5ctl - Revision history

OCA at 09:09, 20 March 2024

2024-03-20T09:09:15Z

← Older revision		Revision as of 09:09, 20 March 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5ctl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CTL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CTL FirstGlance]. <br>		<table><tr><td colspan='2'>[[5ctl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CTL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CTL FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EB9:N-(1-ETHYL-2-OXO-1,2-DIHYDROBENZO[CD]INDOL-6-YL)BENZENESULFONAMIDE'>EB9</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.51Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EB9:N-(1-ETHYL-2-OXO-1,2-DIHYDROBENZO[CD]INDOL-6-YL)BENZENESULFONAMIDE'>EB9</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ctl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ctl OCA], [https://pdbe.org/5ctl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ctl RCSB], [https://www.ebi.ac.uk/pdbsum/5ctl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ctl ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ctl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ctl OCA], [https://pdbe.org/5ctl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ctl RCSB], [https://www.ebi.ac.uk/pdbsum/5ctl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ctl ProSAT]</span></td></tr>
	</table>		</table>
Line 11:		Line 12:
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).		[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	The discovery of inhibitors of bromodomain and extra terminal domain (BET) has achieved great progress, and at least seven inhibitors have progressed into clinical trials for the treatment of cancer or inflammatory diseases. Here, we describe the identification, optimization, and evaluation of benzo[cd]indol-2(1H)-one containing compounds as a new class of BET bromodomain inhibitors, starting from structure-based virtual screening (SBVS). Through structure-based optimization, potent compounds were obtained with significantly improved activity. The two most potent compounds bind to the BRD4 bromodomain, with Kd values of 124 and 137 nM. Selected compounds exhibited high selectivity over other non-BET subfamily members. Notably, compound 85 demonstrated a reasonable antiproliferation effect on MV4;11 leukemia cells and exhibited a good pharmacokinetic profile with high oral bioavailability (75.8%) and moderate half-life (T1/2 = 3.95 h). The resulting lead molecule 85 represents a new, potent, and selective class of BET bromodomain inhibitors for the development of therapeutics to treat cancer and inflammatory diseases.

	Discovery of Benzo[cd]indol-2(1H)-ones as Potent and Specific BET Bromodomain Inhibitors: Structure-Based Virtual Screening, Optimization, and Biological Evaluation.,Xue X, Zhang Y, Liu Z, Song M, Xing Y, Xiang Q, Wang Z, Tu Z, Zhou Y, Ding K, Xu Y J Med Chem. 2016 Jan 12. PMID:26731490<ref>PMID:26731490</ref>

	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~<div class="pdbe-citations 5ctl" style="background-color:#fffaf0;"></div>~~

	==See Also==		==See Also==

OCA at 12:27, 14 June 2023

2023-06-14T12:27:34Z

← Older revision		Revision as of 12:27, 14 June 2023
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	<StructureSection load='5ctl' size='340' side='right'caption='[[5ctl]], [[Resolution\|resolution]] 2.51Å' scene=''>		<StructureSection load='5ctl' size='340' side='right'caption='[[5ctl]], [[Resolution\|resolution]] 2.51Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5ctl]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CTL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5CTL FirstGlance]. <br>		<table><tr><td colspan='2'>[[5ctl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CTL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CTL FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EB9:N-(1-ETHYL-2-OXO-1,2-DIHYDROBENZO[CD]INDOL-6-YL)BENZENESULFONAMIDE'>EB9</scene>~~</td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EB9:N-(1-ETHYL-2-OXO-1,2-DIHYDROBENZO[CD]INDOL-6-YL)BENZENESULFONAMIDE'>EB9</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5cp5\|5cp5]], [[5cpe\|5cpe]], [[5coi\|5coi]], [[5cqt\|5cqt]], [[5crm\|5crm]], [[5crz\|5crz]], [[5cs8\|5cs8]]</td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ctl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ctl OCA], [https://pdbe.org/5ctl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ctl RCSB], [https://www.ebi.ac.uk/pdbsum/5ctl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ctl ProSAT]</span></td></tr>
	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BRD4, HUNK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ctl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ctl OCA], [~~http~~://pdbe.org/5ctl PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5ctl RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5ctl PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5ctl ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[~~[http~~://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>		[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).		[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Liu, Z]]		[[Category: Liu Z]]
	[[Category: Song, M]]		[[Category: Song M]]
	[[Category: Xu, Y]]		[[Category: Xu Y]]
	[[Category: Xue, X]]		[[Category: Xue X]]
	[[Category: Zhang, Y]]		[[Category: Zhang Y]]
	~~[[Category: Brd4]]~~
	~~[[Category: Bromodomain]]~~
	~~[[Category: Four alpha helice]]~~
	~~[[Category: Signaling protein-inhibitor complex~~]]

OCA at 10:22, 1 April 2020

2020-04-01T10:22:47Z

← Older revision		Revision as of 10:22, 1 April 2020
Line 1:		Line 1:

