5cfd - Revision history

OCA at 11:44, 9 May 2024

2024-05-09T11:44:55Z

← Older revision		Revision as of 11:44, 9 May 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5cfd]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saffold_virus Saffold virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CFD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CFD FirstGlance]. <br>		<table><tr><td colspan='2'>[[5cfd]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saffold_virus Saffold virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CFD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CFD FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cfd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cfd OCA], [https://pdbe.org/5cfd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cfd RCSB], [https://www.ebi.ac.uk/pdbsum/5cfd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cfd ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cfd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cfd OCA], [https://pdbe.org/5cfd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cfd RCSB], [https://www.ebi.ac.uk/pdbsum/5cfd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cfd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 12:03, 14 June 2023

2023-06-14T12:03:04Z

← Older revision		Revision as of 12:03, 14 June 2023
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	<StructureSection load='5cfd' size='340' side='right'caption='[[5cfd]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='5cfd' size='340' side='right'caption='[[5cfd]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5cfd]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Htcv-saffold Htcv-saffold~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CFD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5CFD FirstGlance]. <br>		<table><tr><td colspan='2'>[[5cfd]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saffold_virus Saffold virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CFD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CFD FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5cfd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cfd OCA], [~~http~~://pdbe.org/5cfd PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5cfd RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5cfd PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5cfd ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cfd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cfd OCA], [https://pdbe.org/5cfd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cfd RCSB], [https://www.ebi.ac.uk/pdbsum/5cfd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cfd ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/POLG_SAFV POLG_SAFV] Forms a complex with host RAN and probably binds to exportins carrying activated MAPK in order to mediate the hyperphosphorylation of host Phe/Gly containing nuclear pore proteins (Nups) resulting in cessation of active nucleocytoplasmic transport (Probable). Proteins with NLS signals fail to import, cellular mRNAs fail to export, and some proteins small enough for diffusion are not retained anymore (efflux) (By similarity). The resulting inhibition of cellular protein synthesis serves to ensure maximal viral gene expression and to evade host immune response (By similarity).[UniProtKB:Q66765]<ref>PMID:26115166</ref> Forms an icosahedral capsid of pseudo T=3 symmetry with capsid proteins VP2 and VP3. Together they form an icosahedral capsid composed of 60 copies of each VP1, VP2, and VP3, with a diameter of approximately 300 Angstroms.VP4 lies on the inner surface of the protein shell formed by VP1, VP2 and VP3. All the three latter proteins contain a beta-sheet structure called beta-barrel jelly roll. VP1 is situated at the 12 fivefold axes, whereas VP2 and VP3 are located at the quasi-sixfold axes.<ref>PMID:27279624</ref> Forms an icosahedral capsid of pseudo T=3 symmetry with capsid proteins VP2 and VP3. Together they form an icosahedral capsid composed of 60 copies of each VP1, VP2, and VP3, with a diameter of approximately 300 Angstroms.VP4 lies on the inner surface of the protein shell formed by VP1, VP2 and VP3. All the three latter proteins contain a beta-sheet structure called beta-barrel jelly roll. VP1 is situated at the 12 fivefold axes, whereas VP2 and VP3 are located at the quasi-sixfold axes.<ref>PMID:27279624</ref> Forms an icosahedral capsid of pseudo T=3 symmetry with capsid proteins VP2 and VP3. Together they form an icosahedral capsid composed of 60 copies of each VP1, VP2, and VP3, with a diameter of approximately 300 Angstroms.VP4 lies on the inner surface of the protein shell formed by VP1, VP2 and VP3. All the three latter proteins contain a beta-sheet structure called beta-barrel jelly roll. VP1 is situated at the 12 fivefold axes, whereas VP2 and VP3 are located at the quasi-sixfold axes.<ref>PMID:27279624</ref> Lies on the inner surface of the capsid shell (PubMed:27279624). After binding to the host receptor, the capsid undergoes conformational changes (By similarity). Capsid protein VP4 is released, capsid protein VP1 N-terminus is externalized, and together, they shape a pore in the host membrane through which the viral genome is translocated into the host cell cytoplasm. After genome has been released, the channel shrinks (By similarity).[UniProtKB:P03300]<ref>PMID:27279624</ref> VP0 precursor is a component of immature procapsids.[UniProtKB:P08617] Involved in host translation shutoff by inhibiting cap-dependent mRNA translation (By similarity). Nuclear localization is required for this function (By similarity). The resulting inhibition of cellular protein synthesis serves to ensure maximal viral gene expression and to evade host immune response (By similarity). Inhibits the phosphorylation of the leader protein (PubMed:25210192).[UniProtKB:Q66765]<ref>PMID:25210192</ref> Affects membrane integrity and causes an increase in membrane permeability. Associates with and induces structural rearrangements of intracellular membranes (By similarity). It displays RNA-binding, nucleotide binding and NTPase activities (By similarity).[UniProtKB:P03305][UniProtKB:P08545] Serves as membrane anchor via its hydrophobic domain. Forms a primer, VPg-pU, which is utilized by the polymerase for the initiation of RNA chains.[UniProtKB:P03304] Cysteine protease that generates mature viral proteins from the precursor polyprotein (By similarity). In addition to its proteolytic activity, it binds to viral RNA, and thus influences viral genome replication. RNA and substrate cooperatively bind to the protease. Cleaves host PABP1, this cleavage is important for viral replication (By similarity).[UniProtKB:P03304][UniProtKB:P12296] Replicates the genomic and antigenomic RNAs by recognizing replications specific signals (By similarity). Performs VPg uridylylation (By similarity).[UniProtKB:P12296]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Htcv-saffold]]~~
	[[Category: Large Structures]]		[[Category: Large Structures]]
	~~[[Category: Mullapudi, E]]~~
	~~[[Category: Plevka, P]]~~
	~~[[Category: Capsid]]~~
	~~[[Category: Dtt]]~~
	~~[[Category: Pathogen]]~~
	[[Category: Saffold virus]]		[[Category: Saffold virus]]
	[[Category: ~~Virion~~]]		[[Category: Mullapudi E]]
	[[Category: ~~Virus~~]]		[[Category: Plevka P]]

