5cus - Revision history

OCA at 08:40, 27 September 2023

2023-09-27T08:40:40Z

← Older revision		Revision as of 08:40, 27 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5cus]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CUS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CUS FirstGlance]. <br>		<table><tr><td colspan='2'>[[5cus]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CUS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CUS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.2Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cus FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cus OCA], [https://pdbe.org/5cus PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cus RCSB], [https://www.ebi.ac.uk/pdbsum/5cus PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cus ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cus FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cus OCA], [https://pdbe.org/5cus PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cus RCSB], [https://www.ebi.ac.uk/pdbsum/5cus PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cus ProSAT]</span></td></tr>
	</table>		</table>

OCA at 12:28, 14 June 2023

2023-06-14T12:28:39Z

← Older revision		Revision as of 12:28, 14 June 2023
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	==Crystal Structure of sErbB3-Fab3379 Complex==		==Crystal Structure of sErbB3-Fab3379 Complex==
	<StructureSection load='5cus' size='340' side='right' caption='[[5cus]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='5cus' size='340' side='right'caption='[[5cus]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5cus]] is a 12 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CUS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5CUS FirstGlance]. <br>		<table><tr><td colspan='2'>[[5cus]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CUS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CUS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene~~></td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ERBB3, HER3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cus FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cus OCA], [https://pdbe.org/5cus PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cus RCSB], [https://www.ebi.ac.uk/pdbsum/5cus PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cus ProSAT]</span></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5cus FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cus OCA], [~~http~~://pdbe.org/5cus PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5cus RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5cus PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5cus ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[~~[http~~://www.uniprot.org/uniprot/ERBB3_HUMAN ERBB3_HUMAN]] Defects in ERBB3 are the cause of lethal congenital contracture syndrome type 2 (LCCS2) [MIM:[~~http~~://omim.org/entry/607598 607598]]; also called Israeli Bedouin multiple contracture syndrome type A. LCCS2 is an autosomal recessive neurogenic form of a neonatally lethal arthrogryposis that is associated with atrophy of the anterior horn of the spinal cord. The LCCS2 syndrome is characterized by multiple joint contractures, anterior horn atrophy in the spinal cord, and a unique feature of a markedly distended urinary bladder. The phenotype suggests a spinal cord neuropathic etiology.<ref>PMID:17701904</ref>		[https://www.uniprot.org/uniprot/ERBB3_HUMAN ERBB3_HUMAN] Defects in ERBB3 are the cause of lethal congenital contracture syndrome type 2 (LCCS2) [MIM:[https://omim.org/entry/607598 607598]; also called Israeli Bedouin multiple contracture syndrome type A. LCCS2 is an autosomal recessive neurogenic form of a neonatally lethal arthrogryposis that is associated with atrophy of the anterior horn of the spinal cord. The LCCS2 syndrome is characterized by multiple joint contractures, anterior horn atrophy in the spinal cord, and a unique feature of a markedly distended urinary bladder. The phenotype suggests a spinal cord neuropathic etiology.<ref>PMID:17701904</ref>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/ERBB3_HUMAN ERBB3_HUMAN]] Binds and is activated by neuregulins and NTAK.<ref>PMID:15358134</ref>		[https://www.uniprot.org/uniprot/ERBB3_HUMAN ERBB3_HUMAN] Binds and is activated by neuregulins and NTAK.<ref>PMID:15358134</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: ~~Receptor protein-tyrosine kinase~~]]		[[Category: Large Structures]]
	[[Category: Lee, S]]		[[Category: Lee S]]
	[[Category: Schlessinger, J]]		[[Category: Schlessinger J]]
	~~[[Category: Antibody]]~~
	~~[[Category: Erbb3]]~~
	~~[[Category: Transferase~~]]

OCA at 09:50, 22 November 2017

2017-11-22T09:50:23Z

← Older revision		Revision as of 09:50, 22 November 2017
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	==Crystal Structure of sErbB3-Fab3379 Complex==		==Crystal Structure of sErbB3-Fab3379 Complex==
	<StructureSection load='5cus' size='340' side='right' caption='[[5cus]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='5cus' size='340' side='right' caption='[[5cus]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5cus]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CUS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CUS FirstGlance]. <br>		<table><tr><td colspan='2'>[[5cus]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CUS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CUS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ERBB3, HER3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cus FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cus OCA], [http://pdbe.org/5cus PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cus RCSB], [http://www.ebi.ac.uk/pdbsum/5cus PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cus FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cus OCA], [http://pdbe.org/5cus PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cus RCSB], [http://www.ebi.ac.uk/pdbsum/5cus PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5cus ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Human]]
	[[Category: Receptor protein-tyrosine kinase]]		[[Category: Receptor protein-tyrosine kinase]]
	[[Category: Lee, S]]		[[Category: Lee, S]]

