5cef - Revision history

OCA at 08:37, 27 September 2023

2023-09-27T08:37:20Z

← Older revision		Revision as of 08:37, 27 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5cef]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Cryptococcus_neoformans_var._neoformans_JEC21 Cryptococcus neoformans var. neoformans JEC21]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CEF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CEF FirstGlance]. <br>		<table><tr><td colspan='2'>[[5cef]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Cryptococcus_neoformans_var._neoformans_JEC21 Cryptococcus neoformans var. neoformans JEC21]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CEF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CEF FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cef FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cef OCA], [https://pdbe.org/5cef PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cef RCSB], [https://www.ebi.ac.uk/pdbsum/5cef PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cef ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cef FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cef OCA], [https://pdbe.org/5cef PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cef RCSB], [https://www.ebi.ac.uk/pdbsum/5cef PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cef ProSAT]</span></td></tr>
	</table>		</table>

OCA at 12:01, 14 June 2023

2023-06-14T12:01:25Z

← Older revision		Revision as of 12:01, 14 June 2023
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	<StructureSection load='5cef' size='340' side='right'caption='[[5cef]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='5cef' size='340' side='right'caption='[[5cef]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5cef]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Crynj Crynj~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CEF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5CEF FirstGlance]. <br>		<table><tr><td colspan='2'>[[5cef]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Cryptococcus_neoformans_var._neoformans_JEC21 Cryptococcus neoformans var. neoformans JEC21]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CEF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CEF FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene~~></td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CNA02450 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=214684 CRYNJ])</td></tr>~~		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cef FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cef OCA], [https://pdbe.org/5cef PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cef RCSB], [https://www.ebi.ac.uk/pdbsum/5cef PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cef ProSAT]</span></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aspartate-semialdehyde_dehydrogenase Aspartate-semialdehyde dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.11 1.2.1.11] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5cef FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cef OCA], [~~http~~://pdbe.org/5cef PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5cef RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5cef PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5cef ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/Q5KPK7_CRYNJ Q5KPK7_CRYNJ]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Aspartate-semialdehyde dehydrogenase]]~~		[[Category: Cryptococcus neoformans var. neoformans JEC21]]
	~~[[Category: Crynj~~]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Dahal~~, G P~~]]		[[Category: Dahal GP]]
	[[Category: Viola~~, R E]]~~		[[Category: Viola RE]]
	~~[[Category: Oxidoreductase]]~~
	~~[[Category: Rossmann fold~~]]

OCA at 15:59, 11 December 2019

2019-12-11T15:59:51Z

← Older revision		Revision as of 15:59, 11 December 2019
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	==Cystal structure of aspartate semialdehyde dehydrogenase from Cryptococcus neoformans==		==Cystal structure of aspartate semialdehyde dehydrogenase from Cryptococcus neoformans==
	<StructureSection load='5cef' size='340' side='right' caption='[[5cef]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='5cef' size='340' side='right'caption='[[5cef]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5cef]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CEF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CEF FirstGlance]. <br>		<table><tr><td colspan='2'>[[5cef]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Crynj Crynj]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CEF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CEF FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CNA02450 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=214684 CRYNJ])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aspartate-semialdehyde_dehydrogenase Aspartate-semialdehyde dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.11 1.2.1.11] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aspartate-semialdehyde_dehydrogenase Aspartate-semialdehyde dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.11 1.2.1.11] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cef FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cef OCA], [http://pdbe.org/5cef PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cef RCSB], [http://www.ebi.ac.uk/pdbsum/5cef PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5cef ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cef FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cef OCA], [http://pdbe.org/5cef PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cef RCSB], [http://www.ebi.ac.uk/pdbsum/5cef PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5cef ProSAT]</span></td></tr>
Line 19:		Line 20:

	==See Also==		==See Also==
	*[[Aspartate-semialdehyde dehydrogenase\|Aspartate-semialdehyde dehydrogenase]]		*[[Aspartate-semialdehyde dehydrogenase 3D structures\|Aspartate-semialdehyde dehydrogenase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Aspartate-semialdehyde dehydrogenase]]		[[Category: Aspartate-semialdehyde dehydrogenase]]
			[[Category: Crynj]]
			[[Category: Large Structures]]
	[[Category: Dahal, G P]]		[[Category: Dahal, G P]]
	[[Category: Viola, R E]]		[[Category: Viola, R E]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Rossmann fold]]		[[Category: Rossmann fold]]

OCA at 10:57, 13 September 2017

2017-09-13T10:57:02Z

← Older revision		Revision as of 10:57, 13 September 2017
Line 1:		Line 1:

