5ccf - Revision history

OCA at 08:36, 27 September 2023

2023-09-27T08:36:56Z

← Older revision		Revision as of 08:36, 27 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5ccf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CCF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CCF FirstGlance]. <br>		<table><tr><td colspan='2'>[[5ccf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CCF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CCF FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ccf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ccf OCA], [https://pdbe.org/5ccf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ccf RCSB], [https://www.ebi.ac.uk/pdbsum/5ccf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ccf ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ccf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ccf OCA], [https://pdbe.org/5ccf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ccf RCSB], [https://www.ebi.ac.uk/pdbsum/5ccf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ccf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 11:58, 14 June 2023

2023-06-14T11:58:27Z

← Older revision		Revision as of 11:58, 14 June 2023
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	<StructureSection load='5ccf' size='340' side='right'caption='[[5ccf]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='5ccf' size='340' side='right'caption='[[5ccf]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5ccf]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CCF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5CCF FirstGlance]. <br>		<table><tr><td colspan='2'>[[5ccf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CCF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CCF FirstGlance]. <br>
	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ck7\|5ck7]]</td></tr>~~		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ccf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ccf OCA], [https://pdbe.org/5ccf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ccf RCSB], [https://www.ebi.ac.uk/pdbsum/5ccf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ccf ProSAT]</span></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Adpgk ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/ADP-specific_glucokinase ADP-specific glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.147 2.7.1.147] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ccf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ccf OCA], [~~http~~://pdbe.org/5ccf PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5ccf RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5ccf PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5ccf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/ADPGK_MOUSE ADPGK_MOUSE]] Catalyzes the phosphorylation of D-glucose to D-glucose 6-phosphate using ADP as the phosphate donor. GDP and CDP can replace ADP, but with reduced efficiency.		[https://www.uniprot.org/uniprot/ADPGK_MOUSE ADPGK_MOUSE] Catalyzes the phosphorylation of D-glucose to D-glucose 6-phosphate using ADP as the phosphate donor. GDP and CDP can replace ADP, but with reduced efficiency.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: ADP-specific glucokinase]]~~
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Lk3 transgenic mice~~]]		[[Category: Mus musculus]]
	[[Category: Richter~~, J P~~]]		[[Category: Richter JP]]
	[[Category: Ronimus~~, R S~~]]		[[Category: Ronimus RS]]
	[[Category: Sutherland-Smith~~, A J]]~~		[[Category: Sutherland-Smith AJ]]
	~~[[Category: Adpgk]]~~
	~~[[Category: Glucose-6-phosphate]]~~
	~~[[Category: Kinase]]~~
	~~[[Category: Ribokinase]]~~
	~~[[Category: Transferase~~]]

OCA at 06:21, 19 June 2019

2019-06-19T06:21:46Z

← Older revision		Revision as of 06:21, 19 June 2019
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	==Structure of Mouse ADP-Dependent Glucokinase==		==Structure of Mouse ADP-Dependent Glucokinase==
	<StructureSection load='5ccf' size='340' side='right' caption='[[5ccf]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='5ccf' size='340' side='right'caption='[[5ccf]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5ccf]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CCF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CCF FirstGlance]. <br>		<table><tr><td colspan='2'>[[5ccf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CCF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CCF FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ck7\|5ck7]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ck7\|5ck7]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Adpgk ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/ADP-specific_glucokinase ADP-specific glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.147 2.7.1.147] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/ADP-specific_glucokinase ADP-specific glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.147 2.7.1.147] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ccf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ccf OCA], [http://pdbe.org/5ccf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ccf RCSB], [http://www.ebi.ac.uk/pdbsum/5ccf PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ccf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ccf OCA], [http://pdbe.org/5ccf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ccf RCSB], [http://www.ebi.ac.uk/pdbsum/5ccf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ccf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/ADPGK_MOUSE ADPGK_MOUSE]] Catalyzes the phosphorylation of D-glucose to D-glucose 6-phosphate using ADP as the phosphate donor. GDP and CDP can replace ADP, but with reduced efficiency.		[[http://www.uniprot.org/uniprot/ADPGK_MOUSE ADPGK_MOUSE]] Catalyzes the phosphorylation of D-glucose to D-glucose 6-phosphate using ADP as the phosphate donor. GDP and CDP can replace ADP, but with reduced efficiency.
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The enzyme-catalyzed phosphorylation of glucose to glucose-6-phosphate is a reaction central to the metabolism of all life. ADP-dependent glucokinase (ADPGK) catalyzes glucose-6-phosphate production, utilizing ADP as a phosphoryl donor in contrast to the more well characterized ATP-requiring hexokinases. ADPGK is found in Archaea and metazoa; in Archaea, ADPGK participates in a glycolytic role, but a function in most eukaryotic cell types remains unknown. We have determined structures of the eukaryotic ADPGK revealing a ribokinase-like tertiary fold similar to archaeal orthologues but with significant differences in some secondary structural elements. Both the unliganded and the AMP-bound ADPGK structures are in the "open" conformation. The structures reveal the presence of a disulfide bond between conserved cysteines that is positioned at the nucleotide-binding loop of eukaryotic ADPGK. The AMP-bound ADPGK structure defines the nucleotide-binding site with one of the disulfide bond cysteines coordinating the AMP with its main chain atoms, a nucleotide-binding motif that appears unique to eukaryotic ADPGKs. Key amino acids at the active site are structurally conserved between mammalian and archaeal ADPGK, and site-directed mutagenesis has confirmed residues essential for enzymatic activity. ADPGK is substrate inhibited by high glucose concentration and shows high specificity for glucose, with no activity for other sugars, as determined by NMR spectroscopy, including 2-deoxyglucose, the glucose analogue used for tumor detection by positron emission tomography.

