5cd7 - Revision history

OCA at 08:46, 23 October 2024

2024-10-23T08:46:09Z

← Older revision		Revision as of 08:46, 23 October 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5cd7]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CD7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CD7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[5cd7]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CD7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CD7 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.502Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cd7 OCA], [https://pdbe.org/5cd7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cd7 RCSB], [https://www.ebi.ac.uk/pdbsum/5cd7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cd7 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cd7 OCA], [https://pdbe.org/5cd7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cd7 RCSB], [https://www.ebi.ac.uk/pdbsum/5cd7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cd7 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 12:00, 14 June 2023

2023-06-14T12:00:08Z

← Older revision		Revision as of 12:00, 14 June 2023
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	<StructureSection load='5cd7' size='340' side='right'caption='[[5cd7]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='5cd7' size='340' side='right'caption='[[5cd7]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5cd7]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CD7 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5CD7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[5cd7]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CD7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CD7 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~</td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>~~</td></tr>~~		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cd7 OCA], [https://pdbe.org/5cd7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cd7 RCSB], [https://www.ebi.ac.uk/pdbsum/5cd7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cd7 ProSAT]</span></td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5cd8\|5cd8]], [[5cd9\|5cd9]]~~</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5cd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cd7 OCA], [~~http~~://pdbe.org/5cd7 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5cd7 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5cd7 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5cd7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/OSKA_DROME OSKA_DROME]] Organizes the germ plasm and directs localization of the posterior determinant nanos. Oskar protein is required to keep nos RNA and staufen protein at the posterior pole.<ref>PMID:1641021</ref> <ref>PMID:2070416</ref> <ref>PMID:2070417</ref>		[https://www.uniprot.org/uniprot/OSKA_DROME OSKA_DROME] Organizes the germ plasm and directs localization of the posterior determinant nanos. Oskar protein is required to keep nos RNA and staufen protein at the posterior pole.<ref>PMID:1641021</ref> <ref>PMID:2070416</ref> <ref>PMID:2070417</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Drosophila melanogaster]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Hu, M]]		[[Category: Hu M]]
	[[Category: Lehmann, R]]		[[Category: Lehmann R]]
	[[Category: Wang, M]]		[[Category: Wang M]]
	[[Category: Xu~~, R M~~]]		[[Category: Xu RM]]
	[[Category: Yang, N]]		[[Category: Yang N]]
	[[Category: Yu, Z]]		[[Category: Yu Z]]
	~~[[Category: 3'-utr]]~~
	~~[[Category: Dimerization]]~~
	~~[[Category: Rna binding protein~~]]

OCA at 11:32, 27 March 2020

2020-03-27T11:32:57Z

← Older revision		Revision as of 11:32, 27 March 2020
Line 1:		Line 1:

	==Crystal structure of the NTD L199M of Drosophila Oskar protein==		==Crystal structure of the NTD L199M of Drosophila Oskar protein==
	<StructureSection load='5cd7' size='340' side='right' caption='[[5cd7]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='5cd7' size='340' side='right'caption='[[5cd7]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5cd7]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CD7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CD7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[5cd7]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CD7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CD7 FirstGlance]. <br>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Hu, M]]		[[Category: Hu, M]]
	[[Category: Lehmann, R]]		[[Category: Lehmann, R]]

OCA at 09:58, 18 October 2017

2017-10-18T09:58:03Z

← Older revision		Revision as of 09:58, 18 October 2017
Line 1:		Line 1:

	==Crystal structure of the NTD L199M of Drosophila Oskar protein==		==Crystal structure of the NTD L199M of Drosophila Oskar protein==
	<StructureSection load='5cd7' size='340' side='right' caption='[[5cd7]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='5cd7' size='340' side='right' caption='[[5cd7]], [[Resolution\|resolution]] 2.50Å' scene=''>
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	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5cd8\|5cd8]], [[5cd9\|5cd9]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5cd8\|5cd8]], [[5cd9\|5cd9]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cd7 OCA], [http://pdbe.org/5cd7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cd7 RCSB], [http://www.ebi.ac.uk/pdbsum/5cd7 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cd7 OCA], [http://pdbe.org/5cd7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cd7 RCSB], [http://www.ebi.ac.uk/pdbsum/5cd7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5cd7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 08:13, 30 September 2015