OCA at 11:36, 27 March 2020

2020-03-27T11:36:15Z

← Older revision		Revision as of 11:36, 27 March 2020
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	==Crystal Structure of DTT treated Human Cardiovirus SAFV-3==		==Crystal Structure of DTT treated Human Cardiovirus SAFV-3==
	<StructureSection load='5cfd' size='340' side='right' caption='[[5cfd]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='5cfd' size='340' side='right'caption='[[5cfd]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5cfd]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Htcv-saffold Htcv-saffold]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CFD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CFD FirstGlance]. <br>		<table><tr><td colspan='2'>[[5cfd]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Htcv-saffold Htcv-saffold]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CFD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CFD FirstGlance]. <br>
Line 20:		Line 20:
	</StructureSection>		</StructureSection>
	[[Category: Htcv-saffold]]		[[Category: Htcv-saffold]]
			[[Category: Large Structures]]
	[[Category: Mullapudi, E]]		[[Category: Mullapudi, E]]
	[[Category: Plevka, P]]		[[Category: Plevka, P]]

OCA at 06:54, 15 February 2018

2018-02-15T06:54:03Z

← Older revision		Revision as of 06:54, 15 February 2018
Line 3:		Line 3:
	<StructureSection load='5cfd' size='340' side='right' caption='[[5cfd]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='5cfd' size='340' side='right' caption='[[5cfd]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5cfd]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CFD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CFD FirstGlance]. <br>		<table><tr><td colspan='2'>[[5cfd]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Htcv-saffold Htcv-saffold]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CFD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CFD FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cfd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cfd OCA], [http://pdbe.org/5cfd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cfd RCSB], [http://www.ebi.ac.uk/pdbsum/5cfd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5cfd ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cfd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cfd OCA], [http://pdbe.org/5cfd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cfd RCSB], [http://www.ebi.ac.uk/pdbsum/5cfd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5cfd ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Htcv-saffold]]
	[[Category: Mullapudi, E]]		[[Category: Mullapudi, E]]
	[[Category: Plevka, P]]		[[Category: Plevka, P]]

