5bpp - Revision history

OCA at 09:07, 20 March 2024

2024-03-20T09:07:59Z

← Older revision		Revision as of 09:07, 20 March 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5bpp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BPP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5BPP FirstGlance]. <br>		<table><tr><td colspan='2'>[[5bpp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BPP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5BPP FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A4Z:2-(4-BUTOXYPHENYL)-N-HYDROXYACETAMIDE'>A4Z</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=YB:YTTERBIUM+(III)+ION'>YB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.03Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A4Z:2-(4-BUTOXYPHENYL)-N-HYDROXYACETAMIDE'>A4Z</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=YB:YTTERBIUM+(III)+ION'>YB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5bpp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bpp OCA], [https://pdbe.org/5bpp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5bpp RCSB], [https://www.ebi.ac.uk/pdbsum/5bpp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5bpp ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5bpp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bpp OCA], [https://pdbe.org/5bpp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5bpp RCSB], [https://www.ebi.ac.uk/pdbsum/5bpp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5bpp ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/LKHA4_HUMAN LKHA4_HUMAN] Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity.<ref>PMID:1897988</ref> <ref>PMID:1975494</ref> <ref>PMID:2244921</ref> <ref>PMID:12207002</ref> <ref>PMID:11917124</ref> <ref>PMID:15078870</ref> <ref>PMID:18804029</ref>		[https://www.uniprot.org/uniprot/LKHA4_HUMAN LKHA4_HUMAN] Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity.<ref>PMID:1897988</ref> <ref>PMID:1975494</ref> <ref>PMID:2244921</ref> <ref>PMID:12207002</ref> <ref>PMID:11917124</ref> <ref>PMID:15078870</ref> <ref>PMID:18804029</ref>
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	Neutrophils play an important role in the occurrence and development of acute lung injury (ALI). Leukotriene B4 (LTB4), a hydrolysis product of epoxide leukotriene A4 (LTA4) catalyzed by LTA4 hydrolase (LTA4H), is one of the most potent chemoattractants for neutrophil. Bufexamac is a drug widely used as an anti-inflammatory agent on the skin, however, the mechanism of action is still not fully understood. In this study, we found bufexamac was capable of specifically inhibiting LTA4H enzymatic activity and revealed the mode of interaction of bufexamac and LTA4H using X-ray crystallography. Moreover, bufexamac significantly prevented the production of LTB4 in neutrophil and inhibited the fMLP-induced neutrophil migration through inhibition of LTA4H. Finally, bufexamac significantly attenuated lung inflammation as reflected by reduced LTB4 levels and weakened neutrophil infiltration in bronchoalveolar lavage fluid from a lipopolysaccharide-induced ALI mouse model. In summary, our study indicates that bufexamac acts as an inhibitor of LTB4 biosynthesis and may have potential clinical applications for the treatment of ALI.

	Bufexamac ameliorates LPS-induced acute lung injury in mice by targeting LTA4H.,Xiao Q, Dong N, Yao X, Wu D, Lu Y, Mao F, Zhu J, Li J, Huang J, Chen A, Huang L, Wang X, Yang G, He G, Xu Y, Lu W Sci Rep. 2016 Apr 29;6:25298. doi: 10.1038/srep25298. PMID:27126280<ref>PMID:27126280</ref>		==See Also==
			*[[Leukotriene A4 Hydrolase\|Leukotriene A4 Hydrolase]]
	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~<div class~~=~~"pdbe-citations 5bpp" style~~=~~"background-color:#fffaf0;"></div>~~
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:03, 7 June 2023

