5doi - Revision history

OCA at 09:10, 20 March 2024

2024-03-20T09:10:15Z

← Older revision		Revision as of 09:10, 20 March 2024
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	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/TAP19_TETTS TAP19_TETTS] Component of a CST-like subcomplex of the holoenzyme telomerase ribonucleoprotein complex, which stimulates telomerase complementary-strand synthesis (PubMed:26551074). Telomerase is an essential ribonucleoprotein enzyme that copies new telomeric repeats onto chromosome ends by repetitively synthesizing the short telomere-repeat sequence 5'-TTGGGG-3' using an RNA template component TER (PubMed:26551074). The CST-like subcomplex (also named 7-4-1) binds telomeric single-stranded DNA and coordinates telomere G-strand and C-strand synthesis (PubMed:26551074).<ref>PMID:26551074</ref>		[https://www.uniprot.org/uniprot/TAP19_TETTS TAP19_TETTS] Component of a CST-like subcomplex of the holoenzyme telomerase ribonucleoprotein complex, which stimulates telomerase complementary-strand synthesis (PubMed:26551074). Telomerase is an essential ribonucleoprotein enzyme that copies new telomeric repeats onto chromosome ends by repetitively synthesizing the short telomere-repeat sequence 5'-TTGGGG-3' using an RNA template component TER (PubMed:26551074). The CST-like subcomplex (also named 7-4-1) binds telomeric single-stranded DNA and coordinates telomere G-strand and C-strand synthesis (PubMed:26551074).<ref>PMID:26551074</ref>
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	Tetrahymena telomerase holoenzyme subunits p75, p45 and p19 form a subcomplex (7-4-1) peripheral to the catalytic core. We report structures of p45 and p19 and reveal them as the Stn1 and Ten1 subunits of the CST complex, which stimulates telomerase complementary-strand synthesis. 7-4-1 binds telomeric single-stranded DNA, and mutant p19 overexpression causes telomere 3'-overhang elongation. We propose that telomerase-tethered Tetrahymena CST coordinates telomere G-strand and C-strand synthesis.

	The Tetrahymena telomerase p75-p45-p19 subcomplex is a unique CST complex.,Wan B, Tang T, Upton H, Shuai J, Zhou Y, Li S, Chen J, Brunzelle JS, Zeng Z, Collins K, Wu J, Lei M Nat Struct Mol Biol. 2015 Nov 9. doi: 10.1038/nsmb.3126. PMID:26551074<ref>PMID:26551074</ref>

	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~<div class="pdbe-citations 5doi" style="background-color:#fffaf0;"></div>~~

	==See Also==		==See Also==

OCA at 21:53, 28 June 2023

2023-06-28T21:53:03Z

← Older revision		Revision as of 21:53, 28 June 2023
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	<StructureSection load='5doi' size='340' side='right'caption='[[5doi]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='5doi' size='340' side='right'caption='[[5doi]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5doi]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Tetth Tetth~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DOI OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5DOI FirstGlance]. <br>		<table><tr><td colspan='2'>[[5doi]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Tetrahymena_thermophila Tetrahymena thermophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DOI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DOI FirstGlance]. <br>
	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[5dof\|5dof]], [[5dok\|5dok]]</td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">TAP19 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax~~.~~cgi?mode=Info~~&~~srchmode=5&id=5911 TETTH]), TAP45 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5911 TETTH])~~</td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5doi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5doi OCA], [https://pdbe.org/5doi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5doi RCSB], [https://www.ebi.ac.uk/pdbsum/5doi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5doi ProSAT]</span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5doi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5doi OCA], [~~http~~://pdbe.org/5doi PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5doi RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5doi PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5doi ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/TAP19_TETTS TAP19_TETTS] Component of a CST-like subcomplex of the holoenzyme telomerase ribonucleoprotein complex, which stimulates telomerase complementary-strand synthesis (PubMed:26551074). Telomerase is an essential ribonucleoprotein enzyme that copies new telomeric repeats onto chromosome ends by repetitively synthesizing the short telomere-repeat sequence 5'-TTGGGG-3' using an RNA template component TER (PubMed:26551074). The CST-like subcomplex (also named 7-4-1) binds telomeric single-stranded DNA and coordinates telomere G-strand and C-strand synthesis (PubMed:26551074).<ref>PMID:26551074</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Tetth~~]]		[[Category: Tetrahymena thermophila]]
	[[Category: Lei, M]]		[[Category: Lei M]]
	[[Category: Tang, T]]		[[Category: Tang T]]
	[[Category: Wan, B]]		[[Category: Wan B]]
	[[Category: Wu, J]]		[[Category: Wu J]]
	~~[[Category: Dna binding protein]]~~
	~~[[Category: Ob fold]]~~
	~~[[Category: Telomerase]]~~
	~~[[Category: Tetrahymena~~]]

