5cs2 - Revision history

OCA at 11:22, 10 January 2024

2024-01-10T11:22:41Z

← Older revision		Revision as of 11:22, 10 January 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5cs2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7] and [https://en.wikipedia.org/wiki/Streptomyces Streptomyces]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CS2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CS2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[5cs2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7] and [https://en.wikipedia.org/wiki/Streptomyces Streptomyces]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CS2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CS2 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=54C:(BETAR)-BETA-HYDROXY-1-{2-[(2R)-OXIRAN-2-YL]PROPAN-2-YL}-L-TRYPTOPHAN'>54C</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MLE:N-METHYLLEUCINE'>MLE</scene>, <scene name='pdbligand=WLU:(4R)-5-HYDROXY-N-METHYL-L-LEUCINE'>WLU</scene>, <scene name='pdbligand=WPA:(BETAR)-BETA-METHOXY-L-PHENYLALANINE'>WPA</scene>, <scene name='pdbligand=WVL:(2S,3R)-2-AMINO-3,5-DIMETHYLHEX-4-ENOIC+ACID'>WVL</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.65Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=54C:(BETAR)-BETA-HYDROXY-1-{2-[(2R)-OXIRAN-2-YL]PROPAN-2-YL}-L-TRYPTOPHAN'>54C</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MLE:N-METHYLLEUCINE'>MLE</scene>, <scene name='pdbligand=WLU:(4R)-5-HYDROXY-N-METHYL-L-LEUCINE'>WLU</scene>, <scene name='pdbligand=WPA:(BETAR)-BETA-METHOXY-L-PHENYLALANINE'>WPA</scene>, <scene name='pdbligand=WVL:(2S,3R)-2-AMINO-3,5-DIMETHYLHEX-4-ENOIC+ACID'>WVL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cs2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cs2 OCA], [https://pdbe.org/5cs2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cs2 RCSB], [https://www.ebi.ac.uk/pdbsum/5cs2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cs2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cs2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cs2 OCA], [https://pdbe.org/5cs2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cs2 RCSB], [https://www.ebi.ac.uk/pdbsum/5cs2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cs2 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 12:25, 14 June 2023

2023-06-14T12:25:35Z

← Older revision		Revision as of 12:25, 14 June 2023
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	<StructureSection load='5cs2' size='340' side='right'caption='[[5cs2]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='5cs2' size='340' side='right'caption='[[5cs2]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5cs2]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Plaf7 Plaf7~~] and [~~http~~://en.wikipedia.org/wiki/Streptomyces Streptomyces]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CS2 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5CS2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[5cs2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7] and [https://en.wikipedia.org/wiki/Streptomyces Streptomyces]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CS2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CS2 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=54C:(BETAR)-BETA-HYDROXY-1-{2-[(2R)-OXIRAN-2-YL]PROPAN-2-YL}-L-TRYPTOPHAN'>54C</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MLE:N-METHYLLEUCINE'>MLE</scene>, <scene name='pdbligand=WLU:(4R)-5-HYDROXY-N-METHYL-L-LEUCINE'>WLU</scene>, <scene name='pdbligand=WPA:(BETAR)-BETA-METHOXY-L-PHENYLALANINE'>WPA</scene>, <scene name='pdbligand=WVL:(2S,3R)-2-AMINO-3,5-DIMETHYLHEX-4-ENOIC+ACID'>WVL</scene></td></tr>
	~~<tr~~ id~~='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class~~="~~sblockDat~~"><scene name='pdbligand=54C:(BETAR)-BETA-HYDROXY-1-{2-[(2R)-OXIRAN-2-YL]PROPAN-2-YL}-L-TRYPTOPHAN'>54C</scene>, <scene name='pdbligand=MLE:N-METHYLLEUCINE'>MLE</scene>, <scene name='pdbligand=WLU:(4R)-5-HYDROXY-N-METHYL-L-LEUCINE'>WLU</scene>, <scene name='pdbligand=WPA:(BETAR)-BETA-METHOXY-L-PHENYLALANINE'>WPA</scene>, <scene name='pdbligand=WVL:(2S,3R)-2-AMINO-3,5-DIMETHYLHEX-4-ENOIC+ACID'>WVL</scene>~~</td></tr>~~		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cs2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cs2 OCA], [https://pdbe.org/5cs2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cs2 RCSB], [https://www.ebi.ac.uk/pdbsum/5cs2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cs2 ProSAT]</span></td></tr>
	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PF14_0349 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36329 PLAF7])~~</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5cs2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cs2 OCA], [~~http~~://pdbe.org/5cs2 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5cs2 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5cs2 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5cs2 ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/Q8IL97_PLAF7 Q8IL97_PLAF7]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Plaf7~~]]		[[Category: Plasmodium falciparum 3D7]]
	[[Category: Streptomyces]]		[[Category: Streptomyces]]
	[[Category: Delmas, C]]		[[Category: Delmas C]]
	[[Category: Gerhartz, B]]		[[Category: Gerhartz B]]
	[[Category: Hinniger, A]]		[[Category: Hinniger A]]
	[[Category: Ostermann, N]]		[[Category: Ostermann N]]
	[[Category: Schmitt, E]]		[[Category: Schmitt E]]
	~~[[Category: Anti-plasmodial activity]]~~
	~~[[Category: Cyclomarin some]]~~
	~~[[Category: Diadenosine triphosphate hydrolase]]~~
	~~[[Category: Hydrolase]]~~
	~~[[Category: Malaria]]~~
	~~[[Category: Plasmodium falciparum~~]]

