5alg - Revision history

OCA at 11:12, 10 January 2024

2024-01-10T11:12:36Z

← Older revision		Revision as of 11:12, 10 January 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5alg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ALG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ALG FirstGlance]. <br>		<table><tr><td colspan='2'>[[5alg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ALG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ALG FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=R4N:4-[(3-CHLOROPHENYL)METHYL]-N-[[(3S)-2,3-DIHYDRO-1,4-BENZODIOXIN-3-YL]METHYL]-3-OXIDANYLIDENE-1,4-BENZOTHIAZINE-6-CARBOXAMIDE'>R4N</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=R4N:4-[(3-CHLOROPHENYL)METHYL]-N-[[(3S)-2,3-DIHYDRO-1,4-BENZODIOXIN-3-YL]METHYL]-3-OXIDANYLIDENE-1,4-BENZOTHIAZINE-6-CARBOXAMIDE'>R4N</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5alg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5alg OCA], [https://pdbe.org/5alg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5alg RCSB], [https://www.ebi.ac.uk/pdbsum/5alg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5alg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5alg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5alg OCA], [https://pdbe.org/5alg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5alg RCSB], [https://www.ebi.ac.uk/pdbsum/5alg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5alg ProSAT]</span></td></tr>
	</table>		</table>

OCA at 06:12, 31 May 2023

2023-05-31T06:12:55Z

← Older revision		Revision as of 06:12, 31 May 2023
Line 3:		Line 3:
	<StructureSection load='5alg' size='340' side='right'caption='[[5alg]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='5alg' size='340' side='right'caption='[[5alg]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5alg]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ALG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ALG FirstGlance]. <br>		<table><tr><td colspan='2'>[[5alg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ALG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ALG FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=R4N:4-[(3-CHLOROPHENYL)METHYL]-N-[[(3S)-2,3-DIHYDRO-1,4-BENZODIOXIN-3-YL]METHYL]-3-OXIDANYLIDENE-1,4-BENZOTHIAZINE-6-CARBOXAMIDE'>R4N</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=R4N:4-[(3-CHLOROPHENYL)METHYL]-N-[[(3S)-2,3-DIHYDRO-1,4-BENZODIOXIN-3-YL]METHYL]-3-OXIDANYLIDENE-1,4-BENZOTHIAZINE-6-CARBOXAMIDE'>R4N</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ak3\|5ak3]], [[5ak4\|5ak4]], [[5ak5\|5ak5]], [[5ak6\|5ak6]], [[5ake\|5ake]], [[5akg\|5akg]], [[5akh\|5akh]], [[5aki\|5aki]], [[5akj\|5akj]], [[5akk\|5akk]], [[5akl\|5akl]], [[5akx\|5akx]], [[5aky\|5aky]], [[5akz\|5akz]], [[5ald\|5ald]], [[5ale\|5ale]], [[5alf\|5alf]], [[5alh\|5alh]], [[5ali\|5ali]], [[5alj\|5alj]], [[5alk\|5alk]], [[5all\|5all]], [[5alm\|5alm]], [[5aln\|5aln]], [[5alo\|5alo]], [[5alp\|5alp]], [[5alq\|5alq]], [[5alr\|5alr]], [[5als\|5als]], [[5alt\|5alt]], [[5alu\|5alu]], [[5alv\|5alv]], [[5alw\|5alw]], [[5alx\|5alx]], [[5aly\|5aly]], [[5alz\|5alz]], [[5am0\|5am0]], [[5am1\|5am1]], [[5am2\|5am2]], [[5am3\|5am3]], [[5am4\|5am4]], [[5am5\|5am5]]</td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5alg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5alg OCA], [https://pdbe.org/5alg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5alg RCSB], [https://www.ebi.ac.uk/pdbsum/5alg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5alg ProSAT]</span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5alg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5alg OCA], [~~http~~://pdbe.org/5alg PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5alg RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5alg PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5alg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/HYES_HUMAN HYES_HUMAN]] Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides. Also determines steady-state levels of physiological mediators. The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid, 12-phosphonooxy-octadec-9E-enoic acid, and p-nitrophenyl phospate.<ref>PMID:12574508</ref> <ref>PMID:12574510</ref>		[https://www.uniprot.org/uniprot/HYES_HUMAN HYES_HUMAN] Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides. Also determines steady-state levels of physiological mediators. The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid, 12-phosphonooxy-octadec-9E-enoic acid, and p-nitrophenyl phospate.<ref>PMID:12574508</ref> <ref>PMID:12574510</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Kack, H]]		[[Category: Kack H]]
	[[Category: Oster, L]]		[[Category: Oster L]]
	[[Category: Tapani, S]]		[[Category: Tapani S]]
	[[Category: Xue, Y]]		[[Category: Xue Y]]
	~~[[Category: Hydrolase~~]]