OCA at 08:12, 8 April 2020

2020-04-08T08:12:30Z

← Older revision		Revision as of 08:12, 8 April 2020
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	==Crystal structure of Tetrahymena p45N and p19==		==Crystal structure of Tetrahymena p45N and p19==
	<StructureSection load='5doi' size='340' side='right' caption='[[5doi]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='5doi' size='340' side='right'caption='[[5doi]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5doi]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DOI OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca.weizmann.ac~~.~~il/oca-docs~~/fgij/fg.htm?mol=5DOI FirstGlance]. <br>		<table><tr><td colspan='2'>[[5doi]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Tetth Tetth]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DOI OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5DOI FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5dof\|5dof]], [[5dok\|5dok]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5dof\|5dof]], [[5dok\|5dok]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5doi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5doi OCA], [http://pdbe.org/5doi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5doi RCSB], [http://www.ebi.ac.uk/pdbsum/5doi PDBsum]</span></td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TAP19 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5911 TETTH]), TAP45 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5911 TETTH])</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5doi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5doi OCA], [http://pdbe.org/5doi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5doi RCSB], [http://www.ebi.ac.uk/pdbsum/5doi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5doi ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</div>		</div>
	<div class="pdbe-citations 5doi" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5doi" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[P19\|P19]]
			*[[Telomerase-associated protein\|Telomerase-associated protein]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
			[[Category: Tetth]]
	[[Category: Lei, M]]		[[Category: Lei, M]]
	[[Category: Tang, T]]		[[Category: Tang, T]]

OCA at 04:38, 1 December 2015

2015-12-01T04:38:31Z

← Older revision		Revision as of 04:38, 1 December 2015
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	'''~~Unreleased~~ structure'''		==Crystal structure of Tetrahymena p45N and p19==
			<StructureSection load='5doi' size='340' side='right' caption='[[5doi]], [[Resolution\|resolution]] 2.20Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[5doi]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DOI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DOI FirstGlance]. <br>
			</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5dof\|5dof]], [[5dok\|5dok]]</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5doi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5doi OCA], [http://pdbe.org/5doi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5doi RCSB], [http://www.ebi.ac.uk/pdbsum/5doi PDBsum]</span></td></tr>
			</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Tetrahymena telomerase holoenzyme subunits p75, p45 and p19 form a subcomplex (7-4-1) peripheral to the catalytic core. We report structures of p45 and p19 and reveal them as the Stn1 and Ten1 subunits of the CST complex, which stimulates telomerase complementary-strand synthesis. 7-4-1 binds telomeric single-stranded DNA, and mutant p19 overexpression causes telomere 3'-overhang elongation. We propose that telomerase-tethered Tetrahymena CST coordinates telomere G-strand and C-strand synthesis.

	The ~~entry 5doi~~ is ~~ON HOLD until Paper Publication~~		The Tetrahymena telomerase p75-p45-p19 subcomplex is a unique CST complex.,Wan B, Tang T, Upton H, Shuai J, Zhou Y, Li S, Chen J, Brunzelle JS, Zeng Z, Collins K, Wu J, Lei M Nat Struct Mol Biol. 2015 Nov 9. doi: 10.1038/nsmb.3126. PMID:26551074<ref>PMID:26551074</ref>

	~~Authors: Wan~~, B.~~, Tang, T~~.~~, Wu, J., Lei, M~~.		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~Description~~: ~~Crystal structure of Tetrahymena p45N and p19~~		<div class="pdbe-citations 5doi" style="background-color:#fffaf0;"></div>
	~~[[Category: Unreleased Structures]]~~		== References ==
			<references/>
			__TOC__
			</StructureSection>
	[[Category: Lei, M]]		[[Category: Lei, M]]
			[[Category: Tang, T]]
	[[Category: Wan, B]]		[[Category: Wan, B]]
	[[Category: Wu, J]]		[[Category: Wu, J]]
	[[Category: ~~Tang, T~~]]		[[Category: Dna binding protein]]
			[[Category: Ob fold]]
			[[Category: Telomerase]]
			[[Category: Tetrahymena]]

OCA: Protected "5doi" [edit=sysop:move=sysop]

2015-09-30T13:16:57Z

Protected "5doi" [edit=sysop:move=sysop]

← Older revision	Revision as of 13:16, 30 September 2015
(No difference)

OCA: New page: '''Unreleased structure''' The entry 5doi is ON HOLD until Paper Publication Authors: Wan, B., Tang, T., Wu, J., Lei, M. Description: Crystal structure of Tetrahymena p45N and p19 [[Ca...

2015-09-30T13:16:56Z

New page: '''Unreleased structure''' The entry 5doi is ON HOLD until Paper Publication Authors: Wan, B., Tang, T., Wu, J., Lei, M. Description: Crystal structure of Tetrahymena p45N and p19 [[Ca...

New page

'''Unreleased structure'''

The entry 5doi is ON HOLD until Paper Publication

Authors: Wan, B., Tang, T., Wu, J., Lei, M.

Description: Crystal structure of Tetrahymena p45N and p19
[[Category: Unreleased Structures]]
[[Category: Lei, M]]
[[Category: Wan, B]]
[[Category: Wu, J]]
[[Category: Tang, T]]