5cd3 - Revision history

OCA at 11:59, 14 June 2023

2023-06-14T11:59:59Z

← Older revision		Revision as of 11:59, 14 June 2023
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	<StructureSection load='5cd3' size='340' side='right'caption='[[5cd3]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='5cd3' size='340' side='right'caption='[[5cd3]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5cd3]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CD3 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5CD3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[5cd3]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CD3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CD3 FirstGlance]. <br>
	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5cd5\|5cd5]]</td></tr>~~		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cd3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cd3 OCA], [https://pdbe.org/5cd3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cd3 RCSB], [https://www.ebi.ac.uk/pdbsum/5cd3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cd3 ProSAT]</span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5cd3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cd3 OCA], [~~http~~://pdbe.org/5cd3 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5cd3 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5cd3 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5cd3 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Kong, L]]		[[Category: Kong L]]
	[[Category: Wilson~~, I A]]~~		[[Category: Wilson IA]]
	~~[[Category: Cd4 binding site]]~~
	~~[[Category: Gp120]]~~
	~~[[Category: Hiv-1]]~~
	~~[[Category: Immune system]]~~
	~~[[Category: Vrc01~~]]

OCA at 07:16, 10 June 2020

2020-06-10T07:16:58Z

← Older revision		Revision as of 07:16, 10 June 2020
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	==Structure of immature VRC01-class antibody DRVIA7==		==Structure of immature VRC01-class antibody DRVIA7==
	<StructureSection load='5cd3' size='340' side='right' caption='[[5cd3]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='5cd3' size='340' side='right'caption='[[5cd3]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5cd3]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CD3 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5CD3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[5cd3]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CD3 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5CD3 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5cd5\|5cd5]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5cd5\|5cd5]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5cd3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cd3 OCA], [http://pdbe.org/5cd3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cd3 RCSB], [http://www.ebi.ac.uk/pdbsum/5cd3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5cd3 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5cd3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cd3 OCA], [http://pdbe.org/5cd3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cd3 RCSB], [http://www.ebi.ac.uk/pdbsum/5cd3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5cd3 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Kong, L]]		[[Category: Kong, L]]
	[[Category: Wilson, I A]]		[[Category: Wilson, I A]]

OCA at 10:19, 5 September 2018

2018-09-05T10:19:51Z

← Older revision		Revision as of 10:19, 5 September 2018
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	<StructureSection load='5cd3' size='340' side='right' caption='[[5cd3]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='5cd3' size='340' side='right' caption='[[5cd3]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5cd3]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CD3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CD3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[5cd3]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CD3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CD3 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5cd5\|5cd5]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5cd5\|5cd5]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cd3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cd3 OCA], [http://pdbe.org/5cd3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cd3 RCSB], [http://www.ebi.ac.uk/pdbsum/5cd3 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cd3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cd3 OCA], [http://pdbe.org/5cd3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cd3 RCSB], [http://www.ebi.ac.uk/pdbsum/5cd3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5cd3 ProSAT]</span></td></tr>
	</table>		</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			VRC01-class antibodies neutralize diverse HIV-1 strains by targeting the conserved CD4-binding site. Despite extensive investigations, crucial events in the early stage of VRC01 development remain elusive. We demonstrated how VRC01-class antibodies emerged in a Chinese donor by antigen-specific single B cell sorting, structural and functional studies, and longitudinal antibody and virus repertoire analyses. A monoclonal antibody DRVIA7 with modest neutralizing breadth was isolated that displayed a subset of VRC01 signatures. X-ray and EM structures revealed a VRC01-like angle of approach, but less favorable interactions between the DRVIA7 light-chain CDR1 and the N terminus with N276 and V5 glycans of gp120. Although the DRVIA7 lineage was unable to acquire broad neutralization, longitudinal analysis revealed a repertoire-encoded VRC01 light-chain CDR3 signature and VRC01-like neutralizing heavy-chain precursors that rapidly matured within 2 years. Thus, light chain accommodation of the glycan shield should be taken into account in vaccine design targeting this conserved site of vulnerability.