2023-06-07T06:03:04Z

← Older revision		Revision as of 06:03, 7 June 2023
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	<StructureSection load='5bpp' size='340' side='right'caption='[[5bpp]], [[Resolution\|resolution]] 2.03Å' scene=''>		<StructureSection load='5bpp' size='340' side='right'caption='[[5bpp]], [[Resolution\|resolution]] 2.03Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5bpp]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BPP OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5BPP FirstGlance]. <br>		<table><tr><td colspan='2'>[[5bpp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BPP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5BPP FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A4Z:2-(4-BUTOXYPHENYL)-N-HYDROXYACETAMIDE'>A4Z</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=YB:YTTERBIUM+(III)+ION'>YB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A4Z:2-(4-BUTOXYPHENYL)-N-HYDROXYACETAMIDE'>A4Z</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=YB:YTTERBIUM+(III)+ION'>YB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5aen\|5aen]]</td></tr>~~		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5bpp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bpp OCA], [https://pdbe.org/5bpp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5bpp RCSB], [https://www.ebi.ac.uk/pdbsum/5bpp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5bpp ProSAT]</span></td></tr>
	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LTA4H, LTA4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Leukotriene-A(4)_hydrolase Leukotriene-A(4) hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.3.2.6 3.3.2.6] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5bpp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bpp OCA], [~~http~~://pdbe.org/5bpp PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5bpp RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5bpp PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5bpp ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/LKHA4_HUMAN LKHA4_HUMAN]] Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity.<ref>PMID:1897988</ref> <ref>PMID:1975494</ref> <ref>PMID:2244921</ref> <ref>PMID:12207002</ref> <ref>PMID:11917124</ref> <ref>PMID:15078870</ref> <ref>PMID:18804029</ref>		[https://www.uniprot.org/uniprot/LKHA4_HUMAN LKHA4_HUMAN] Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity.<ref>PMID:1897988</ref> <ref>PMID:1975494</ref> <ref>PMID:2244921</ref> <ref>PMID:12207002</ref> <ref>PMID:11917124</ref> <ref>PMID:15078870</ref> <ref>PMID:18804029</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Dong~~, N N~~]]		[[Category: Dong NN]]
	[[Category: Huang, J]]		[[Category: Huang J]]
	[[Category: Lu~~, W Q~~]]		[[Category: Lu WQ]]
	[[Category: Ou~~, P Y~~]]		[[Category: Ou PY]]
	[[Category: Wu, D]]		[[Category: Wu D]]
	[[Category: Xiao, Q]]		[[Category: Xiao Q]]
	~~[[Category: Complex]]~~
	~~[[Category: Enzyme]]~~
	~~[[Category: Hydrolase-hydrolase inhibitor complex]]~~
	~~[[Category: Inflammation]]~~
	~~[[Category: Inhibitor~~]]

OCA at 08:53, 11 March 2020

2020-03-11T08:53:54Z

← Older revision		Revision as of 08:53, 11 March 2020
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	==Structure of human Leukotriene A4 hydrolase in complex with inhibitor 4AZ==		==Structure of human Leukotriene A4 hydrolase in complex with inhibitor 4AZ==
	<StructureSection load='5bpp' size='340' side='right' caption='[[5bpp]], [[Resolution\|resolution]] 2.03Å' scene=''>		<StructureSection load='5bpp' size='340' side='right'caption='[[5bpp]], [[Resolution\|resolution]] 2.03Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5bpp]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BPP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BPP FirstGlance]. <br>		<table><tr><td colspan='2'>[[5bpp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BPP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BPP FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A4Z:2-(4-BUTOXYPHENYL)-N-HYDROXYACETAMIDE'>A4Z</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=YB:YTTERBIUM+(III)+ION'>YB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A4Z:2-(4-BUTOXYPHENYL)-N-HYDROXYACETAMIDE'>A4Z</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=YB:YTTERBIUM+(III)+ION'>YB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5aen\|5aen]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5aen\|5aen]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LTA4H, LTA4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Leukotriene-A(4)_hydrolase Leukotriene-A(4) hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.3.2.6 3.3.2.6] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Leukotriene-A(4)_hydrolase Leukotriene-A(4) hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.3.2.6 3.3.2.6] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bpp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bpp OCA], [http://pdbe.org/5bpp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5bpp RCSB], [http://www.ebi.ac.uk/pdbsum/5bpp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5bpp ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bpp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bpp OCA], [http://pdbe.org/5bpp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5bpp RCSB], [http://www.ebi.ac.uk/pdbsum/5bpp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5bpp ProSAT]</span></td></tr>
Line 24:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Dong, N N]]		[[Category: Dong, N N]]
	[[Category: Huang, J]]		[[Category: Huang, J]]

OCA at 15:56, 10 August 2016

2016-08-10T15:56:09Z

← Older revision		Revision as of 15:56, 10 August 2016
Line 1:		Line 1:
	~~'''Unreleased structure'''~~

