5e8a - Revision history

OCA at 06:16, 5 July 2023

2023-07-05T06:16:50Z

← Older revision		Revision as of 06:16, 5 July 2023
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	<StructureSection load='5e8a' size='340' side='right'caption='[[5e8a]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='5e8a' size='340' side='right'caption='[[5e8a]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5e8a]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E8A OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5E8A FirstGlance]. <br>		<table><tr><td colspan='2'>[[5e8a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E8A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5E8A FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5KS:3-DEOXY-3-[4-(4-FLUOROPHENYL)-1H-1,2,3-TRIAZOL-1-YL]-BETA-D-GALACTOPYRANOSYL+3-DEOXY-3-[4-(4-FLUOROPHENYL)-1H-1,2,3-TRIAZOL-1-YL]-1-THIO-BETA-D-GALACTOPYRANOSIDE'>5KS</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>~~</td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.5Å</td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5e89\|5e89]], [[5e88\|5e88]]</td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5KS:3-DEOXY-3-[4-(4-FLUOROPHENYL)-1H-1,2,3-TRIAZOL-1-YL]-BETA-D-GALACTOPYRANOSYL+3-DEOXY-3-[4-(4-FLUOROPHENYL)-1H-1,2,3-TRIAZOL-1-YL]-1-THIO-BETA-D-GALACTOPYRANOSIDE'>5KS</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LGALS3, MAC2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5e8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e8a OCA], [https://pdbe.org/5e8a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5e8a RCSB], [https://www.ebi.ac.uk/pdbsum/5e8a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5e8a ProSAT]</span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5e8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e8a OCA], [~~http~~://pdbe.org/5e8a PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5e8a RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5e8a PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5e8a ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/LEG3_HUMAN LEG3_HUMAN]] Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.<ref>PMID:15181153</ref> <ref>PMID:19594635</ref> <ref>PMID:19616076</ref>		[https://www.uniprot.org/uniprot/LEG3_HUMAN LEG3_HUMAN] Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.<ref>PMID:15181153</ref> <ref>PMID:19594635</ref> <ref>PMID:19616076</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Blanchard, H]]		[[Category: Blanchard H]]
	[[Category: Collins~~, P M]]~~		[[Category: Collins PM]]
	~~[[Category: Beta sandwich]]~~
	~~[[Category: Carbohydrate binding protein]]~~
	~~[[Category: Carbohydrate-recognition]]~~
	~~[[Category: Inhibitor]]~~
	~~[[Category: Sugar binding protein]]~~
	~~[[Category: Sugar binding protein-inhibitor complex~~]]

OCA at 06:47, 22 April 2020

2020-04-22T06:47:37Z

← Older revision		Revision as of 06:47, 22 April 2020
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	==Crystal structure of Human galectin-3 CRD in complex with 4-fluophenyl-1,2,3-triazolyl thiodigalactoside inhibitor==		==Crystal structure of Human galectin-3 CRD in complex with 4-fluophenyl-1,2,3-triazolyl thiodigalactoside inhibitor==
	<StructureSection load='5e8a' size='340' side='right' caption='[[5e8a]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='5e8a' size='340' side='right'caption='[[5e8a]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5e8a]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E8A OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca.weizmann.ac~~.~~il/oca-docs~~/fgij/fg.htm?mol=5E8A FirstGlance]. <br>		<table><tr><td colspan='2'>[[5e8a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E8A OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5E8A FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5KS:3-DEOXY-3-[4-(4-FLUOROPHENYL)-1H-1,2,3-TRIAZOL-1-YL]-BETA-D-GALACTOPYRANOSYL+3-DEOXY-3-[4-(4-FLUOROPHENYL)-1H-1,2,3-TRIAZOL-1-YL]-1-THIO-BETA-D-GALACTOPYRANOSIDE'>5KS</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5KS:3-DEOXY-3-[4-(4-FLUOROPHENYL)-1H-1,2,3-TRIAZOL-1-YL]-BETA-D-GALACTOPYRANOSYL+3-DEOXY-3-[4-(4-FLUOROPHENYL)-1H-1,2,3-TRIAZOL-1-YL]-1-THIO-BETA-D-GALACTOPYRANOSIDE'>5KS</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5e89\|5e89]], [[5e88\|5e88]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5e89\|5e89]], [[5e88\|5e88]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5e8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e8a OCA], [http://pdbe.org/5e8a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5e8a RCSB], [http://www.ebi.ac.uk/pdbsum/5e8a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5e8a ProSAT]</span></td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LGALS3, MAC2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5e8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e8a OCA], [http://pdbe.org/5e8a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5e8a RCSB], [http://www.ebi.ac.uk/pdbsum/5e8a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5e8a ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 5e8a" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5e8a" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Galectin 3D structures\|Galectin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Blanchard, H]]		[[Category: Blanchard, H]]
	[[Category: Collins, P M]]		[[Category: Collins, P M]]