OCA at 08:41, 11 March 2020

2020-03-11T08:41:22Z

← Older revision		Revision as of 08:41, 11 March 2020
Line 1:		Line 1:

	==ligand complex structure of soluble epoxide hydrolase==		==ligand complex structure of soluble epoxide hydrolase==
	<StructureSection load='5alg' size='340' side='right' caption='[[5alg]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='5alg' size='340' side='right'caption='[[5alg]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5alg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ALG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ALG FirstGlance]. <br>		<table><tr><td colspan='2'>[[5alg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ALG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ALG FirstGlance]. <br>
Line 21:		Line 21:

	==See Also==		==See Also==
	*[[Epoxide hydrolase\|Epoxide hydrolase]]		*[[Epoxide hydrolase 3D structures\|Epoxide hydrolase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 27:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Kack, H]]		[[Category: Kack, H]]
	[[Category: Oster, L]]		[[Category: Oster, L]]

OCA at 06:44, 4 April 2018

2018-04-04T06:44:17Z

← Older revision		Revision as of 06:44, 4 April 2018
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 5alg" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5alg" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Epoxide hydrolase\|Epoxide hydrolase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 16:34, 16 November 2017

2017-11-16T16:34:08Z

← Older revision		Revision as of 16:34, 16 November 2017
Line 1:		Line 1:

