5dds - Revision history

OCA at 08:40, 9 April 2025

2025-04-09T08:40:40Z

← Older revision		Revision as of 08:40, 9 April 2025
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5dds]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Actinoalloteichus_sp._WH1-2216-6 Actinoalloteichus sp. WH1-2216-6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DDS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DDS FirstGlance]. <br>		<table><tr><td colspan='2'>[[5dds]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Actinoalloteichus_sp._WH1-2216-6 Actinoalloteichus sp. WH1-2216-6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DDS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DDS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5dds FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dds OCA], [https://pdbe.org/5dds PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5dds RCSB], [https://www.ebi.ac.uk/pdbsum/5dds PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5dds ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5dds FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dds OCA], [https://pdbe.org/5dds PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5dds RCSB], [https://www.ebi.ac.uk/pdbsum/5dds PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5dds ProSAT]</span></td></tr>
	</table>		</table>

OCA at 10:31, 21 June 2023

2023-06-21T10:31:36Z

← Older revision		Revision as of 10:31, 21 June 2023
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	<StructureSection load='5dds' size='340' side='right'caption='[[5dds]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='5dds' size='340' side='right'caption='[[5dds]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5dds]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Actinoalloteichus_sp.~~_wh1~~-2216-6 Actinoalloteichus sp. ~~wh1~~-2216-6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DDS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5DDS FirstGlance]. <br>		<table><tr><td colspan='2'>[[5dds]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Actinoalloteichus_sp._WH1-2216-6 Actinoalloteichus sp. WH1-2216-6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DDS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DDS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ddu\|5ddu]], [[5ddw\|5ddw]]</td></tr>~~		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5dds FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dds OCA], [https://pdbe.org/5dds PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5dds RCSB], [https://www.ebi.ac.uk/pdbsum/5dds PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5dds ProSAT]</span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5dds FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dds OCA], [~~http~~://pdbe.org/5dds PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5dds RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5dds PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5dds ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/H8Y6N2_9PSEU H8Y6N2_9PSEU]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Actinoalloteichus sp. ~~wh1~~-2216-6]]		[[Category: Actinoalloteichus sp. WH1-2216-6]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Feng, Z]]		[[Category: Feng Z]]
	[[Category: Liu, J]]		[[Category: Liu J]]
	[[Category: Xu, J]]		[[Category: Xu J]]
	~~[[Category: Aminotransferase]]~~
	~~[[Category: Caerulomycin some]]~~
	~~[[Category: Plp]]~~
	~~[[Category: Transferase~~]]

OCA at 08:00, 8 April 2020

2020-04-08T08:00:25Z

← Older revision		Revision as of 08:00, 8 April 2020
Line 1:		Line 1:

	==Crystal structure of aminotransferase CrmG from Actinoalloteichus sp. WH1-2216-6 in complex with PLP==		==Crystal structure of aminotransferase CrmG from Actinoalloteichus sp. WH1-2216-6 in complex with PLP==
	<StructureSection load='5dds' size='340' side='right' caption='[[5dds]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='5dds' size='340' side='right'caption='[[5dds]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5dds]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DDS OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca.weizmann.ac~~.~~il/oca-docs~~/fgij/fg.htm?mol=5DDS FirstGlance]. <br>		<table><tr><td colspan='2'>[[5dds]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Actinoalloteichus_sp._wh1-2216-6 Actinoalloteichus sp. wh1-2216-6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DDS OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5DDS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ddu\|5ddu]], [[5ddw\|5ddw]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ddu\|5ddu]], [[5ddw\|5ddw]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5dds FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dds OCA], [http://pdbe.org/5dds PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dds RCSB], [http://www.ebi.ac.uk/pdbsum/5dds PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5dds ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5dds FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dds OCA], [http://pdbe.org/5dds PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dds RCSB], [http://www.ebi.ac.uk/pdbsum/5dds PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5dds ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Actinoalloteichus sp. wh1-2216-6]]
			[[Category: Large Structures]]
	[[Category: Feng, Z]]		[[Category: Feng, Z]]
	[[Category: Liu, J]]		[[Category: Liu, J]]

OCA at 15:58, 10 August 2016

2016-08-10T15:58:46Z

← Older revision		Revision as of 15:58, 10 August 2016
Line 1:		Line 1:
	~~'''Unreleased structure'''~~