OCA at 02:33, 13 July 2016

2016-07-13T02:33:52Z

← Older revision		Revision as of 02:33, 13 July 2016
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5cfd]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CFD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CFD FirstGlance]. <br>		<table><tr><td colspan='2'>[[5cfd]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CFD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CFD FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cfd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cfd OCA], [http://pdbe.org/5cfd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cfd RCSB], [http://www.ebi.ac.uk/pdbsum/5cfd PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cfd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cfd OCA], [http://pdbe.org/5cfd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cfd RCSB], [http://www.ebi.ac.uk/pdbsum/5cfd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5cfd ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 15:50, 23 June 2016

2016-06-23T15:50:08Z

@@ Line 6: / Line 6: @@
 </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cfd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cfd OCA], [http://pdbe.org/5cfd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cfd RCSB], [http://www.ebi.ac.uk/pdbsum/5cfd PDBsum]</span></td></tr>
 </table>
 __TOC__
 </StructureSection>

OCA at 22:23, 20 June 2016

2016-06-20T22:23:04Z

← Older revision		Revision as of 22:23, 20 June 2016
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	~~'''Unreleased structure'''~~

	~~The entry~~ 5cfd is ~~ON HOLD~~		==Crystal Structure of DTT treated Human Cardiovirus SAFV-3==
			<StructureSection load='5cfd' size='340' side='right' caption='[[5cfd]], [[Resolution\|resolution]] 2.50Å' scene=''>
	~~Authors~~: ~~Mullapudi~~, E., ~~Plevka~~, P.		== Structural highlights ==
			<table><tr><td colspan='2'>[[5cfd]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CFD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CFD FirstGlance]. <br>
	~~Description: Crystal Structure of DTT treated Human Cardiovirus SAFV-3~~		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cfd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cfd OCA], [http://pdbe.org/5cfd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cfd RCSB], [http://www.ebi.ac.uk/pdbsum/5cfd PDBsum]</span></td></tr>
	[[Category: ~~Unreleased Structures~~]]		</table>
			__TOC__
			</StructureSection>
			[[Category: Mullapudi, E]]
	[[Category: Plevka, P]]		[[Category: Plevka, P]]
	[[Category: ~~Mullapudi, E~~]]		[[Category: Capsid]]
			[[Category: Dtt]]
			[[Category: Pathogen]]
			[[Category: Saffold virus]]
			[[Category: Virion]]
			[[Category: Virus]]

OCA at 13:04, 22 July 2015

2015-07-22T13:04:13Z

← Older revision		Revision as of 13:04, 22 July 2015
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 5cfd is ON HOLD ~~until sometime in the future~~		The entry 5cfd is ON HOLD

	Authors: Mullapudi, E., Plevka, P.		Authors: Mullapudi, E., Plevka, P.

OCA: Protected "5cfd" [edit=sysop:move=sysop]

2015-07-15T12:30:20Z

Protected "5cfd" [edit=sysop:move=sysop]

← Older revision	Revision as of 12:30, 15 July 2015
(No difference)

OCA: New page: '''Unreleased structure''' The entry 5cfd is ON HOLD until sometime in the future Authors: Mullapudi, E., Plevka, P. Description: Crystal Structure of DTT treated Human Cardiovirus SAF...

2015-07-15T12:30:19Z

New page: '''Unreleased structure''' The entry 5cfd is ON HOLD until sometime in the future Authors: Mullapudi, E., Plevka, P. Description: Crystal Structure of DTT treated Human Cardiovirus SAF...

New page

'''Unreleased structure'''

The entry 5cfd is ON HOLD until sometime in the future

Authors: Mullapudi, E., Plevka, P.

Description: Crystal Structure of DTT treated Human Cardiovirus SAFV-3
[[Category: Unreleased Structures]]
[[Category: Plevka, P]]
[[Category: Mullapudi, E]]