A_HUMAN DYR1A_HUMAN]] Defects in DYRK1A are the cause of mental retardation autosomal dominant type 7 (MRD7) [MIM:[http://omim.org/entry/614104 614104]]. A disease characterized by primary microcephaly, severe mental retardation without speech, anxious autistic behavior, and dysmorphic features, including bitemporal narrowing, deep-set eyes, large simple ears, and a pointed nasal tip. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period.<ref>PMID:21294719</ref>
			== Function ==
			[[http://www.uniprot.org/uniprot/DYR1A_HUMAN DYR1A_HUMAN]] May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates.<ref>PMID:8769099</ref>
			== References ==
			<references/>
			__TOC__
			</StructureSection>
			[[Category: Dual-specificity kinase]]
	[[Category: Rothweiler, U]]		[[Category: Rothweiler, U]]
			[[Category: Transferase]]

OCA at 20:36, 10 May 2016

2016-05-10T20:36:58Z

← Older revision		Revision as of 20:36, 10 May 2016
Line 5:		Line 5:
	Authors: Rothweiler, U.		Authors: Rothweiler, U.

	Description: DYRK1A IN COMPLEX WITH METHOXY ~~BENZOTHIAZOLE~~ FRAGMENT		Description: DYRK1A IN COMPLEX WITH METHOXY BENZOTHIAZOL FRAGMENT
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Rothweiler, U]]		[[Category: Rothweiler, U]]

OCA at 09:34, 2 September 2015

2015-09-02T09:34:40Z

← Older revision		Revision as of 09:34, 2 September 2015
Line 5:		Line 5:
	Authors: Rothweiler, U.		Authors: Rothweiler, U.

	Description: DYRK1A IN COMPLEX WITH METHOXY ~~BENZOTHIAZOL~~ FRAGMENT		Description: DYRK1A IN COMPLEX WITH METHOXY BENZOTHIAZOLE FRAGMENT
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Rothweiler, U]]		[[Category: Rothweiler, U]]

OCA: Protected "5a4e" [edit=sysop:move=sysop]

2015-06-17T13:31:16Z

Protected "5a4e" [edit=sysop:move=sysop]

← Older revision	Revision as of 13:31, 17 June 2015
(No difference)

OCA: New page: '''Unreleased structure''' The entry 5a4e is ON HOLD until Paper Publication Authors: Rothweiler, U. Description: DYRK1A IN COMPLEX WITH METHOXY BENZOTHIAZOL FRAGMENT [[Category: Unrel...

2015-06-17T13:31:15Z

New page: '''Unreleased structure''' The entry 5a4e is ON HOLD until Paper Publication Authors: Rothweiler, U. Description: DYRK1A IN COMPLEX WITH METHOXY BENZOTHIAZOL FRAGMENT [[Category: Unrel...

New page

'''Unreleased structure'''

The entry 5a4e is ON HOLD until Paper Publication

Authors: Rothweiler, U.

Description: DYRK1A IN COMPLEX WITH METHOXY BENZOTHIAZOL FRAGMENT
[[Category: Unreleased Structures]]
[[Category: Rothweiler, U]]