5cmp - Revision history

OCA at 08:39, 27 September 2023

2023-09-27T08:39:22Z

← Older revision		Revision as of 08:39, 27 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5cmp]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CMP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CMP FirstGlance]. <br>		<table><tr><td colspan='2'>[[5cmp]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CMP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CMP FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.601Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cmp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cmp OCA], [https://pdbe.org/5cmp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cmp RCSB], [https://www.ebi.ac.uk/pdbsum/5cmp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cmp ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cmp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cmp OCA], [https://pdbe.org/5cmp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cmp RCSB], [https://www.ebi.ac.uk/pdbsum/5cmp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cmp ProSAT]</span></td></tr>
	</table>		</table>

OCA at 12:16, 14 June 2023

2023-06-14T12:16:46Z

← Older revision		Revision as of 12:16, 14 June 2023
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	==human FLRT3 LRR domain==		==human FLRT3 LRR domain==
	<StructureSection load='5cmp' size='340' side='right' caption='[[5cmp]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='5cmp' size='340' side='right'caption='[[5cmp]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5cmp]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CMP OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5CMP FirstGlance]. <br>		<table><tr><td colspan='2'>[[5cmp]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CMP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CMP FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>~~</td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5cmn\|5cmn]]</td></tr>~~		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cmp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cmp OCA], [https://pdbe.org/5cmp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cmp RCSB], [https://www.ebi.ac.uk/pdbsum/5cmp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cmp ProSAT]</span></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FLRT3, KIAA1469, UNQ856/PRO1865 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5cmp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cmp OCA], [~~http~~://pdbe.org/5cmp PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5cmp RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5cmp PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5cmp ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[~~[http~~://www.uniprot.org/uniprot/FLRT3_HUMAN FLRT3_HUMAN]] Kallmann syndrome. The disease is caused by mutations affecting distinct genetic loci, including the gene represented in this entry. Some patients carrying mutations in FLRT3 also have a mutation in another HH-associated gene including FGFR1, HS6ST1 and FGF17 (PubMed:23643382).<ref>PMID:23643382</ref>		[https://www.uniprot.org/uniprot/FLRT3_HUMAN FLRT3_HUMAN] Kallmann syndrome. The disease is caused by mutations affecting distinct genetic loci, including the gene represented in this entry. Some patients carrying mutations in FLRT3 also have a mutation in another HH-associated gene including FGFR1, HS6ST1 and FGF17 (PubMed:23643382).<ref>PMID:23643382</ref>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/FLRT3_HUMAN FLRT3_HUMAN]] May have a function in cell adhesion and/or receptor signaling.		[https://www.uniprot.org/uniprot/FLRT3_HUMAN FLRT3_HUMAN] May have a function in cell adhesion and/or receptor signaling.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: ~~Arac, D~~]]		[[Category: Large Structures]]
	[[Category: ~~Lu, Y~~]]		[[Category: Arac D]]
	[[Category: ~~Salzman, G~~]]		[[Category: Lu Y]]
	[[Category: ~~Cell adhesion]]~~		[[Category: Salzman G]]
	~~[[Category: Lrr repeat~~]]

OCA at 18:13, 16 November 2017

2017-11-16T18:13:10Z

← Older revision		Revision as of 18:13, 16 November 2017
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	==human FLRT3 LRR domain==		==human FLRT3 LRR domain==
	<StructureSection load='5cmp' size='340' side='right' caption='[[5cmp]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='5cmp' size='340' side='right' caption='[[5cmp]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5cmp]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CMP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CMP FirstGlance]. <br>		<table><tr><td colspan='2'>[[5cmp]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CMP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CMP FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5cmn\|5cmn]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5cmn\|5cmn]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cmp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cmp OCA], [http://pdbe.org/5cmp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cmp RCSB], [http://www.ebi.ac.uk/pdbsum/5cmp PDBsum]</span></td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FLRT3, KIAA1469, UNQ856/PRO1865 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cmp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cmp OCA], [http://pdbe.org/5cmp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cmp RCSB], [http://www.ebi.ac.uk/pdbsum/5cmp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5cmp ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Human]]
	[[Category: Arac, D]]		[[Category: Arac, D]]
	[[Category: Lu, Y]]		[[Category: Lu, Y]]

OCA at 06:29, 30 September 2015

2015-09-30T06:29:10Z

← Older revision		Revision as of 06:29, 30 September 2015
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5cmn\|5cmn]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5cmn\|5cmn]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cmp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cmp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5cmp RCSB], [http://www.ebi.ac.uk/pdbsum/5cmp PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cmp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cmp OCA], [http://pdbe.org/5cmp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cmp RCSB], [http://www.ebi.ac.uk/pdbsum/5cmp PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 5cmp" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 14:40, 12 August 2015