OCA at 06:50, 10 September 2016

2016-09-10T06:50:50Z

@@ Line 1: / Line 1: @@
-The entry 5e8a is ON HOLD  until Paper Publication
+==Crystal structure of Human galectin-3 CRD in complex with 4-fluophenyl-1,2,3-triazolyl thiodigalactoside inhibitor==
-Authors: Collins, P.M., Blanchard, H.
+Galectin-3-Binding Glycomimetics that Strongly Reduce Bleomycin-Induced Lung Fibrosis and Modulate Intracellular Glycan Recognition.,Delaine T, Collins P, MacKinnon A, Sharma G, Stegmayr J, Rajput VK, Mandal S, Cumpstey I, Larumbe A, Salameh BA, Kahl-Knutsson B, van Hattum H, van Scherpenzeel M, Pieters RJ, Sethi T, Schambye H, Oredsson S, Leffler H, Blanchard H, Nilsson UJ Chembiochem. 2016 Jun 29. doi: 10.1002/cbic.201600285. PMID:27356186<ref>PMID:27356186</ref>
-Description: Crystal structure of Human galectin-3 CRD in complex with 4-fluophenyl-1,2,3-triazolyl thiodigalactoside inhibitor
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
 [[Category: Blanchard, H]]
-[[Category: Collins, P.M]]
+[[Category: Collins, P M]]

OCA at 02:30, 1 December 2015

2015-12-01T02:30:59Z

← Older revision		Revision as of 02:30, 1 December 2015
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 5e8a is ON HOLD		The entry 5e8a is ON HOLD until Paper Publication

	Authors: Collins, P.M., Blanchard, H.		Authors: Collins, P.M., Blanchard, H.

OCA: Protected "5e8a" [edit=sysop:move=sysop]

2015-10-22T04:30:21Z

Protected "5e8a" [edit=sysop:move=sysop]

← Older revision	Revision as of 04:30, 22 October 2015
(No difference)

OCA: New page: '''Unreleased structure''' The entry 5e8a is ON HOLD Authors: Collins, P.M., Blanchard, H. Description: Crystal structure of Human galectin-3 CRD in complex with 4-fluophenyl-1,2,3-tri...

2015-10-22T04:30:20Z

New page: '''Unreleased structure''' The entry 5e8a is ON HOLD Authors: Collins, P.M., Blanchard, H. Description: Crystal structure of Human galectin-3 CRD in complex with 4-fluophenyl-1,2,3-tri...

New page

'''Unreleased structure'''

The entry 5e8a is ON HOLD

Authors: Collins, P.M., Blanchard, H.

Description: Crystal structure of Human galectin-3 CRD in complex with 4-fluophenyl-1,2,3-triazolyl thiodigalactoside inhibitor
[[Category: Unreleased Structures]]
[[Category: Blanchard, H]]
[[Category: Collins, P.M]]