OCA at 08:02, 21 May 2019

2019-05-21T08:02:55Z

← Older revision		Revision as of 08:02, 21 May 2019
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	==Crystal structure of Plasmodium falciparum diadenosine triphosphate hydrolase in complex with Cyclomarin A==		==Crystal structure of Plasmodium falciparum diadenosine triphosphate hydrolase in complex with Cyclomarin A==
	<StructureSection load='5cs2' size='340' side='right' caption='[[5cs2]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='5cs2' size='340' side='right'caption='[[5cs2]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5cs2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Streptomyces Streptomyces]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CS2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CS2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[5cs2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plaf7 Plaf7] and [http://en.wikipedia.org/wiki/Streptomyces Streptomyces]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CS2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CS2 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=54C:(BETAR)-BETA-HYDROXY-1-{2-[(2R)-OXIRAN-2-YL]PROPAN-2-YL}-L-TRYPTOPHAN'>54C</scene>, <scene name='pdbligand=MLE:N-METHYLLEUCINE'>MLE</scene>, <scene name='pdbligand=WLU:(4R)-5-HYDROXY-N-METHYL-L-LEUCINE'>WLU</scene>, <scene name='pdbligand=WPA:(BETAR)-BETA-METHOXY-L-PHENYLALANINE'>WPA</scene>, <scene name='pdbligand=WVL:(2S,3R)-2-AMINO-3,5-DIMETHYLHEX-4-ENOIC+ACID'>WVL</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=54C:(BETAR)-BETA-HYDROXY-1-{2-[(2R)-OXIRAN-2-YL]PROPAN-2-YL}-L-TRYPTOPHAN'>54C</scene>, <scene name='pdbligand=MLE:N-METHYLLEUCINE'>MLE</scene>, <scene name='pdbligand=WLU:(4R)-5-HYDROXY-N-METHYL-L-LEUCINE'>WLU</scene>, <scene name='pdbligand=WPA:(BETAR)-BETA-METHOXY-L-PHENYLALANINE'>WPA</scene>, <scene name='pdbligand=WVL:(2S,3R)-2-AMINO-3,5-DIMETHYLHEX-4-ENOIC+ACID'>WVL</scene></td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PF14_0349 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36329 PLAF7])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cs2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cs2 OCA], [http://pdbe.org/5cs2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cs2 RCSB], [http://www.ebi.ac.uk/pdbsum/5cs2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5cs2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cs2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cs2 OCA], [http://pdbe.org/5cs2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cs2 RCSB], [http://www.ebi.ac.uk/pdbsum/5cs2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5cs2 ProSAT]</span></td></tr>
	</table>		</table>
Line 21:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
			[[Category: Plaf7]]
	[[Category: Streptomyces]]		[[Category: Streptomyces]]
	[[Category: Delmas, C]]		[[Category: Delmas, C]]

OCA at 16:49, 18 August 2017

2017-08-18T16:49:37Z

← Older revision		Revision as of 16:49, 18 August 2017
Line 1:		Line 1:

	==Crystal structure of Plasmodium falciparum diadenosine triphosphate hydrolase in complex with Cyclomarin A==		==Crystal structure of Plasmodium falciparum diadenosine triphosphate hydrolase in complex with Cyclomarin A==
	<StructureSection load='5cs2' size='340' side='right' caption='[[5cs2]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='5cs2' size='340' side='right' caption='[[5cs2]], [[Resolution\|resolution]] 1.65Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=54C:(BETAR)-BETA-HYDROXY-1-{2-[(2R)-OXIRAN-2-YL]PROPAN-2-YL}-L-TRYPTOPHAN'>54C</scene>, <scene name='pdbligand=MLE:N-METHYLLEUCINE'>MLE</scene>, <scene name='pdbligand=WLU:(4R)-5-HYDROXY-N-METHYL-L-LEUCINE'>WLU</scene>, <scene name='pdbligand=WPA:(BETAR)-BETA-METHOXY-L-PHENYLALANINE'>WPA</scene>, <scene name='pdbligand=WVL:(2S,3R)-2-AMINO-3,5-DIMETHYLHEX-4-ENOIC+ACID'>WVL</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=54C:(BETAR)-BETA-HYDROXY-1-{2-[(2R)-OXIRAN-2-YL]PROPAN-2-YL}-L-TRYPTOPHAN'>54C</scene>, <scene name='pdbligand=MLE:N-METHYLLEUCINE'>MLE</scene>, <scene name='pdbligand=WLU:(4R)-5-HYDROXY-N-METHYL-L-LEUCINE'>WLU</scene>, <scene name='pdbligand=WPA:(BETAR)-BETA-METHOXY-L-PHENYLALANINE'>WPA</scene>, <scene name='pdbligand=WVL:(2S,3R)-2-AMINO-3,5-DIMETHYLHEX-4-ENOIC+ACID'>WVL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cs2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cs2 OCA], [http://pdbe.org/5cs2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cs2 RCSB], [http://www.ebi.ac.uk/pdbsum/5cs2 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cs2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cs2 OCA], [http://pdbe.org/5cs2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cs2 RCSB], [http://www.ebi.ac.uk/pdbsum/5cs2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5cs2 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 18:17, 27 January 2016

2016-01-27T18:17:11Z

← Older revision		Revision as of 18:17, 27 January 2016
Line 1:		Line 1:
	'''~~Unreleased~~ structure'''		==Crystal structure of Plasmodium falciparum diadenosine triphosphate hydrolase in complex with Cyclomarin A==
			<StructureSection load='5cs2' size='340' side='right' caption='[[5cs2]], [[Resolution\|resolution]] 1.65Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[5cs2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Streptomyces Streptomyces]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CS2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CS2 FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
			<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=54C:(BETAR)-BETA-HYDROXY-1-{2-[(2R)-OXIRAN-2-YL]PROPAN-2-YL}-L-TRYPTOPHAN'>54C</scene>, <scene name='pdbligand=MLE:N-METHYLLEUCINE'>MLE</scene>, <scene name='pdbligand=WLU:(4R)-5-HYDROXY-N-METHYL-L-LEUCINE'>WLU</scene>, <scene name='pdbligand=WPA:(BETAR)-BETA-METHOXY-L-PHENYLALANINE'>WPA</scene>, <scene name='pdbligand=WVL:(2S,3R)-2-AMINO-3,5-DIMETHYLHEX-4-ENOIC+ACID'>WVL</scene></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cs2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cs2 OCA], [http://pdbe.org/5cs2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cs2 RCSB], [http://www.ebi.ac.uk/pdbsum/5cs2 PDBsum]</span></td></tr>
			</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Malaria continues to be one of the most devastating human diseases despite many efforts to limit its spread by prevention of infection or by pharmaceutical treatment of patients. We have conducted a screen for antiplasmodial compounds by using a natural product library. Here we report on cyclomarin A as a potent growth inhibitor of Plasmodium falciparum and the identification of its molecular target, diadenosine triphosphate hydrolase (PfAp3Aase), by chemical proteomics. Using a biochemical assay, we could show that cyclomarin A is a specific inhibitor of the plasmodial enzyme but not of the closest human homologue hFHIT. Co-crystallisation experiments demonstrate a unique binding mode of the inhibitor. One molecule of cyclomarin A binds a dimeric PfAp3Aase and prevents the formation of the enzymesubstrate complex. These results validate PfAp3Aase as a new drug target for the treatment of malaria. We have previously elucidated the structurally unrelated regulatory subunit ClpC1 of the ClpP protease as the molecular target of cyclomarin A in Mycobacterium tuberculosis. Thus, cyclomarin A is a rare example of a natural product with two distinct and specific modes of action.