OCA at 19:17, 30 November 2015

2015-11-30T19:17:42Z

← Older revision		Revision as of 19:17, 30 November 2015
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	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/ERBB3_HUMAN ERBB3_HUMAN]] Binds and is activated by neuregulins and NTAK.<ref>PMID:15358134</ref>		[[http://www.uniprot.org/uniprot/ERBB3_HUMAN ERBB3_HUMAN]] Binds and is activated by neuregulins and NTAK.<ref>PMID:15358134</ref>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			ErbB3 (HER3) is a member of the EGF receptor (EGFR) family of receptor tyrosine kinases, which, unlike the other three family members, contains a pseudo kinase in place of a tyrosine kinase domain. In cancer, ErbB3 activation is driven by a ligand-dependent mechanism through the formation of heterodimers with EGFR, ErbB2, or ErbB4 or via a ligand-independent process through heterodimerization with ErbB2 overexpressed in breast tumors or other cancers. Here we describe the crystal structure of the Fab fragment of an antagonistic monoclonal antibody KTN3379, currently in clinical development in human cancer patients, in complex with the ErbB3 extracellular domain. The structure reveals a unique allosteric mechanism for inhibition of ligand-dependent or ligand-independent ErbB3-driven cancers by binding to an epitope that locks ErbB3 in an inactive conformation. Given the similarities in the mechanism of ErbB receptor family activation, these findings could facilitate structure-based design of antibodies that inhibit EGFR and ErbB4 by an allosteric mechanism.

			Inhibition of ErbB3 by a monoclonal antibody that locks the extracellular domain in an inactive configuration.,Lee S, Greenlee EB, Amick JR, Ligon GF, Lillquist JS, Natoli EJ Jr, Hadari Y, Alvarado D, Schlessinger J Proc Natl Acad Sci U S A. 2015 Oct 27;112(43):13225-30. doi:, 10.1073/pnas.1518361112. Epub 2015 Oct 12. PMID:26460020<ref>PMID:26460020</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 5cus" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 04:08, 16 October 2015

2015-10-16T04:08:24Z

← Older revision		Revision as of 04:08, 16 October 2015
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	'''~~Unreleased structure~~'''		==Crystal Structure of sErbB3-Fab3379 Complex==
			<StructureSection load='5cus' size='340' side='right' caption='[[5cus]], [[Resolution\|resolution]] 3.20Å' scene=''>
	~~The entry~~ 5cus is ~~ON HOLD until Paper Publication~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[5cus]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CUS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CUS FirstGlance]. <br>
	~~Authors~~: ~~Lee~~, S., ~~Schlessinger~~, J.		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
			<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>
	~~Description~~: ~~Crystal Structure~~ of ~~sErbB3-Fab3379 Complex~~		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cus FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cus OCA], [http://pdbe.org/5cus PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cus RCSB], [http://www.ebi.ac.uk/pdbsum/5cus PDBsum]</span></td></tr>
	[[Category: ~~Unreleased Structures~~]]		</table>
			== Disease ==
			[[http://www.uniprot.org/uniprot/ERBB3_HUMAN ERBB3_HUMAN]] Defects in ERBB3 are the cause of lethal congenital contracture syndrome type 2 (LCCS2) [MIM:[http://omim.org/entry/607598 607598]]; also called Israeli Bedouin multiple contracture syndrome type A. LCCS2 is an autosomal recessive neurogenic form of a neonatally lethal arthrogryposis that is associated with atrophy of the anterior horn of the spinal cord. The LCCS2 syndrome is characterized by multiple joint contractures, anterior horn atrophy in the spinal cord, and a unique feature of a markedly distended urinary bladder. The phenotype suggests a spinal cord neuropathic etiology.<ref>PMID:17701904</ref>
			== Function ==
			[[http://www.uniprot.org/uniprot/ERBB3_HUMAN ERBB3_HUMAN]] Binds and is activated by neuregulins and NTAK.<ref>PMID:15358134</ref>
			== References ==
			<references/>
			__TOC__
			</StructureSection>
			[[Category: Receptor protein-tyrosine kinase]]
	[[Category: Lee, S]]		[[Category: Lee, S]]
	[[Category: Schlessinger, J]]		[[Category: Schlessinger, J]]
			[[Category: Antibody]]
			[[Category: Erbb3]]
			[[Category: Transferase]]

OCA at 12:09, 26 August 2015

2015-08-26T12:09:45Z

← Older revision		Revision as of 12:09, 26 August 2015
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 5cus is ON HOLD		The entry 5cus is ON HOLD until Paper Publication

	Authors: Lee, S., Schlessinger, J.		Authors: Lee, S., Schlessinger, J.

OCA: Protected "5cus" [edit=sysop:move=sysop]

2015-08-05T18:58:48Z

Protected "5cus" [edit=sysop:move=sysop]

← Older revision	Revision as of 18:58, 5 August 2015
(No difference)

OCA: New page: '''Unreleased structure''' The entry 5cus is ON HOLD Authors: Lee, S., Schlessinger, J. Description: Crystal Structure of sErbB3-Fab3379 Complex Category: Unreleased Structures [[C...

2015-08-05T18:58:47Z

New page: '''Unreleased structure''' The entry 5cus is ON HOLD Authors: Lee, S., Schlessinger, J. Description: Crystal Structure of sErbB3-Fab3379 Complex Category: Unreleased Structures [[C...

New page

'''Unreleased structure'''

The entry 5cus is ON HOLD

Authors: Lee, S., Schlessinger, J.

Description: Crystal Structure of sErbB3-Fab3379 Complex
[[Category: Unreleased Structures]]
[[Category: Lee, S]]
[[Category: Schlessinger, J]]