	==Crystal Structure of the first bromodomain of human BRD4 in complex with benzo[cd]indol-2(1H)-one ligand==		==Crystal Structure of the first bromodomain of human BRD4 in complex with benzo[cd]indol-2(1H)-one ligand==
	<StructureSection load='5ctl' size='340' side='right' caption='[[5ctl]], [[Resolution\|resolution]] 2.51Å' scene=''>		<StructureSection load='5ctl' size='340' side='right'caption='[[5ctl]], [[Resolution\|resolution]] 2.51Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5ctl]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CTL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CTL FirstGlance]. <br>		<table><tr><td colspan='2'>[[5ctl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CTL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CTL FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EB9:N-(1-ETHYL-2-OXO-1,2-DIHYDROBENZO[CD]INDOL-6-YL)BENZENESULFONAMIDE'>EB9</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EB9:N-(1-ETHYL-2-OXO-1,2-DIHYDROBENZO[CD]INDOL-6-YL)BENZENESULFONAMIDE'>EB9</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5cp5\|5cp5]], [[5cpe\|5cpe]], [[5coi\|5coi]], [[5cqt\|5cqt]], [[5crm\|5crm]], [[5crz\|5crz]], [[5cs8\|5cs8]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5cp5\|5cp5]], [[5cpe\|5cpe]], [[5coi\|5coi]], [[5cqt\|5cqt]], [[5crm\|5crm]], [[5crz\|5crz]], [[5cs8\|5cs8]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ctl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ctl OCA], [http://pdbe.org/5ctl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ctl RCSB], [http://www.ebi.ac.uk/pdbsum/5ctl PDBsum]</span></td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BRD4, HUNK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ctl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ctl OCA], [http://pdbe.org/5ctl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ctl RCSB], [http://www.ebi.ac.uk/pdbsum/5ctl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ctl ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 23:		Line 24:

	==See Also==		==See Also==
	*[[Bromodomain-containing protein\|Bromodomain-containing protein]]		*[[Bromodomain-containing protein 3D structures\|Bromodomain-containing protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Liu, Z]]		[[Category: Liu, Z]]
	[[Category: Song, M]]		[[Category: Song, M]]

OCA at 20:04, 9 March 2016

2016-03-09T20:04:14Z

← Older revision		Revision as of 20:04, 9 March 2016
Line 1:		Line 1:

	==Crystal Structure of the first bromodomain of human BRD4 in complex with benzo[cd]indol-2(1H)-one ligand==		==Crystal Structure of the first bromodomain of human BRD4 in complex with benzo[cd]indol-2(1H)-one ligand==
	<StructureSection load='5ctl' size='340' side='right' caption='[[5ctl]], [[Resolution\|resolution]] 2.51Å' scene=''>		<StructureSection load='5ctl' size='340' side='right' caption='[[5ctl]], [[Resolution\|resolution]] 2.51Å' scene=''>
Line 20:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 5ctl" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5ctl" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Bromodomain-containing protein\|Bromodomain-containing protein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 18:31, 27 January 2016

2016-01-27T18:31:39Z

← Older revision		Revision as of 18:31, 27 January 2016
Line 11:		Line 11:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).		[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The discovery of inhibitors of bromodomain and extra terminal domain (BET) has achieved great progress, and at least seven inhibitors have progressed into clinical trials for the treatment of cancer or inflammatory diseases. Here, we describe the identification, optimization, and evaluation of benzo[cd]indol-2(1H)-one containing compounds as a new class of BET bromodomain inhibitors, starting from structure-based virtual screening (SBVS). Through structure-based optimization, potent compounds were obtained with significantly improved activity. The two most potent compounds bind to the BRD4 bromodomain, with Kd values of 124 and 137 nM. Selected compounds exhibited high selectivity over other non-BET subfamily members. Notably, compound 85 demonstrated a reasonable antiproliferation effect on MV4;11 leukemia cells and exhibited a good pharmacokinetic profile with high oral bioavailability (75.8%) and moderate half-life (T1/2 = 3.95 h). The resulting lead molecule 85 represents a new, potent, and selective class of BET bromodomain inhibitors for the development of therapeutics to treat cancer and inflammatory diseases.