			The Structural and Functional Characterization of Mammalian ADP-dependent Glucokinase.,Richter JP, Goroncy AK, Ronimus RS, Sutherland-Smith AJ J Biol Chem. 2016 Feb 19;291(8):3694-704. doi: 10.1074/jbc.M115.679902. Epub 2015, Nov 10. PMID:26555263<ref>PMID:26555263</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 5ccf" style="background-color:#fffaf0;"></div>
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ADP-specific glucokinase]]		[[Category: ADP-specific glucokinase]]
			[[Category: Large Structures]]
			[[Category: Lk3 transgenic mice]]
	[[Category: Richter, J P]]		[[Category: Richter, J P]]
	[[Category: Ronimus, R S]]		[[Category: Ronimus, R S]]

OCA at 18:59, 1 December 2015

2015-12-01T18:59:15Z

← Older revision		Revision as of 18:59, 1 December 2015
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	'''~~Unreleased structure~~'''		==Structure of Mouse ADP-Dependent Glucokinase==
			<StructureSection load='5ccf' size='340' side='right' caption='[[5ccf]], [[Resolution\|resolution]] 2.10Å' scene=''>
	~~The entry~~ 5ccf is ~~ON HOLD~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[5ccf]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CCF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CCF FirstGlance]. <br>
	~~Authors~~: ~~Richter~~, J.P., ~~Ronimus~~, R.S., ~~Sutherland~~-~~Smith~~, ~~A.J~~.		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ck7\|5ck7]]</td></tr>
			<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/ADP-specific_glucokinase ADP-specific glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.147 2.7.1.147] </span></td></tr>
	~~Description~~:		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ccf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ccf OCA], [http://pdbe.org/5ccf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ccf RCSB], [http://www.ebi.ac.uk/pdbsum/5ccf PDBsum]</span></td></tr>
	[[Category: ~~Unreleased Structures~~]]		</table>
	[[Category: Ronimus, R.S]]		== Function ==
	[[Category: Sutherland-Smith, A.J]]		[[http://www.uniprot.org/uniprot/ADPGK_MOUSE ADPGK_MOUSE]] Catalyzes the phosphorylation of D-glucose to D-glucose 6-phosphate using ADP as the phosphate donor. GDP and CDP can replace ADP, but with reduced efficiency.
	[[Category: ~~Richter, J.P~~]]		__TOC__
			</StructureSection>
			[[Category: ADP-specific glucokinase]]
			[[Category: Richter, J P]]
			[[Category: Ronimus, R S]]
			[[Category: Sutherland-Smith, A J]]
			[[Category: Adpgk]]
			[[Category: Glucose-6-phosphate]]
			[[Category: Kinase]]
			[[Category: Ribokinase]]
			[[Category: Transferase]]

OCA: Protected "5ccf" [edit=sysop:move=sysop]

2015-07-08T13:59:47Z

Protected "5ccf" [edit=sysop:move=sysop]

← Older revision	Revision as of 13:59, 8 July 2015
(No difference)

OCA: New page: '''Unreleased structure''' The entry 5ccf is ON HOLD Authors: Richter, J.P., Ronimus, R.S., Sutherland-Smith, A.J. Description: Category: Unreleased Structures [[Category: Ronimus...

2015-07-08T13:59:46Z

New page: '''Unreleased structure''' The entry 5ccf is ON HOLD Authors: Richter, J.P., Ronimus, R.S., Sutherland-Smith, A.J. Description: Category: Unreleased Structures [[Category: Ronimus...

New page

'''Unreleased structure'''

The entry 5ccf is ON HOLD

Authors: Richter, J.P., Ronimus, R.S., Sutherland-Smith, A.J.

Description:
[[Category: Unreleased Structures]]
[[Category: Ronimus, R.S]]
[[Category: Sutherland-Smith, A.J]]
[[Category: Richter, J.P]]