2015-08-12T14:40:15Z

← Older revision		Revision as of 14:40, 12 August 2015
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	'''~~Unreleased~~ structure'''		==human FLRT3 LRR domain==
			<StructureSection load='5cmp' size='340' side='right' caption='[[5cmp]], [[Resolution\|resolution]] 2.60Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[5cmp]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CMP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CMP FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5cmn\|5cmn]]</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cmp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cmp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5cmp RCSB], [http://www.ebi.ac.uk/pdbsum/5cmp PDBsum]</span></td></tr>
			</table>
			== Disease ==
			[[http://www.uniprot.org/uniprot/FLRT3_HUMAN FLRT3_HUMAN]] Kallmann syndrome. The disease is caused by mutations affecting distinct genetic loci, including the gene represented in this entry. Some patients carrying mutations in FLRT3 also have a mutation in another HH-associated gene including FGFR1, HS6ST1 and FGF17 (PubMed:23643382).<ref>PMID:23643382</ref>
			== Function ==
			[[http://www.uniprot.org/uniprot/FLRT3_HUMAN FLRT3_HUMAN]] May have a function in cell adhesion and/or receptor signaling.
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Fibronectin leucine-rich repeat transmembrane proteins (FLRTs) are cell-adhesion molecules with emerging functions in cortical development and synapse formation. Their extracellular regions interact with latrophilins (LPHNs) to mediate synapse development, and with Uncoordinated-5 (UNC5)/netrin receptors to control the migration of neurons in the developing cortex. Here, we present the crystal structures of FLRT3 in isolation and in complex with LPHN3. The LPHN3/FLRT3 structure reveals that LPHN3 binds to FLRT3 at a site distinct from UNC5. Structure-based mutations specifically disrupt LPHN3/FLRT3 binding, but do not disturb their interactions with other proteins or their cell-membrane localization. Thus, they can be used as molecular tools to dissect the functions of FLRTs and LPHNs in vivo. Our results suggest that UNC5 and LPHN3 can simultaneously bind to FLRT3, forming a trimeric complex, and that FLRT3 may form transsynaptic complexes with both LPHN3 and UNC5. These findings provide molecular insights for understanding the role of cell-adhesion proteins in synapse function.

	~~The entry 5cmp is ON HOLD until Paper Publication~~		Structural Basis of Latrophilin-FLRT-UNC5 Interaction in Cell Adhesion.,Lu YC, Nazarko OV, Sando R 3rd, Salzman GS, Sudhof TC, Arac D Structure. 2015 Jul 28. pii: S0969-2126(15)00277-4. doi:, 10.1016/j.str.2015.06.024. PMID:26235030<ref>PMID:26235030</ref>

	~~Authors: Lu~~, Y.~~, Salzman, G~~.~~, Arac, D~~.		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~Description: human FLRT3 LRR domain~~		== References ==
	~~[[Category: Unreleased Structures]]~~		<references/>
			__TOC__
			</StructureSection>
	[[Category: Arac, D]]		[[Category: Arac, D]]
	[[Category: Lu, Y]]		[[Category: Lu, Y]]
	[[Category: Salzman, G]]		[[Category: Salzman, G]]
			[[Category: Cell adhesion]]
			[[Category: Lrr repeat]]

OCA at 18:43, 5 August 2015

2015-08-05T18:43:39Z

← Older revision		Revision as of 18:43, 5 August 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 5cmp is ON HOLD		The entry 5cmp is ON HOLD until Paper Publication

	Authors: Lu, Y., Salzman, G., Arac. D.		Authors: Lu, Y., Salzman, G., Arac, D.

	Description: human FLRT3 LRR domain		Description: human FLRT3 LRR domain
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
			[[Category: Arac, D]]
	[[Category: Lu, Y]]		[[Category: Lu, Y]]
	[[Category: Salzman, G]]		[[Category: Salzman, G]]
	~~[[Category: Arac. D]]~~

OCA at 13:34, 29 July 2015

2015-07-29T13:34:44Z

← Older revision		Revision as of 13:34, 29 July 2015
Line 3:		Line 3:
	The entry 5cmp is ON HOLD		The entry 5cmp is ON HOLD

	Authors: ~~Yue~~ Lu, ~~Gabriel~~ Salzman, ~~Demet~~ Arac		Authors: Lu, Y., Salzman, G., Arac. D.

	Description: human FLRT3 LRR domain		Description: human FLRT3 LRR domain
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: ~~Yue~~ Lu, ~~Gabriel~~ Salzman, ~~Demet~~ Arac]]		[[Category: Lu, Y]]
			[[Category: Salzman, G]]
			[[Category: Arac. D]]

OCA: Protected "5cmp" [edit=sysop:move=sysop]

2015-07-22T13:21:48Z

Protected "5cmp" [edit=sysop:move=sysop]

← Older revision	Revision as of 13:21, 22 July 2015
(No difference)

OCA: New page: '''Unreleased structure''' The entry 5cmp is ON HOLD Authors: Yue Lu, Gabriel Salzman, Demet Arac Description: human FLRT3 LRR domain Category: Unreleased Structures [[Category: Yu...

2015-07-22T13:21:47Z

New page: '''Unreleased structure''' The entry 5cmp is ON HOLD Authors: Yue Lu, Gabriel Salzman, Demet Arac Description: human FLRT3 LRR domain Category: Unreleased Structures [[Category: Yu...

New page

'''Unreleased structure'''

The entry 5cmp is ON HOLD

Authors: Yue Lu, Gabriel Salzman, Demet Arac

Description: human FLRT3 LRR domain
[[Category: Unreleased Structures]]
[[Category: Yue Lu, Gabriel Salzman, Demet Arac]]