5cs4 - Revision history

OCA at 12:25, 14 June 2023

2023-06-14T12:25:38Z

← Older revision		Revision as of 12:25, 14 June 2023
Line 3:		Line 3:
	<StructureSection load='5cs4' size='340' side='right'caption='[[5cs4]], [[Resolution\|resolution]] 3.19Å' scene=''>		<StructureSection load='5cs4' size='340' side='right'caption='[[5cs4]], [[Resolution\|resolution]] 3.19Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5cs4]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Baker's_yeast Baker's yeast~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CS4 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5CS4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[5cs4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CS4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CS4 FirstGlance]. <br>
	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>~~</td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5cs0\|5cs0]], [[5csa\|5csa]], [[5csk\|5csk]], [[5csl\|5csl]]</td></tr>~~		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cs4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cs4 OCA], [https://pdbe.org/5cs4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cs4 RCSB], [https://www.ebi.ac.uk/pdbsum/5cs4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cs4 ProSAT]</span></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ACC1, ABP2, FAS3, MTR7, YNR016C, N3175 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5cs4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cs4 OCA], [~~http~~://pdbe.org/5cs4 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5cs4 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5cs4 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5cs4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/ACAC_YEAST ACAC_YEAST]] Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Involved in the synthesis of very-long-chain fatty acid synthesis which is required to maintain a functional nuclear envelope. Required for acylation and vacuolar membrane association of VAC8 which is necessary to maintain a normal morphology of the vacuole.<ref>PMID:6108218</ref> <ref>PMID:6103540</ref> <ref>PMID:8943372</ref> <ref>PMID:10757783</ref> <ref>PMID:12730220</ref>		[https://www.uniprot.org/uniprot/ACAC_YEAST ACAC_YEAST] Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Involved in the synthesis of very-long-chain fatty acid synthesis which is required to maintain a functional nuclear envelope. Required for acylation and vacuolar membrane association of VAC8 which is necessary to maintain a normal morphology of the vacuole.<ref>PMID:6108218</ref> <ref>PMID:6103540</ref> <ref>PMID:8943372</ref> <ref>PMID:10757783</ref> <ref>PMID:12730220</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Baker's yeast]]~~
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Tong, L~~]]		[[Category: Saccharomyces cerevisiae S288C]]
	[[Category: ~~Wei, J~~]]		[[Category: Tong L]]
	[[Category: ~~Acetyl-coa carboxylase]]~~		[[Category: Wei J]]
	~~[[Category: Ligase~~]]

OCA at 11:15, 25 December 2019

2019-12-25T11:15:56Z

← Older revision		Revision as of 11:15, 25 December 2019
Line 1:		Line 1:

	==Crystal structure of domains AC3-AC5 of yeast acetyl-CoA carboxylase==		==Crystal structure of domains AC3-AC5 of yeast acetyl-CoA carboxylase==
	<StructureSection load='5cs4' size='340' side='right' caption='[[5cs4]], [[Resolution\|resolution]] 3.19Å' scene=''>		<StructureSection load='5cs4' size='340' side='right'caption='[[5cs4]], [[Resolution\|resolution]] 3.19Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5cs4]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CS4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CS4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[5cs4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CS4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CS4 FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5cs0\|5cs0]], [[5csa\|5csa]], [[5csk\|5csk]], [[5csl\|5csl]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5cs0\|5cs0]], [[5csa\|5csa]], [[5csk\|5csk]], [[5csl\|5csl]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ACC1, ABP2, FAS3, MTR7, YNR016C, N3175 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cs4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cs4 OCA], [http://pdbe.org/5cs4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cs4 RCSB], [http://www.ebi.ac.uk/pdbsum/5cs4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5cs4 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cs4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cs4 OCA], [http://pdbe.org/5cs4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cs4 RCSB], [http://www.ebi.ac.uk/pdbsum/5cs4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5cs4 ProSAT]</span></td></tr>
	</table>		</table>
Line 19:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 5cs4" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5cs4" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Acetyl-CoA carboxylase 3D structures\|Acetyl-CoA carboxylase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Baker's yeast]]
			[[Category: Large Structures]]
	[[Category: Tong, L]]		[[Category: Tong, L]]
	[[Category: Wei, J]]		[[Category: Wei, J]]
	[[Category: Acetyl-coa carboxylase]]		[[Category: Acetyl-coa carboxylase]]
	[[Category: Ligase]]		[[Category: Ligase]]

OCA at 16:39, 15 November 2017

2017-11-15T16:39:51Z

← Older revision		Revision as of 16:39, 15 November 2017
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 5cs4" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5cs4" style="background-color:#fffaf0;"></div>

	~~==See Also==~~
	*[[Acetyl-CoA carboxylase\|Acetyl-CoA carboxylase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 17:11, 18 August 2017

2017-08-18T17:11:39Z

← Older revision		Revision as of 17:11, 18 August 2017
Line 1:		Line 1:

	==Crystal structure of domains AC3-AC5 of yeast acetyl-CoA carboxylase==		==Crystal structure of domains AC3-AC5 of yeast acetyl-CoA carboxylase==
	<StructureSection load='5cs4' size='340' side='right' caption='[[5cs4]], [[Resolution\|resolution]] 3.19Å' scene=''>		<StructureSection load='5cs4' size='340' side='right' caption='[[5cs4]], [[Resolution\|resolution]] 3.19Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5cs0\|5cs0]], [[5csa\|5csa]], [[5csk\|5csk]], [[5csl\|5csl]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5cs0\|5cs0]], [[5csa\|5csa]], [[5csk\|5csk]], [[5csl\|5csl]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cs4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cs4 OCA], [http://pdbe.org/5cs4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cs4 RCSB], [http://www.ebi.ac.uk/pdbsum/5cs4 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cs4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cs4 OCA], [http://pdbe.org/5cs4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cs4 RCSB], [http://www.ebi.ac.uk/pdbsum/5cs4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5cs4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 5cs4" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5cs4" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Acetyl-CoA carboxylase\|Acetyl-CoA carboxylase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 21:05, 30 November 2015