			Key gp120 Glycans Pose Roadblocks to the Rapid Development of VRC01-Class Antibodies in an HIV-1-Infected Chinese Donor.,Kong L, Ju B, Chen Y, He L, Ren L, Liu J, Hong K, Su B, Wang Z, Ozorowski G, Ji X, Hua Y, Chen Y, Deller MC, Hao Y, Feng Y, Garces F, Wilson R, Dai K, O'Dell S, McKee K, Mascola JR, Ward AB, Wyatt RT, Li Y, Wilson IA, Zhu J, Shao Y Immunity. 2016 Apr 19;44(4):939-50. doi: 10.1016/j.immuni.2016.03.006. Epub 2016 , Apr 5. PMID:27067056<ref>PMID:27067056</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 5cd3" style="background-color:#fffaf0;"></div>
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Human]]
	[[Category: Kong, L]]		[[Category: Kong, L]]
	[[Category: Wilson, I A]]		[[Category: Wilson, I A]]

OCA at 04:05, 12 May 2016

2016-05-12T04:05:15Z

← Older revision		Revision as of 04:05, 12 May 2016
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	~~'''Unreleased structure'''~~

	~~The entry~~ 5cd3 ~~is ON HOLD until Paper Publication~~		==Structure of immature VRC01-class antibody DRVIA7==
			<StructureSection load='5cd3' size='340' side='right' caption='[[5cd3]], [[Resolution\|resolution]] 2.90Å' scene=''>
	~~Authors~~: ~~Kong, L~~.~~, Wilson, I~~.A.		== Structural highlights ==
			<table><tr><td colspan='2'>[[5cd3]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CD3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CD3 FirstGlance]. <br>
	~~Description~~:		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5cd5\|5cd5]]</td></tr>
	[[~~Category~~: ~~Unreleased Structures~~]]		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cd3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cd3 OCA], [http://pdbe.org/5cd3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cd3 RCSB], [http://www.ebi.ac.uk/pdbsum/5cd3 PDBsum]</span></td></tr>
	[[~~Category~~: ~~Wilson~~, I.A]]		</table>
			__TOC__
			</StructureSection>
	[[Category: Kong, L]]		[[Category: Kong, L]]
			[[Category: Wilson, I A]]
			[[Category: Cd4 binding site]]
			[[Category: Gp120]]
			[[Category: Hiv-1]]
			[[Category: Immune system]]
			[[Category: Vrc01]]

OCA at 10:27, 16 December 2015

2015-12-16T10:27:58Z

← Older revision		Revision as of 10:27, 16 December 2015
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	Description:		Description:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
			[[Category: Wilson, I.A]]
	[[Category: Kong, L]]		[[Category: Kong, L]]
	~~[[Category: Wilson, I.A]]~~

OCA at 18:26, 5 August 2015

2015-08-05T18:26:52Z

← Older revision		Revision as of 18:26, 5 August 2015
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 5cd3 is ON HOLD		The entry 5cd3 is ON HOLD until Paper Publication

	Authors: Kong, L., Wilson, I.A.		Authors: Kong, L., Wilson, I.A.

OCA: Protected "5cd3" [edit=sysop:move=sysop]

2015-07-15T12:24:02Z

Protected "5cd3" [edit=sysop:move=sysop]

← Older revision	Revision as of 12:24, 15 July 2015
(No difference)

OCA: New page: '''Unreleased structure''' The entry 5cd3 is ON HOLD Authors: Kong, L., Wilson, I.A. Description: Category: Unreleased Structures Category: Kong, L Category: Wilson, I.A

2015-07-15T12:24:00Z

New page: '''Unreleased structure''' The entry 5cd3 is ON HOLD Authors: Kong, L., Wilson, I.A. Description: Category: Unreleased Structures Category: Kong, L Category: Wilson, I.A

New page

'''Unreleased structure'''

The entry 5cd3 is ON HOLD

Authors: Kong, L., Wilson, I.A.

Description:
[[Category: Unreleased Structures]]
[[Category: Kong, L]]
[[Category: Wilson, I.A]]