	~~The entry 5cs2 is ON HOLD until Paper Publication~~		Gift from Nature: Cyclomarin A Kills Mycobacteria and Malaria Parasites by Distinct Modes of Action.,Burstner N, Roggo S, Ostermann N, Blank J, Delmas C, Freuler F, Gerhartz B, Hinniger A, Hoepfner D, Liechty B, Mihalic M, Murphy J, Pistorius D, Rottmann M, Thomas JR, Schirle M, Schmitt EK Chembiochem. 2015 Nov;16(17):2433-6. doi: 10.1002/cbic.201500472. Epub 2015 Oct, 16. PMID:26472355<ref>PMID:26472355</ref>

	~~Authors: Ostermann~~, N.~~, Schmitt, E~~.~~, Gerhartz, B., Hinniger, A., Delmas, C~~.		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~Description~~: ~~Crystal structure of Plasmodium falciparum diadenosine triphosphate hydrolase in complex with Cyclomarin A~~		<div class="pdbe-citations 5cs2" style="background-color:#fffaf0;"></div>
	[[Category: ~~Unreleased Structures~~]]		== References ==
	[[Category: ~~Schmitt~~, E]]		<references/>
			__TOC__
			</StructureSection>
			[[Category: Streptomyces]]
			[[Category: Delmas, C]]
	[[Category: Gerhartz, B]]		[[Category: Gerhartz, B]]
	[[Category: Hinniger, A]]		[[Category: Hinniger, A]]
	[[Category: Ostermann, N]]		[[Category: Ostermann, N]]
	[[Category: ~~Delmas~~, C]]		[[Category: Schmitt, E]]
			[[Category: Anti-plasmodial activity]]
			[[Category: Cyclomarin some]]
			[[Category: Diadenosine triphosphate hydrolase]]
			[[Category: Hydrolase]]
			[[Category: Malaria]]
			[[Category: Plasmodium falciparum]]

OCA at 11:01, 20 August 2015

2015-08-20T11:01:44Z

← Older revision		Revision as of 11:01, 20 August 2015
Line 3:		Line 3:
	The entry 5cs2 is ON HOLD until Paper Publication		The entry 5cs2 is ON HOLD until Paper Publication

	Authors: Schmitt, E., Gerhartz, B., Hinniger, A., Delmas, C.		Authors: Ostermann, N., Schmitt, E., Gerhartz, B., Hinniger, A., Delmas, C.

	Description: Crystal structure of Plasmodium falciparum diadenosine triphosphate hydrolase in complex with Cyclomarin A		Description: Crystal structure of Plasmodium falciparum diadenosine triphosphate hydrolase in complex with Cyclomarin A
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	[[Category: Gerhartz, B]]		[[Category: Gerhartz, B]]
	[[Category: Hinniger, A]]		[[Category: Hinniger, A]]
			[[Category: Ostermann, N]]
	[[Category: Delmas, C]]		[[Category: Delmas, C]]

OCA: Protected "5cs2" [edit=sysop:move=sysop]

2015-07-29T13:48:56Z

Protected "5cs2" [edit=sysop:move=sysop]

← Older revision	Revision as of 13:48, 29 July 2015
(No difference)

OCA: New page: '''Unreleased structure''' The entry 5cs2 is ON HOLD until Paper Publication Authors: Schmitt, E., Gerhartz, B., Hinniger, A., Delmas, C. Description: Crystal structure of Plasmodium f...

2015-07-29T13:48:55Z

New page: '''Unreleased structure''' The entry 5cs2 is ON HOLD until Paper Publication Authors: Schmitt, E., Gerhartz, B., Hinniger, A., Delmas, C. Description: Crystal structure of Plasmodium f...

New page

'''Unreleased structure'''

The entry 5cs2 is ON HOLD until Paper Publication

Authors: Schmitt, E., Gerhartz, B., Hinniger, A., Delmas, C.

Description: Crystal structure of Plasmodium falciparum diadenosine triphosphate hydrolase in complex with Cyclomarin A
[[Category: Unreleased Structures]]
[[Category: Schmitt, E]]
[[Category: Gerhartz, B]]
[[Category: Hinniger, A]]
[[Category: Delmas, C]]