2015-11-30T21:05:05Z

← Older revision		Revision as of 21:05, 30 November 2015
Line 1:		Line 1:
	'''~~Unreleased~~ structure'''		==Crystal structure of domains AC3-AC5 of yeast acetyl-CoA carboxylase==
			<StructureSection load='5cs4' size='340' side='right' caption='[[5cs4]], [[Resolution\|resolution]] 3.19Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[5cs4]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CS4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CS4 FirstGlance]. <br>
			</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5cs0\|5cs0]], [[5csa\|5csa]], [[5csk\|5csk]], [[5csl\|5csl]]</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cs4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cs4 OCA], [http://pdbe.org/5cs4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cs4 RCSB], [http://www.ebi.ac.uk/pdbsum/5cs4 PDBsum]</span></td></tr>
			</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/ACAC_YEAST ACAC_YEAST]] Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Involved in the synthesis of very-long-chain fatty acid synthesis which is required to maintain a functional nuclear envelope. Required for acylation and vacuolar membrane association of VAC8 which is necessary to maintain a normal morphology of the vacuole.<ref>PMID:6108218</ref> <ref>PMID:6103540</ref> <ref>PMID:8943372</ref> <ref>PMID:10757783</ref> <ref>PMID:12730220</ref>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Acetyl-CoA carboxylase (ACC) has crucial roles in fatty acid metabolism and is an attractive target for drug discovery against diabetes, cancer and other diseases. Saccharomyces cerevisiae ACC (ScACC) is crucial for the production of very-long-chain fatty acids and the maintenance of the nuclear envelope. ACC contains biotin carboxylase (BC) and carboxyltransferase (CT) activities, and its biotin is linked covalently to the biotin carboxyl carrier protein (BCCP). Most eukaryotic ACCs are 250-kilodalton (kDa), multi-domain enzymes and function as homodimers and higher oligomers. They contain a unique, 80-kDa central region that shares no homology with other proteins. Although the structures of the BC, CT and BCCP domains and other biotin-dependent carboxylase holoenzymes are known, there is currently no structural information on the ACC holoenzyme. Here we report the crystal structure of the full-length, 500-kDa holoenzyme dimer of ScACC. The structure is remarkably different from that of the other biotin-dependent carboxylases. The central region contains five domains and is important for positioning the BC and CT domains for catalysis. The structure unexpectedly reveals a dimer of the BC domain and extensive conformational differences compared to the structure of the BC domain alone, which is a monomer. These structural changes reveal why the BC domain alone is catalytically inactive and define the molecular mechanism for the inhibition of eukaryotic ACC by the natural product soraphen A and by phosphorylation of a Ser residue just before the BC domain core in mammalian ACC. The BC and CT active sites are separated by 80 A, and the entire BCCP domain must translocate during catalysis.

	~~The entry 5cs4 is ON HOLD until Paper Publication~~		Crystal structure of the 500-kDa yeast acetyl-CoA carboxylase holoenzyme dimer.,Wei J, Tong L Nature. 2015 Oct 29;526(7575):723-7. doi: 10.1038/nature15375. Epub 2015 Oct 12. PMID:26458104<ref>PMID:26458104</ref>

	~~Authors: Wei~~, J.~~, Tong, L~~.		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~Description~~:		<div class="pdbe-citations 5cs4" style="background-color:#fffaf0;"></div>
	[[Category: ~~Unreleased Structures~~]]		== References ==
			<references/>
			__TOC__
			</StructureSection>
			[[Category: Tong, L]]
	[[Category: Wei, J]]		[[Category: Wei, J]]
	[[Category: ~~Tong, L~~]]		[[Category: Acetyl-coa carboxylase]]
			[[Category: Ligase]]

OCA at 18:52, 5 August 2015

2015-08-05T18:52:57Z

← Older revision		Revision as of 18:52, 5 August 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 5cs4 is ON HOLD		The entry 5cs4 is ON HOLD until Paper Publication

	Authors: Wei, J., Tong, L.		Authors: Wei, J., Tong, L.

OCA: Protected "5cs4" [edit=sysop:move=sysop]

2015-07-29T13:49:05Z

Protected "5cs4" [edit=sysop:move=sysop]

← Older revision	Revision as of 13:49, 29 July 2015
(No difference)

OCA: New page: '''Unreleased structure''' The entry 5cs4 is ON HOLD Authors: Wei, J., Tong, L. Description: Category: Unreleased Structures Category: Wei, J Category: Tong, L

2015-07-29T13:49:04Z

New page: '''Unreleased structure''' The entry 5cs4 is ON HOLD Authors: Wei, J., Tong, L. Description: Category: Unreleased Structures Category: Wei, J Category: Tong, L

New page

'''Unreleased structure'''

The entry 5cs4 is ON HOLD

Authors: Wei, J., Tong, L.

Description:
[[Category: Unreleased Structures]]
[[Category: Wei, J]]
[[Category: Tong, L]]