	==ligand complex structure of soluble epoxide hydrolase==		==ligand complex structure of soluble epoxide hydrolase==
	<StructureSection load='5alg' size='340' side='right' caption='[[5alg]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='5alg' size='340' side='right' caption='[[5alg]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5alg]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ALG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ALG FirstGlance]. <br>		<table><tr><td colspan='2'>[[5alg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ALG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ALG FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=R4N:4-[(3-CHLOROPHENYL)METHYL]-N-[[(3S)-2,3-DIHYDRO-1,4-BENZODIOXIN-3-YL]METHYL]-3-OXIDANYLIDENE-1,4-BENZOTHIAZINE-6-CARBOXAMIDE'>R4N</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=R4N:4-[(3-CHLOROPHENYL)METHYL]-N-[[(3S)-2,3-DIHYDRO-1,4-BENZODIOXIN-3-YL]METHYL]-3-OXIDANYLIDENE-1,4-BENZOTHIAZINE-6-CARBOXAMIDE'>R4N</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ak3\|5ak3]], [[5ak4\|5ak4]], [[5ak5\|5ak5]], [[5ak6\|5ak6]], [[5ake\|5ake]], [[5akg\|5akg]], [[5akh\|5akh]], [[5aki\|5aki]], [[5akj\|5akj]], [[5akk\|5akk]], [[5akl\|5akl]], [[5akx\|5akx]], [[5aky\|5aky]], [[5akz\|5akz]], [[5ald\|5ald]], [[5ale\|5ale]], [[5alf\|5alf]], [[5alh\|5alh]], [[5ali\|5ali]], [[5alj\|5alj]], [[5alk\|5alk]], [[5all\|5all]], [[5alm\|5alm]], [[5aln\|5aln]], [[5alo\|5alo]], [[5alp\|5alp]], [[5alq\|5alq]], [[5alr\|5alr]], [[5als\|5als]], [[5alt\|5alt]], [[5alu\|5alu]], [[5alv\|5alv]], [[5alw\|5alw]], [[5alx\|5alx]], [[5aly\|5aly]], [[5alz\|5alz]], [[5am0\|5am0]], [[5am1\|5am1]], [[5am2\|5am2]], [[5am3\|5am3]], [[5am4\|5am4]], [[5am5\|5am5]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ak3\|5ak3]], [[5ak4\|5ak4]], [[5ak5\|5ak5]], [[5ak6\|5ak6]], [[5ake\|5ake]], [[5akg\|5akg]], [[5akh\|5akh]], [[5aki\|5aki]], [[5akj\|5akj]], [[5akk\|5akk]], [[5akl\|5akl]], [[5akx\|5akx]], [[5aky\|5aky]], [[5akz\|5akz]], [[5ald\|5ald]], [[5ale\|5ale]], [[5alf\|5alf]], [[5alh\|5alh]], [[5ali\|5ali]], [[5alj\|5alj]], [[5alk\|5alk]], [[5all\|5all]], [[5alm\|5alm]], [[5aln\|5aln]], [[5alo\|5alo]], [[5alp\|5alp]], [[5alq\|5alq]], [[5alr\|5alr]], [[5als\|5als]], [[5alt\|5alt]], [[5alu\|5alu]], [[5alv\|5alv]], [[5alw\|5alw]], [[5alx\|5alx]], [[5aly\|5aly]], [[5alz\|5alz]], [[5am0\|5am0]], [[5am1\|5am1]], [[5am2\|5am2]], [[5am3\|5am3]], [[5am4\|5am4]], [[5am5\|5am5]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5alg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5alg OCA], [http://pdbe.org/5alg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5alg RCSB], [http://www.ebi.ac.uk/pdbsum/5alg PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5alg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5alg OCA], [http://pdbe.org/5alg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5alg RCSB], [http://www.ebi.ac.uk/pdbsum/5alg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5alg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 5alg" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5alg" style="background-color:#fffaf0;"></div>

	~~==See Also==~~
	*[[Epoxide hydrolase\|Epoxide hydrolase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Human]]
	[[Category: Kack, H]]		[[Category: Kack, H]]
	[[Category: Oster, L]]		[[Category: Oster, L]]