			Discovery of Benzo[cd]indol-2(1H)-ones as Potent and Specific BET Bromodomain Inhibitors: Structure-Based Virtual Screening, Optimization, and Biological Evaluation.,Xue X, Zhang Y, Liu Z, Song M, Xing Y, Xiang Q, Wang Z, Tu Z, Zhou Y, Ding K, Xu Y J Med Chem. 2016 Jan 12. PMID:26731490<ref>PMID:26731490</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 5ctl" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
Line 22:		Line 31:
	[[Category: Brd4]]		[[Category: Brd4]]
	[[Category: Bromodomain]]		[[Category: Bromodomain]]
	~~[[Category: Dna binding protein-dna binding protein inhibitor complex]]~~
	[[Category: Four alpha helice]]		[[Category: Four alpha helice]]
	[[Category: ~~Inhibitor~~ complex]]		[[Category: Signaling protein-inhibitor complex]]

OCA at 20:30, 13 January 2016

2016-01-13T20:30:18Z

← Older revision		Revision as of 20:30, 13 January 2016
Line 1:		Line 1:
	'''~~Unreleased structure~~'''		==Crystal Structure of the first bromodomain of human BRD4 in complex with benzo[cd]indol-2(1H)-one ligand==
			<StructureSection load='5ctl' size='340' side='right' caption='[[5ctl]], [[Resolution\|resolution]] 2.51Å' scene=''>
	~~The entry~~ 5ctl is ~~ON HOLD until Paper Publication~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[5ctl]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CTL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CTL FirstGlance]. <br>
	~~Authors~~: ~~Zhang~~, Y., ~~Song~~, M., ~~Liu~~, Z., ~~Xue~~, X., Xu, Y.		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EB9:N-(1-ETHYL-2-OXO-1,2-DIHYDROBENZO[CD]INDOL-6-YL)BENZENESULFONAMIDE'>EB9</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5cp5\|5cp5]], [[5cpe\|5cpe]], [[5coi\|5coi]], [[5cqt\|5cqt]], [[5crm\|5crm]], [[5crz\|5crz]], [[5cs8\|5cs8]]</td></tr>
	~~Description~~: ~~Crystal Structure of the first bromodomain of human~~ BRD4 in ~~complex~~ with ~~benzo~~[cd]~~indol-2~~(1H)~~-one ligand~~		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ctl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ctl OCA], [http://pdbe.org/5ctl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ctl RCSB], [http://www.ebi.ac.uk/pdbsum/5ctl PDBsum]</span></td></tr>
	[[Category: ~~Unreleased Structures~~]]		</table>
			== Disease ==
			[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
			== Function ==
			[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
			== References ==
			<references/>
			__TOC__
			</StructureSection>
			[[Category: Liu, Z]]
			[[Category: Song, M]]
	[[Category: Xu, Y]]		[[Category: Xu, Y]]
			[[Category: Xue, X]]
	[[Category: Zhang, Y]]		[[Category: Zhang, Y]]
	[[Category: ~~Xue, X~~]]		[[Category: Brd4]]
	[[Category: ~~Liu, Z~~]]		[[Category: Bromodomain]]
	[[Category: ~~Song, M~~]]		[[Category: Dna binding protein-dna binding protein inhibitor complex]]
			[[Category: Four alpha helice]]
			[[Category: Inhibitor complex]]

OCA at 10:42, 16 December 2015

2015-12-16T10:42:44Z

← Older revision		Revision as of 10:42, 16 December 2015
Line 9:		Line 9:
	[[Category: Xu, Y]]		[[Category: Xu, Y]]
	[[Category: Zhang, Y]]		[[Category: Zhang, Y]]
			[[Category: Xue, X]]
	[[Category: Liu, Z]]		[[Category: Liu, Z]]
	[[Category: Song, M]]		[[Category: Song, M]]
	~~[[Category: Xue, X]]~~

OCA at 13:27, 12 August 2015

2015-08-12T13:27:18Z

← Older revision		Revision as of 13:27, 12 August 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 5ctl is ON HOLD		The entry 5ctl is ON HOLD until Paper Publication

	Authors: Zhang, Y., Song, M., Liu, Z., Xue, X., Xu, Y.		Authors: Zhang, Y., Song, M., Liu, Z., Xue, X., Xu, Y.

OCA: Protected "5ctl" [edit=sysop:move=sysop]

2015-07-29T13:52:23Z

Protected "5ctl" [edit=sysop:move=sysop]

← Older revision	Revision as of 13:52, 29 July 2015
(No difference)

OCA: New page: '''Unreleased structure''' The entry 5ctl is ON HOLD Authors: Zhang, Y., Song, M., Liu, Z., Xue, X., Xu, Y. Description: Crystal Structure of the first bromodomain of human BRD4 in com...

2015-07-29T13:52:21Z

New page: '''Unreleased structure''' The entry 5ctl is ON HOLD Authors: Zhang, Y., Song, M., Liu, Z., Xue, X., Xu, Y. Description: Crystal Structure of the first bromodomain of human BRD4 in com...

New page

'''Unreleased structure'''

The entry 5ctl is ON HOLD

Authors: Zhang, Y., Song, M., Liu, Z., Xue, X., Xu, Y.

Description: Crystal Structure of the first bromodomain of human BRD4 in complex with benzo[cd]indol-2(1H)-one ligand
[[Category: Unreleased Structures]]
[[Category: Xu, Y]]
[[Category: Zhang, Y]]
[[Category: Liu, Z]]
[[Category: Song, M]]
[[Category: Xue, X]]