	==Cystal structure of aspartate semialdehyde dehydrogenase from Cryptococcus neoformans==		==Cystal structure of aspartate semialdehyde dehydrogenase from Cryptococcus neoformans==
	<StructureSection load='5cef' size='340' side='right' caption='[[5cef]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='5cef' size='340' side='right' caption='[[5cef]], [[Resolution\|resolution]] 2.60Å' scene=''>
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aspartate-semialdehyde_dehydrogenase Aspartate-semialdehyde dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.11 1.2.1.11] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aspartate-semialdehyde_dehydrogenase Aspartate-semialdehyde dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.11 1.2.1.11] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cef FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cef OCA], [http://pdbe.org/5cef PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cef RCSB], [http://www.ebi.ac.uk/pdbsum/5cef PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cef FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cef OCA], [http://pdbe.org/5cef PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cef RCSB], [http://www.ebi.ac.uk/pdbsum/5cef PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5cef ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</div>		</div>
	<div class="pdbe-citations 5cef" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5cef" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Aspartate-semialdehyde dehydrogenase\|Aspartate-semialdehyde dehydrogenase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 18:59, 1 December 2015

2015-12-01T18:59:32Z

← Older revision		Revision as of 18:59, 1 December 2015
Line 1:		Line 1:
	'''~~Unreleased~~ structure'''		==Cystal structure of aspartate semialdehyde dehydrogenase from Cryptococcus neoformans==
			<StructureSection load='5cef' size='340' side='right' caption='[[5cef]], [[Resolution\|resolution]] 2.60Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[5cef]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CEF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CEF FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
			<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aspartate-semialdehyde_dehydrogenase Aspartate-semialdehyde dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.11 1.2.1.11] </span></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cef FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cef OCA], [http://pdbe.org/5cef PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cef RCSB], [http://www.ebi.ac.uk/pdbsum/5cef PDBsum]</span></td></tr>
			</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Aspartate semialdehyde dehydrogenase (ASADH) functions at a critical junction in the aspartate-biosynthetic pathway and represents a valid target for antimicrobial drug design. This enzyme catalyzes the NADPH-dependent reductive dephosphorylation of beta-aspartyl phosphate to produce the key intermediate aspartate semialdehyde. Production of this intermediate represents the first committed step in the biosynthesis of the essential amino acids methionine, isoleucine and threonine in fungi, and also the amino acid lysine in bacteria. The structure of a new fungal form of ASADH from Cryptococcus neoformans has been determined to 2.6 A resolution. The overall structure of CnASADH is similar to those of its bacterial orthologs, but with some critical differences both in biological assembly and in secondary-structural features that can potentially be exploited for the development of species-selective drugs.

	~~The entry 5cef is ON HOLD until Paper Publication~~		Structure of a fungal form of aspartate semialdehyde dehydrogenase from Cryptococcus neoformans.,Dahal G, Viola RE Acta Crystallogr F Struct Biol Commun. 2015 Nov 1;71(Pt 11):1365-71. doi:, 10.1107/S2053230X15017495. Epub 2015 Oct 23. PMID:26527262<ref>PMID:26527262</ref>

	~~Authors: Dahal~~, G.P.~~, Viola, R.E~~.		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~Description~~: ~~Cystal structure of aspartate semialdehyde dehydrogenase from Cryptococcus neoformans~~		<div class="pdbe-citations 5cef" style="background-color:#fffaf0;"></div>
	[[Category: ~~Unreleased Structures~~]]		== References ==
	[[Category: Dahal, G.P]]		<references/>
	[[Category: Viola, R.E]]		__TOC__
			</StructureSection>
			[[Category: Aspartate-semialdehyde dehydrogenase]]
			[[Category: Dahal, G P]]
			[[Category: Viola, R E]]
			[[Category: Oxidoreductase]]
			[[Category: Rossmann fold]]

OCA at 18:29, 5 August 2015

2015-08-05T18:29:13Z

← Older revision		Revision as of 18:29, 5 August 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 5cef is ON HOLD		The entry 5cef is ON HOLD until Paper Publication

	Authors: Dahal, G.P., Viola, R.E.		Authors: Dahal, G.P., Viola, R.E.

OCA: Protected "5cef" [edit=sysop:move=sysop]

2015-07-15T12:28:07Z

Protected "5cef" [edit=sysop:move=sysop]

← Older revision	Revision as of 12:28, 15 July 2015
(No difference)

OCA: New page: '''Unreleased structure''' The entry 5cef is ON HOLD Authors: Dahal, G.P., Viola, R.E. Description: Cystal structure of aspartate semialdehyde dehydrogenase from Cryptococcus neoforman...

2015-07-15T12:28:05Z

New page: '''Unreleased structure''' The entry 5cef is ON HOLD Authors: Dahal, G.P., Viola, R.E. Description: Cystal structure of aspartate semialdehyde dehydrogenase from Cryptococcus neoforman...

New page

'''Unreleased structure'''

The entry 5cef is ON HOLD

Authors: Dahal, G.P., Viola, R.E.

Description: Cystal structure of aspartate semialdehyde dehydrogenase from Cryptococcus neoformans
[[Category: Unreleased Structures]]
[[Category: Dahal, G.P]]
[[Category: Viola, R.E]]