OCA at 07:45, 30 September 2015

2015-09-30T07:45:54Z

← Older revision		Revision as of 07:45, 30 September 2015
Line 5:		Line 5:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=R4N:4-[(3-CHLOROPHENYL)METHYL]-N-[[(3S)-2,3-DIHYDRO-1,4-BENZODIOXIN-3-YL]METHYL]-3-OXIDANYLIDENE-1,4-BENZOTHIAZINE-6-CARBOXAMIDE'>R4N</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=R4N:4-[(3-CHLOROPHENYL)METHYL]-N-[[(3S)-2,3-DIHYDRO-1,4-BENZODIOXIN-3-YL]METHYL]-3-OXIDANYLIDENE-1,4-BENZOTHIAZINE-6-CARBOXAMIDE'>R4N</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ak3\|5ak3]], [[5ak4\|5ak4]], [[5ak5\|5ak5]], [[5ak6\|5ak6]], [[5ake\|5ake]], [[5akg\|5akg]], [[5akh\|5akh]], [[5aki\|5aki]], [[5akj\|5akj]], [[5akk\|5akk]], [[5akl\|5akl]], [[5akx\|5akx]], [[5aky\|5aky]], [[5akz\|5akz]], [[5ald\|5ald]], [[5ale\|5ale]], [[5alf\|5alf]], [[5alh\|5alh]], [[5ali\|5ali]], [[5alj\|5alj]], [[5alk\|5alk]], [[5all\|5all]], [[5alm\|5alm]], [[5aln\|5aln]], [[5alo\|5alo]], [[5alp\|5alp]], [[5alq\|5alq]], [[5alr\|5alr]], [[5als\|5als]], [[5alt\|5alt]], [[5alu\|5alu]], [[5alv\|5alv]], [[5alw\|5alw]], [[5alx\|5alx]], [[5aly\|5aly]], [[5alz\|5alz]], [[5am0\|5am0]], [[5am1\|5am1]], [[5am2\|5am2]], [[5am3\|5am3]], [[5am4\|5am4]], [[5am5\|5am5]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ak3\|5ak3]], [[5ak4\|5ak4]], [[5ak5\|5ak5]], [[5ak6\|5ak6]], [[5ake\|5ake]], [[5akg\|5akg]], [[5akh\|5akh]], [[5aki\|5aki]], [[5akj\|5akj]], [[5akk\|5akk]], [[5akl\|5akl]], [[5akx\|5akx]], [[5aky\|5aky]], [[5akz\|5akz]], [[5ald\|5ald]], [[5ale\|5ale]], [[5alf\|5alf]], [[5alh\|5alh]], [[5ali\|5ali]], [[5alj\|5alj]], [[5alk\|5alk]], [[5all\|5all]], [[5alm\|5alm]], [[5aln\|5aln]], [[5alo\|5alo]], [[5alp\|5alp]], [[5alq\|5alq]], [[5alr\|5alr]], [[5als\|5als]], [[5alt\|5alt]], [[5alu\|5alu]], [[5alv\|5alv]], [[5alw\|5alw]], [[5alx\|5alx]], [[5aly\|5aly]], [[5alz\|5alz]], [[5am0\|5am0]], [[5am1\|5am1]], [[5am2\|5am2]], [[5am3\|5am3]], [[5am4\|5am4]], [[5am5\|5am5]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5alg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5alg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5alg RCSB], [http://www.ebi.ac.uk/pdbsum/5alg PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5alg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5alg OCA], [http://pdbe.org/5alg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5alg RCSB], [http://www.ebi.ac.uk/pdbsum/5alg PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 5alg" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Epoxide hydrolase\|Epoxide hydrolase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:20, 13 May 2015

2015-05-13T12:20:30Z

← Older revision		Revision as of 12:20, 13 May 2015
Line 1:		Line 1:
	'''~~Unreleased~~ structure'''		==ligand complex structure of soluble epoxide hydrolase==
			<StructureSection load='5alg' size='340' side='right' caption='[[5alg]], [[Resolution\|resolution]] 2.40Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[5alg]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ALG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ALG FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=R4N:4-[(3-CHLOROPHENYL)METHYL]-N-[[(3S)-2,3-DIHYDRO-1,4-BENZODIOXIN-3-YL]METHYL]-3-OXIDANYLIDENE-1,4-BENZOTHIAZINE-6-CARBOXAMIDE'>R4N</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ak3\|5ak3]], [[5ak4\|5ak4]], [[5ak5\|5ak5]], [[5ak6\|5ak6]], [[5ake\|5ake]], [[5akg\|5akg]], [[5akh\|5akh]], [[5aki\|5aki]], [[5akj\|5akj]], [[5akk\|5akk]], [[5akl\|5akl]], [[5akx\|5akx]], [[5aky\|5aky]], [[5akz\|5akz]], [[5ald\|5ald]], [[5ale\|5ale]], [[5alf\|5alf]], [[5alh\|5alh]], [[5ali\|5ali]], [[5alj\|5alj]], [[5alk\|5alk]], [[5all\|5all]], [[5alm\|5alm]], [[5aln\|5aln]], [[5alo\|5alo]], [[5alp\|5alp]], [[5alq\|5alq]], [[5alr\|5alr]], [[5als\|5als]], [[5alt\|5alt]], [[5alu\|5alu]], [[5alv\|5alv]], [[5alw\|5alw]], [[5alx\|5alx]], [[5aly\|5aly]], [[5alz\|5alz]], [[5am0\|5am0]], [[5am1\|5am1]], [[5am2\|5am2]], [[5am3\|5am3]], [[5am4\|5am4]], [[5am5\|5am5]]</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5alg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5alg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5alg RCSB], [http://www.ebi.ac.uk/pdbsum/5alg PDBsum]</span></td></tr>
			</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/HYES_HUMAN HYES_HUMAN]] Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides. Also determines steady-state levels of physiological mediators. The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid, 12-phosphonooxy-octadec-9E-enoic acid, and p-nitrophenyl phospate.<ref>PMID:12574508</ref> <ref>PMID:12574510</ref>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Fragment-based drug discovery relies upon structural information for efficient compound progression, yet it is often challenging to generate structures with bound fragments. A summary of recent literature reveals that a wide repertoire of experimental procedures is employed to generate ligand-bound crystal structures successfully. We share in-house experience from setting up and executing fragment crystallography in a project that resulted in 55 complex structures. The ligands span five orders of magnitude in affinity and the resulting structures are made available to be of use, for example, for development of computational methods. Analysis of the results revealed that ligand properties such as potency, ligand efficiency (LE) and, to some degree, clogP influence the success of complex structure generation.