	~~The entry~~ 5dds is ~~ON HOLD until Paper~~ Publication		==Crystal structure of aminotransferase CrmG from Actinoalloteichus sp. WH1-2216-6 in complex with PLP==
			<StructureSection load='5dds' size='340' side='right' caption='[[5dds]], [[Resolution\|resolution]] 2.60Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[5dds]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DDS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DDS FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ddu\|5ddu]], [[5ddw\|5ddw]]</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dds FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dds OCA], [http://pdbe.org/5dds PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dds RCSB], [http://www.ebi.ac.uk/pdbsum/5dds PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5dds ProSAT]</span></td></tr>
			</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Caerulomycin A (CRM A 1) belongs to a family of natural products containing a 2,2'-bipyridyl ring core structure and is currently under development as a potent novel immunosuppressive agent. Herein, we report the functional characterization, kinetic analysis, substrate specificity, and structure insights of an aminotransferase CrmG in 1 biosynthesis. The aminotransferase CrmG was confirmed to catalyze a key transamination reaction to convert an aldehyde group to an amino group in the 1 biosynthetic pathway, preferring l-glutamate and l-glutamine as the amino donor substrates. The crystal structures of CrmG in complex with the cofactor 5'-pyridoxal phosphate (PLP) or 5'-pyridoxamine phosphate (PMP) or the acceptor substrate were determined to adopt a canonical fold-type I of PLP-dependent enzymes with a unique small additional domain. The structure guided site-directed mutagenesis identified key amino acid residues for substrate binding and catalytic activities, thus providing insights into the transamination mechanism of CrmG.

	~~Authors:~~ Xu, J., Feng, Z., Liu, J.		Biochemical and Structural Insights into the Aminotransferase CrmG in Caerulomycin Biosynthesis.,Zhu Y, Xu J, Mei X, Feng Z, Zhang L, Zhang Q, Zhang G, Zhu W, Liu J, Zhang C ACS Chem Biol. 2016 Apr 15;11(4):943-52. doi: 10.1021/acschembio.5b00984. Epub, 2016 Jan 12. PMID:26714051<ref>PMID:26714051</ref>

	~~Description: Crystal structure~~ of ~~aminotransferase CrmG from Actinoalloteichus sp~~. ~~WH1~~-~~2216~~-~~6 in complex with PLP~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~[[Category: Unreleased Structures]]~~		</div>
	~~[[Category: Xu, J]]~~		<div class="pdbe-citations 5dds" style="background-color:#fffaf0;"></div>
			== References ==
			<references/>
			__TOC__
			</StructureSection>
	[[Category: Feng, Z]]		[[Category: Feng, Z]]
	[[Category: Liu, J]]		[[Category: Liu, J]]
			[[Category: Xu, J]]
			[[Category: Aminotransferase]]
			[[Category: Caerulomycin some]]
			[[Category: Plp]]
			[[Category: Transferase]]

OCA at 11:05, 16 December 2015

2015-12-16T11:05:56Z

← Older revision		Revision as of 11:05, 16 December 2015
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	Description: Crystal structure of aminotransferase CrmG from Actinoalloteichus sp. WH1-2216-6 in complex with PLP		Description: Crystal structure of aminotransferase CrmG from Actinoalloteichus sp. WH1-2216-6 in complex with PLP
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
			[[Category: Xu, J]]
	[[Category: Feng, Z]]		[[Category: Feng, Z]]
	[[Category: Liu, J]]		[[Category: Liu, J]]
	~~[[Category: Xu, J]]~~

OCA at 10:04, 9 September 2015

2015-09-09T10:04:11Z

← Older revision		Revision as of 10:04, 9 September 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 5dds is ON HOLD		The entry 5dds is ON HOLD until Paper Publication

	Authors: Xu, J., Feng, Z., Liu, J.		Authors: Xu, J., Feng, Z., Liu, J.

OCA: Protected "5dds" [edit=sysop:move=sysop]

2015-09-02T11:31:12Z

Protected "5dds" [edit=sysop:move=sysop]

← Older revision	Revision as of 11:31, 2 September 2015
(No difference)

OCA: New page: '''Unreleased structure''' The entry 5dds is ON HOLD Authors: Xu, J., Feng, Z., Liu, J. Description: Crystal structure of aminotransferase CrmG from Actinoalloteichus sp. WH1-2216-6 in...

2015-09-02T11:31:11Z

New page: '''Unreleased structure''' The entry 5dds is ON HOLD Authors: Xu, J., Feng, Z., Liu, J. Description: Crystal structure of aminotransferase CrmG from Actinoalloteichus sp. WH1-2216-6 in...

New page

'''Unreleased structure'''

The entry 5dds is ON HOLD

Authors: Xu, J., Feng, Z., Liu, J.

Description: Crystal structure of aminotransferase CrmG from Actinoalloteichus sp. WH1-2216-6 in complex with PLP
[[Category: Unreleased Structures]]
[[Category: Feng, Z]]
[[Category: Liu, J]]
[[Category: Xu, J]]