2015-09-30T08:13:07Z

← Older revision		Revision as of 08:13, 30 September 2015
Line 6:		Line 6:
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5cd8\|5cd8]], [[5cd9\|5cd9]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5cd8\|5cd8]], [[5cd9\|5cd9]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cd7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5cd7 RCSB], [http://www.ebi.ac.uk/pdbsum/5cd7 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cd7 OCA], [http://pdbe.org/5cd7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cd7 RCSB], [http://www.ebi.ac.uk/pdbsum/5cd7 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/OSKA_DROME OSKA_DROME]] Organizes the germ plasm and directs localization of the posterior determinant nanos. Oskar protein is required to keep nos RNA and staufen protein at the posterior pole.<ref>PMID:1641021</ref> <ref>PMID:2070416</ref> <ref>PMID:2070417</ref>		[[http://www.uniprot.org/uniprot/OSKA_DROME OSKA_DROME]] Organizes the germ plasm and directs localization of the posterior determinant nanos. Oskar protein is required to keep nos RNA and staufen protein at the posterior pole.<ref>PMID:1641021</ref> <ref>PMID:2070416</ref> <ref>PMID:2070417</ref>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Oskar (Osk) protein plays critical roles during Drosophila germ cell development, yet its functions in germ-line formation and body patterning remain poorly understood. This situation contrasts sharply with the vast knowledge about the function and mechanism of osk mRNA localization. Osk is predicted to have an N-terminal LOTUS domain (Osk-N), which has been suggested to bind RNA, and a C-terminal hydrolase-like domain (Osk-C) of unknown function. Here, we report the crystal structures of Osk-N and Osk-C. Osk-N shows a homodimer of winged-helix-fold modules, but without detectable RNA-binding activity. Osk-C has a lipase-fold structure but lacks critical catalytic residues at the putative active site. Surprisingly, we found that Osk-C binds the 3'UTRs of osk and nanos mRNA in vitro. Mutational studies identified a region of Osk-C important for mRNA binding. These results suggest possible functions of Osk in the regulation of stability, regulation of translation, and localization of relevant mRNAs through direct interaction with their 3'UTRs, and provide structural insights into a novel protein-RNA interaction motif involving a hydrolase-related domain.

			Structure of Drosophila Oskar reveals a novel RNA binding protein.,Yang N, Yu Z, Hu M, Wang M, Lehmann R, Xu RM Proc Natl Acad Sci U S A. 2015 Sep 15;112(37):11541-6. doi:, 10.1073/pnas.1515568112. Epub 2015 Aug 31. PMID:26324911<ref>PMID:26324911</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 5cd7" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:35, 2 September 2015

2015-09-02T12:35:23Z

← Older revision		Revision as of 12:35, 2 September 2015
Line 1:		Line 1:
	'''~~Unreleased structure~~'''		==Crystal structure of the NTD L199M of Drosophila Oskar protein==
			<StructureSection load='5cd7' size='340' side='right' caption='[[5cd7]], [[Resolution\|resolution]] 2.50Å' scene=''>
	~~The entry~~ 5cd7 is ~~ON HOLD until Paper Publication~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[5cd7]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CD7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CD7 FirstGlance]. <br>
	~~Authors~~: ~~Yang~~, N., Hu, M.~~, Yu, Z~~.~~, Wang, M~~., ~~Lehmann, R~~.~~, Xu, R~~.M.		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
			<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	~~Description~~: ~~Crystal structure~~ of the ~~NTD L199M of Drosophila~~ Oskar protein		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5cd8\|5cd8]], [[5cd9\|5cd9]]</td></tr>
	[[Category: ~~Unreleased Structures~~]]		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cd7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5cd7 RCSB], [http://www.ebi.ac.uk/pdbsum/5cd7 PDBsum]</span></td></tr>
			</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/OSKA_DROME OSKA_DROME]] Organizes the germ plasm and directs localization of the posterior determinant nanos. Oskar protein is required to keep nos RNA and staufen protein at the posterior pole.<ref>PMID:1641021</ref> <ref>PMID:2070416</ref> <ref>PMID:2070417</ref>
			== References ==
			<references/>
			__TOC__
			</StructureSection>
			[[Category: Hu, M]]
			[[Category: Lehmann, R]]
	[[Category: Wang, M]]		[[Category: Wang, M]]
			[[Category: Xu, R M]]
			[[Category: Yang, N]]
	[[Category: Yu, Z]]		[[Category: Yu, Z]]
	[[Category: ~~Xu, R.M~~]]		[[Category: 3'-utr]]
	[[Category: ~~Yang, N~~]]		[[Category: Dimerization]]
	[[Category: ~~Hu, M]]~~		[[Category: Rna binding protein]]
	~~[[Category: Lehmann, R~~]]

OCA: Protected "5cd7" [edit=sysop:move=sysop]

2015-07-15T12:24:15Z

Protected "5cd7" [edit=sysop:move=sysop]

← Older revision	Revision as of 12:24, 15 July 2015
(No difference)

OCA: New page: '''Unreleased structure''' The entry 5cd7 is ON HOLD until Paper Publication Authors: Yang, N., Hu, M., Yu, Z., Wang, M., Lehmann, R., Xu, R.M. Description: Crystal structure of the NT...

2015-07-15T12:24:13Z

New page: '''Unreleased structure''' The entry 5cd7 is ON HOLD until Paper Publication Authors: Yang, N., Hu, M., Yu, Z., Wang, M., Lehmann, R., Xu, R.M. Description: Crystal structure of the NT...

New page

'''Unreleased structure'''

The entry 5cd7 is ON HOLD until Paper Publication

Authors: Yang, N., Hu, M., Yu, Z., Wang, M., Lehmann, R., Xu, R.M.

Description: Crystal structure of the NTD L199M of Drosophila Oskar protein
[[Category: Unreleased Structures]]
[[Category: Wang, M]]
[[Category: Yu, Z]]
[[Category: Xu, R.M]]
[[Category: Yang, N]]
[[Category: Hu, M]]
[[Category: Lehmann, R]]