5amd - Revision history

OCA at 11:13, 10 January 2024

2024-01-10T11:13:20Z

← Older revision		Revision as of 11:13, 10 January 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5amd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AMD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AMD FirstGlance]. <br>		<table><tr><td colspan='2'>[[5amd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AMD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AMD FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=45I:2-[(2-PHENYLETHYL)SULFAMOYL]-4-SULFAMOYLBENZOIC+ACID'>45I</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.5Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=45I:2-[(2-PHENYLETHYL)SULFAMOYL]-4-SULFAMOYLBENZOIC+ACID'>45I</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5amd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5amd OCA], [https://pdbe.org/5amd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5amd RCSB], [https://www.ebi.ac.uk/pdbsum/5amd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5amd ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5amd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5amd OCA], [https://pdbe.org/5amd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5amd RCSB], [https://www.ebi.ac.uk/pdbsum/5amd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5amd ProSAT]</span></td></tr>
	</table>		</table>

OCA at 06:14, 31 May 2023

2023-05-31T06:14:24Z

← Older revision		Revision as of 06:14, 31 May 2023
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	<StructureSection load='5amd' size='340' side='right'caption='[[5amd]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='5amd' size='340' side='right'caption='[[5amd]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5amd]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AMD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5AMD FirstGlance]. <br>		<table><tr><td colspan='2'>[[5amd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AMD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AMD FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=45I:2-[(2-PHENYLETHYL)SULFAMOYL]-4-SULFAMOYLBENZOIC+ACID'>45I</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=45I:2-[(2-PHENYLETHYL)SULFAMOYL]-4-SULFAMOYLBENZOIC+ACID'>45I</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5amg\|5amg]], [[5aml\|5aml]]</td></tr>~~		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5amd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5amd OCA], [https://pdbe.org/5amd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5amd RCSB], [https://www.ebi.ac.uk/pdbsum/5amd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5amd ProSAT]</span></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5amd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5amd OCA], [~~http~~://pdbe.org/5amd PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5amd RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5amd PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5amd ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[~~[http~~://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[~~http~~://omim.org/entry/259730 259730]]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref>		[https://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[https://omim.org/entry/259730 259730]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>		[https://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Carbonate dehydratase]]~~		[[Category: Homo sapiens]]
	~~[[Category: Human~~]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Leitans, J]]		[[Category: Leitans J]]
	[[Category: Tars, K]]		[[Category: Tars K]]
	[[Category: Zalubovskis, R]]		[[Category: Zalubovskis R]]
	~~[[Category: Ca 2]]~~
	~~[[Category: Ca ii]]~~
	~~[[Category: Lyase~~]]

OCA at 08:23, 4 November 2020

2020-11-04T08:23:54Z

← Older revision		Revision as of 08:23, 4 November 2020
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	==Three dimensional structure of human carbonic anhydrase II in complex with 2-((2-Phenylethyl)sulfamoyl)-4-sulfamoylbenzoic acid==		==Three dimensional structure of human carbonic anhydrase II in complex with 2-((2-Phenylethyl)sulfamoyl)-4-sulfamoylbenzoic acid==
	<StructureSection load='5amd' size='340' side='right' caption='[[5amd]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='5amd' size='340' side='right'caption='[[5amd]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5amd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AMD OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5AMD FirstGlance]. <br>		<table><tr><td colspan='2'>[[5amd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AMD OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5AMD FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=45I:2-[(2-PHENYLETHYL)SULFAMOYL]-4-SULFAMOYLBENZOIC+ACID'>45I</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=45I:2-[(2-PHENYLETHYL)SULFAMOYL]-4-SULFAMOYLBENZOIC+ACID'>45I</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5amg\|5amg]], [[5aml\|5aml]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5amg\|5amg]], [[5aml\|5aml]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5amd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5amd OCA], [http://pdbe.org/5amd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5amd RCSB], [http://www.ebi.ac.uk/pdbsum/5amd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5amd ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5amd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5amd OCA], [http://pdbe.org/5amd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5amd RCSB], [http://www.ebi.ac.uk/pdbsum/5amd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5amd ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	==See Also==		==See Also==
	*[[Carbonic anhydrase\|Carbonic anhydrase]]		*[[Carbonic anhydrase 3D structures\|Carbonic anhydrase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	[[Category: Carbonate dehydratase]]		[[Category: Carbonate dehydratase]]
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Leitans, J]]		[[Category: Leitans, J]]
	[[Category: Tars, K]]		[[Category: Tars, K]]

OCA at 09:16, 30 January 2019

2019-01-30T09:16:59Z

← Older revision		Revision as of 09:16, 30 January 2019
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	</div>		</div>
	<div class="pdbe-citations 5amd" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5amd" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Carbonic anhydrase\|Carbonic anhydrase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:02, 17 January 2018

2018-01-17T08:02:04Z

← Older revision		Revision as of 08:02, 17 January 2018
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	<StructureSection load='5amd' size='340' side='right' caption='[[5amd]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='5amd' size='340' side='right' caption='[[5amd]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5amd]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AMD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AMD FirstGlance]. <br>		<table><tr><td colspan='2'>[[5amd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AMD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AMD FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=45I:2-[(2-PHENYLETHYL)SULFAMOYL]-4-SULFAMOYLBENZOIC+ACID'>45I</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=45I:2-[(2-PHENYLETHYL)SULFAMOYL]-4-SULFAMOYLBENZOIC+ACID'>45I</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5amg\|5amg]], [[5aml\|5aml]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5amg\|5amg]], [[5aml\|5aml]]</td></tr>
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	</StructureSection>		</StructureSection>
	[[Category: Carbonate dehydratase]]		[[Category: Carbonate dehydratase]]
			[[Category: Human]]
	[[Category: Leitans, J]]		[[Category: Leitans, J]]
	[[Category: Tars, K]]		[[Category: Tars, K]]