	~~The entry~~ 5bpp is ~~ON HOLD~~ ~~until Paper~~ Publication		==Structure of human Leukotriene A4 hydrolase in complex with inhibitor 4AZ==
			<StructureSection load='5bpp' size='340' side='right' caption='[[5bpp]], [[Resolution\|resolution]] 2.03Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[5bpp]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BPP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BPP FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A4Z:2-(4-BUTOXYPHENYL)-N-HYDROXYACETAMIDE'>A4Z</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=YB:YTTERBIUM+(III)+ION'>YB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5aen\|5aen]]</td></tr>
			<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Leukotriene-A(4)_hydrolase Leukotriene-A(4) hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.3.2.6 3.3.2.6] </span></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bpp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bpp OCA], [http://pdbe.org/5bpp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5bpp RCSB], [http://www.ebi.ac.uk/pdbsum/5bpp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5bpp ProSAT]</span></td></tr>
			</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/LKHA4_HUMAN LKHA4_HUMAN]] Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity.<ref>PMID:1897988</ref> <ref>PMID:1975494</ref> <ref>PMID:2244921</ref> <ref>PMID:12207002</ref> <ref>PMID:11917124</ref> <ref>PMID:15078870</ref> <ref>PMID:18804029</ref>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Neutrophils play an important role in the occurrence and development of acute lung injury (ALI). Leukotriene B4 (LTB4), a hydrolysis product of epoxide leukotriene A4 (LTA4) catalyzed by LTA4 hydrolase (LTA4H), is one of the most potent chemoattractants for neutrophil. Bufexamac is a drug widely used as an anti-inflammatory agent on the skin, however, the mechanism of action is still not fully understood. In this study, we found bufexamac was capable of specifically inhibiting LTA4H enzymatic activity and revealed the mode of interaction of bufexamac and LTA4H using X-ray crystallography. Moreover, bufexamac significantly prevented the production of LTB4 in neutrophil and inhibited the fMLP-induced neutrophil migration through inhibition of LTA4H. Finally, bufexamac significantly attenuated lung inflammation as reflected by reduced LTB4 levels and weakened neutrophil infiltration in bronchoalveolar lavage fluid from a lipopolysaccharide-induced ALI mouse model. In summary, our study indicates that bufexamac acts as an inhibitor of LTB4 biosynthesis and may have potential clinical applications for the treatment of ALI.

	~~Authors: Huang~~, J., ~~Dong~~, ~~N.N.~~, ~~Xiao~~, Q., Ou, ~~P.Y.~~, Wu, D., Lu, W.Q.		Bufexamac ameliorates LPS-induced acute lung injury in mice by targeting LTA4H.,Xiao Q, Dong N, Yao X, Wu D, Lu Y, Mao F, Zhu J, Li J, Huang J, Chen A, Huang L, Wang X, Yang G, He G, Xu Y, Lu W Sci Rep. 2016 Apr 29;6:25298. doi: 10.1038/srep25298. PMID:27126280<ref>PMID:27126280</ref>

	~~Description~~: ~~Structure of human Leukotriene A4 hydrolase in complex with inhibitor 4AZ~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	[[Category: ~~Unreleased Structures~~]]		</div>
	[[Category: Ou, ~~P.Y~~]]		<div class="pdbe-citations 5bpp" style="background-color:#fffaf0;"></div>
	[[Category: Lu, W.Q]]		== References ==
			<references/>
			__TOC__
			</StructureSection>
			[[Category: Dong, N N]]
			[[Category: Huang, J]]
			[[Category: Lu, W Q]]
			[[Category: Ou, P Y]]
	[[Category: Wu, D]]		[[Category: Wu, D]]
	[[Category: Xiao, Q]]		[[Category: Xiao, Q]]
	[[Category: ~~Huang, J~~]]		[[Category: Complex]]
	[[Category: ~~Dong, N.N~~]]		[[Category: Enzyme]]
			[[Category: Hydrolase-hydrolase inhibitor complex]]
			[[Category: Inflammation]]
			[[Category: Inhibitor]]

OCA at 21:31, 3 August 2016

2016-08-03T21:31:03Z

← Older revision		Revision as of 21:31, 3 August 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 5bpp is ON HOLD		The entry 5bpp is ON HOLD until Paper Publication

	Authors: Huang, J., Dong, N.N., Xiao, Q., Ou, P.Y., Wu, D., Lu, W.Q.		Authors: Huang, J., Dong, N.N., Xiao, Q., Ou, P.Y., Wu, D., Lu, W.Q.