	~~The entry 5alg is ON HOLD until Paper Publication~~		Successful generation of structural information for fragment-based drug discovery.,Oster L, Tapani S, Xue Y, Kack H Drug Discov Today. 2015 Apr 28. pii: S1359-6446(15)00154-3. doi:, 10.1016/j.drudis.2015.04.005. PMID:25931264<ref>PMID:25931264</ref>

	~~Authors: Oster~~, L.~~, Tapani,~~ S.~~, Xue, Y., Kack, H~~.		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~Description: ligand complex structure of soluble epoxide hydrolase~~		== References ==
	~~[[Category: Unreleased Structures]]~~		<references/>
			__TOC__
			</StructureSection>
	[[Category: Kack, H]]		[[Category: Kack, H]]
			[[Category: Oster, L]]
	[[Category: Tapani, S]]		[[Category: Tapani, S]]
	~~[[Category: Oster, L]]~~
	[[Category: Xue, Y]]		[[Category: Xue, Y]]
			[[Category: Hydrolase]]

OCA at 12:23, 1 April 2015

2015-04-01T12:23:17Z

← Older revision		Revision as of 12:23, 1 April 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 5alg is ON HOLD		The entry 5alg is ON HOLD until Paper Publication

	Authors: Oster, L., Tapani, S., Xue, Y., Kack, H.		Authors: Oster, L., Tapani, S., Xue, Y., Kack, H.

OCA: Protected "5alg" [edit=sysop:move=sysop]

2015-03-18T11:13:20Z

Protected "5alg" [edit=sysop:move=sysop]

← Older revision	Revision as of 11:13, 18 March 2015
(No difference)

OCA: New page: '''Unreleased structure''' The entry 5alg is ON HOLD Authors: Oster, L., Tapani, S., Xue, Y., Kack, H. Description: ligand complex structure of soluble epoxide hydrolase [[Category: Un...

2015-03-18T11:13:19Z

New page: '''Unreleased structure''' The entry 5alg is ON HOLD Authors: Oster, L., Tapani, S., Xue, Y., Kack, H. Description: ligand complex structure of soluble epoxide hydrolase [[Category: Un...

New page

'''Unreleased structure'''

The entry 5alg is ON HOLD

Authors: Oster, L., Tapani, S., Xue, Y., Kack, H.

Description: ligand complex structure of soluble epoxide hydrolase
[[Category: Unreleased Structures]]
[[Category: Kack, H]]
[[Category: Tapani, S]]
[[Category: Oster, L]]
[[Category: Xue, Y]]