OCA at 09:59, 10 March 2017

2017-03-10T09:59:16Z

← Older revision		Revision as of 09:59, 10 March 2017
Line 1:		Line 1:

	==Three dimensional structure of human carbonic anhydrase II in complex with 2-((2-Phenylethyl)sulfamoyl)-4-sulfamoylbenzoic acid==		==Three dimensional structure of human carbonic anhydrase II in complex with 2-((2-Phenylethyl)sulfamoyl)-4-sulfamoylbenzoic acid==
	<StructureSection load='5amd' size='340' side='right' caption='[[5amd]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='5amd' size='340' side='right' caption='[[5amd]], [[Resolution\|resolution]] 1.50Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5amg\|5amg]], [[5aml\|5aml]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5amg\|5amg]], [[5aml\|5aml]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5amd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5amd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5amd RCSB], [http://www.ebi.ac.uk/pdbsum/5amd PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5amd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5amd OCA], [http://pdbe.org/5amd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5amd RCSB], [http://www.ebi.ac.uk/pdbsum/5amd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5amd ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 5amd" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:03, 8 April 2015

2015-04-08T11:03:30Z

← Older revision		Revision as of 11:03, 8 April 2015
Line 1:		Line 1:
	'''~~Unreleased~~ structure'''		==Three dimensional structure of human carbonic anhydrase II in complex with 2-((2-Phenylethyl)sulfamoyl)-4-sulfamoylbenzoic acid==
			<StructureSection load='5amd' size='340' side='right' caption='[[5amd]], [[Resolution\|resolution]] 1.50Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[5amd]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AMD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AMD FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=45I:2-[(2-PHENYLETHYL)SULFAMOYL]-4-SULFAMOYLBENZOIC+ACID'>45I</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5amg\|5amg]], [[5aml\|5aml]]</td></tr>
			<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5amd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5amd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5amd RCSB], [http://www.ebi.ac.uk/pdbsum/5amd PDBsum]</span></td></tr>
			</table>
			== Disease ==
			[[http://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[http://omim.org/entry/259730 259730]]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref>
			== Function ==
			[[http://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			1-N-Alkylated-6-sulfamoyl saccharin derivatives were prepared and assayed as carbonic anhydrase inhibitors (CAIs). During X-ray crystallographic experiments an unexpected hydrolysis of the isothiazole ring was evidenced which allowed us to prepare highly potent enzyme inhibitors with selectivity for some isoforms with medical applications.

	~~The entry 5amd is ON HOLD until Paper Publication~~		X-ray crystallography-promoted drug design of carbonic anhydrase inhibitors.,Ivanova J, Leitans J, Tanc M, Kazaks A, Zalubovskis R, Supuran CT, Tars K Chem Commun (Camb). 2015 Mar 27. PMID:25813715<ref>PMID:25813715</ref>

	~~Authors: Leitans~~, J.~~, Tars, K~~.~~, Zalubovskis, R~~.		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~Description~~: ~~Three dimensional structure of human carbonic anhydrase II in complex with 2-((2-Phenylethyl)sulfamoyl)-4-sulfamoylbenzoic acid~~		== References ==
	[[Category: ~~Unreleased Structures~~]]		<references/>
			__TOC__
			</StructureSection>
			[[Category: Carbonate dehydratase]]
			[[Category: Leitans, J]]
			[[Category: Tars, K]]
	[[Category: Zalubovskis, R]]		[[Category: Zalubovskis, R]]
	[[Category: ~~Tars, K~~]]		[[Category: Ca 2]]
	[[Category: ~~Leitans, J~~]]		[[Category: Ca ii]]
			[[Category: Lyase]]

OCA: Protected "5amd" [edit=sysop:move=sysop]

2015-03-18T11:14:49Z

Protected "5amd" [edit=sysop:move=sysop]

← Older revision	Revision as of 11:14, 18 March 2015
(No difference)

OCA: New page: '''Unreleased structure''' The entry 5amd is ON HOLD until Paper Publication Authors: Leitans, J., Tars, K., Zalubovskis, R. Description: Three dimensional structure of human carbonic ...

2015-03-18T11:14:48Z

New page: '''Unreleased structure''' The entry 5amd is ON HOLD until Paper Publication Authors: Leitans, J., Tars, K., Zalubovskis, R. Description: Three dimensional structure of human carbonic ...

New page

'''Unreleased structure'''

The entry 5amd is ON HOLD until Paper Publication

Authors: Leitans, J., Tars, K., Zalubovskis, R.

Description: Three dimensional structure of human carbonic anhydrase II in complex with 2-((2-Phenylethyl)sulfamoyl)-4-sulfamoylbenzoic acid
[[Category: Unreleased Structures]]
[[Category: Zalubovskis, R]]
[[Category: Tars, K]]
[[Category: Leitans, J]]