OCA at 08:53, 27 July 2016

2016-07-27T08:53:50Z

← Older revision		Revision as of 08:53, 27 July 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 5bpp is ON HOLD ~~until Paper Publication~~		The entry 5bpp is ON HOLD

	Authors: Huang, J., Dong, N.N., Xiao, Q., Ou, P.Y., Wu, D., Lu, Q.W.		Authors: Huang, J., Dong, N.N., Xiao, Q., Ou, P.Y., Wu, D., Lu, W.Q.

	Description: Structure of human Leukotriene A4 hydrolase in complex with inhibitor 4AZ		Description: Structure of human Leukotriene A4 hydrolase in complex with inhibitor 4AZ
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Ou, P.Y]]		[[Category: Ou, P.Y]]
			[[Category: Lu, W.Q]]
	[[Category: Wu, D]]		[[Category: Wu, D]]
	~~[[Category: Lu, Q.W]]~~
	[[Category: Xiao, Q]]		[[Category: Xiao, Q]]
	[[Category: Huang, J]]		[[Category: Huang, J]]
	[[Category: Dong, N.N]]		[[Category: Dong, N.N]]

OCA at 10:08, 16 December 2015

2015-12-16T10:08:49Z

← Older revision		Revision as of 10:08, 16 December 2015
Line 7:		Line 7:
	Description: Structure of human Leukotriene A4 hydrolase in complex with inhibitor 4AZ		Description: Structure of human Leukotriene A4 hydrolase in complex with inhibitor 4AZ
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
			[[Category: Ou, P.Y]]
			[[Category: Wu, D]]
	[[Category: Lu, Q.W]]		[[Category: Lu, Q.W]]
	[[Category: Xiao, Q]]		[[Category: Xiao, Q]]
	[[Category: Huang, J]]		[[Category: Huang, J]]
	[[Category: Dong, N.N]]		[[Category: Dong, N.N]]
	~~[[Category: Ou, P.Y]]~~
	~~[[Category: Wu, D]]~~

OCA at 10:01, 9 December 2015

2015-12-09T10:01:26Z

← Older revision		Revision as of 10:01, 9 December 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 5bpp is ON HOLD		The entry 5bpp is ON HOLD until Paper Publication

	Authors: Huang, J., Dong, N.N., Xiao, Q., Ou, P.Y., Wu, D., Lu, Q.W.		Authors: Huang, J., Dong, N.N., Xiao, Q., Ou, P.Y., Wu, D., Lu, Q.W.

OCA at 12:51, 10 June 2015

2015-06-10T12:51:45Z

← Older revision		Revision as of 12:51, 10 June 2015
Line 3:		Line 3:
	The entry 5bpp is ON HOLD		The entry 5bpp is ON HOLD

	Authors: ~~Jin~~ Huang, ~~Ningning~~ Dong, ~~Qiang~~ Xiao, ~~Ping Yang~~ Ou, ~~Dang~~ Wu, ~~Qiang Wei~~ Lu		Authors: Huang, J., Dong, N.N., Xiao, Q., Ou, P.Y., Wu, D., Lu, Q.W.

	Description: Structure of human Leukotriene A4 hydrolase in complex with inhibitor 4AZ		Description: Structure of human Leukotriene A4 hydrolase in complex with inhibitor 4AZ
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: ~~Jin~~ Huang, ~~Ningning~~ Dong, ~~Qiang Xiao, Ping Yang~~ Ou, ~~Dang~~ Wu, ~~Qiang Wei Lu~~]]		[[Category: Lu, Q.W]]
			[[Category: Xiao, Q]]
			[[Category: Huang, J]]
			[[Category: Dong, N.N]]
			[[Category: Ou, P.Y]]
			[[Category: Wu, D]]

OCA: Protected "5bpp" [edit=sysop:move=sysop]

2015-06-03T11:46:48Z

Protected "5bpp" [edit=sysop:move=sysop]

← Older revision	Revision as of 11:46, 3 June 2015
(No difference)